TissGeneSummary for SLC16A12 |
Gene summary |
Basic gene information | Gene symbol | SLC16A12 |
Gene name | solute carrier family 16, member 12 | |
Synonyms | CJMG|MCT12 | |
Cytomap | UCSC genome browser: 10q23.31 | |
Type of gene | protein-coding | |
RefGenes | NM_213606.3, | |
Description | monocarboxylate transporter 12monocarboxylic acid transporter 12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) | |
Modification date | 20141207 | |
dbXrefs | MIM : 611910 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152779 | ||
HPRD : 17365 | ||
Vega : OTTHUMG00000018714 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC16A12 | |
BioGPS: 387700 | ||
Pathway | NCI Pathway Interaction Database: SLC16A12 | |
KEGG: SLC16A12 | ||
REACTOME: SLC16A12 | ||
Pathway Commons: SLC16A12 | ||
Context | iHOP: SLC16A12 | |
ligand binding site mutation search in PubMed: SLC16A12 | ||
UCL Cancer Institute: SLC16A12 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPAAD | |
Reference showing the relevant tissue of SLC16A12 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:1902598 | creatine transmembrane transport | 23578822 | GO:1902598 | creatine transmembrane transport | 23578822 |
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TissGeneExp for SLC16A12 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.118215887 | 2.28357627 | -3.401792157 | 7.10E-21 | 9.46E-20 |
KIRP | 5.544298145 | 7.702248145 | -2.15795 | 1.48E-06 | 7.24E-06 |
KIRC | 6.619541548 | 7.984734603 | -1.365193056 | 1.60E-07 | 4.39E-07 |
KICH | 3.27402427 | 7.66894427 | -4.39492 | 6.82E-09 | 3.75E-08 |
COAD | -2.651962192 | -0.465081422 | -2.186880769 | 1.49E-12 | 3.63E-11 |
BRCA | -1.447463204 | 1.656971007 | -3.104434211 | 4.96E-46 | 2.43E-44 |
LUAD | 0.953484891 | 2.58712627 | -1.633641379 | 5.00E-07 | 1.73E-06 |
STAD | -1.996483105 | -0.551745605 | -1.4447375 | 0.000119 | 0.000901114 |
PRAD | -1.172187192 | 0.276453193 | -1.448640385 | 0.000145 | 0.000590809 |
THCA | 2.221247456 | 3.488137287 | -1.266889831 | 0.000212 | 0.000552198 |
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TissGene-miRNA for SLC16A12 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.025 | -0.26 | 78 |
ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.025 | -0.26 | 78 |
UCS | hsa-miR-106a-5p | MIMAT0000103 | 0.011 | -0.34 | 56 |
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TissGeneMut for SLC16A12 |
TissGeneSNV for SLC16A12 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S259F | SKCM | 3 |
p.S289F | SKCM | 2 |
p.G328E | SKCM | 2 |
p.S409* | CESC | 1 |
p.P348L | SKCM | 1 |
p.M359T | KIRP | 1 |
p.S226L | BLCA | 1 |
p.G122* | SKCM | 1 |
p.R8W | SKCM | 1 |
p.G18C | LUAD | 1 |
p.P368Q | THYM | 1 |
p.W47X | SKCM | 1 |
p.E217* | UCEC | 1 |
p.G147S | STAD | 1 |
p.E447* | UCEC | 1 |
p.G328V | LIHC | 1 |
p.G23E | SKCM | 1 |
p.S493Y | READ | 1 |
p.F353L | PAAD | 1 |
p.S172F | LUAD | 1 |
p.S153G | BRCA | 1 |
p.S257Y | COAD | 1 |
p.L180I | UCEC | 1 |
p.D404V | HNSC | 1 |
p.G361V | ESCA | 1 |
p.S256L | SKCM | 1 |
p.S449P | READ | 1 |
p.Q371X | DLBC | 1 |
p.G331V | ESCA | 1 |
p.G358V | LIHC | 1 |
p.G358E | SKCM | 1 |
p.L193F | HNSC | 1 |
p.D469H | UCEC | 1 |
p.W17G | PRAD | 1 |
p.T398I | COAD | 1 |
p.Y273H | LIHC | 1 |
p.W17* | SKCM | 1 |
p.F383L | PAAD | 1 |
p.S379* | CESC | 1 |
p.A326V | SKCM | 1 |
p.W59* | SKCM | 1 |
p.W89X | SKCM | 1 |
p.G23R | LUAD | 1 |
p.X517W | LGG | 1 |
p.L100P | KIRP | 1 |
p.Y303H | LIHC | 1 |
p.L125V | LUAD | 1 |
p.A257V | PRAD | 1 |
p.S226L | SKCM | 1 |
p.A85T | COAD | 1 |
p.S408I | LIHC | 1 |
p.Q442H | STAD | 1 |
p.R174W | LGG | 1 |
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TissGeneCNV for SLC16A12 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC16A12 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC16A12 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC16A12 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC16A12 |
TissGeneDrug for SLC16A12 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC16A12 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036646 | Age-related cataract | 3 | BeFree |
umls:C0086543 | Cataract | 2 | BeFree,GAD |
umls:C0302254 | Juvenile cataract | 2 | BeFree |
umls:C0017980 | Glycosuria, Renal | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0266544 | Microcornea | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C2677587 | Cataract, Juvenile, With Microcornea And Glucosuria | 0 | CLINVAR,CTD_human,ORPHANET |