TissGeneSummary for KRT35 |
Gene summary |
Basic gene information | Gene symbol | KRT35 |
Gene name | keratin 35 | |
Synonyms | HA5|Ha-5|KRTHA5|hHa5 | |
Cytomap | UCSC genome browser: 17q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_002280.4, | |
Description | HHa5 hair keratin type I intermediate filamentK35hair keratin, type I Ha5hard keratin, type I, 5keratin, hair, acidic, 5keratin, type I cuticular Ha5keratin-35 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602764 | |
HGNC : HGNC | ||
Ensembl : ENSG00000197079 | ||
HPRD : 04138 | ||
Vega : OTTHUMG00000133425 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT35 | |
BioGPS: 3886 | ||
Pathway | NCI Pathway Interaction Database: KRT35 | |
KEGG: KRT35 | ||
REACTOME: KRT35 | ||
Pathway Commons: KRT35 | ||
Context | iHOP: KRT35 | |
ligand binding site mutation search in PubMed: KRT35 | ||
UCL Cancer Institute: KRT35 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of KRT35 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KRT35 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.780032707 | -0.652693172 | -1.127339535 | 0.00335 | 0.009638747 |
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TissGene-miRNA for KRT35 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KRT35 |
TissGeneSNV for KRT35 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R387W | CESC | 1 |
p.M110K | LUAD | 1 |
p.T260I | SKCM | 1 |
p.W102* | SKCM | 1 |
p.E196G | LIHC | 1 |
p.A429V | STAD | 1 |
p.A30T | UCEC | 1 |
p.R357W | CESC | 1 |
p.A79T | SKCM | 1 |
p.A399V | LUAD | 1 |
p.Q125K | SKCM | 1 |
p.P398L | LUAD | 1 |
p.R264Q | LGG | 1 |
p.E152K | CESC | 1 |
p.G59R | SKCM | 1 |
p.S36Y | COAD | 1 |
p.D186N | SKCM | 1 |
p.C392G | KIRP | 1 |
p.E285G | UCEC | 1 |
p.A30S | CHOL | 1 |
p.R116C | UCEC | 1 |
p.P398S | SKCM | 1 |
p.R424Q | LUAD | 1 |
p.E374D | LUAD | 1 |
p.R234Q | LGG | 1 |
p.P445L | SKCM | 1 |
p.G20E | SKCM | 1 |
p.P395S | SKCM | 1 |
p.G86D | BRCA | 1 |
p.S420F | STAD | 1 |
p.G23A | SKCM | 1 |
p.G23V | SKCM | 1 |
p.C441Y | COAD | 1 |
p.R128H | UCEC | 1 |
p.R375W | ESCA | 1 |
p.R213S | HNSC | 1 |
p.D375Y | LUAD | 1 |
p.A2T | UCEC | 1 |
p.L182R | HNSC | 1 |
p.P43S | HNSC | 1 |
p.S390F | STAD | 1 |
p.Y111F | LIHC | 1 |
p.R454Q | LUAD | 1 |
p.G54S | HNSC | 1 |
p.A78T | UCEC | 1 |
p.A109T | SKCM | 1 |
p.R438H | STAD | 1 |
p.P73H | THYM | 1 |
p.V160M | LGG | 1 |
p.G403C | LUAD | 1 |
p.A123T | UCEC | 1 |
p.P425S | SKCM | 1 |
p.Q194L | LIHC | 1 |
p.G172D | LGG | 1 |
p.R281H | UCEC | 1 |
p.S161F | SKCM | 1 |
p.C392G | ESCA | 1 |
p.S332N | STAD | 1 |
p.R345W | ESCA | 1 |
p.A78T | STAD | 1 |
p.E60K | SKCM | 1 |
p.R389Q | COAD | 1 |
p.E121D | READ | 1 |
p.R98S | LUAD | 1 |
p.L212R | HNSC | 1 |
p.E141K | THCA | 1 |
p.C271* | LUSC | 1 |
p.A123S | LUAD | 1 |
p.S48I | GBM | 1 |
p.A93S | LUAD | 1 |
p.R318C | UCEC | 1 |
p.R347H | STAD | 1 |
p.Q194K | LIHC | 1 |
p.A322T | READ | 1 |
p.R149Q | STAD | 1 |
p.R375W | LUAD | 1 |
p.W132X | SKCM | 1 |
p.S390P | THCA | 1 |
p.R163W | SARC | 1 |
p.R163P | BLCA | 1 |
p.A21S | PCPG | 1 |
p.A322T | SKCM | 1 |
p.R264Q | STAD | 1 |
p.D106N | SKCM | 1 |
p.R345W | LUAD | 1 |
p.R107H | COAD | 1 |
p.P428S | SKCM | 1 |
p.R193P | BLCA | 1 |
p.L258S | BLCA | 1 |
p.R149Q | READ | 1 |
p.Q164L | LIHC | 1 |
p.P415L | SKCM | 1 |
p.A48T | STAD | 1 |
p.E238K | SKCM | 1 |
p.D216N | SKCM | 1 |
p.D76N | SKCM | 1 |
p.A254V | LUAD | 1 |
p.N440T | OV | 1 |
p.S390C | BLCA | 1 |
p.L124P | SKCM | 1 |
p.A292T | SKCM | 1 |
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TissGeneCNV for KRT35 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KRT35 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KRT35 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KRT35 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KRT35 |
TissGeneDrug for KRT35 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KRT35 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019163 | Hepatitis B | 1 | BeFree |