TissGeneSummary for ILDR2 |
Gene summary |
Basic gene information | Gene symbol | ILDR2 |
Gene name | immunoglobulin-like domain containing receptor 2 | |
Synonyms | C1orf32|dJ782G3.1 | |
Cytomap | UCSC genome browser: 1q24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_199351.2, | |
Description | immunoglobulin-like domain-containing receptor 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 12724 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ILDR2 | |
BioGPS: 387597 | ||
Pathway | NCI Pathway Interaction Database: ILDR2 | |
KEGG: ILDR2 | ||
REACTOME: ILDR2 | ||
Pathway Commons: ILDR2 | ||
Context | iHOP: ILDR2 | |
ligand binding site mutation search in PubMed: ILDR2 | ||
UCL Cancer Institute: ILDR2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of ILDR2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for ILDR2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.880368203 | -3.082455045 | 1.202086842 | 1.05E-19 | 7.24E-19 |
KICH | -3.085160484 | 0.516367516 | -3.601528 | 3.97E-13 | 5.11E-12 |
LIHC | -0.635932484 | -2.276956484 | 1.641024 | 1.23E-05 | 5.09E-05 |
KIRC | 0.341597294 | 1.361741738 | -1.020144444 | 0.00028 | 0.000562258 |
LUSC | -2.086139307 | -1.008164798 | -1.07797451 | 7.51E-05 | 0.000158061 |
Top |
TissGene-miRNA for ILDR2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for ILDR2 |
TissGeneSNV for ILDR2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R398* | SKCM | 2 |
p.R398X | SKCM | 2 |
p.T335S | HNSC | 1 |
p.R101* | SKCM | 1 |
p.D151Y | UCEC | 1 |
p.L91F | UCEC | 1 |
p.S105L | SKCM | 1 |
p.Q22X | SKCM | 1 |
p.T420K | LUAD | 1 |
p.G114R | SKCM | 1 |
p.G432E | SKCM | 1 |
p.S69F | SKCM | 1 |
p.V250F | LUAD | 1 |
p.R327K | SKCM | 1 |
p.S10Y | UCEC | 1 |
p.M274I | SKCM | 1 |
p.D609N | KIRP | 1 |
p.S96N | READ | 1 |
p.R386C | ACC | 1 |
p.P324L | SKCM | 1 |
p.G67E | SKCM | 1 |
p.V197I | UCEC | 1 |
p.A241T | SKCM | 1 |
p.Q131P | BLCA | 1 |
p.C209Y | UCEC | 1 |
p.V125D | BLCA | 1 |
p.R41C | SKCM | 1 |
p.R606H | LUAD | 1 |
p.R101X | SKCM | 1 |
p.R386H | HNSC | 1 |
p.P281T | LUAD | 1 |
p.Q63H | LUAD | 1 |
p.A464V | KIRC | 1 |
p.R329T | CESC | 1 |
p.L422M | LUAD | 1 |
p.L70F | PRAD | 1 |
p.R326G | OV | 1 |
p.P150S | SKCM | 1 |
p.S228F | SKCM | 1 |
p.G265E | LUAD | 1 |
p.D430N | SKCM | 1 |
p.D2G | STAD | 1 |
p.D397N | SKCM | 1 |
p.S400C | SKCM | 1 |
p.R386H | COAD | 1 |
p.E396K | SKCM | 1 |
p.Y373C | BLCA | 1 |
p.S421Y | ESCA | 1 |
p.S287Y | LUAD | 1 |
p.S347C | LUAD | 1 |
p.H354Y | STAD | 1 |
p.R97W | LUAD | 1 |
p.G239R | SKCM | 1 |
p.R65C | SKCM | 1 |
p.G245W | LUAD | 1 |
p.R295C | SKCM | 1 |
p.R459C | LIHC | 1 |
p.G108S | LUAD | 1 |
p.G245A | PRAD | 1 |
p.A320T | LUAD | 1 |
p.M429I | SKCM | 1 |
p.V103A | STAD | 1 |
p.M184I | KIRC | 1 |
p.G265V | SKCM | 1 |
p.H278Q | GBM | 1 |
p.M309I | SKCM | 1 |
p.Q22* | SKCM | 1 |
p.G297S | SKCM | 1 |
p.D346Y | ESCA | 1 |
p.R65H | STAD | 1 |
p.A180S | SKCM | 1 |
p.S421T | ESCA | 1 |
p.P232H | LUAD | 1 |
p.S527L | UCS | 1 |
p.L80V | CESC | 1 |
p.Y117F | LIHC | 1 |
p.K29N | UCEC | 1 |
p.D323E | LUAD | 1 |
p.R83I | UCEC | 1 |
p.R357K | CESC | 1 |
p.I183M | SKCM | 1 |
p.E344D | LUAD | 1 |
p.P362L | KIRC | 1 |
p.R7K | OV | 1 |
p.P247L | SKCM | 1 |
p.G155E | SKCM | 1 |
p.A384S | ACC | 1 |
p.P423L | COAD | 1 |
p.P281S | STAD | 1 |
p.D428E | PRAD | 1 |
p.G67V | UCEC | 1 |
p.R350H | COAD | 1 |
p.P247L | TGCT | 1 |
p.G141R | COAD | 1 |
p.S109L | BLCA | 1 |
Top |
TissGeneCNV for ILDR2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for ILDR2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA961434 | RAB3GAP1-ILDR2 | chr2:135926780 | chr1:166884911 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0YM-01A | PBX1-ILDR2 | In-frame | Chr1:164532548 | Chr1:166927338 |
Top |
TissGeneNet for ILDR2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for ILDR2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for ILDR2 |
TissGeneDrug for ILDR2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for ILDR2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0029456 | Osteoporosis | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |