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| TissGeneSummary for KRT17 |
 Gene summary |
| Basic gene information | Gene symbol | KRT17 |
| Gene name | keratin 17 | |
| Synonyms | K17|PC|PC2|PCHC1 | |
| Cytomap | UCSC genome browser: 17q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000422.2, | |
| Description | 39.1CK-17cytokeratin-17keratin 17 epitope S1keratin 17 epitope S2keratin 17 epitope S4keratin, type I cytoskeletal 17keratin-17 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 148069 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000128422 | ||
| HPRD : 01019 | ||
| Vega : OTTHUMG00000133505 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KRT17 | |
| BioGPS: 3872 | ||
| Pathway | NCI Pathway Interaction Database: KRT17 | |
| KEGG: KRT17 | ||
| REACTOME: KRT17 | ||
| Pathway Commons: KRT17 | ||
| Context | iHOP: KRT17 | |
| ligand binding site mutation search in PubMed: KRT17 | ||
| UCL Cancer Institute: KRT17 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastCervixSkinThymus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCACESCSKCMTHYM | |
| Reference showing the relevant tissue of KRT17 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KRT17 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 6.388244671 | 0.030762319 | 6.357482353 | 5.02E-24 | 9.66E-23 |
| THCA | -1.722756924 | -4.650382347 | 2.927625424 | 1.19E-07 | 5.13E-07 |
| KICH | -5.274267093 | -2.737575093 | -2.536692 | 1.39E-05 | 4.27E-05 |
| COAD | -1.800470939 | -5.226324786 | 3.425853846 | 4.18E-07 | 2.56E-06 |
| HNSC | 9.158032907 | 6.27704686 | 2.880986047 | 1.59E-09 | 2.42E-08 |
| BRCA | 0.668223258 | 3.623846065 | -2.955622807 | 6.56E-10 | 2.37E-09 |
| STAD | 1.061845407 | -3.508038968 | 4.569884375 | 1.01E-06 | 1.63E-05 |
| LUAD | 0.997481183 | -0.43173261 | 1.429213793 | 0.000633 | 0.001419819 |
| KIRC | -4.169960149 | -3.047874038 | -1.122086111 | 0.000494 | 0.000964333 |
| PRAD | 2.030548291 | 3.573655984 | -1.543107692 | 2.52E-05 | 0.000125776 |
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| TissGene-miRNA for KRT17 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KRT17 |
| TissGeneSNV for KRT17 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q338X | ESCA | 1 |
| p.G246C | PAAD | 1 |
| p.L79M | SARC | 1 |
| p.G68V | ACC | 1 |
| p.L353P | UCEC | 1 |
| p.R268S | KIRP | 1 |
| p.F169S | COAD | 1 |
| p.S28F | SKCM | 1 |
| p.E255K | SKCM | 1 |
| p.R201I | LUAD | 1 |
| p.R117C | COAD | 1 |
| p.A202S | LIHC | 1 |
| p.R94H | GBM | 1 |
| p.V337M | COAD | 1 |
| p.R170C | BRCA | 1 |
| p.A228T | STAD | 1 |
| p.S24L | SKCM | 1 |
| p.R94C | BRCA | 1 |
| p.L371M | THYM | 1 |
| p.R357C | LIHC | 1 |
| p.Q352K | BRCA | 1 |
| p.R257H | STAD | 1 |
| p.E272K | BRCA | 1 |
| p.V114A | KIRP | 1 |
| p.E332D | UCEC | 1 |
| p.I312K | READ | 1 |
| p.E107K | LUAD | 1 |
| p.R432H | THYM | 1 |
| p.D417N | SKCM | 1 |
| p.A202D | LUAD | 1 |
| p.T306S | BLCA | 1 |
| p.G53R | STAD | 1 |
| p.S323F | SKCM | 1 |
| p.G344W | LUSC | 1 |
| p.E332D | PAAD | 1 |
| p.D151N | STAD | 1 |
| p.G70D | UCEC | 1 |
| p.R357C | SKCM | 1 |
| p.R432C | LUSC | 1 |
| p.R386C | STAD | 1 |
| p.S17F | SKCM | 1 |
| p.S58C | BLCA | 1 |
| p.G43E | SKCM | 1 |
| p.R357C | LUAD | 1 |
| p.K262X | DLBC | 1 |
| p.R191H | UCEC | 1 |
| p.G82R | SKCM | 1 |
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| TissGeneCNV for KRT17 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KRT17 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A8I1-01A | OXR1-KRT17 | Out-of-Frame | chr8:107758090 | chr17:39778006 |
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| TissGeneNet for KRT17 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KRT17, FKBP4, CHD3, EZR, IKBKB, MAP3K14, KHDRBS1, MAP1LC3B, KRT8, IFT57, VDR, CDT1, DEDD, SNAPIN, KRT7, GJB3, KRT6A, RALGDS, CASP2, DEDD2, CFLAR (tumor) | KRT17, FKBP4, MDM2, TNFRSF1A, CEBPB, USP7, TRAF1, MAP3K14, CASP1, TNFAIP3, EGFR, FAS, NOD1, XIAP, MSN, KRT7, TRADD, GJB3, RAD17, KRT6A, VIM (normal) |
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| COAD (tumor) | COAD (normal) |
| KRT17, NR1H3, COPS6, CASP3, CASP4, TCF4, NLK, TRAF2, BIRC2, SIRT1, SORBS1, VDR, MSN, CDT1, KRT7, TRADD, PEA15, NR2F6, CASP2, UCHL1, CLIP3 (tumor) | KRT17, NR1H3, SMAD3, CHD3, BCL2L1, CASP4, TCF4, KRT8, HDAC7, SORBS1, MSN, SNAPIN, KRT7, GJB3, CASP14, PEA15, KRT6A, VIM, CASP2, UCHL1, CLIP3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KRT17, FADD, YWHAZ, SUMO2, GRB2, EZR, YWHAQ, IKBKB, CASP1, SMAD4, VDR, MSN, CDT1, ARHGDIA, GJB3, CASP14, H2AFX, KRT6A, GBAS, DEDD2, KRT72 (tumor) | KRT17, UBC, YWHAZ, EZR, TNFRSF1A, CEBPB, MAP3K14, CASP4, SMAD4, USP1, SIRT1, VDR, ATM, SNAPIN, ARHGDIA, GJB3, USP2, CASP14, KRT6A, CASP9, CASP2 (normal) |
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| KICH (tumor) | KICH (normal) |
| KRT17, SQSTM1, YWHAZ, EZR, TNFRSF1A, SIRT3, CEBPB, MAPK1, MYC, MAP3K14, YWHAB, RHOA, TNFAIP3, KRT8, FAS, MAPK6, ARHGDIA, KRT7, PEA15, RAD17, VIM (tumor) | KRT17, CASP3, TNFRSF1A, IKBKB, MYC, CASP1, RHOA, CASP4, TCF4, TRAF2, TNFAIP3, TFCP2, NOD1, FASLG, GJB3, USP2, PEA15, RAD17, KRT6A, VIM, NPHS1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KRT17, TNFRSF10B, CASP3, YWHAZ, MDM2, TNFRSF1A, CEBPB, MYC, CASP1, RHOA, CASP4, TNFAIP3, KRT8, YWHAH, FAS, KRT7, GJB3, PEA15, H2AFX, KRT6A, VIM (tumor) | KRT17, APC, SUMO2, CHD3, CEBPB, MAPK1, MAPK8, CHUK, BIRC2, RAB3GAP2, MAP1LC3A, CCDC85B, ATM, ARHGDIA, KRT7, GJB3, CASP14, H2AFX, RAD17, KRT6A, UCHL1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KRT17, TNFRSF10B, YWHAZ, TNFRSF1A, CEBPB, MAPK1, TRAF1, MYC, CASP1, RHOA, CASP4, TNFAIP3, KRT8, YWHAH, FAS, CDT1, ARHGDIA, KRT7, GJB3, PEA15, VIM (tumor) | KRT17, SQSTM1, APC, SMAD3, SUMO2, CHD3, IKBKB, YWHAE, CHUK, KRT8, NOD1, VDR, DEDD, ARHGDIA, KRT7, GJB3, USP2, RAD17, KRT6A, CASP2, NR1H4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KRT17, TNFRSF10B, YWHAZ, CHD3, IKBKB, MYC, YWHAB, RHOA, TCF4, BIRC2, TNFAIP3, HDAC7, FAS, IFT57, VDR, KRT7, CASP14, PEA15, KRT6A, NR2F6, GBAS (tumor) | KRT17, FADD, EZR, TRAF1, KHDRBS1, CASP4, TRAF2, HDAC7, YWHAH, NOD1, KRT7, GJB3, CASP14, H2AFX, KRT6A, VIM, RALGDS, CASP2, UCHL1, CLIP3, RNF34 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KRT17, FKBP4, YWHAZ, MDM2, GRB2, EZR, BCL2L1, CTNNB1, STK4, KHDRBS1, BTRC, KRT8, FAS, IFT57, TRADD, GJB3, USP2, FAF1, KRT6A, CASP9, RNF34 (tumor) | KRT17, SMAD3, EZR, TNFRSF1A, BCL2L1, CEBPB, YWHAB, NLK, KRT8, SIRT1, HDAC7, MAPK6, ARHGDIA, KRT7, GJB3, CASP14, RAD17, KRT6A, CASP9, NR1H2, NR1H4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KRT17, BCL2L1, RHOA, SMAD4, TRAF2, CASP8AP2, RAB3GAP2, USP1, CCDC85B, TNFSF10, ARHGDIA, TRADD, GJB3, USP2, H2AFX, RAD17, BFAR, KRT6A, NR1H2, RALGDS, CFLAR (tumor) | KRT17, NR1H3, SMAD3, YWHAZ, TNFRSF1A, MYC, MAP3K14, NLK, EGFR, USP1, SIRT1, SORBS1, FASLG, TNFSF10, MAPK6, GJB3, NLRC4, RAD17, KRT6A, CLIP3, RNF34 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KRT17, TNFRSF10B, NR1H3, UBC, EZR, TNFRSF1A, CEBPB, MYC, MAP3K14, CASP1, CASP4, SMAD4, RAB3GAP2, SIRT1, VDR, TNFSF10, KRT7, TRADD, GJB3, KRT6A, RALGDS (tumor) | KRT17, SQSTM1, SMAD3, TNFRSF1A, CEBPB, USP7, TRAF1, YWHAQ, MAP3K14, CASP1, NLK, TNFAIP3, HDAC7, VDR, KRT7, GJB3, USP2, CASP14, KRT6A, GBAS, CLIP3 (normal) |
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| STAD (tumor) | STAD (normal) |
| KRT17, TRAF6, SMAD3, UBC, YWHAZ, RALBP1, MAPK8, SKP2, EGFR, YWHAH, IFT57, MAPK6, GJB3, CASP14, KRT6A, VIM, PGK1, RALGDS, CASP2, CFLAR, RNF34 (tumor) | KRT17, TNFRSF10B, SMAD3, UBC, YWHAZ, EZR, RALBP1, BCL2L1, TRAF1, STK4, MAP3K14, CASP1, KRT8, FASLG, MAPK6, KRT7, GJB3, NLRC4, KRT6A, RNF34, NPHS1 (normal) |
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| THCA (tumor) | THCA (normal) |
| KRT17, TNFRSF10B, UBC, TNFRSF1A, TRAF1, MYC, MAP3K14, CASP1, CASP4, SMAD4, TNFAIP3, YWHAH, FAS, NLRC4, PEA15, H2AFX, KRT6A, VIM, RALGDS, CFLAR, NPHS1 (tumor) | KRT17, TNFRSF10B, FKBP4, YWHAZ, TNFRSF1A, BCL2L1, CEBPB, MYC, MAP3K14, CASP4, NLK, YWHAH, FAS, NOD1, GJB3, NLRC4, RAD17, KRT6A, GBAS, RALGDS, CLIP3 (normal) |
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| TissGeneProg for KRT17 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KRT17 |
| TissGeneDrug for KRT17 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KRT17 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1721007 | Pachyonychia Congenita, Type 2 (disorder) | 15 | BeFree,CLINVAR,UNIPROT |
| umls:C0265334 | Pachyonychia Congenita | 11 | BeFree,CTD_human,LHGDN,ORPHANET |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 4 | BeFree,LHGDN |
| umls:C0033860 | Psoriasis | 4 | BeFree,LHGDN |
| umls:C0259771 | Steatocystoma multiplex | 4 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0020608 | Hypodontia | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0037286 | Skin Neoplasms | 2 | BeFree,CTD_human |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree,LHGDN |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 1 | CTD_human |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | LHGDN |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0010709 | Cyst | 1 | BeFree |
| umls:C0014511 | Epithelial cyst | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0020676 | Hypothyroidism | 1 | BeFree |
| umls:C0022596 | Palmoplantar Keratosis | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0031511 | Pheochromocytoma | 1 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0079298 | Epidermolysis Bullosa Simplex | 1 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
| umls:C0221260 | Dystrophia unguium | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0263454 | Chloracne | 1 | CTD_human |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
| umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree |
| umls:C0553580 | Ewings sarcoma | 1 | BeFree |
| umls:C0553723 | Squamous cell carcinoma of skin | 1 | BeFree |
| umls:C0598608 | Hyperhomocysteinemia | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1336076 | Sporadic Breast Carcinoma | 1 | BeFree |
| umls:C1368683 | Epithelioma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 1 | BeFree |
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