TissGeneSummary for GBP7 |
Gene summary |
Basic gene information | Gene symbol | GBP7 |
Gene name | guanylate binding protein 7 | |
Synonyms | GBP4L | |
Cytomap | UCSC genome browser: 1p22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_207398.2, | |
Description | GBP-7GTP-binding protein 7guanine nucleotide-binding protein 7guanylate-binding protein 7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612468 | |
HGNC : HGNC | ||
Ensembl : ENSG00000213512 | ||
HPRD : 13432 | ||
Vega : OTTHUMG00000010659 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GBP7 | |
BioGPS: 388646 | ||
Pathway | NCI Pathway Interaction Database: GBP7 | |
KEGG: GBP7 | ||
REACTOME: GBP7 | ||
Pathway Commons: GBP7 | ||
Context | iHOP: GBP7 | |
ligand binding site mutation search in PubMed: GBP7 | ||
UCL Cancer Institute: GBP7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of GBP7 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GBP7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.106413283 | 1.27289456 | -1.379307843 | 2.44E-10 | 8.86E-10 |
LUAD | -0.330744115 | 1.214055885 | -1.5448 | 6.37E-14 | 5.72E-13 |
LIHC | 6.74539154 | 9.78445554 | -3.039064 | 6.98E-08 | 5.12E-07 |
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TissGene-miRNA for GBP7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GBP7 |
TissGeneSNV for GBP7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F227L | HNSC | 1 |
p.Q507E | SKCM | 1 |
p.L597I | UCEC | 1 |
p.E525Q | LUAD | 1 |
p.Q507E | PCPG | 1 |
p.A307V | UCEC | 1 |
p.A203V | SARC | 1 |
p.H248R | LGG | 1 |
p.D182N | SKCM | 1 |
p.P109S | SKCM | 1 |
p.L460P | LIHC | 1 |
p.E485K | SKCM | 1 |
p.K57T | UCEC | 1 |
p.R253X | STAD | 1 |
p.A316T | SKCM | 1 |
p.E162K | SKCM | 1 |
p.E458K | HNSC | 1 |
p.K188N | SARC | 1 |
p.A330V | BLCA | 1 |
p.E544Q | BLCA | 1 |
p.S422P | UCEC | 1 |
p.H551Q | LUAD | 1 |
p.N56K | LUAD | 1 |
p.F268L | COAD | 1 |
p.A33V | SKCM | 1 |
p.E186K | SKCM | 1 |
p.L67Q | BRCA | 1 |
p.V120L | PRAD | 1 |
p.S73C | HNSC | 1 |
p.G453* | UCEC | 1 |
p.R577X | READ | 1 |
p.R412W | HNSC | 1 |
p.R253* | STAD | 1 |
p.A339T | LIHC | 1 |
p.E458K | SKCM | 1 |
p.D103N | LUAD | 1 |
p.P429L | UCEC | 1 |
p.H333L | LUAD | 1 |
p.Q36H | UCEC | 1 |
p.M515I | SKCM | 1 |
p.G102S | BRCA | 1 |
p.P450H | THYM | 1 |
p.E458K | UCEC | 1 |
p.K390R | UCEC | 1 |
p.L246F | HNSC | 1 |
p.F273L | THYM | 1 |
p.P84S | PRAD | 1 |
p.K441M | SKCM | 1 |
p.D258N | SKCM | 1 |
p.K230I | LUAD | 1 |
p.E105* | UCEC | 1 |
p.K533N | ESCA | 1 |
p.E15Q | CESC | 1 |
p.I474M | BRCA | 1 |
p.E164* | BLCA | 1 |
p.D237H | BLCA | 1 |
p.M534I | SKCM | 1 |
p.F126L | BLCA | 1 |
p.A606V | PRAD | 1 |
p.K620T | ESCA | 1 |
p.E99D | READ | 1 |
p.T14I | COAD | 1 |
p.F426L | UCEC | 1 |
p.Q380* | SKCM | 1 |
p.L185M | LUAD | 1 |
p.P309L | SKCM | 1 |
p.L300M | STAD | 1 |
p.D197V | SKCM | 1 |
p.D197E | STAD | 1 |
p.E388D | BRCA | 1 |
p.K390N | BRCA | 1 |
p.V327A | SKCM | 1 |
p.M368I | DLBC | 1 |
p.E186K | HNSC | 1 |
p.I152M | BRCA | 1 |
p.A307V | LUAD | 1 |
p.Q507E | COAD | 1 |
p.G453E | SKCM | 1 |
p.E283Q | READ | 1 |
p.Q340H | LUAD | 1 |
p.Y541F | KIRP | 1 |
p.F268L | UCEC | 1 |
p.D103V | ESCA | 1 |
p.A276T | UCEC | 1 |
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TissGeneCNV for GBP7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GBP7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GBP7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GBP7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GBP7 |
TissGeneDrug for GBP7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GBP7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024535 | Malaria, Falciparum | 1 | GAD |