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| TissGeneSummary for KLKB1 |
 Gene summary |
| Basic gene information | Gene symbol | KLKB1 |
| Gene name | kallikrein B, plasma (Fletcher factor) 1 | |
| Synonyms | KLK3|PPK | |
| Cytomap | UCSC genome browser: 4q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000892.3, | |
| Description | Fletcher factorkininogeninplasma kallikreinplasma kallikrein heavy chainplasma kallikrein light chainplasma prekallikrein | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 229000 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164344 | ||
| HPRD : 01971 | ||
| Vega : OTTHUMG00000150347 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KLKB1 | |
| BioGPS: 3818 | ||
| Pathway | NCI Pathway Interaction Database: KLKB1 | |
| KEGG: KLKB1 | ||
| REACTOME: KLKB1 | ||
| Pathway Commons: KLKB1 | ||
| Context | iHOP: KLKB1 | |
| ligand binding site mutation search in PubMed: KLKB1 | ||
| UCL Cancer Institute: KLKB1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of KLKB1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0031639 | plasminogen activation | 89876 | GO:0051919 | positive regulation of fibrinolysis | 89876 | GO:0031639 | plasminogen activation | 89876 | GO:0051919 | positive regulation of fibrinolysis | 89876 |
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| TissGeneExp for KLKB1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.309540184 | -0.101253342 | -1.208286842 | 1.73E-16 | 9.85E-16 |
| KICH | -0.531383237 | 2.170376763 | -2.70176 | 1.00E-10 | 7.71E-10 |
| LUSC | -1.651391629 | 0.215610332 | -1.867001961 | 1.08E-15 | 7.42E-15 |
| LIHC | 7.757802763 | 9.832020763 | -2.074218 | 3.41E-12 | 6.01E-11 |
| LUAD | -1.047766409 | 0.010450832 | -1.058217241 | 4.40E-07 | 1.54E-06 |
| BLCA | -1.627179658 | -0.440690184 | -1.186489474 | 0.00963 | 0.043708408 |
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| TissGene-miRNA for KLKB1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KLKB1 |
| TissGeneSNV for KLKB1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S151L | SKCM | 3 |
| p.H234Y | SKCM | 2 |
| p.P440S | KIRC | 1 |
| p.R591H | SKCM | 1 |
| p.F524L | HNSC | 1 |
| p.S251L | SARC | 1 |
| p.V226M | UCEC | 1 |
| p.V392A | SKCM | 1 |
| p.G173E | SKCM | 1 |
| p.R228Q | HNSC | 1 |
| p.D460G | LIHC | 1 |
| p.R560Q | COAD | 1 |
| p.K526N | COAD | 1 |
| p.G378E | LUAD | 1 |
| p.K500N | STAD | 1 |
| p.T84I | STAD | 1 |
| p.M121K | GBM | 1 |
| p.V96G | SKCM | 1 |
| p.C548Y | DLBC | 1 |
| p.G588E | SKCM | 1 |
| p.R390S | HNSC | 1 |
| p.V309A | COAD | 1 |
| p.G94D | SKCM | 1 |
| p.S352F | SKCM | 1 |
| p.Y243F | SARC | 1 |
| p.Q405K | GBM | 1 |
| p.D81N | UCEC | 1 |
| p.L336F | PAAD | 1 |
| p.G200_splice | LUSC | 1 |
| p.V185M | BRCA | 1 |
| p.D456H | ESCA | 1 |
| p.R390H | UCEC | 1 |
| p.H202Y | LUSC | 1 |
| p.L196P | UCS | 1 |
| p.R92X | READ | 1 |
| p.D114Y | PRAD | 1 |
| p.V36L | SKCM | 1 |
| p.L592F | LUAD | 1 |
| p.P337S | SKCM | 1 |
| p.R228L | STAD | 1 |
| p.H158Y | SKCM | 1 |
| p.G118A | CESC | 1 |
| p.V131G | SKCM | 1 |
| p.R390H | PRAD | 1 |
| p.Q553X | PAAD | 1 |
| p.G299E | SKCM | 1 |
| p.W247X | SKCM | 1 |
| p.E343* | SKCM | 1 |
| p.T154M | LUAD | 1 |
| p.C548Y | COAD | 1 |
| p.R163Q | STAD | 1 |
| p.E135D | STAD | 1 |
| p.P541S | SKCM | 1 |
| p.R327H | LUAD | 1 |
| p.S97Y | HNSC | 1 |
| p.L542F | SKCM | 1 |
| p.C141Y | COAD | 1 |
| p.K556N | ESCA | 1 |
| p.R92Q | UCEC | 1 |
| p.T154M | LGG | 1 |
| p.S381C | BLCA | 1 |
| p.Q532* | SKCM | 1 |
| p.V317L | LUSC | 1 |
| p.L281F | SKCM | 1 |
| p.Q24E | CESC | 1 |
| p.H106Y | HNSC | 1 |
| p.K139Q | SKCM | 1 |
| p.A485S | THYM | 1 |
| p.E468* | UCEC | 1 |
| p.F30L | SKCM | 1 |
| p.E547* | UCEC | 1 |
| p.R604C | COAD | 1 |
| p.S525L | SKCM | 1 |
| p.R327C | SKCM | 1 |
| p.G570V | ESCA | 1 |
| p.S506F | SKCM | 1 |
| p.S397C | LUSC | 1 |
| p.S398A | SKCM | 1 |
| p.S268F | SKCM | 1 |
| p.T612N | UCS | 1 |
| p.V562I | LUSC | 1 |
| p.T229I | UCEC | 1 |
| p.S190L | BLCA | 1 |
| p.V317D | KIRC | 1 |
| p.T86I | STAD | 1 |
| p.D70V | LGG | 1 |
| p.S578A | UCEC | 1 |
| p.G565D | LUSC | 1 |
| p.R446H | READ | 1 |
| p.G521R | UCEC | 1 |
| p.Q553* | PAAD | 1 |
| p.E198K | LUSC | 1 |
| p.K476T | UCS | 1 |
| p.G569E | LGG | 1 |
| p.F348L | LUAD | 1 |
| p.R146C | SKCM | 1 |
| p.I595N | SKCM | 1 |
| p.W541* | SKCM | 1 |
| p.K285R | UCEC | 1 |
| p.R604H | COAD | 1 |
| p.E606K | SKCM | 1 |
| p.W247* | SKCM | 1 |
| p.C166R | HNSC | 1 |
| p.S143N | COAD | 1 |
| p.Q103K | OV | 1 |
| p.A361V | STAD | 1 |
| p.C340G | UCEC | 1 |
| p.W620C | LUAD | 1 |
| p.P440S | SKCM | 1 |
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| TissGeneCNV for KLKB1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KLKB1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KLKB1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| COAD (tumor) | COAD (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| KICH (tumor) | KICH (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| STAD (tumor) | STAD (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| THCA (tumor) | THCA (normal) |
| KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (tumor) | KLKB1, MST1, SERPINA5, KNG1, IGFBP3, HGF, HGFAC, TFPI2, F12 (normal) |
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| TissGeneProg for KLKB1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KLKB1 |
| TissGeneDrug for KLKB1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KLKB1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 27 | BeFree |
| umls:C0600139 | Prostate carcinoma | 27 | BeFree |
| umls:C0019243 | Angioedemas, Hereditary | 5 | BeFree |
| umls:C0022596 | Palmoplantar Keratosis | 5 | BeFree |
| umls:C0272339 | Prekallikrein deficiency | 5 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree,GAD |
| umls:C0870082 | Hyperkeratosis | 4 | BeFree |
| umls:C0025221 | Meleda Disease | 3 | BeFree |
| umls:C0265334 | Pachyonychia Congenita | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0014356 | Enterocolitis | 2 | BeFree,RGD |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree |
| umls:C0024143 | Lupus Nephritis | 2 | BeFree |
| umls:C0035078 | Kidney Failure | 2 | BeFree |
| umls:C0149871 | Deep Vein Thrombosis | 2 | BeFree |
| umls:C0993582 | Arthritis, Experimental | 2 | RGD |
| umls:C2316810 | Chronic kidney disease stage 5 | 2 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree,GAD,LHGDN |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | RGD |
| umls:C0022593 | Keratosis | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | RGD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | GWASCAT |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0079153 | Hyperkeratosis, Epidermolytic | 1 | BeFree |
| umls:C0079298 | Epidermolysis Bullosa Simplex | 1 | BeFree |
| umls:C0085580 | Essential Hypertension | 1 | BeFree |
| umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
| umls:C0233656 | Mental condensation | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | RGD |
| umls:C0265998 | ANONYCHIA | 1 | BeFree |
| umls:C0340708 | Deep vein thrombosis of lower limb | 1 | BeFree |
| umls:C0343110 | Epidermolytic palmoplantar keratoderma of Vorner | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0796563 | Localized Malignant Neoplasm | 1 | BeFree |
| umls:C1334407 | Localized Carcinoma | 1 | BeFree |
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