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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC16A12
check button Gene summary
Basic gene informationGene symbolSLC16A12
Gene namesolute carrier family 16, member 12
SynonymsCJMG|MCT12
CytomapUCSC genome browser: 10q23.31
Type of geneprotein-coding
RefGenesNM_213606.3,
Descriptionmonocarboxylate transporter 12monocarboxylic acid transporter 12solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
Modification date20141207
dbXrefs MIM : 611910
HGNC : HGNC
Ensembl : ENSG00000152779
HPRD : 17365
Vega : OTTHUMG00000018714
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC16A12
BioGPS: 387700
PathwayNCI Pathway Interaction Database: SLC16A12
KEGG: SLC16A12
REACTOME: SLC16A12
Pathway Commons: SLC16A12
ContextiHOP: SLC16A12
ligand binding site mutation search in PubMed: SLC16A12
UCL Cancer Institute: SLC16A12
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyPancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHPAAD
Reference showing the relevant tissue of SLC16A12
Description by TissGene annotationsProtective TissGene in OS
Protective TissGene in RFS
Have significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:1902598creatine transmembrane transport23578822
GO:1902598creatine transmembrane transport23578822


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TissGeneExp for SLC16A12

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-1.1182158872.28357627-3.4017921577.10E-219.46E-20
KIRP5.5442981457.702248145-2.157951.48E-067.24E-06
KIRC6.6195415487.984734603-1.3651930561.60E-074.39E-07
KICH3.274024277.66894427-4.394926.82E-093.75E-08
COAD-2.651962192-0.465081422-2.1868807691.49E-123.63E-11
BRCA-1.4474632041.656971007-3.1044342114.96E-462.43E-44
LUAD0.9534848912.58712627-1.6336413795.00E-071.73E-06
STAD-1.996483105-0.551745605-1.44473750.0001190.000901114
PRAD-1.1721871920.276453193-1.4486403850.0001450.000590809
THCA2.2212474563.488137287-1.2668898310.0002120.000552198


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TissGene-miRNA for SLC16A12

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-520d-3pMIMAT00028560.025-0.2678
ACChsa-miR-520d-3pMIMAT00028560.025-0.2678
UCShsa-miR-106a-5pMIMAT00001030.011-0.3456


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TissGeneMut for SLC16A12
TissGeneSNV for SLC16A12

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S259FSKCM3
p.S289FSKCM2
p.G328ESKCM2
p.S409*CESC1
p.P348LSKCM1
p.M359TKIRP1
p.S226LBLCA1
p.G122*SKCM1
p.R8WSKCM1
p.G18CLUAD1
p.P368QTHYM1
p.W47XSKCM1
p.E217*UCEC1
p.G147SSTAD1
p.E447*UCEC1
p.G328VLIHC1
p.G23ESKCM1
p.S493YREAD1
p.F353LPAAD1
p.S172FLUAD1
p.S153GBRCA1
p.S257YCOAD1
p.L180IUCEC1
p.D404VHNSC1
p.G361VESCA1
p.S256LSKCM1
p.S449PREAD1
p.Q371XDLBC1
p.G331VESCA1
p.G358VLIHC1
p.G358ESKCM1
p.L193FHNSC1
p.D469HUCEC1
p.W17GPRAD1
p.T398ICOAD1
p.Y273HLIHC1
p.W17*SKCM1
p.F383LPAAD1
p.S379*CESC1
p.A326VSKCM1
p.W59*SKCM1
p.W89XSKCM1
p.G23RLUAD1
p.X517WLGG1
p.L100PKIRP1
p.Y303HLIHC1
p.L125VLUAD1
p.A257VPRAD1
p.S226LSKCM1
p.A85TCOAD1
p.S408ILIHC1
p.Q442HSTAD1
p.R174WLGG1


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TissGeneCNV for SLC16A12

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SLC16A12

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for SLC16A12

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for SLC16A12

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SLC16A12
TissGeneDrug for SLC16A12

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SLC16A12

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0036646Age-related cataract3BeFree
umls:C0086543Cataract2BeFree,GAD
umls:C0302254Juvenile cataract2BeFree
umls:C0017980Glycosuria, Renal1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0266544Microcornea1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C2677587Cataract, Juvenile, With Microcornea And Glucosuria0CLINVAR,CTD_human,ORPHANET