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| TissGeneSummary for KRT2 |
 Gene summary |
| Basic gene information | Gene symbol | KRT2 |
| Gene name | keratin 2 | |
| Synonyms | CK-2e|K2e|KRT2A|KRT2E|KRTE | |
| Cytomap | UCSC genome browser: 12q13.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000423.2, | |
| Description | cytokeratin-2eepithelial keratin-2ekeratin, type II cytoskeletal 2 epidermalkeratin-2 epidermiskeratin-2etype-II keratin Kb2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600194 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000172867 | ||
| HPRD : 02560 | ||
| Vega : OTTHUMG00000169748 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KRT2 | |
| BioGPS: 3849 | ||
| Pathway | NCI Pathway Interaction Database: KRT2 | |
| KEGG: KRT2 | ||
| REACTOME: KRT2 | ||
| Pathway Commons: KRT2 | ||
| Context | iHOP: KRT2 | |
| ligand binding site mutation search in PubMed: KRT2 | ||
| UCL Cancer Institute: KRT2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of KRT2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0031424 | keratinization | 12598329 | GO:0032980 | keratinocyte activation | 12598329 | GO:0043616 | keratinocyte proliferation | 12598329 | GO:0051546 | keratinocyte migration | 15737202 | GO:0031424 | keratinization | 12598329 | GO:0032980 | keratinocyte activation | 12598329 | GO:0043616 | keratinocyte proliferation | 12598329 | GO:0051546 | keratinocyte migration | 15737202 |
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| TissGeneExp for KRT2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -0.497074569 | 0.880975431 | -1.37805 | 0.00576 | 0.021845261 |
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| TissGene-miRNA for KRT2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KRT2 |
| TissGeneSNV for KRT2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E398K | SKCM | 2 |
| p.L163P | LUSC | 1 |
| p.G140D | LGG | 1 |
| p.G551S | BLCA | 1 |
| p.D281N | SKCM | 1 |
| p.E476V | STAD | 1 |
| p.S41F | BLCA | 1 |
| p.R544X | LIHC | 1 |
| p.A448S | KIRP | 1 |
| p.Q404H | LUAD | 1 |
| p.E628Q | LUSC | 1 |
| p.P138T | LUSC | 1 |
| p.R275H | PAAD | 1 |
| p.G13E | SKCM | 1 |
| p.G594R | SKCM | 1 |
| p.G219D | COAD | 1 |
| p.K390N | UCEC | 1 |
| p.S101G | COAD | 1 |
| p.R362K | SKCM | 1 |
| p.A452S | STAD | 1 |
| p.N400S | OV | 1 |
| p.D387N | UCEC | 1 |
| p.C42Y | KIRC | 1 |
| p.V165M | SKCM | 1 |
| p.P227S | SKCM | 1 |
| p.R61Q | SKCM | 1 |
| p.H412Y | LUAD | 1 |
| p.A425T | LGG | 1 |
| p.G136E | LUAD | 1 |
| p.G133* | LUSC | 1 |
| p.G67E | SKCM | 1 |
| p.S637C | LIHC | 1 |
| p.D346Y | UCEC | 1 |
| p.R639I | UCEC | 1 |
| p.R275H | UCEC | 1 |
| p.E180K | ESCA | 1 |
| p.A350T | STAD | 1 |
| p.R341H | UCEC | 1 |
| p.K287Q | STAD | 1 |
| p.A278D | THYM | 1 |
| p.E253V | LUAD | 1 |
| p.L335F | BLCA | 1 |
| p.S509L | BLCA | 1 |
| p.A457V | LUAD | 1 |
| p.F282C | STAD | 1 |
| p.A478T | COAD | 1 |
| p.E368V | BRCA | 1 |
| p.Q172H | HNSC | 1 |
| p.R430H | UCEC | 1 |
| p.R544* | LIHC | 1 |
| p.P143R | KIRP | 1 |
| p.S158N | STAD | 1 |
| p.T329I | BRCA | 1 |
| p.G615E | CESC | 1 |
| p.L135* | LUAD | 1 |
| p.G522R | UCEC | 1 |
| p.E487K | COAD | 1 |
| p.R122C | COAD | 1 |
| p.A438V | SKCM | 1 |
| p.R45H | STAD | 1 |
| p.G523C | HNSC | 1 |
| p.E178D | ESCA | 1 |
| p.R179C | STAD | 1 |
| p.R92K | CESC | 1 |
| p.G588E | SKCM | 1 |
| p.G125S | SKCM | 1 |
| p.A354V | SKCM | 1 |
| p.S509L | SKCM | 1 |
| p.V29A | PAAD | 1 |
| p.A85T | KICH | 1 |
| p.D270N | SKCM | 1 |
| p.E152K | SKCM | 1 |
| p.L135I | LUAD | 1 |
| p.L236F | SKCM | 1 |
| p.R34Q | STAD | 1 |
| p.A360T | PRAD | 1 |
| p.R458W | LIHC | 1 |
| p.S235N | SKCM | 1 |
| p.G611R | SKCM | 1 |
| p.A472P | HNSC | 1 |
| p.G78E | SKCM | 1 |
| p.A360S | LUAD | 1 |
| p.G618V | SKCM | 1 |
| p.E178D | LUAD | 1 |
| p.G615V | LUSC | 1 |
| p.R544Q | GBM | 1 |
| p.K237E | STAD | 1 |
| p.N251T | PAAD | 1 |
| p.D462G | STAD | 1 |
| p.D259Y | LUAD | 1 |
| p.Y375C | LIHC | 1 |
| p.T504K | OV | 1 |
| p.G529R | COAD | 1 |
| p.R10L | KIRP | 1 |
| p.S191F | LUAD | 1 |
| p.G112S | SKCM | 1 |
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| TissGeneCNV for KRT2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KRT2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KRT2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| COAD (tumor) | COAD (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| KICH (tumor) | KICH (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| STAD (tumor) | STAD (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| THCA (tumor) | THCA (normal) |
| KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (tumor) | KRT2, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, MDM2, CUL4B, CUL3, CUL1, HDGF, PITX3, DCUN1D1, NEDD8, CUL4A, POU5F1 (normal) |
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| TissGeneProg for KRT2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KRT2 |
| TissGeneDrug for KRT2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KRT2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0432306 | Ichthyosis Bullosa of Siemens | 16 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0079153 | Hyperkeratosis, Epidermolytic | 5 | BeFree |
| umls:C0343110 | Epidermolytic palmoplantar keratoderma of Vorner | 3 | BeFree |
| umls:C0022104 | Irritable Bowel Syndrome | 2 | BeFree |
| umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1838440 | ICHTHYOSIS EXFOLIATIVA | 1 | BeFree,CLINVAR |
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