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| TissGeneSummary for CAPN8 |
 Gene summary |
| Basic gene information | Gene symbol | CAPN8 |
| Gene name | calpain 8 | |
| Synonyms | nCL-2 | |
| Cytomap | UCSC genome browser: 1q41 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001143962.1, | |
| Description | calpain-8new calpain 2stomach-specific M-type calpain | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000203697 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CAPN8 | |
| BioGPS: 388743 | ||
| Pathway | NCI Pathway Interaction Database: CAPN8 | |
| KEGG: CAPN8 | ||
| REACTOME: CAPN8 | ||
| Pathway Commons: CAPN8 | ||
| Context | iHOP: CAPN8 | |
| ligand binding site mutation search in PubMed: CAPN8 | ||
| UCL Cancer Institute: CAPN8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of CAPN8 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CAPN8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -3.860840924 | -1.542125647 | -2.318715278 | 2.52E-10 | 8.58E-10 |
| THCA | -2.164213876 | -3.835522351 | 1.671308475 | 1.02E-09 | 5.88E-09 |
| LUSC | -1.094686758 | 3.622311282 | -4.716998039 | 6.73E-17 | 5.30E-16 |
| KICH | -2.386702758 | -0.382242758 | -2.00446 | 0.0057 | 0.010802064 |
| KIRP | -3.359936758 | -1.688580508 | -1.67135625 | 0.00188 | 0.004817097 |
| HNSC | -3.406728618 | -2.12929606 | -1.277432558 | 0.000687 | 0.002449683 |
| PRAD | -2.08059445 | -0.781657912 | -1.298936538 | 0.000356 | 0.001305722 |
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| TissGene-miRNA for CAPN8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CAPN8 |
| TissGeneSNV for CAPN8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G59D | UCEC | 1 |
| p.E270K | UCEC | 1 |
| p.R418C | UCEC | 1 |
| p.L656I | SARC | 1 |
| p.R421Q | UCEC | 1 |
| p.T570M | SARC | 1 |
| p.Q624H | LIHC | 1 |
| p.P68T | UCEC | 1 |
| p.R94G | CESC | 1 |
| p.V44I | UCEC | 1 |
| p.G540V | BRCA | 1 |
| p.Y516H | UCEC | 1 |
| p.F131I | ESCA | 1 |
| p.E395K | CESC | 1 |
| p.Q145K | CESC | 1 |
| p.R36K | UCEC | 1 |
| p.S467F | UCEC | 1 |
| p.E251K | SARC | 1 |
| p.Q86R | UCEC | 1 |
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| TissGeneCNV for CAPN8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CAPN8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CA945138 | CAPN8-CAPN8 | chr1:223716377 | chr1:223716378 |
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| TissGeneNet for CAPN8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CAPN8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CAPN8 |
| TissGeneDrug for CAPN8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CAPN8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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