TissGeneSummary for C1QTNF9B |
Gene summary |
Basic gene information | Gene symbol | C1QTNF9B |
Gene name | C1q and tumor necrosis factor related protein 9B | |
Synonyms | CTRP9B | |
Cytomap | UCSC genome browser: 13q12.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001007537.2, NR_104426.1, | |
Description | C1q/TNF-related protein 9Bcollagen triple helix repeat-containingcomplement C1q and tumor necrosis factor-related protein 9B | |
Modification date | 20141207 | |
dbXrefs | MIM : 614148 | |
HGNC : HGNC | ||
Ensembl : ENSG00000205863 | ||
HPRD : 17369 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C1QTNF9B | |
BioGPS: 387911 | ||
Pathway | NCI Pathway Interaction Database: C1QTNF9B | |
KEGG: C1QTNF9B | ||
REACTOME: C1QTNF9B | ||
Pathway Commons: C1QTNF9B | ||
Context | iHOP: C1QTNF9B | |
ligand binding site mutation search in PubMed: C1QTNF9B | ||
UCL Cancer Institute: C1QTNF9B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C1QTNF9B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C1QTNF9B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.040528838 | 1.465420284 | -2.505949123 | 4.74E-50 | 3.14E-48 |
COAD | -1.247167637 | -0.12959456 | -1.117573077 | 0.000125 | 0.000442447 |
HNSC | -1.62788812 | -0.570699748 | -1.057188372 | 5.03E-05 | 0.000243912 |
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TissGene-miRNA for C1QTNF9B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C1QTNF9B |
TissGeneSNV for C1QTNF9B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G185E | SKCM | 2 |
p.G47E | SKCM | 2 |
p.E230K | BLCA | 1 |
p.E230K | SKCM | 1 |
p.M154V | STAD | 1 |
p.V281M | STAD | 1 |
p.G47R | UCEC | 1 |
p.R45* | UCEC | 1 |
p.K73T | UCEC | 1 |
p.G50S | SKCM | 1 |
p.G270R | SKCM | 1 |
p.G56R | SKCM | 1 |
p.G270E | SKCM | 1 |
p.P102T | LUAD | 1 |
p.G116R | SKCM | 1 |
p.G86D | UCEC | 1 |
p.E189Q | HNSC | 1 |
p.S290G | PRAD | 1 |
p.D278Y | UCEC | 1 |
p.G146D | LUAD | 1 |
p.G176E | BLCA | 1 |
p.T209M | ESCA | 1 |
p.G298E | DLBC | 1 |
p.P215S | SKCM | 1 |
p.G194S | PRAD | 1 |
p.S259Y | LUAD | 1 |
p.M301V | SKCM | 1 |
p.G98E | HNSC | 1 |
p.T209M | SARC | 1 |
p.G158V | LGG | 1 |
p.R76Q | SKCM | 1 |
p.F258L | BLCA | 1 |
p.G107E | HNSC | 1 |
p.P31S | SKCM | 1 |
p.G104R | SKCM | 1 |
p.E230K | STAD | 1 |
p.R24M | PAAD | 1 |
p.G98E | SKCM | 1 |
p.G107E | SKCM | 1 |
p.R178W | STAD | 1 |
p.R178Q | THCA | 1 |
p.D320N | SKCM | 1 |
p.G50S | THYM | 1 |
p.G80E | SKCM | 1 |
p.G143E | SKCM | 1 |
p.G179E | SKCM | 1 |
p.D54N | HNSC | 1 |
p.A48V | UCEC | 1 |
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TissGeneCNV for C1QTNF9B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C1QTNF9B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C1QTNF9B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C1QTNF9B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C1QTNF9B |
TissGeneDrug for C1QTNF9B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C1QTNF9B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0271183 | Severe myopia | 1 | BeFree |