TissGeneSummary for IGFL3 |
Gene summary |
Basic gene information | Gene symbol | IGFL3 |
Gene name | IGF-like family member 3 | |
Synonyms | UNQ483 | |
Cytomap | UCSC genome browser: 19q13.32 | |
Type of gene | protein-coding | |
RefGenes | NM_207393.1, | |
Description | RPRC483insulin growth factor-like family member 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610546 | |
HGNC : HGNC | ||
Ensembl : ENSG00000188624 | ||
HPRD : 17140 | ||
Vega : OTTHUMG00000172904 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IGFL3 | |
BioGPS: 388555 | ||
Pathway | NCI Pathway Interaction Database: IGFL3 | |
KEGG: IGFL3 | ||
REACTOME: IGFL3 | ||
Pathway Commons: IGFL3 | ||
Context | iHOP: IGFL3 | |
ligand binding site mutation search in PubMed: IGFL3 | ||
UCL Cancer Institute: IGFL3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of IGFL3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IGFL3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.741358438 | -1.980426859 | 1.239068421 | 2.70E-13 | 1.24E-12 |
LUSC | -0.387848377 | -1.943969945 | 1.556121569 | 4.78E-06 | 1.13E-05 |
COAD | -0.929694606 | -1.965756144 | 1.036061538 | 0.00385 | 0.009520711 |
HNSC | 1.151126772 | -0.690933693 | 1.842060465 | 0.000429 | 0.00163049 |
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TissGene-miRNA for IGFL3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IGFL3 |
TissGeneSNV for IGFL3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.C106Y | LUSC | 1 |
p.G101C | LUSC | 1 |
p.C82* | PAAD | 1 |
p.S62F | SKCM | 1 |
p.P50S | SKCM | 1 |
p.C82X | PAAD | 1 |
p.S86Y | UCEC | 1 |
p.Y48C | COAD | 1 |
p.R68C | STAD | 1 |
p.Q20K | ESCA | 1 |
p.V122A | KIRP | 1 |
p.S86F | SKCM | 1 |
p.H107D | HNSC | 1 |
p.G24E | HNSC | 1 |
p.F17L | HNSC | 1 |
p.G70S | SKCM | 1 |
p.G101D | UCEC | 1 |
p.P39S | CESC | 1 |
p.V122F | KIRP | 1 |
p.W13C | BLCA | 1 |
p.P50L | SKCM | 1 |
p.L100P | SKCM | 1 |
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TissGeneCNV for IGFL3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IGFL3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for IGFL3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IGFL3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IGFL3 |
TissGeneDrug for IGFL3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IGFL3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |