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TissGeneSummary for KHK |
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Basic gene information | Gene symbol | KHK |
Gene name | ketohexokinase (fructokinase) | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_000221.2, NM_006488.2, | |
Description | hepatic fructokinaseketohexokinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 614058 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138030 | ||
HPRD : 11774 | ||
Vega : OTTHUMG00000097077 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KHK | |
BioGPS: 3795 | ||
Pathway | NCI Pathway Interaction Database: KHK | |
KEGG: KHK | ||
REACTOME: KHK | ||
Pathway Commons: KHK | ||
Context | iHOP: KHK | |
ligand binding site mutation search in PubMed: KHK | ||
UCL Cancer Institute: KHK | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of KHK | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0046835 | carbohydrate phosphorylation | 22371574 | GO:0046835 | carbohydrate phosphorylation | 22371574 |
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TissGeneExp for KHK |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 5.35278161 | 6.89938561 | -1.546604 | 8.44E-08 | 6.03E-07 |
KICH | -0.37124039 | 3.65633161 | -4.027572 | 5.04E-11 | 4.22E-10 |
KIRP | 2.183140235 | 4.99611211 | -2.812971875 | 2.69E-07 | 1.52E-06 |
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TissGene-miRNA for KHK |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KHK |
TissGeneSNV for KHK |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V49I | COAD | 2 |
p.R152Q | UCEC | 1 |
p.K165N | LUSC | 1 |
p.R216T | SARC | 1 |
p.E26D | THYM | 1 |
p.Q146H | KIRC | 1 |
p.S62L | LUAD | 1 |
p.F71Y | KIRP | 1 |
p.R279T | CESC | 1 |
p.L53F | UCEC | 1 |
p.R176Q | COAD | 1 |
p.Q38R | KIRC | 1 |
p.S28W | BLCA | 1 |
p.R77H | KIRC | 1 |
p.V264I | COAD | 1 |
p.W37C | KIRP | 1 |
p.F245L | KIRP | 1 |
p.D243A | MESO | 1 |
p.R78Q | STAD | 1 |
p.L208F | LUAD | 1 |
p.S144P | KIRC | 1 |
p.A232S | HNSC | 1 |
p.R279K | SKCM | 1 |
p.Y79H | CESC | 1 |
p.R78C | HNSC | 1 |
p.V264I | STAD | 1 |
p.A155T | PRAD | 1 |
p.A143T | COAD | 1 |
p.A244T | HNSC | 1 |
p.A232S | LUSC | 1 |
p.R84H | STAD | 1 |
p.E29D | COAD | 1 |
p.R77C | ACC | 1 |
p.A43T | UCS | 1 |
p.A204T | STAD | 1 |
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TissGeneCNV for KHK |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KHK |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KHK |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KHK |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KHK |
TissGeneDrug for KHK |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KHK |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0268160 | Deficiency of fructokinase | 3 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree,LHGDN |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0018799 | Heart Diseases | 1 | BeFree |
umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
umls:C0920715 | myocardial hypoxia | 1 | BeFree |
umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |