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| TissGeneSummary for KNG1 |
 Gene summary |
| Basic gene information | Gene symbol | KNG1 |
| Gene name | kininogen 1 | |
| Synonyms | BDK|BK|KNG | |
| Cytomap | UCSC genome browser: 3q27 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000893.3, NM_001102416.2,NM_001166451.1, | |
| Description | HMWKalpha-2-thiol proteinase inhibitorbradykininfitzgerald factorhigh molecular weight kininogenkininogen-1williams-Fitzgerald-Flaujeac factor | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 612358 | |
| HGNC : HGNC | ||
| HPRD : 01970 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KNG1 | |
| BioGPS: 3827 | ||
| Pathway | NCI Pathway Interaction Database: KNG1 | |
| KEGG: KNG1 | ||
| REACTOME: KNG1 | ||
| Pathway Commons: KNG1 | ||
| Context | iHOP: KNG1 | |
| ligand binding site mutation search in PubMed: KNG1 | ||
| UCL Cancer Institute: KNG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of KNG1 | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007162 | negative regulation of cell adhesion | 11970955 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 16014619 | GO:0010951 | negative regulation of endopeptidase activity | 3488317 | GO:0030195 | negative regulation of blood coagulation | 11970955 | GO:0045861 | negative regulation of proteolysis | 3488317 | GO:0007162 | negative regulation of cell adhesion | 11970955 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 16014619 | GO:0010951 | negative regulation of endopeptidase activity | 3488317 | GO:0030195 | negative regulation of blood coagulation | 11970955 | GO:0045861 | negative regulation of proteolysis | 3488317 |
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| TissGeneExp for KNG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.162854568 | 12.48885144 | -11.32599688 | 1.56E-32 | 7.00E-30 |
| KIRC | 1.109549012 | 12.39331568 | -11.28376667 | 5.77E-52 | 6.16E-50 |
| KICH | 5.180634068 | 12.62610207 | -7.445468 | 1.79E-11 | 1.62E-10 |
| LIHC | 13.75637807 | 14.93886007 | -1.182482 | 0.000733 | 0.002060751 |
| COAD | 0.469661299 | 2.723965145 | -2.254303846 | 4.83E-05 | 0.000189312 |
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| TissGene-miRNA for KNG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KNG1 |
| TissGeneSNV for KNG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R392Q | SKCM | 2 |
| p.L568F | COAD | 1 |
| p.Q139K | BLCA | 1 |
| p.K315N | READ | 1 |
| p.G227V | LUAD | 1 |
| p.S623T | LUAD | 1 |
| p.R184W | PAAD | 1 |
| p.E434K | SKCM | 1 |
| p.G518V | LUSC | 1 |
| p.W519* | STAD | 1 |
| p.R417W | OV | 1 |
| p.S604L | HNSC | 1 |
| p.Q53H | LUSC | 1 |
| p.G411C | UCEC | 1 |
| p.C264F | LUSC | 1 |
| p.D584N | KIRC | 1 |
| p.D350N | LUAD | 1 |
| p.S599L | SKCM | 1 |
| p.R58L | LUSC | 1 |
| p.C370F | THYM | 1 |
| p.R58H | THYM | 1 |
| p.Q53R | UCEC | 1 |
| p.D32Y | KIRP | 1 |
| p.K31N | HNSC | 1 |
| p.G192* | LUSC | 1 |
| p.S561F | BLCA | 1 |
| p.D638N | UCEC | 1 |
| p.D155N | LGG | 1 |
| p.G502D | KIRC | 1 |
| p.S386L | SKCM | 1 |
| p.E466K | SKCM | 1 |
| p.D567N | SKCM | 1 |
| p.E132K | HNSC | 1 |
| p.N210K | STAD | 1 |
| p.T557I | BRCA | 1 |
| p.T326A | STAD | 1 |
| p.I591N | LIHC | 1 |
| p.S377L | SKCM | 1 |
| p.A36T | SKCM | 1 |
| p.A418E | HNSC | 1 |
| p.W222* | UCEC | 1 |
| p.E540* | UCEC | 1 |
| p.D236N | BLCA | 1 |
| p.A313S | LUAD | 1 |
| p.P547T | LUAD | 1 |
| p.Q139R | BLCA | 1 |
| p.G616E | SKCM | 1 |
| p.S243P | STAD | 1 |
| p.R196Q | SKCM | 1 |
| p.T532I | UCEC | 1 |
| p.W587X | SKCM | 1 |
| p.G597C | UCEC | 1 |
| p.I576V | LIHC | 1 |
| p.D638N | UCS | 1 |
| p.R417W | UCEC | 1 |
| p.E529K | BLCA | 1 |
| p.M631I | SKCM | 1 |
| p.G458R | SKCM | 1 |
| p.G81W | LUAD | 1 |
| p.A36D | UCEC | 1 |
| p.D236N | SKCM | 1 |
| p.N205T | KIRP | 1 |
| p.E434X | COAD | 1 |
| p.S175F | SKCM | 1 |
| p.V490A | STAD | 1 |
| p.R617C | ACC | 1 |
| p.S577L | HNSC | 1 |
| p.E279* | HNSC | 1 |
| p.D565N | BRCA | 1 |
| p.T110I | LUSC | 1 |
| p.N626S | LUAD | 1 |
| p.R196Q | LGG | 1 |
| p.E80V | SKCM | 1 |
| p.G424E | GBM | 1 |
| p.G597S | LIHC | 1 |
| p.E132D | THYM | 1 |
| p.G460C | KIRP | 1 |
| p.R240Q | STAD | 1 |
| p.D302Y | LUSC | 1 |
| p.R58H | UCEC | 1 |
| p.I301T | BRCA | 1 |
| p.C328R | STAD | 1 |
| p.E543K | LGG | 1 |
| p.S153N | UCEC | 1 |
| p.E20K | SKCM | 1 |
| p.W587* | SKCM | 1 |
| p.R240Q | UCEC | 1 |
| p.R240Q | COAD | 1 |
| p.S275N | STAD | 1 |
| p.W360* | SKCM | 1 |
| p.R449H | STAD | 1 |
| p.E132K | LUSC | 1 |
| p.Q564K | LUAD | 1 |
| p.S275N | UCEC | 1 |
| p.Q124H | LUSC | 1 |
| p.L193F | COAD | 1 |
| p.P627S | SKCM | 1 |
| p.R427C | SKCM | 1 |
| p.T532I | COAD | 1 |
| p.E395K | SKCM | 1 |
| p.E419K | SKCM | 1 |
| p.S604L | SKCM | 1 |
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| TissGeneCNV for KNG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KNG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AU120291 | WDR74-KNG1 | chr11:62609281 | chr3:186435141 | |
| Chimerdb3.0 | ChiTaRs | NA | DA640348 | KNG1-ALB | chr3:186435462 | chr4:74270004 | |
| Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA2X-11A | KNG1-ALB | 3'UTR-CDS | chr3:186461677 | chr4:74279250 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-6972-01A | ST6GAL1-KNG1 | Out-of-frame | Chr3:186761098 | Chr3:186461494 |
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| TissGeneNet for KNG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KNG1, COPS6, CTSL1, GP1BA, KRT1, APP, THBS1, PITX3, PLG, MEP1A, HNF1A, F2, CAPN2, ITGB2, VTN, CAPN1, AGT, F11, CTSG, CTSS, KLKB1 (tumor) | KNG1, COPS6, HNF4A, CTSL1, APP, ELANE, THBS1, PLG, MEP1A, HNF1A, F2, ITGB2, FTL, VTN, HABP2, CAPN1, AGT, CD93, F11, CPN1, KLKB1 (normal) |
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| COAD (tumor) | COAD (normal) |
| KNG1, COPS6, HNF4A, KRT1, APP, MEP1A, HNF1A, CAPN2, ITGB2, VTN, CAPN1, AGT, CD93, F11, CTSG, PLAUR, CTSK, CPN1, CTSS, RXFP4, KLK1 (tumor) | KNG1, COPS6, HNF4A, CTSL1, PITX3, PLG, MEP1A, HNF1A, F2, CAPN2, ITGB2, FTL, HABP2, AGT, CD93, F11, PLAUR, CPN1, CTSS, RXFP4, KLK1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KNG1, COPS6, HNF4A, CTSL1, GP1BA, KRT1, ELANE, PITX3, PLG, MEP1A, F2, CAPN2, ITGB2, VTN, HABP2, PREP, F11, CTSG, CTSK, CPN1, KLKB1 (tumor) | KNG1, HNF4A, APP, THBS1, PLG, MEP1A, HNF1A, F2, CAPN2, FTL, VTN, HABP2, CAPN1, AGT, F11, PLAUR, CTSK, CPN1, RXFP4, KLK1, KLKB1 (normal) |
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| KICH (tumor) | KICH (normal) |
| KNG1, COPS6, CTSL1, KRT1, APP, ELANE, THBS1, PLG, MEP1A, CAPN2, ITGB2, HABP2, AGT, CD93, F11, CTSG, PLAUR, CTSK, CTSS, RXFP4, KLK1 (tumor) | KNG1, COPS6, CTSL1, GP1BA, APP, ELANE, PITX3, MEP1A, HNF1A, F2, FTL, VTN, HABP2, AGT, PREP, F11, CTSG, CTSK, CPN1, RXFP4, KLK1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KNG1, COPS6, CTSL1, GP1BA, THBS1, PITX3, PLG, MEP1A, F2, CAPN2, ITGB2, HABP2, AGT, CD93, F11, CTSG, PLAUR, CTSK, CTSS, RXFP4, KLK1 (tumor) | KNG1, COPS6, THBS1, PITX3, PLG, F2, CAPN2, ITGB2, FTL, VTN, HABP2, CAPN1, CD93, PREP, F11, PLAUR, CTSK, CPN1, CTSS, RXFP4, KLK1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KNG1, CTSL1, KRT1, APP, ELANE, THBS1, PITX3, HNF1A, CAPN2, ITGB2, VTN, HABP2, AGT, F11, CTSG, PLAUR, CTSK, CPN1, CTSS, RXFP4, KLKB1 (tumor) | KNG1, COPS6, HNF4A, THBS1, PITX3, PLG, HNF1A, F2, CAPN2, FTL, VTN, HABP2, CAPN1, AGT, CD93, PREP, F11, CTSK, CPN1, CTSS, KLK1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KNG1, COPS6, HNF4A, ELANE, THBS1, PITX3, PLG, HNF1A, F2, CAPN2, ITGB2, FTL, VTN, HABP2, AGT, CD93, F11, PLAUR, CTSK, CPN1, KLKB1 (tumor) | KNG1, HNF4A, APP, THBS1, PITX3, PLG, HNF1A, F2, CAPN2, ITGB2, VTN, HABP2, CAPN1, AGT, F11, PLAUR, CTSK, CPN1, RXFP4, KLK1, KLKB1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KNG1, COPS6, CTSL1, KRT1, ELANE, PITX3, PLG, MEP1A, F2, CAPN2, ITGB2, FTL, VTN, HABP2, AGT, CD93, F11, PLAUR, CTSK, CTSS, RXFP4 (tumor) | KNG1, HNF4A, CTSL1, APP, THBS1, PITX3, PLG, MEP1A, HNF1A, F2, CAPN2, ITGB2, FTL, VTN, CAPN1, PREP, F11, CTSK, CPN1, KLK1, KLKB1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KNG1, KRT1, APP, THBS1, PITX3, PLG, MEP1A, HNF1A, F2, ITGB2, FTL, VTN, HABP2, CAPN1, F11, CTSG, PLAUR, CPN1, CTSS, RXFP4, KLK1 (tumor) | KNG1, HNF4A, CTSL1, APP, PLG, MEP1A, HNF1A, F2, CAPN2, FTL, VTN, HABP2, CAPN1, AGT, CD93, F11, PLAUR, CPN1, RXFP4, KLK1, KLKB1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KNG1, CTSL1, GP1BA, KRT1, APP, PITX3, PLG, HNF1A, F2, ITGB2, VTN, HABP2, CAPN1, AGT, CD93, PREP, F11, CTSK, CTSS, RXFP4, KLK1 (tumor) | KNG1, COPS6, HNF4A, CTSL1, APP, ELANE, PLG, MEP1A, HNF1A, F2, FTL, VTN, HABP2, CAPN1, AGT, CD93, PREP, F11, CTSG, PLAUR, CPN1 (normal) |
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| STAD (tumor) | STAD (normal) |
| KNG1, CTSL1, GP1BA, KRT1, APP, ELANE, PITX3, MEP1A, HNF1A, F2, CAPN2, FTL, VTN, CAPN1, AGT, CD93, PREP, F11, CPN1, RXFP4, KLKB1 (tumor) | KNG1, COPS6, HNF4A, KRT1, ELANE, PITX3, PLG, MEP1A, HNF1A, F2, CAPN2, ITGB2, FTL, VTN, HABP2, CAPN1, AGT, F11, CPN1, CTSS, RXFP4 (normal) |
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| THCA (tumor) | THCA (normal) |
| KNG1, COPS6, HNF4A, KRT1, APP, ELANE, PLG, HNF1A, F2, ITGB2, FTL, HABP2, CD93, PREP, F11, CTSG, PLAUR, CTSS, RXFP4, KLK1, KLKB1 (tumor) | KNG1, COPS6, HNF4A, CTSL1, THBS1, PLG, HNF1A, F2, CAPN2, ITGB2, VTN, HABP2, AGT, PREP, F11, PLAUR, CTSK, CPN1, CTSS, KLK1, KLKB1 (normal) |
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| TissGeneProg for KNG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KNG1 |
| TissGeneDrug for KNG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KNG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019243 | Angioedemas, Hereditary | 31 | BeFree,CTD_human |
| umls:C0020538 | Hypertensive disease | 14 | BeFree,GAD,LHGDN |
| umls:C0020429 | Hyperalgesia | 12 | BeFree,CTD_human |
| umls:C0007222 | Cardiovascular Diseases | 9 | BeFree,GAD |
| umls:C0085580 | Essential Hypertension | 9 | BeFree |
| umls:C0010200 | Coughing | 8 | BeFree,CTD_human |
| umls:C0020649 | Hypotension | 8 | CTD_human |
| umls:C0004096 | Asthma | 7 | BeFree |
| umls:C0030193 | Pain | 6 | BeFree,CTD_human |
| umls:C0018802 | Congestive heart failure | 5 | BeFree |
| umls:C0010068 | Coronary heart disease | 4 | BeFree |
| umls:C0018801 | Heart failure | 4 | BeFree |
| umls:C2931758 | Acquired angioedema | 4 | BeFree,CTD_human |
| umls:C0006118 | Brain Neoplasms | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 3 | BeFree,GAD |
| umls:C0017638 | Glioma | 3 | BeFree |
| umls:C0022658 | Kidney Diseases | 3 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 3 | BeFree |
| umls:C0028754 | Obesity | 3 | BeFree |
| umls:C0149721 | Left Ventricular Hypertrophy | 3 | BeFree |
| umls:C0272340 | High molecular weight kininogen deficiency | 3 | BeFree,CLINVAR,CTD_human,ORPHANET |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 3 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 3 | BeFree,GAD |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree |
| umls:C0011609 | Drug Eruptions | 2 | CTD_human |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0021368 | Inflammation | 2 | LHGDN |
| umls:C0027055 | Myocardial Reperfusion Injury | 2 | CTD_human |
| umls:C0027819 | Neuroblastoma | 2 | BeFree |
| umls:C0035078 | Kidney Failure | 2 | BeFree |
| umls:C0152171 | Idiopathic pulmonary hypertension | 2 | BeFree |
| umls:C0700095 | Central neuroblastoma | 2 | BeFree |
| umls:C2609414 | Acute kidney injury | 2 | CTD_human |
| umls:C0002792 | anaphylaxis | 1 | CTD_human |
| umls:C0003811 | Cardiac Arrhythmia | 1 | CTD_human |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0013604 | Edema | 1 | CTD_human |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0015379 | Extravasation of Diagnostic and Therapeutic Materials | 1 | CTD_human |
| umls:C0019158 | Hepatitis | 1 | BeFree |
| umls:C0019159 | Hepatitis A | 1 | BeFree |
| umls:C0020452 | Hyperemia | 1 | CTD_human |
| umls:C0020517 | Hypersensitivity | 1 | CTD_human |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032285 | Pneumonia | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0036211 | Sarcoma 180 | 1 | BeFree |
| umls:C0040053 | Thrombosis | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0041234 | Chagas Disease | 1 | BeFree |
| umls:C0086942 | Rous Sarcoma | 1 | BeFree |
| umls:C0150055 | Chronic pain | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
| umls:C0178879 | Urinary tract obstruction | 1 | BeFree |
| umls:C0220650 | Metastatic malignant neoplasm to brain | 1 | BeFree |
| umls:C0221232 | Welts | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242994 | Hantavirus Infections | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | LHGDN |
| umls:C0264408 | Childhood asthma | 1 | BeFree |
| umls:C0265099 | Basilar artery thrombosis | 1 | BeFree |
| umls:C0333240 | Acute edema | 1 | BeFree |
| umls:C0349637 | Common acute lymphoblastic leukemia | 1 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
| umls:C0375024 | Hantavirus infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
| umls:C0406317 | Chronic small plaque psoriasis | 1 | BeFree |
| umls:C0428977 | Bradycardia | 1 | CTD_human |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0741923 | cardiac event | 1 | BeFree |
| umls:C0850803 | Anaphylaxis (non medication) | 1 | BeFree |
| umls:C0852077 | Blood Coagulation Disorders, Inherited | 1 | GAD |
| umls:C0878544 | Cardiomyopathies | 1 | GAD |
| umls:C0920646 | Renal ischaemia | 1 | BeFree |
| umls:C0993582 | Arthritis, Experimental | 1 | RGD |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1304177 | Idiopathic angioedema | 1 | BeFree |
| umls:C1384514 | Conn Syndrome | 1 | BeFree |
| umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |
| umls:C1519666 | Tumor-Associated Vasculature | 1 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C1857728 | Hereditary Angioedema Type III | 1 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 1 | BeFree |
| umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
| umls:C3714636 | Pneumonitis | 1 | BeFree |
| umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |
| umls:C1856719 | Kininogen Deficiency, Total | 0 | CLINVAR |
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