TissGeneSummary for KPNA5 |
Gene summary |
Basic gene information | Gene symbol | KPNA5 |
Gene name | karyopherin alpha 5 (importin alpha 6) | |
Synonyms | IPOA6|SRP6 | |
Cytomap | UCSC genome browser: 6q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002269.2, | |
Description | importin alpha 6importin subunit alpha-6karyopherin subunit alpha-5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604545 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196911 | ||
HPRD : 05179 | ||
Vega : OTTHUMG00000015448 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KPNA5 | |
BioGPS: 3841 | ||
Pathway | NCI Pathway Interaction Database: KPNA5 | |
KEGG: KPNA5 | ||
REACTOME: KPNA5 | ||
Pathway Commons: KPNA5 | ||
Context | iHOP: KPNA5 | |
ligand binding site mutation search in PubMed: KPNA5 | ||
UCL Cancer Institute: KPNA5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KPNA5 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KPNA5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.269192677 | 0.750193287 | -1.019385965 | 1.12E-18 | 7.25E-18 |
KICH | -0.849552818 | 0.405095182 | -1.254648 | 8.26E-07 | 3.13E-06 |
THCA | -0.058621699 | 1.133396945 | -1.192018644 | 2.41E-12 | 2.00E-11 |
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TissGene-miRNA for KPNA5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-106b-5p | MIMAT0000680 | 0.0096 | -0.33 | 60 |
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TissGeneMut for KPNA5 |
TissGeneSNV for KPNA5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V275L | LUAD | 1 |
p.A236T | KIRC | 1 |
p.P316S | ACC | 1 |
p.Y504X | STAD | 1 |
p.L179P | KIRP | 1 |
p.R30Q | UCEC | 1 |
p.E483* | LUAD | 1 |
p.E475K | UCEC | 1 |
p.R262* | PRAD | 1 |
p.R319G | CHOL | 1 |
p.R396H | PRAD | 1 |
p.K18E | THYM | 1 |
p.G322S | LGG | 1 |
p.N521I | CESC | 1 |
p.S315L | BLCA | 1 |
p.E140D | UCEC | 1 |
p.P384L | SKCM | 1 |
p.Q529K | LGG | 1 |
p.L500V | BLCA | 1 |
p.N450H | UCEC | 1 |
p.E388D | HNSC | 1 |
p.Q538* | SKCM | 1 |
p.E182K | CESC | 1 |
p.Q291E | HNSC | 1 |
p.N52D | UCEC | 1 |
p.E64Q | ACC | 1 |
p.Y281D | KIRP | 1 |
p.L479V | BLCA | 1 |
p.M62I | SARC | 1 |
p.L390F | STAD | 1 |
p.D98N | BRCA | 1 |
p.P247S | SKCM | 1 |
p.Q124H | LGG | 1 |
p.C425X | THYM | 1 |
p.G243D | STAD | 1 |
p.R138I | UCEC | 1 |
p.P173L | SKCM | 1 |
p.R138I | READ | 1 |
p.R262Q | UCEC | 1 |
p.P384R | LUAD | 1 |
p.E304K | COAD | 1 |
p.P173L | STAD | 1 |
p.W150C | ESCA | 1 |
p.T406S | COAD | 1 |
p.Y504* | STAD | 1 |
p.V441A | BRCA | 1 |
p.A3D | STAD | 1 |
p.P115H | STAD | 1 |
p.A171G | GBM | 1 |
p.Q538X | SKCM | 1 |
p.I330V | PRAD | 1 |
p.E184K | CESC | 1 |
p.S251I | LUSC | 1 |
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TissGeneCNV for KPNA5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KPNA5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA207010 | KPNA5-LOC152217 | chr6:117055887 | chr3:196670119 |
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TissGeneNet for KPNA5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KPNA5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KPNA5 |
TissGeneDrug for KPNA5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KPNA5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |