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| TissGeneSummary for ARG1 |
 Gene summary |
| Basic gene information | Gene symbol | ARG1 |
| Gene name | arginase 1 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 6q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000045.3, NM_001244438.1, | |
| Description | arginase, liverarginase-1liver-type arginasetype I arginase | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 608313 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118520 | ||
| HPRD : 01947 | ||
| Vega : OTTHUMG00000015566 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ARG1 | |
| BioGPS: 383 | ||
| Pathway | NCI Pathway Interaction Database: ARG1 | |
| KEGG: ARG1 | ||
| REACTOME: ARG1 | ||
| Pathway Commons: ARG1 | ||
| Context | iHOP: ARG1 | |
| ligand binding site mutation search in PubMed: ARG1 | ||
| UCL Cancer Institute: ARG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of ARG1 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ARG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 10.58510411 | 12.98651211 | -2.401408 | 9.00E-07 | 4.84E-06 |
| STAD | -0.39485552 | 0.79043823 | -1.18529375 | 0.00531 | 0.020379164 |
| HNSC | 1.076019408 | 2.894579873 | -1.818560465 | 0.0037 | 0.010471698 |
| LUSC | 0.036165007 | 1.093219909 | -1.057054902 | 0.00155 | 0.002799198 |
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| TissGene-miRNA for ARG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ARG1 |
| TissGeneSNV for ARG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G235R | STAD | 1 |
| p.R21Q | BRCA | 1 |
| p.F162L | BRCA | 1 |
| p.I307V | LIHC | 1 |
| p.I299V | LIHC | 1 |
| p.G154E | SKCM | 1 |
| p.G305R | UCEC | 1 |
| p.T292I | SKCM | 1 |
| p.P144L | LUSC | 1 |
| p.A112V | UCEC | 1 |
| p.S16* | LUAD | 1 |
| p.S72Y | UCEC | 1 |
| p.F15L | BLCA | 1 |
| p.I8T | PAAD | 1 |
| p.Y317H | ESCA | 1 |
| p.P20S | UCEC | 1 |
| p.G178V | SARC | 1 |
| p.D52E | LUAD | 1 |
| p.P63L | HNSC | 1 |
| p.R255T | SARC | 1 |
| p.T166I | STAD | 1 |
| p.G243R | STAD | 1 |
| p.E38D | BLCA | 1 |
| p.F239V | UCS | 1 |
| p.V24L | OV | 1 |
| p.G235R | PRAD | 1 |
| p.E151K | SKCM | 1 |
| p.V84E | LUSC | 1 |
| p.F231V | UCS | 1 |
| p.T127N | SKCM | 1 |
| p.G283E | SKCM | 1 |
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| TissGeneCNV for ARG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ARG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-B6-A0IQ-01A | MAP7-ARG1 | Out-of-frame | Chr6:136871480 | Chr6:131904200 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-6978-01A | ATXN1-ARG1 | 5UTR-CDS | Chr6:16658007 | Chr6:131900251 |
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| TissGeneNet for ARG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| COAD (tumor) | COAD (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| KICH (tumor) | KICH (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| STAD (tumor) | STAD (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| THCA (tumor) | THCA (normal) |
| ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (tumor) | ARG1, UBC, ESR1, RAD21, UCHL5, FLOT1, C12orf44, USP53, NOS1, ALDH4A1, ARG2 (normal) |
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| TissGeneProg for ARG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ARG1 |
| TissGeneDrug for ARG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB03904 | Urea | Small molecule | Approved |
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| TissGeneDisease for ARG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0268548 | Hyperargininemia | 12 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0004096 | Asthma | 11 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0003850 | Arteriosclerosis | 3 | BeFree |
| umls:C0004153 | Atherosclerosis | 3 | BeFree |
| umls:C0020538 | Hypertensive disease | 3 | LHGDN,RGD |
| umls:C0022116 | Ischemia | 3 | BeFree |
| umls:C0027051 | Myocardial Infarction | 3 | BeFree,GAD,LHGDN |
| umls:C0264408 | Childhood asthma | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
| umls:C0020542 | Pulmonary Hypertension | 2 | BeFree,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree,LHGDN |
| umls:C0027819 | Neuroblastoma | 2 | BeFree |
| umls:C0032927 | Precancerous Conditions | 2 | CTD_human,GAD |
| umls:C0037116 | Silicosis | 2 | CTD_human,RGD |
| umls:C0041296 | Tuberculosis | 2 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
| umls:C0700095 | Central neuroblastoma | 2 | BeFree |
| umls:C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
| umls:C0003123 | Anorexia | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0008370 | Cholestasis | 1 | RGD |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0010068 | Coronary heart disease | 1 | BeFree,GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0018500 | Hair Diseases | 1 | CTD_human |
| umls:C0018923 | Hemangiosarcoma | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0020440 | Hypercapnia | 1 | RGD |
| umls:C0021053 | Immune System Diseases | 1 | CTD_human |
| umls:C0021368 | Inflammation | 1 | GAD |
| umls:C0021655 | Insulin Resistance | 1 | RGD |
| umls:C0021833 | Intestinal Fistula | 1 | RGD |
| umls:C0023281 | Leishmaniasis | 1 | CTD_human |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | RGD |
| umls:C0023895 | Liver diseases | 1 | RGD |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0026838 | Muscle Spasticity | 1 | BeFree |
| umls:C0026848 | Myopathy | 1 | CTD_human |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0038356 | Stomach Neoplasms | 1 | GAD |
| umls:C0041956 | Ureteral obstruction | 1 | RGD |
| umls:C0042164 | Uveitis | 1 | RGD |
| umls:C0079487 | Helicobacter Infections | 1 | GAD |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0085311 | Diffuse cutaneous leishmaniasis | 1 | BeFree |
| umls:C0085605 | Liver Failure | 1 | RGD |
| umls:C0149939 | Obstructive nephropathy | 1 | BeFree |
| umls:C0155877 | Allergic asthma | 1 | BeFree |
| umls:C0206624 | Hepatoblastoma | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0235557 | Pulmonary granuloma | 1 | BeFree |
| umls:C0241910 | Hepatitis, Autoimmune | 1 | LHGDN |
| umls:C0242706 | Hyperoxia | 1 | RGD |
| umls:C0267941 | Pancreatitis, Acute Necrotizing | 1 | RGD |
| umls:C0278694 | Disseminated neuroblastoma | 1 | BeFree |
| umls:C0340288 | Stable angina | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0392707 | Atopy | 1 | GAD |
| umls:C0426970 | Spastic Quadriplegia | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0683322 | Mental impairment | 1 | BeFree |
| umls:C0751753 | Carbamoyl-Phosphate Synthase I Deficiency Disease | 1 | BeFree |
| umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
| umls:C0856742 | Post MI | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
| umls:C0949664 | Tauopathies | 1 | BeFree |
| umls:C1135161 | Stage 4S neuroblastoma | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | BeFree |
| umls:C2609414 | Acute kidney injury | 1 | RGD |
| umls:C3714753 | RETINOSCHISIS 1, X-LINKED, JUVENILE | 1 | BeFree |
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