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| TissGeneSummary for KRT10 |
 Gene summary |
| Basic gene information | Gene symbol | KRT10 |
| Gene name | keratin 10 | |
| Synonyms | BCIE|BIE|CK10|EHK|K10|KPP | |
| Cytomap | UCSC genome browser: 17q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000421.3, | |
| Description | CK-10cytokeratin 10keratin, type I cytoskeletal 10keratin-10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 148080 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000186395 | ||
| HPRD : 01021 | ||
| Vega : OTTHUMG00000133368 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KRT10 | |
| BioGPS: 3858 | ||
| Pathway | NCI Pathway Interaction Database: KRT10 | |
| KEGG: KRT10 | ||
| REACTOME: KRT10 | ||
| Pathway Commons: KRT10 | ||
| Context | iHOP: KRT10 | |
| ligand binding site mutation search in PubMed: KRT10 | ||
| UCL Cancer Institute: KRT10 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSKCM | |
| Reference showing the relevant tissue of KRT10 | ||
| Description by TissGene annotations | TissgsLTS Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KRT10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.842150643 | 0.181556525 | 1.660594118 | 9.27E-12 | 3.89E-11 |
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| TissGene-miRNA for KRT10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KRT10 |
| TissGeneSNV for KRT10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G490S | LIHC | 7 |
| p.H491Y | KIRP | 2 |
| p.H491P | LIHC | 2 |
| p.Q223H | CESC | 1 |
| p.R464L | SKCM | 1 |
| p.H10N | LUAD | 1 |
| p.G18* | STAD | 1 |
| p.H491Y | LIHC | 1 |
| p.T366I | THYM | 1 |
| p.Q357H | OV | 1 |
| p.E426* | STAD | 1 |
| p.E426X | STAD | 1 |
| p.G99E | SKCM | 1 |
| p.R156H | COAD | 1 |
| p.G68R | LUAD | 1 |
| p.R441Q | HNSC | 1 |
| p.M150T | STAD | 1 |
| p.A391T | SKCM | 1 |
| p.R59L | SKCM | 1 |
| p.E426K | STAD | 1 |
| p.Q447* | BLCA | 1 |
| p.K163R | STAD | 1 |
| p.S12F | BLCA | 1 |
| p.G121S | COAD | 1 |
| p.R86C | SKCM | 1 |
| p.G69D | SKCM | 1 |
| p.A250T | SKCM | 1 |
| p.S56C | CESC | 1 |
| p.G22E | SKCM | 1 |
| p.G45E | SKCM | 1 |
| p.R86H | LGG | 1 |
| p.E426Q | HNSC | 1 |
| p.S570F | SKCM | 1 |
| p.E146K | SKCM | 1 |
| p.S562C | BLCA | 1 |
| p.G21E | SKCM | 1 |
| p.G99R | SKCM | 1 |
| p.G465D | LUAD | 1 |
| p.R165Q | HNSC | 1 |
| p.R399C | PRAD | 1 |
| p.R165W | UCEC | 1 |
| p.S571F | SKCM | 1 |
| p.H491Y | ESCA | 1 |
| p.R450H | BLCA | 1 |
| p.S143Y | LUAD | 1 |
| p.E249D | THYM | 1 |
| p.D352N | SKCM | 1 |
| p.G191R | SKCM | 1 |
| p.S483F | SARC | 1 |
| p.E330D | STAD | 1 |
| p.H566Y | SKCM | 1 |
| p.S360T | LIHC | 1 |
| p.R256C | ESCA | 1 |
| p.R194S | BLCA | 1 |
| p.E350X | COAD | 1 |
| p.S93T | OV | 1 |
| p.E289D | HNSC | 1 |
| p.A267V | SKCM | 1 |
| p.R35K | SKCM | 1 |
| p.Y200C | COAD | 1 |
| p.H487P | SARC | 1 |
| p.S547Y | PAAD | 1 |
| p.R295Q | LUAD | 1 |
| p.E278K | BLCA | 1 |
| p.E168* | HNSC | 1 |
| p.R15C | SKCM | 1 |
| p.I203T | COAD | 1 |
| p.G490S | KIRP | 1 |
| p.E249K | LUAD | 1 |
| p.S547Y | KIRC | 1 |
| p.N219S | SKCM | 1 |
| p.G28E | SKCM | 1 |
| p.G467E | SKCM | 1 |
| p.G254V | CHOL | 1 |
| p.L418X | LIHC | 1 |
| p.R422* | UCEC | 1 |
| p.Y584C | LUSC | 1 |
| p.H491P | ESCA | 1 |
| p.H487P | KIRP | 1 |
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| TissGeneCNV for KRT10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KRT10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChimerDB 2.0 | NA | NA | TMSB10-KRT10 | chr2:84986734 | chr17:36228255 | |
| Chimerdb3.0 | ChiTaRs | NA | BM967028 | KRT10-KRT10 | chr17:38974467 | chr17:38974369 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-M9-A5M8-01A | ERBB2-KRT10 | 5'UTR-CDS | chr17:37851434 | chr17:38977369 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-M9-A5M8-01A | ERBB2-KRT10 | Out-of-Frame | chr17:37856564 | chr17:38977369 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A3QQ-01A | TANC2-KRT10 | Out-of-frame | Chr17:61345234 | Chr17:38974734 |
| TCGAfusionPortal | PRADA | SKCM | TCGA-EB-A1NK-01A | KRT10-ARFGEF2 | 3UTR-CDS | Chr17:38974369 | Chr20:47615777 |
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| TissGeneNet for KRT10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KRT10, COPS6, CAND1, CUL5, SMAD3, UBC, YWHAZ, SRC, CUL4B, MME, COPS5, HDGF, UCHL5, EVPL, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, POU5F1, TJP1, GLE1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, HNF4A, UBC, CUL4B, CUL3, CUL1, COPS5, PITX3, UCHL5, EVPL, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, PRKCZ, TJP1, GLE1 (normal) |
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| COAD (tumor) | COAD (normal) |
| KRT10, COPS6, CUL5, CUL2, SMAD3, YWHAZ, NFKB2, SRC, CUL4B, MME, COPS5, PITX3, AKT1, UCHL5, EVPL, DCUN1D1, NEDD8, TRAF3IP1, PRKCZ, TJP1, GLE1 (tumor) | KRT10, COPS6, CAND1, CUL2, HNF4A, YWHAZ, NFKB2, CUL4B, CUL3, CUL1, COPS5, PITX3, AKT1, UCHL5, EVPL, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, TJP1, GLE1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KRT10, CAND1, CUL5, HNF4A, SMAD3, YWHAZ, NFKB2, MDM2, SRC, MME, HDGF, PITX3, ALB, AKT1, UCHL5, EVPL, NEDD8, CUL4A, TRAF3IP1, PRKCZ, GLE1 (tumor) | KRT10, COPS6, CUL5, CUL2, SMAD3, UBC, YWHAZ, NFKB2, MDM2, CUL4B, CUL3, COPS5, HDGF, UCHL5, EVPL, NEDD8, TRAF3IP1, PRKCZ, POU5F1, TJP1, GLE1 (normal) |
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| KICH (tumor) | KICH (normal) |
| KRT10, COPS6, CAND1, CUL5, HNF4A, UBC, YWHAZ, MDM2, SRC, CUL4B, MME, COPS5, AKT1, UCHL5, EVPL, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, TJP1, GLE1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, HNF4A, SMAD3, UBC, NFKB2, MDM2, SRC, CUL4B, COPS5, HDGF, PITX3, ALB, EVPL, DCUN1D1, NEDD8, CUL4A, TJP1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KRT10, COPS6, CAND1, CUL5, HNF4A, UBC, YWHAZ, MDM2, CUL4B, MME, CUL1, COPS5, PITX3, ALB, UCHL5, EVPL, NEDD8, TRAF3IP1, POU5F1, TJP1, GLE1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, NFKB2, SRC, CUL4B, CUL3, COPS5, PITX3, UCHL5, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, TJP1, GLE1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KRT10, COPS6, CAND1, CUL5, HNF4A, SMAD3, UBC, YWHAZ, MME, COPS5, PITX3, ALB, AKT1, EVPL, DCUN1D1, NEDD8, TRAF3IP1, PRKCZ, POU5F1, TJP1, GLE1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, UBC, NFKB2, MDM2, CUL4B, MME, COPS5, PITX3, UCHL5, EVPL, DCUN1D1, NEDD8, CUL4A, PRKCZ, POU5F1, TJP1, GLE1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KRT10, COPS6, CAND1, CUL5, HNF4A, SMAD3, YWHAZ, MDM2, CUL3, MME, COPS5, HDGF, PITX3, ALB, UCHL5, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, PRKCZ, TJP1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, HNF4A, UBC, YWHAZ, NFKB2, MDM2, CUL1, COPS5, HDGF, PITX3, UCHL5, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, POU5F1, TJP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KRT10, COPS6, CAND1, CUL2, SMAD3, UBC, NFKB2, CUL4B, CUL3, MME, CUL1, COPS5, HDGF, PITX3, AKT1, EVPL, NEDD8, CUL4A, TRAF3IP1, POU5F1, TJP1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, YWHAZ, NFKB2, MDM2, COPS5, HDGF, AKT1, UCHL5, EVPL, DCUN1D1, NEDD8, TRAF3IP1, POU5F1, TJP1, GLE1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KRT10, COPS6, CUL5, CUL2, HNF4A, SMAD3, UBC, SRC, CUL4B, MME, CUL1, COPS5, PITX3, ALB, AKT1, UCHL5, EVPL, DCUN1D1, NEDD8, TRAF3IP1, TJP1 (tumor) | KRT10, SMAD3, YWHAZ, NFKB2, MDM2, SRC, CUL3, CUL1, COPS5, HDGF, PITX3, ALB, AKT1, EVPL, DCUN1D1, NEDD8, TRAF3IP1, PRKCZ, POU5F1, TJP1, GLE1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KRT10, COPS6, CAND1, CUL5, HNF4A, SMAD3, UBC, YWHAZ, CUL4B, CUL3, MME, COPS5, HDGF, PITX3, AKT1, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, POU5F1, TJP1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, NFKB2, MDM2, CUL4B, COPS5, ALB, UCHL5, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, PRKCZ, POU5F1, TJP1, GLE1 (normal) |
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| STAD (tumor) | STAD (normal) |
| KRT10, CAND1, CUL5, CUL2, HNF4A, SMAD3, YWHAZ, NFKB2, MDM2, SRC, CUL4B, CUL3, MME, COPS5, AKT1, UCHL5, EVPL, DCUN1D1, NEDD8, TRAF3IP1, TJP1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, UBC, YWHAZ, NFKB2, MDM2, CUL1, COPS5, HDGF, PITX3, AKT1, EVPL, DCUN1D1, NEDD8, TRAF3IP1, PRKCZ, POU5F1, GLE1 (normal) |
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| THCA (tumor) | THCA (normal) |
| KRT10, COPS6, CAND1, CUL5, CUL2, SMAD3, UBC, MDM2, SRC, CUL4B, CUL3, COPS5, HDGF, UCHL5, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, PRKCZ, TJP1, GLE1 (tumor) | KRT10, COPS6, CAND1, CUL5, CUL2, SMAD3, YWHAZ, SRC, CUL4B, CUL3, MME, COPS5, PITX3, ALB, DCUN1D1, NEDD8, CUL4A, TRAF3IP1, PRKCZ, TJP1, GLE1 (normal) |
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| TissGeneProg for KRT10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KRT10 |
| TissGeneDrug for KRT10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KRT10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0079153 | Hyperkeratosis, Epidermolytic | 45 | BeFree,CLINVAR,CTD_human,LHGDN,ORPHANET,UNIPROT |
| umls:C0343110 | Epidermolytic palmoplantar keratoderma of Vorner | 30 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 6 | BeFree,CTD_human,LHGDN |
| umls:C0022596 | Palmoplantar Keratosis | 6 | BeFree |
| umls:C0037274 | Dermatologic disorders | 6 | BeFree |
| umls:C0870082 | Hyperkeratosis | 5 | BeFree |
| umls:C3665704 | Congenital reticular ichthyosiform erythroderma | 4 | BeFree,CTD_human,ORPHANET |
| umls:C0037277 | Skin Diseases, Genetic | 3 | BeFree |
| umls:C1843463 | Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis | 3 | BeFree,CTD_human,ORPHANET,UNIPROT |
| umls:C0011606 | Exfoliative dermatitis | 2 | BeFree |
| umls:C0079298 | Epidermolysis Bullosa Simplex | 2 | BeFree |
| umls:C0334082 | NEVUS, EPIDERMAL (disorder) | 2 | BeFree |
| umls:C0005859 | Bloom Syndrome | 1 | BeFree |
| umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
| umls:C0011649 | Dermoid Cyst | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0020757 | Ichthyoses | 1 | BeFree |
| umls:C0020758 | Congenital ichthyosis | 1 | BeFree |
| umls:C0022584 | Keratoderma, Palmoplantar, Diffuse | 1 | BeFree |
| umls:C0024198 | Lyme Disease | 1 | LHGDN |
| umls:C0037286 | Skin Neoplasms | 1 | CTD_human |
| umls:C0039538 | Teratoma | 1 | LHGDN |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0311375 | Arsenic Poisoning | 1 | CTD_human |
| umls:C0343731 | Penile warts | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | LHGDN |
| umls:C1836681 | Erythrokeratoderma, Reticular | 0 | CLINVAR |
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