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| TissGeneSummary for C2orf78 |
 Gene summary |
| Basic gene information | Gene symbol | C2orf78 |
| Gene name | chromosome 2 open reading frame 78 | |
| Synonyms | COG5373|hCG1989538 | |
| Cytomap | UCSC genome browser: 2p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001080474.1, | |
| Description | uncharacterized protein C2orf78 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000187833 | ||
| Vega : OTTHUMG00000152819 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C2orf78 | |
| BioGPS: 388960 | ||
| Pathway | NCI Pathway Interaction Database: C2orf78 | |
| KEGG: C2orf78 | ||
| REACTOME: C2orf78 | ||
| Pathway Commons: C2orf78 | ||
| Context | iHOP: C2orf78 | |
| ligand binding site mutation search in PubMed: C2orf78 | ||
| UCL Cancer Institute: C2orf78 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of C2orf78 | ||
| Description by TissGene annotations | Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C2orf78 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for C2orf78 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C2orf78 |
| TissGeneSNV for C2orf78 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G434E | SKCM | 2 |
| p.P684L | SKCM | 2 |
| p.E909K | SKCM | 2 |
| p.E355K | SKCM | 2 |
| p.R753Q | SKCM | 1 |
| p.S818L | SKCM | 1 |
| p.P454S | STAD | 1 |
| p.S584F | SKCM | 1 |
| p.G266V | LUAD | 1 |
| p.Q428* | SKCM | 1 |
| p.D645Y | ESCA | 1 |
| p.S265C | BLCA | 1 |
| p.G641R | SKCM | 1 |
| p.Y269* | LUSC | 1 |
| p.K816E | LUAD | 1 |
| p.E913K | SKCM | 1 |
| p.L656Q | LUAD | 1 |
| p.S103R | LUAD | 1 |
| p.A351V | SKCM | 1 |
| p.N420D | SKCM | 1 |
| p.Q81K | PRAD | 1 |
| p.G649R | SKCM | 1 |
| p.M628T | STAD | 1 |
| p.S316R | READ | 1 |
| p.R855C | STAD | 1 |
| p.S228Y | UCEC | 1 |
| p.Q274E | CESC | 1 |
| p.M246I | LUAD | 1 |
| p.P767L | SKCM | 1 |
| p.S437F | STAD | 1 |
| p.M912I | CESC | 1 |
| p.S11F | BRCA | 1 |
| p.A239D | UCEC | 1 |
| p.D464G | OV | 1 |
| p.P722S | SKCM | 1 |
| p.F650L | UCS | 1 |
| p.L671F | READ | 1 |
| p.R753Q | LUAD | 1 |
| p.G591E | SKCM | 1 |
| p.G649R | LUSC | 1 |
| p.K647N | STAD | 1 |
| p.S317N | SKCM | 1 |
| p.Q611H | LUAD | 1 |
| p.P466H | UCEC | 1 |
| p.M628I | STAD | 1 |
| p.F904I | STAD | 1 |
| p.L718F | BRCA | 1 |
| p.S158Y | LUAD | 1 |
| p.S496C | COAD | 1 |
| p.L379R | UCEC | 1 |
| p.P389S | SKCM | 1 |
| p.G641W | LIHC | 1 |
| p.A893S | UCEC | 1 |
| p.S85T | GBM | 1 |
| p.A513D | UCEC | 1 |
| p.G381E | SKCM | 1 |
| p.C490F | LUSC | 1 |
| p.E701Q | HNSC | 1 |
| p.S224C | HNSC | 1 |
| p.K608N | BLCA | 1 |
| p.L345F | LUAD | 1 |
| p.E252K | SKCM | 1 |
| p.L142I | UCEC | 1 |
| p.P863L | SKCM | 1 |
| p.Y920H | KIRP | 1 |
| p.F650L | UCEC | 1 |
| p.R500S | OV | 1 |
| p.L460V | LUSC | 1 |
| p.R737Q | SARC | 1 |
| p.R884K | SKCM | 1 |
| p.P327S | SKCM | 1 |
| p.S63R | LUAD | 1 |
| p.P770L | SKCM | 1 |
| p.P684S | SKCM | 1 |
| p.P179L | SKCM | 1 |
| p.D144N | SKCM | 1 |
| p.E685K | SKCM | 1 |
| p.G429E | SKCM | 1 |
| p.P684Q | LUSC | 1 |
| p.P204S | SKCM | 1 |
| p.R769Q | SKCM | 1 |
| p.E916Q | CESC | 1 |
| p.P669T | LUAD | 1 |
| p.V862A | STAD | 1 |
| p.G62R | SKCM | 1 |
| p.E324Q | LUAD | 1 |
| p.F315L | LIHC | 1 |
| p.G714E | SKCM | 1 |
| p.T446R | LUAD | 1 |
| p.R744C | HNSC | 1 |
| p.D497H | BRCA | 1 |
| p.P794L | SKCM | 1 |
| p.E701Q | LUSC | 1 |
| p.Y166* | LUAD | 1 |
| p.S898F | SKCM | 1 |
| p.A479T | STAD | 1 |
| p.G534V | LUSC | 1 |
| p.K371T | SKCM | 1 |
| p.P856S | SKCM | 1 |
| p.N195K | UCEC | 1 |
| p.Q407K | LUAD | 1 |
| p.P767T | KICH | 1 |
| p.G434R | SKCM | 1 |
| p.R884T | LUAD | 1 |
| p.A183D | LUSC | 1 |
| p.L741I | LUAD | 1 |
| p.I380T | LUAD | 1 |
| p.M628T | COAD | 1 |
| p.K790T | UCEC | 1 |
| p.E414K | SKCM | 1 |
| p.L846I | UCEC | 1 |
| p.Q611K | LUAD | 1 |
| p.S312P | UCEC | 1 |
| p.R836Q | DLBC | 1 |
| p.K620X | COAD | 1 |
| p.Q793P | KIRC | 1 |
| p.A809V | COAD | 1 |
| p.Y750D | KIRP | 1 |
| p.R825W | COAD | 1 |
| p.Q844* | SKCM | 1 |
| p.E680D | LUAD | 1 |
| p.S653F | SKCM | 1 |
| p.R744C | LUAD | 1 |
| p.T869R | ESCA | 1 |
| p.L418I | UCEC | 1 |
| p.T367I | SKCM | 1 |
| p.R607W | CESC | 1 |
| p.P41S | LUAD | 1 |
| p.E878K | BLCA | 1 |
| p.E874K | SKCM | 1 |
| p.Q428H | SKCM | 1 |
| p.S743* | LUAD | 1 |
| p.S263T | LGG | 1 |
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| TissGeneCNV for C2orf78 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C2orf78 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BLCA | TCGA-FD-A3SM-01A | ZNF638-C2orf78 | 5UTR-CDS | Chr2:71558995 | Chr2:74040604 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A135-01A | TET3-C2orf78 | In-frame | Chr2:74275538 | Chr2:74040604 |
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| TissGeneNet for C2orf78 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C2orf78 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C2orf78 |
| TissGeneDrug for C2orf78 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C2orf78 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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