TissGeneSummary for KRT2 |
Gene summary |
Basic gene information | Gene symbol | KRT2 |
Gene name | keratin 2 | |
Synonyms | CK-2e|K2e|KRT2A|KRT2E|KRTE | |
Cytomap | UCSC genome browser: 12q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_000423.2, | |
Description | cytokeratin-2eepithelial keratin-2ekeratin, type II cytoskeletal 2 epidermalkeratin-2 epidermiskeratin-2etype-II keratin Kb2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600194 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172867 | ||
HPRD : 02560 | ||
Vega : OTTHUMG00000169748 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT2 | |
BioGPS: 3849 | ||
Pathway | NCI Pathway Interaction Database: KRT2 | |
KEGG: KRT2 | ||
REACTOME: KRT2 | ||
Pathway Commons: KRT2 | ||
Context | iHOP: KRT2 | |
ligand binding site mutation search in PubMed: KRT2 | ||
UCL Cancer Institute: KRT2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of KRT2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0031424 | keratinization | 12598329 | GO:0032980 | keratinocyte activation | 12598329 | GO:0043616 | keratinocyte proliferation | 12598329 | GO:0051546 | keratinocyte migration | 15737202 | GO:0031424 | keratinization | 12598329 | GO:0032980 | keratinocyte activation | 12598329 | GO:0043616 | keratinocyte proliferation | 12598329 | GO:0051546 | keratinocyte migration | 15737202 |
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TissGeneExp for KRT2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -0.497074569 | 0.880975431 | -1.37805 | 0.00576 | 0.021845261 |
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TissGene-miRNA for KRT2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KRT2 |
TissGeneSNV for KRT2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E398K | SKCM | 2 |
p.L163P | LUSC | 1 |
p.G140D | LGG | 1 |
p.G551S | BLCA | 1 |
p.D281N | SKCM | 1 |
p.E476V | STAD | 1 |
p.S41F | BLCA | 1 |
p.R544X | LIHC | 1 |
p.A448S | KIRP | 1 |
p.Q404H | LUAD | 1 |
p.E628Q | LUSC | 1 |
p.P138T | LUSC | 1 |
p.R275H | PAAD | 1 |
p.G13E | SKCM | 1 |
p.G594R | SKCM | 1 |
p.G219D | COAD | 1 |
p.K390N | UCEC | 1 |
p.S101G | COAD | 1 |
p.R362K | SKCM | 1 |
p.A452S | STAD | 1 |
p.N400S | OV | 1 |
p.D387N | UCEC | 1 |
p.C42Y | KIRC | 1 |
p.V165M | SKCM | 1 |
p.P227S | SKCM | 1 |
p.R61Q | SKCM | 1 |
p.H412Y | LUAD | 1 |
p.A425T | LGG | 1 |
p.G136E | LUAD | 1 |
p.G133* | LUSC | 1 |
p.G67E | SKCM | 1 |
p.S637C | LIHC | 1 |
p.D346Y | UCEC | 1 |
p.R639I | UCEC | 1 |
p.R275H | UCEC | 1 |
p.E180K | ESCA | 1 |
p.A350T | STAD | 1 |
p.R341H | UCEC | 1 |
p.K287Q | STAD | 1 |
p.A278D | THYM | 1 |
p.E253V | LUAD | 1 |
p.L335F | BLCA | 1 |
p.S509L | BLCA | 1 |
p.A457V | LUAD | 1 |
p.F282C | STAD | 1 |
p.A478T | COAD | 1 |
p.E368V | BRCA | 1 |
p.Q172H | HNSC | 1 |
p.R430H | UCEC | 1 |
p.R544* | LIHC | 1 |
p.P143R | KIRP | 1 |
p.S158N | STAD | 1 |
p.T329I | BRCA | 1 |
p.G615E | CESC | 1 |
p.L135* | LUAD | 1 |
p.G522R | UCEC | 1 |
p.E487K | COAD | 1 |
p.R122C | COAD | 1 |
p.A438V | SKCM | 1 |
p.R45H | STAD | 1 |
p.G523C | HNSC | 1 |
p.E178D | ESCA | 1 |
p.R179C | STAD | 1 |
p.R92K | CESC | 1 |
p.G588E | SKCM | 1 |
p.G125S | SKCM | 1 |
p.A354V | SKCM | 1 |
p.S509L | SKCM | 1 |
p.V29A | PAAD | 1 |
p.A85T | KICH | 1 |
p.D270N | SKCM | 1 |
p.E152K | SKCM | 1 |
p.L135I | LUAD | 1 |
p.L236F | SKCM | 1 |
p.R34Q | STAD | 1 |
p.A360T | PRAD | 1 |
p.R458W | LIHC | 1 |
p.S235N | SKCM | 1 |
p.G611R | SKCM | 1 |
p.A472P | HNSC | 1 |
p.G78E | SKCM | 1 |
p.A360S | LUAD | 1 |
p.G618V | SKCM | 1 |
p.E178D | LUAD | 1 |
p.G615V | LUSC | 1 |
p.R544Q | GBM | 1 |
p.K237E | STAD | 1 |
p.N251T | PAAD | 1 |
p.D462G | STAD | 1 |
p.D259Y | LUAD | 1 |
p.Y375C | LIHC | 1 |
p.T504K | OV | 1 |
p.G529R | COAD | 1 |
p.R10L | KIRP | 1 |
p.S191F | LUAD | 1 |
p.G112S | SKCM | 1 |
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TissGeneCNV for KRT2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KRT2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KRT2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KRT2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KRT2 |
TissGeneDrug for KRT2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KRT2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0432306 | Ichthyosis Bullosa of Siemens | 16 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0079153 | Hyperkeratosis, Epidermolytic | 5 | BeFree |
umls:C0343110 | Epidermolytic palmoplantar keratoderma of Vorner | 3 | BeFree |
umls:C0022104 | Irritable Bowel Syndrome | 2 | BeFree |
umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C1838440 | ICHTHYOSIS EXFOLIATIVA | 1 | BeFree,CLINVAR |