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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KLK2
check button Gene summary
Basic gene informationGene symbolKLK2
Gene namekallikrein-related peptidase 2
SynonymsKLK2A2|hGK-1|hK2
CytomapUCSC genome browser: 19q13.41
Type of geneprotein-coding
RefGenesNM_001002231.2,
NM_001256080.1,NM_005551.4,NR_045762.1,NR_045763.1,
NM_001002232.2,
Descriptionglandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatickallikrein-2tissue kallikrein-2
Modification date20141207
dbXrefs MIM : 147960
HGNC : HGNC
Ensembl : ENSG00000167751
HPRD : 01006
Vega : OTTHUMG00000182963
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK2
BioGPS: 3817
PathwayNCI Pathway Interaction Database: KLK2
KEGG: KLK2
REACTOME: KLK2
Pathway Commons: KLK2
ContextiHOP: KLK2
ligand binding site mutation search in PubMed: KLK2
UCL Cancer Institute: KLK2
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRAD
Reference showing the relevant tissue of KLK2Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Ylitalo EB, Thysell E, Jernberg E, Lundholm M, Crnalic S, Egevad L, Stattin P, Widmark A, Bergh A, Wikström P. Eur Urol. 2017 May;71(5):776-787. doi: 10.1016/j.eururo.2016.07.033. Epub 2016 Aug 3. (pmid:27497761)
go to article
Description by TissGene annotationsCancer gene
TissgsKTS
Fused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KLK2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA-1.0952704550.193769896-1.2890403512.26E-065.99E-06
THCA0.6590442054.432334035-3.7732898318.18E-202.97E-18
KICH1.426264002-2.3725759983.798841.78E-091.07E-08
PRAD14.3553350812.585390851.7699442310.0002930.001103551
LUSC-0.917056626-2.030040941.1129843140.0002220.00044479


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TissGene-miRNA for KLK2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KLK2
TissGeneSNV for KLK2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E161KCESC2
p.E84KSKCM1
p.P216SLUAD1
p.M122ILUAD1
p.N260KLUAD1
p.R125CSTAD1
p.P19LSKCM1
p.L217PESCA1
p.D207NCESC1
p.R77WSKCM1
p.E161KSKCM1
p.A147GLUAD1
p.G28VPAAD1
p.A185PLUAD1
p.T203IUCEC1
p.P237SOV1
p.P57TCOAD1
p.R250QSKCM1
p.L217RLUAD1
p.V18LLUSC1
p.Y243HBLCA1
p.S213YUCEC1
p.P240LBRCA1
p.I253MHNSC1
p.S11FSKCM1
p.E238KHNSC1
p.W157CLUAD1
p.S110RLUAD1
p.F81SBRCA1
p.Q39HLUAD1
p.I226MUCS1
p.W29*SKCM1
p.W29XSKCM1
p.E220*LUAD1
p.G46*SKCM1
p.E145KSKCM1
p.M103ILUSC1


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TissGeneCNV for KLK2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KLK2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAHM245386KLK2-ETV1chr19:51378136chr7:13946187
Chimerdb3.0ChiTaRsNAAA658025KLK2-RDH11chr19:51382492chr14:68143994
Chimerdb3.0ChiTaRsNABI047271KLK2-KLK2chr19:51378714chr19:51379342
Chimerdb3.0ChiTaRsadenocarcinomaHM245385KLK2-ETV1chr19:51376775chr7:13946187
Chimerdb3.0FusionScanPRADTCGA-ZG-A9L5-01AKLK2-ORMDL25'UTR-5'UTRchr19:51376775chr12:56211805
Chimerdb3.0FusionScanPRADTCGA-G9-7509-01AKLK2-PVRL2In-Framechr19:51376775chr19:45368527
Chimerdb3.0FusionScanPRADTCGA-V1-A9O5-01AKLK2-FGFR2In-Framechr19:51376775chr10:123310973
Chimerdb3.0FusionScanPRADTCGA-V1-A9O5-06AKLK2-FGFR2In-Framechr19:51376775chr10:123310973
Chimerdb3.0FusionScanPRADTCGA-V1-A9O5-06AKLK2-FGFR2In-Framechr19:51380014chr10:123310973
Chimerdb3.0TopHat-FusionPRADTCGA-ZG-A9LY-01AKLK2-ETV1In-Framechr19:51376774chr7:13950931
Chimerdb3.0TopHat-FusionPRADTCGA-ZG-A9LY-01AKLK2-ETV1Out-of-Framechr19:51376774chr7:13971373
Chimerdb3.0TopHat-FusionPRADTCGA-ZG-A9LY-01AKLK2-ETV1In-Framechr19:51378135chr7:13971373
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-7328-01AKLK2-CELF55'UTR-5'UTRchr19:51382741chr19:3252652
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6378-01ATSEN2-KLK2In-Framechr3:12533590chr19:51377976
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6378-01ATSEN2-KLK2In-Framechr3:12533590chr19:51379727
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6378-01ATSEN2-KLK2Out-of-Framechr3:12533715chr19:51379727
Chimerdb3.0TopHat-FusionPRADTCGA-V1-A9O5-06AKLK2-FGFR2In-Framechr19:51376774chr10:123310972
Chimerdb3.0TopHat-FusionPRADTCGA-G9-7509-01AKLK2-PVRL2In-Framechr19:51376774chr19:45368527
TCGAfusionPortalPRADAPRADTCGA-KK-A6E4-01ATOMM7-KLK23UTR-5UTRChr7:22852592Chr19:51376695


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TissGeneNet for KLK2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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COAD (tumor)COAD (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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HNSC (tumor)HNSC (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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KICH (tumor)KICH (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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KIRC (tumor)KIRC (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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KIRP (tumor)KIRP (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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LIHC (tumor)LIHC (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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LUAD (tumor)LUAD (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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LUSC (tumor)LUSC (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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PRAD (tumor)PRAD (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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STAD (tumor)STAD (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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THCA (tumor)THCA (normal)
KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (tumor)KLK2, POLR2A, AR, SERPINE1, SERPINA3, A2M, SERPINB6, SERPINA5, SEMG1, ERG, IGFBP2, SERPINC1, SERPINA4, SEMG2, SERPINF2 (normal)
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TissGeneProg for KLK2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KLK2
TissGeneDrug for KLK2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KLK2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0376358Malignant neoplasm of prostate28BeFree,GAD
umls:C0600139Prostate carcinoma28BeFree
umls:C0033578Prostatic Neoplasms8CTD_human,GAD,LHGDN
umls:C0006142Malignant neoplasm of breast5BeFree,GAD
umls:C0678222Breast Carcinoma4BeFree
umls:C1704272Benign Prostatic Hyperplasia2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0020538Hypertensive disease1GAD
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0027643Neoplasm Recurrence, Local1GAD
umls:C0032002Pituitary Diseases1BeFree
umls:C0152136Low Tension Glaucoma1BeFree
umls:C0153690Secondary malignant neoplasm of bone1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0339573Glaucoma, Primary Open Angle1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0796563Localized Malignant Neoplasm1BeFree
umls:C1334407Localized Carcinoma1BeFree
umls:C1458155Mammary Neoplasms1LHGDN