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| TissGeneSummary for KCNJ16 |
 Gene summary |
| Basic gene information | Gene symbol | KCNJ16 |
| Gene name | potassium inwardly-rectifying channel, subfamily J, member 16 | |
| Synonyms | BIR9|KIR5.1 | |
| Cytomap | UCSC genome browser: 17q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001270422.1, NM_001291622.1,NM_001291623.1,NM_001291624.1,NM_001291625.1, NM_018658.2,NM_170741.2,NM_170742.2, | |
| Description | inward rectifier K(+) channel Kir5.1inward rectifier K+ channel KIR5.1inward rectifier potassium channel 16potassium channel, inwardly rectifying subfamily J member 16 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605722 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000153822 | ||
| HPRD : 16146 | ||
| Vega : OTTHUMG00000180349 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KCNJ16 | |
| BioGPS: 3773 | ||
| Pathway | NCI Pathway Interaction Database: KCNJ16 | |
| KEGG: KCNJ16 | ||
| REACTOME: KCNJ16 | ||
| Pathway Commons: KCNJ16 | ||
| Context | iHOP: KCNJ16 | |
| ligand binding site mutation search in PubMed: KCNJ16 | ||
| UCL Cancer Institute: KCNJ16 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTHCA | |
| Reference showing the relevant tissue of KCNJ16 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KCNJ16 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -3.619622883 | 0.516581117 | -4.136204 | 2.42E-16 | 9.77E-15 |
| KIRC | 6.38534534 | 8.002781451 | -1.617436111 | 5.63E-26 | 7.42E-25 |
| BRCA | -3.379023374 | 1.368749433 | -4.747772807 | 7.51E-52 | 7.36E-50 |
| KICH | -2.371394883 | 7.794101117 | -10.165496 | 9.48E-17 | 3.21E-15 |
| LUAD | -2.536157917 | -0.135480331 | -2.400677586 | 2.50E-10 | 1.42E-09 |
| STAD | -2.728311258 | -0.319173758 | -2.4091375 | 0.00171 | 0.008113481 |
| PRAD | -3.902282652 | -2.21521919 | -1.687063462 | 0.00276 | 0.007789874 |
| LUSC | -1.989650412 | -0.591348451 | -1.398301961 | 0.00275 | 0.004789637 |
| COAD | -3.831565344 | -2.373157652 | -1.458407692 | 0.000722 | 0.002146407 |
| HNSC | -3.684326883 | -1.572766417 | -2.111560465 | 8.93E-05 | 0.000407556 |
| Top |
| TissGene-miRNA for KCNJ16 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KCNJ16 |
| TissGeneSNV for KCNJ16 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L83I | COAD | 2 |
| p.E292* | LUSC | 1 |
| p.Y166H | LUSC | 1 |
| p.Q452* | SKCM | 1 |
| p.M36I | CESC | 1 |
| p.V59F | LUAD | 1 |
| p.R71C | UCEC | 1 |
| p.A50E | LUAD | 1 |
| p.R406* | STAD | 1 |
| p.S29F | SKCM | 1 |
| p.W306X | READ | 1 |
| p.E13K | SKCM | 1 |
| p.A393T | HNSC | 1 |
| p.A369V | COAD | 1 |
| p.G168E | SKCM | 1 |
| p.V300D | STAD | 1 |
| p.G155R | SKCM | 1 |
| p.R211Q | SKCM | 1 |
| p.R222C | STAD | 1 |
| p.S397Y | ESCA | 1 |
| p.P10R | HNSC | 1 |
| p.V98M | UCEC | 1 |
| p.S144Y | BLCA | 1 |
| p.T232M | STAD | 1 |
| p.G330E | SKCM | 1 |
| p.M1I | CESC | 1 |
| p.H49Q | LUAD | 1 |
| p.K273N | STAD | 1 |
| p.K355R | THCA | 1 |
| p.E434K | SKCM | 1 |
| p.D272Y | LUAD | 1 |
| p.S427F | BLCA | 1 |
| p.R183L | LUAD | 1 |
| p.P436H | LGG | 1 |
| p.R218C | HNSC | 1 |
| p.V94F | LUAD | 1 |
| p.R106H | PRAD | 1 |
| p.G40D | KIRC | 1 |
| p.H134Y | BLCA | 1 |
| p.R268H | STAD | 1 |
| p.A410T | KIRP | 1 |
| p.A428T | HNSC | 1 |
| p.E295Q | LUAD | 1 |
| p.R137H | STAD | 1 |
| p.R371X | STAD | 1 |
| p.R217I | LUAD | 1 |
| p.T99P | SKCM | 1 |
| p.A413T | KIRP | 1 |
| p.R337* | UVM | 1 |
| p.R252I | LUAD | 1 |
| p.L305F | SKCM | 1 |
| p.S179Y | BLCA | 1 |
| p.R222C | COAD | 1 |
| p.I60V | PAAD | 1 |
| p.S392F | BLCA | 1 |
| p.V182M | STAD | 1 |
| p.L340F | SKCM | 1 |
| p.I25V | PAAD | 1 |
| p.H308Y | LIHC | 1 |
| p.W236L | LUAD | 1 |
| p.G365E | SKCM | 1 |
| p.R433K | SKCM | 1 |
| p.K390R | THCA | 1 |
| p.E303* | UCEC | 1 |
| p.G87V | LUAD | 1 |
| p.R302X | UVM | 1 |
| p.E260Q | LUAD | 1 |
| p.P336S | BLCA | 1 |
| p.A378T | KIRP | 1 |
| p.G133E | SKCM | 1 |
| p.D136H | LUAD | 1 |
| p.P421H | LGG | 1 |
| p.W85* | LUAD | 1 |
| p.A15S | BRCA | 1 |
| p.R218L | LUAD | 1 |
| p.R137H | UCEC | 1 |
| p.T422I | UCEC | 1 |
| p.H84Q | LUAD | 1 |
| p.A203S | ESCA | 1 |
| p.A168S | ESCA | 1 |
| p.R35X | PAAD | 1 |
| p.D274V | THYM | 1 |
| p.R35* | PAAD | 1 |
| p.R202H | COAD | 1 |
| p.Y38C | PCPG | 1 |
| p.F219L | BLCA | 1 |
| p.D40Y | CESC | 1 |
| p.D237Y | UCEC | 1 |
| p.R70* | PAAD | 1 |
| p.W120* | LUAD | 1 |
| p.S152F | SKCM | 1 |
| p.W306C | ESCA | 1 |
| p.L272F | GBM | 1 |
| p.D348N | UCEC | 1 |
| p.Y116* | LUAD | 1 |
| p.A369T | UCEC | 1 |
| p.V147M | STAD | 1 |
| Top |
| TissGeneCNV for KCNJ16 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KCNJ16 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-A1-A0SN-01A | TLK2-KCNJ16 | CDS-5'UTR | chr17:60558567 | chr17:68096798 |
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| TissGeneNet for KCNJ16 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| COAD (tumor) | COAD (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| KICH (tumor) | KICH (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| STAD (tumor) | STAD (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| THCA (tumor) | THCA (normal) |
| KCNJ16, KCNJ2, KCNJ15, KCNJ10 (tumor) | KCNJ16, KCNJ2, KCNJ15, KCNJ10 (normal) |
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| TissGeneProg for KCNJ16 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KCNJ16 |
| TissGeneDrug for KCNJ16 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KCNJ16 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2748572 | SeSAME syndrome | 2 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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