TissGeneSummary for POTEC |
Gene summary |
Basic gene information | Gene symbol | POTEC |
Gene name | POTE ankyrin domain family, member C | |
Synonyms | A26B2|CT104.6|POTE-18|POTE18 | |
Cytomap | UCSC genome browser: 18p11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_001137671.1, | |
Description | ANKRD26-like family B member 2ANKRD26-like family B, member 2POTE ankyrin domain family member Ccancer/testis antigen family 104, member 6prostate, ovary, testis-expressed protein on chromosome 18 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000183206 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POTEC | |
BioGPS: 388468 | ||
Pathway | NCI Pathway Interaction Database: POTEC | |
KEGG: POTEC | ||
REACTOME: POTEC | ||
Pathway Commons: POTEC | ||
Context | iHOP: POTEC | |
ligand binding site mutation search in PubMed: POTEC | ||
UCL Cancer Institute: POTEC | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of POTEC | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for POTEC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for POTEC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for POTEC |
TissGeneSNV for POTEC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R477Q | LUAD | 10 |
p.R477Q | THCA | 8 |
p.R477Q | HNSC | 7 |
p.R477Q | BLCA | 5 |
p.R477Q | LGG | 5 |
p.K507E | GBM | 4 |
p.R477Q | GBM | 4 |
p.K507E | LUAD | 4 |
p.R477Q | PRAD | 4 |
p.R477Q | UCEC | 4 |
p.R477Q | SARC | 3 |
p.K507E | BLCA | 3 |
p.R477Q | SKCM | 3 |
p.R477Q | UCS | 2 |
p.R477Q | KIRC | 2 |
p.G487E | HNSC | 2 |
p.K507E | LGG | 2 |
p.K507E | SKCM | 2 |
p.K507E | HNSC | 2 |
p.R477Q | ESCA | 2 |
p.F28C | SKCM | 2 |
p.K507E | PCPG | 2 |
p.R477Q | PCPG | 2 |
p.G239E | SKCM | 2 |
p.H49R | LUAD | 1 |
p.N585K | UCEC | 1 |
p.M61I | PRAD | 1 |
p.D335N | SKCM | 1 |
p.L260V | COAD | 1 |
p.S96R | HNSC | 1 |
p.L514F | SKCM | 1 |
p.G487E | KIRC | 1 |
p.R477Q | PAAD | 1 |
p.G305E | ESCA | 1 |
p.F290C | BLCA | 1 |
p.G25D | SKCM | 1 |
p.M166I | COAD | 1 |
p.E492K | HNSC | 1 |
p.L336I | LUAD | 1 |
p.D156G | COAD | 1 |
p.G487E | THCA | 1 |
p.S75R | LUAD | 1 |
p.H86D | LUAD | 1 |
p.R58K | BLCA | 1 |
p.G487E | PAAD | 1 |
p.T93M | STAD | 1 |
p.R145K | SKCM | 1 |
p.F28C | LIHC | 1 |
p.S89F | SKCM | 1 |
p.L226Q | HNSC | 1 |
p.G487E | PRAD | 1 |
p.R169M | SARC | 1 |
p.F28C | KIRC | 1 |
p.K100R | ESCA | 1 |
p.G74W | LIHC | 1 |
p.R477Q | STAD | 1 |
p.V313I | ACC | 1 |
p.V5F | THCA | 1 |
p.V287G | SKCM | 1 |
p.R136C | GBM | 1 |
p.H67L | LUAD | 1 |
p.E250X | COAD | 1 |
p.G113S | GBM | 1 |
p.A230D | LUAD | 1 |
p.S369C | HNSC | 1 |
p.M61I | BLCA | 1 |
p.E531K | SKCM | 1 |
p.R137* | HNSC | 1 |
p.G150D | SKCM | 1 |
p.S513Y | UCEC | 1 |
p.E394K | SKCM | 1 |
p.T77K | HNSC | 1 |
p.S52F | SKCM | 1 |
p.S89Y | LUAD | 1 |
p.F69L | SARC | 1 |
p.E130K | SKCM | 1 |
p.H29N | UCEC | 1 |
p.D302H | CESC | 1 |
p.K268E | LIHC | 1 |
p.R21M | COAD | 1 |
p.F290C | UCEC | 1 |
p.G76S | HNSC | 1 |
p.S337C | ACC | 1 |
p.D125N | SKCM | 1 |
p.L253V | UCEC | 1 |
p.R477Q | KIRP | 1 |
p.M98V | COAD | 1 |
p.C64S | SARC | 1 |
p.G487E | ESCA | 1 |
p.W101C | LUAD | 1 |
p.S83P | SKCM | 1 |
p.W101F | LUAD | 1 |
p.D50Y | ESCA | 1 |
p.M43V | HNSC | 1 |
p.Y261H | LUAD | 1 |
p.K268E | SKCM | 1 |
p.S112R | UCS | 1 |
p.K293N | UCEC | 1 |
p.E386K | SKCM | 1 |
p.S513Y | COAD | 1 |
p.K168N | BLCA | 1 |
p.D156N | SKCM | 1 |
p.N42K | HNSC | 1 |
p.L57V | LUAD | 1 |
p.W101L | LUAD | 1 |
p.L57F | HNSC | 1 |
p.C72Y | COAD | 1 |
p.R524H | MESO | 1 |
p.K507E | UVM | 1 |
p.R58K | SKCM | 1 |
p.S513P | SKCM | 1 |
p.S513F | CESC | 1 |
p.P398R | LUAD | 1 |
p.S333F | SKCM | 1 |
p.R95M | LUAD | 1 |
p.S515N | HNSC | 1 |
p.D156Y | LUAD | 1 |
p.M43V | GBM | 1 |
p.H104P | ESCA | 1 |
p.L309F | SKCM | 1 |
p.E282K | BLCA | 1 |
p.G47R | SKCM | 1 |
p.S96R | BLCA | 1 |
p.K507E | PRAD | 1 |
p.E266K | LUAD | 1 |
p.L323F | BLCA | 1 |
p.R196Q | BRCA | 1 |
p.A573V | UCEC | 1 |
p.K507E | CESC | 1 |
p.M91I | SKCM | 1 |
p.E384D | UCEC | 1 |
p.R136C | ACC | 1 |
p.V214I | COAD | 1 |
p.K507E | THCA | 1 |
p.G99C | LIHC | 1 |
p.E505K | BLCA | 1 |
p.V214I | HNSC | 1 |
p.G487E | LUAD | 1 |
p.C221R | COAD | 1 |
p.C221R | BLCA | 1 |
p.L336P | SKCM | 1 |
p.G99S | GBM | 1 |
p.E326K | SKCM | 1 |
p.M56I | HNSC | 1 |
p.F69I | SKCM | 1 |
p.E362* | UCEC | 1 |
p.G262C | LUAD | 1 |
p.C102F | HNSC | 1 |
p.D87N | SKCM | 1 |
p.M54I | SKCM | 1 |
p.E138K | THCA | 1 |
p.I158M | SKCM | 1 |
p.D165N | SKCM | 1 |
p.D156Y | BRCA | 1 |
p.T164M | UCEC | 1 |
p.L570R | UCEC | 1 |
p.D50N | PAAD | 1 |
p.N299I | HNSC | 1 |
p.S337C | THCA | 1 |
p.S112R | HNSC | 1 |
p.D48N | SKCM | 1 |
p.G37R | SKCM | 1 |
p.G487E | UCEC | 1 |
p.T3A | PCPG | 1 |
p.C105G | HNSC | 1 |
p.E385K | SKCM | 1 |
p.I501L | LUAD | 1 |
p.K507E | KIRP | 1 |
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TissGeneCNV for POTEC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for POTEC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for POTEC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for POTEC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for POTEC |
TissGeneDrug for POTEC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for POTEC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |