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| TissGeneSummary for KRT34 |
 Gene summary |
| Basic gene information | Gene symbol | KRT34 |
| Gene name | keratin 34 | |
| Synonyms | HA4|Ha-4|KRTHA4|hHa4 | |
| Cytomap | UCSC genome browser: 17q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021013.3, | |
| Description | K34hair keratin, type I Ha4hard keratin, type I, 4keratin, hair, acidic, 4keratin, type I cuticular Ha4keratin-34 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602763 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000131737 | ||
| HPRD : 04137 | ||
| Vega : OTTHUMG00000133436 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KRT34 | |
| BioGPS: 3885 | ||
| Pathway | NCI Pathway Interaction Database: KRT34 | |
| KEGG: KRT34 | ||
| REACTOME: KRT34 | ||
| Pathway Commons: KRT34 | ||
| Context | iHOP: KRT34 | |
| ligand binding site mutation search in PubMed: KRT34 | ||
| UCL Cancer Institute: KRT34 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixSkinUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCSKCMUCEC,UCS | |
| Reference showing the relevant tissue of KRT34 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KRT34 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.967885284 | -2.155648049 | 3.123533333 | 1.15E-13 | 5.93E-13 |
| KIRP | -1.011731321 | -2.071281321 | 1.05955 | 0.0125 | 0.026665081 |
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| TissGene-miRNA for KRT34 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KRT34 |
| TissGeneSNV for KRT34 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A81T | COAD | 2 |
| p.Q30K | THYM | 1 |
| p.A167S | HNSC | 1 |
| p.R319C | KIRC | 1 |
| p.P65T | HNSC | 1 |
| p.Q366* | CESC | 1 |
| p.R21* | SKCM | 1 |
| p.V253M | GBM | 1 |
| p.R117C | STAD | 1 |
| p.E394D | UCEC | 1 |
| p.V261A | LIHC | 1 |
| p.D406N | SKCM | 1 |
| p.S36F | SKCM | 1 |
| p.E219K | SKCM | 1 |
| p.D200Y | LUAD | 1 |
| p.R205C | PAAD | 1 |
| p.S203N | SKCM | 1 |
| p.S351F | SKCM | 1 |
| p.R390Q | SKCM | 1 |
| p.A4V | HNSC | 1 |
| p.G15E | SKCM | 1 |
| p.E313K | BLCA | 1 |
| p.A81T | PAAD | 1 |
| p.S192F | SKCM | 1 |
| p.P74H | LUAD | 1 |
| p.E279K | SKCM | 1 |
| p.R335Q | STAD | 1 |
| p.C414X | LIHC | 1 |
| p.S97R | LUAD | 1 |
| p.L317M | SARC | 1 |
| p.Q103X | THYM | 1 |
| p.L160V | BLCA | 1 |
| p.P8L | SKCM | 1 |
| p.K234T | STAD | 1 |
| p.E369D | UCEC | 1 |
| p.N172K | LUAD | 1 |
| p.N95D | COAD | 1 |
| p.R388H | ESCA | 1 |
| p.R271K | SKCM | 1 |
| p.R55L | LUAD | 1 |
| p.C48* | LUAD | 1 |
| p.R376W | COAD | 1 |
| p.A415T | COAD | 1 |
| p.E120K | SKCM | 1 |
| p.E294K | UCEC | 1 |
| p.E190K | SKCM | 1 |
| p.S46N | UCEC | 1 |
| p.A110T | LIHC | 1 |
| p.R117H | LGG | 1 |
| p.V278M | LUAD | 1 |
| p.E325G | STAD | 1 |
| p.I280M | HNSC | 1 |
| p.A179D | SKCM | 1 |
| p.D107N | SKCM | 1 |
| p.E346D | HNSC | 1 |
| p.V261M | STAD | 1 |
| p.T320K | LUAD | 1 |
| p.M102I | THYM | 1 |
| p.Q136H | COAD | 1 |
| p.L328M | BRCA | 1 |
| p.T397M | STAD | 1 |
| p.L155I | UCEC | 1 |
| p.C54W | LIHC | 1 |
| p.S345N | SKCM | 1 |
| p.P410H | STAD | 1 |
| p.E269K | SKCM | 1 |
| p.R61W | LUAD | 1 |
| p.W288C | LUAD | 1 |
| p.R21K | SKCM | 1 |
| p.E369V | LIHC | 1 |
| p.D336Y | UCEC | 1 |
| p.Q188H | LUAD | 1 |
| p.C68S | LUAD | 1 |
| p.G53S | BLCA | 1 |
| p.R371C | SKCM | 1 |
| p.R205C | BRCA | 1 |
| p.E237* | MESO | 1 |
| p.S60F | LGG | 1 |
| p.R399W | LUAD | 1 |
| p.E375D | COAD | 1 |
| p.E127D | UCEC | 1 |
| p.R55H | PAAD | 1 |
| p.G70S | UCEC | 1 |
| p.R319C | KICH | 1 |
| p.R244C | SKCM | 1 |
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| TissGeneCNV for KRT34 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KRT34 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KRT34 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| COAD (tumor) | COAD (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| KICH (tumor) | KICH (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| STAD (tumor) | STAD (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| THCA (tumor) | THCA (normal) |
| KRT34, USP15, YWHAG, DLG3, PLEKHB2 (tumor) | KRT34, USP15, YWHAG, DLG3, PLEKHB2 (normal) |
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| TissGeneProg for KRT34 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KRT34 |
| TissGeneDrug for KRT34 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KRT34 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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