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| TissGeneSummary for C1QTNF9B |
 Gene summary |
| Basic gene information | Gene symbol | C1QTNF9B |
| Gene name | C1q and tumor necrosis factor related protein 9B | |
| Synonyms | CTRP9B | |
| Cytomap | UCSC genome browser: 13q12.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001007537.2, NR_104426.1, | |
| Description | C1q/TNF-related protein 9Bcollagen triple helix repeat-containingcomplement C1q and tumor necrosis factor-related protein 9B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614148 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000205863 | ||
| HPRD : 17369 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C1QTNF9B | |
| BioGPS: 387911 | ||
| Pathway | NCI Pathway Interaction Database: C1QTNF9B | |
| KEGG: C1QTNF9B | ||
| REACTOME: C1QTNF9B | ||
| Pathway Commons: C1QTNF9B | ||
| Context | iHOP: C1QTNF9B | |
| ligand binding site mutation search in PubMed: C1QTNF9B | ||
| UCL Cancer Institute: C1QTNF9B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of C1QTNF9B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C1QTNF9B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.040528838 | 1.465420284 | -2.505949123 | 4.74E-50 | 3.14E-48 |
| COAD | -1.247167637 | -0.12959456 | -1.117573077 | 0.000125 | 0.000442447 |
| HNSC | -1.62788812 | -0.570699748 | -1.057188372 | 5.03E-05 | 0.000243912 |
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| TissGene-miRNA for C1QTNF9B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C1QTNF9B |
| TissGeneSNV for C1QTNF9B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G185E | SKCM | 2 |
| p.G47E | SKCM | 2 |
| p.E230K | BLCA | 1 |
| p.E230K | SKCM | 1 |
| p.M154V | STAD | 1 |
| p.V281M | STAD | 1 |
| p.G47R | UCEC | 1 |
| p.R45* | UCEC | 1 |
| p.K73T | UCEC | 1 |
| p.G50S | SKCM | 1 |
| p.G270R | SKCM | 1 |
| p.G56R | SKCM | 1 |
| p.G270E | SKCM | 1 |
| p.P102T | LUAD | 1 |
| p.G116R | SKCM | 1 |
| p.G86D | UCEC | 1 |
| p.E189Q | HNSC | 1 |
| p.S290G | PRAD | 1 |
| p.D278Y | UCEC | 1 |
| p.G146D | LUAD | 1 |
| p.G176E | BLCA | 1 |
| p.T209M | ESCA | 1 |
| p.G298E | DLBC | 1 |
| p.P215S | SKCM | 1 |
| p.G194S | PRAD | 1 |
| p.S259Y | LUAD | 1 |
| p.M301V | SKCM | 1 |
| p.G98E | HNSC | 1 |
| p.T209M | SARC | 1 |
| p.G158V | LGG | 1 |
| p.R76Q | SKCM | 1 |
| p.F258L | BLCA | 1 |
| p.G107E | HNSC | 1 |
| p.P31S | SKCM | 1 |
| p.G104R | SKCM | 1 |
| p.E230K | STAD | 1 |
| p.R24M | PAAD | 1 |
| p.G98E | SKCM | 1 |
| p.G107E | SKCM | 1 |
| p.R178W | STAD | 1 |
| p.R178Q | THCA | 1 |
| p.D320N | SKCM | 1 |
| p.G50S | THYM | 1 |
| p.G80E | SKCM | 1 |
| p.G143E | SKCM | 1 |
| p.G179E | SKCM | 1 |
| p.D54N | HNSC | 1 |
| p.A48V | UCEC | 1 |
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| TissGeneCNV for C1QTNF9B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C1QTNF9B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for C1QTNF9B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C1QTNF9B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C1QTNF9B |
| TissGeneDrug for C1QTNF9B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C1QTNF9B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0271183 | Severe myopia | 1 | BeFree |
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