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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KRT6B
check button Gene summary
Basic gene informationGene symbolKRT6B
Gene namekeratin 6B
SynonymsCK-6B|CK6B|K6B|KRTL1|PC2|PC4
CytomapUCSC genome browser: 12q13.13
Type of geneprotein-coding
RefGenesNM_005555.3,
Descriptioncytokeratin 6Bcytokeratin-6Bkeratin, epidermal, type II, K6Bkeratin, type II cytoskeletal 6Bkeratin-6Bkeratin-like 1 (a type II keratin sequence)type-II keratin Kb10
Modification date20141219
dbXrefs MIM : 148042
HGNC : HGNC
Ensembl : ENSG00000185479
HPRD : 01012
Vega : OTTHUMG00000169593
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KRT6B
BioGPS: 3854
PathwayNCI Pathway Interaction Database: KRT6B
KEGG: KRT6B
REACTOME: KRT6B
Pathway Commons: KRT6B
ContextiHOP: KRT6B
ligand binding site mutation search in PubMed: KRT6B
UCL Cancer Institute: KRT6B
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderEsophagusSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCAESCASKCM
Reference showing the relevant tissue of KRT6B
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KRT6B

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA1.7335702753.741876416-2.008306143.39E-068.78E-06
THCA-3.535731494-5.098906071.5631745761.96E-056.09E-05
LUAD-0.350401745-3.3720603663.0216586211.37E-086.03E-08
COAD0.760758467-3.3518761484.1126346154.17E-094.12E-08
LUSC7.21816269-0.9376000558.1557627456.43E-271.81E-25


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TissGene-miRNA for KRT6B

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KRT6B
TissGeneSNV for KRT6B

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G133RSKCM3
p.Q142HLUAD2
p.A286GLUAD1
p.R392ILUAD1
p.E472KGBM1
p.S317YBLCA1
p.R160QPAAD1
p.G46CUCEC1
p.N227SCOAD1
p.R222SLUAD1
p.R232WCOAD1
p.E361*LUAD1
p.L291ICOAD1
p.F297LLUAD1
p.E428KSKCM1
p.K204NLGG1
p.S10GSKCM1
p.G230ESKCM1
p.V481FSTAD1
p.D236NCOAD1
p.T261IUCEC1
p.S332NSKCM1
p.S29ILUAD1
p.R158WUCEC1
p.G57SSKCM1
p.N219SSARC1
p.R42SLUAD1
p.A419VLGG1
p.L298MLUAD1
p.K204TLUAD1
p.V493IUCEC1
p.A175TLIHC1
p.V138FOV1
p.G512*ESCA1
p.E211KSKCM1
p.E162KCESC1
p.R160QLIHC1
p.P147LLIHC1
p.R326CHNSC1
p.G52EHNSC1
p.Y517NLUSC1
p.A352TLGG1
p.R415CUCEC1
p.E351QCESC1
p.G511EUCEC1
p.S76TOV1
p.A50TUCEC1
p.V460GSKCM1
p.G123WSKCM1
p.R415HCOAD1
p.R386HSTAD1
p.E231KSKCM1
p.P128SSKCM1
p.R160WCESC1
p.E479KESCA1
p.L291VLUAD1
p.A410VCOAD1
p.297_298FL>LMLUAD1
p.E394GTHYM1
p.G504CSTAD1
p.A119PKIRP1
p.N21SCESC1
p.R234HBRCA1
p.E353KSTAD1
p.E162*LUAD1
p.D440NSKCM1
p.H312YLGG1
p.K68RESCA1
p.R415SESCA1
p.E479KLUSC1
p.E417*LUAD1
p.R466CUCEC1
p.R182WPRAD1
p.G512XESCA1
p.I167MCESC1
p.T316IPRAD1
p.S332TOV1
p.L144VLUAD1
p.D226HLUAD1
p.Q439KLUAD1
p.E361GLGG1
p.S546RSKCM1
p.E137QBLCA1
p.N21SCOAD1
p.E353QCESC1
p.R466HUCEC1
p.R375CUCEC1
p.E137QLUSC1
p.S237LUCEC1
p.L150VBLCA1


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TissGeneCNV for KRT6B

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KRT6B

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanESCATCGA-VR-A8EW-01AKRT6B-PGDIn-Framechr12:52842625chr1:10463127
Chimerdb3.0TopHat-FusionHNSCTCGA-CV-6955-01AKRT6B-KRT135'UTR-CDSchr12:52845907chr17:39659230
Chimerdb3.0TopHat-FusionHNSCTCGA-CV-6955-01AKRT6B-KRT135'UTR-CDSchr12:52845908chr17:39661564
Chimerdb3.0TopHat-FusionHNSCTCGA-CR-7393-01AKRT6B-KRT135'UTR-CDSchr12:52845907chr17:39659230


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TissGeneNet for KRT6B

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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COAD (tumor)COAD (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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HNSC (tumor)HNSC (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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KICH (tumor)KICH (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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KIRC (tumor)KIRC (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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KIRP (tumor)KIRP (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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LIHC (tumor)LIHC (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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LUAD (tumor)LUAD (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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LUSC (tumor)LUSC (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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PRAD (tumor)PRAD (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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STAD (tumor)STAD (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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THCA (tumor)THCA (normal)
KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (tumor)KRT6B, CAND1, CUL5, TFAP2A, UBC, CUL3, CUL1, COPS5, UCHL5, KRT19, KRT15 (normal)
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TissGeneProg for KRT6B

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KRT6B
TissGeneDrug for KRT6B

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KRT6B

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0265334Pachyonychia Congenita4BeFree,CTD_human,ORPHANET
umls:C1721007Pachyonychia Congenita, Type 2 (disorder)2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1CTD_human
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0026640Mouth Neoplasms1CTD_human
umls:C0031511Pheochromocytoma1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C3714949PACHYONYCHIA CONGENITA 41CLINVAR,UNIPROT