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| TissGeneSummary for KRT6B |
 Gene summary |
| Basic gene information | Gene symbol | KRT6B |
| Gene name | keratin 6B | |
| Synonyms | CK-6B|CK6B|K6B|KRTL1|PC2|PC4 | |
| Cytomap | UCSC genome browser: 12q13.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005555.3, | |
| Description | cytokeratin 6Bcytokeratin-6Bkeratin, epidermal, type II, K6Bkeratin, type II cytoskeletal 6Bkeratin-6Bkeratin-like 1 (a type II keratin sequence)type-II keratin Kb10 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 148042 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185479 | ||
| HPRD : 01012 | ||
| Vega : OTTHUMG00000169593 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KRT6B | |
| BioGPS: 3854 | ||
| Pathway | NCI Pathway Interaction Database: KRT6B | |
| KEGG: KRT6B | ||
| REACTOME: KRT6B | ||
| Pathway Commons: KRT6B | ||
| Context | iHOP: KRT6B | |
| ligand binding site mutation search in PubMed: KRT6B | ||
| UCL Cancer Institute: KRT6B | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderEsophagusSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCAESCASKCM | |
| Reference showing the relevant tissue of KRT6B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KRT6B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 1.733570275 | 3.741876416 | -2.00830614 | 3.39E-06 | 8.78E-06 |
| THCA | -3.535731494 | -5.09890607 | 1.563174576 | 1.96E-05 | 6.09E-05 |
| LUAD | -0.350401745 | -3.372060366 | 3.021658621 | 1.37E-08 | 6.03E-08 |
| COAD | 0.760758467 | -3.351876148 | 4.112634615 | 4.17E-09 | 4.12E-08 |
| LUSC | 7.21816269 | -0.937600055 | 8.155762745 | 6.43E-27 | 1.81E-25 |
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| TissGene-miRNA for KRT6B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KRT6B |
| TissGeneSNV for KRT6B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G133R | SKCM | 3 |
| p.Q142H | LUAD | 2 |
| p.A286G | LUAD | 1 |
| p.R392I | LUAD | 1 |
| p.E472K | GBM | 1 |
| p.S317Y | BLCA | 1 |
| p.R160Q | PAAD | 1 |
| p.G46C | UCEC | 1 |
| p.N227S | COAD | 1 |
| p.R222S | LUAD | 1 |
| p.R232W | COAD | 1 |
| p.E361* | LUAD | 1 |
| p.L291I | COAD | 1 |
| p.F297L | LUAD | 1 |
| p.E428K | SKCM | 1 |
| p.K204N | LGG | 1 |
| p.S10G | SKCM | 1 |
| p.G230E | SKCM | 1 |
| p.V481F | STAD | 1 |
| p.D236N | COAD | 1 |
| p.T261I | UCEC | 1 |
| p.S332N | SKCM | 1 |
| p.S29I | LUAD | 1 |
| p.R158W | UCEC | 1 |
| p.G57S | SKCM | 1 |
| p.N219S | SARC | 1 |
| p.R42S | LUAD | 1 |
| p.A419V | LGG | 1 |
| p.L298M | LUAD | 1 |
| p.K204T | LUAD | 1 |
| p.V493I | UCEC | 1 |
| p.A175T | LIHC | 1 |
| p.V138F | OV | 1 |
| p.G512* | ESCA | 1 |
| p.E211K | SKCM | 1 |
| p.E162K | CESC | 1 |
| p.R160Q | LIHC | 1 |
| p.P147L | LIHC | 1 |
| p.R326C | HNSC | 1 |
| p.G52E | HNSC | 1 |
| p.Y517N | LUSC | 1 |
| p.A352T | LGG | 1 |
| p.R415C | UCEC | 1 |
| p.E351Q | CESC | 1 |
| p.G511E | UCEC | 1 |
| p.S76T | OV | 1 |
| p.A50T | UCEC | 1 |
| p.V460G | SKCM | 1 |
| p.G123W | SKCM | 1 |
| p.R415H | COAD | 1 |
| p.R386H | STAD | 1 |
| p.E231K | SKCM | 1 |
| p.P128S | SKCM | 1 |
| p.R160W | CESC | 1 |
| p.E479K | ESCA | 1 |
| p.L291V | LUAD | 1 |
| p.A410V | COAD | 1 |
| p.297_298FL>LM | LUAD | 1 |
| p.E394G | THYM | 1 |
| p.G504C | STAD | 1 |
| p.A119P | KIRP | 1 |
| p.N21S | CESC | 1 |
| p.R234H | BRCA | 1 |
| p.E353K | STAD | 1 |
| p.E162* | LUAD | 1 |
| p.D440N | SKCM | 1 |
| p.H312Y | LGG | 1 |
| p.K68R | ESCA | 1 |
| p.R415S | ESCA | 1 |
| p.E479K | LUSC | 1 |
| p.E417* | LUAD | 1 |
| p.R466C | UCEC | 1 |
| p.R182W | PRAD | 1 |
| p.G512X | ESCA | 1 |
| p.I167M | CESC | 1 |
| p.T316I | PRAD | 1 |
| p.S332T | OV | 1 |
| p.L144V | LUAD | 1 |
| p.D226H | LUAD | 1 |
| p.Q439K | LUAD | 1 |
| p.E361G | LGG | 1 |
| p.S546R | SKCM | 1 |
| p.E137Q | BLCA | 1 |
| p.N21S | COAD | 1 |
| p.E353Q | CESC | 1 |
| p.R466H | UCEC | 1 |
| p.R375C | UCEC | 1 |
| p.E137Q | LUSC | 1 |
| p.S237L | UCEC | 1 |
| p.L150V | BLCA | 1 |
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| TissGeneCNV for KRT6B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KRT6B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-A8EW-01A | KRT6B-PGD | In-Frame | chr12:52842625 | chr1:10463127 |
| Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-6955-01A | KRT6B-KRT13 | 5'UTR-CDS | chr12:52845907 | chr17:39659230 |
| Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-6955-01A | KRT6B-KRT13 | 5'UTR-CDS | chr12:52845908 | chr17:39661564 |
| Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CR-7393-01A | KRT6B-KRT13 | 5'UTR-CDS | chr12:52845907 | chr17:39659230 |
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| TissGeneNet for KRT6B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| COAD (tumor) | COAD (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| KICH (tumor) | KICH (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| STAD (tumor) | STAD (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| THCA (tumor) | THCA (normal) |
| KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor) | KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal) |
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| TissGeneProg for KRT6B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KRT6B |
| TissGeneDrug for KRT6B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KRT6B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0265334 | Pachyonychia Congenita | 4 | BeFree,CTD_human,ORPHANET |
| umls:C1721007 | Pachyonychia Congenita, Type 2 (disorder) | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 1 | CTD_human |
| umls:C0031511 | Pheochromocytoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C3714949 | PACHYONYCHIA CONGENITA 4 | 1 | CLINVAR,UNIPROT |
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