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| TissGeneSummary for KHK |
 Gene summary |
| Basic gene information | Gene symbol | KHK |
| Gene name | ketohexokinase (fructokinase) | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 2p23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000221.2, NM_006488.2, | |
| Description | hepatic fructokinaseketohexokinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614058 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138030 | ||
| HPRD : 11774 | ||
| Vega : OTTHUMG00000097077 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KHK | |
| BioGPS: 3795 | ||
| Pathway | NCI Pathway Interaction Database: KHK | |
| KEGG: KHK | ||
| REACTOME: KHK | ||
| Pathway Commons: KHK | ||
| Context | iHOP: KHK | |
| ligand binding site mutation search in PubMed: KHK | ||
| UCL Cancer Institute: KHK | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of KHK | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0046835 | carbohydrate phosphorylation | 22371574 | GO:0046835 | carbohydrate phosphorylation | 22371574 |
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| TissGeneExp for KHK |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 5.35278161 | 6.89938561 | -1.546604 | 8.44E-08 | 6.03E-07 |
| KICH | -0.37124039 | 3.65633161 | -4.027572 | 5.04E-11 | 4.22E-10 |
| KIRP | 2.183140235 | 4.99611211 | -2.812971875 | 2.69E-07 | 1.52E-06 |
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| TissGene-miRNA for KHK |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KHK |
| TissGeneSNV for KHK |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V49I | COAD | 2 |
| p.R152Q | UCEC | 1 |
| p.K165N | LUSC | 1 |
| p.R216T | SARC | 1 |
| p.E26D | THYM | 1 |
| p.Q146H | KIRC | 1 |
| p.S62L | LUAD | 1 |
| p.F71Y | KIRP | 1 |
| p.R279T | CESC | 1 |
| p.L53F | UCEC | 1 |
| p.R176Q | COAD | 1 |
| p.Q38R | KIRC | 1 |
| p.S28W | BLCA | 1 |
| p.R77H | KIRC | 1 |
| p.V264I | COAD | 1 |
| p.W37C | KIRP | 1 |
| p.F245L | KIRP | 1 |
| p.D243A | MESO | 1 |
| p.R78Q | STAD | 1 |
| p.L208F | LUAD | 1 |
| p.S144P | KIRC | 1 |
| p.A232S | HNSC | 1 |
| p.R279K | SKCM | 1 |
| p.Y79H | CESC | 1 |
| p.R78C | HNSC | 1 |
| p.V264I | STAD | 1 |
| p.A155T | PRAD | 1 |
| p.A143T | COAD | 1 |
| p.A244T | HNSC | 1 |
| p.A232S | LUSC | 1 |
| p.R84H | STAD | 1 |
| p.E29D | COAD | 1 |
| p.R77C | ACC | 1 |
| p.A43T | UCS | 1 |
| p.A204T | STAD | 1 |
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| TissGeneCNV for KHK |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KHK |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KHK |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| COAD (tumor) | COAD (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| KICH (tumor) | KICH (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| STAD (tumor) | STAD (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| THCA (tumor) | THCA (normal) |
| KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (tumor) | KHK, RNPS1, CD2BP2, CDK5RAP3, ILK, ARRB1, LYZ, SNRPB, DEDD, AP2S1, RANBP3, LCN1 (normal) |
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| TissGeneProg for KHK |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KHK |
| TissGeneDrug for KHK |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KHK |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0268160 | Deficiency of fructokinase | 3 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree,LHGDN |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0018799 | Heart Diseases | 1 | BeFree |
| umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
| umls:C0920715 | myocardial hypoxia | 1 | BeFree |
| umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |
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