TissGeneSummary for SLC9A4 |
Gene summary |
Basic gene information | Gene symbol | SLC9A4 |
Gene name | solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 | |
Synonyms | NHE4 | |
Cytomap | UCSC genome browser: 2q12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001011552.3, | |
Description | NHE-4Na(+)/H(+) exchanger 4sodium/hydrogen exchanger 4solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9 (sodium/hydrogen exchanger), member 4solute carrier family 9 member 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600531 | |
HGNC : HGNC | ||
Ensembl : ENSG00000180251 | ||
HPRD : 15973 | ||
Vega : OTTHUMG00000153093 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC9A4 | |
BioGPS: 389015 | ||
Pathway | NCI Pathway Interaction Database: SLC9A4 | |
KEGG: SLC9A4 | ||
REACTOME: SLC9A4 | ||
Pathway Commons: SLC9A4 | ||
Context | iHOP: SLC9A4 | |
ligand binding site mutation search in PubMed: SLC9A4 | ||
UCL Cancer Institute: SLC9A4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
Reference showing the relevant tissue of SLC9A4 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC9A4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.627812886 | 6.906851003 | -8.534663889 | 4.88E-62 | 9.11E-59 |
LUSC | 0.280607539 | -2.414792461 | 2.6954 | 3.00E-08 | 8.94E-08 |
KIRP | -1.855140316 | 7.010281559 | -8.865421875 | 2.81E-39 | 2.29E-36 |
PRAD | -2.257668441 | -0.945074211 | -1.312594231 | 3.23E-06 | 2.04E-05 |
HNSC | -0.405231813 | 2.582705396 | -2.987937209 | 2.22E-07 | 2.00E-06 |
STAD | 2.090575309 | 4.387697184 | -2.297121875 | 0.0115 | 0.038259615 |
KICH | 4.634748559 | 6.799224559 | -2.164476 | 8.18E-05 | 0.000218001 |
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TissGene-miRNA for SLC9A4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-30c-5p | MIMAT0000244 | 0.024 | -0.3 | 56 |
UCS | hsa-miR-30a-5p | MIMAT0000087 | 0.0037 | -0.39 | 56 |
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TissGeneMut for SLC9A4 |
TissGeneSNV for SLC9A4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D681N | SKCM | 4 |
p.G580E | SKCM | 3 |
p.E217K | SKCM | 2 |
p.R496C | SKCM | 2 |
p.R430* | SKCM | 2 |
p.R430X | SKCM | 2 |
p.D786N | SKCM | 2 |
p.G431E | SKCM | 2 |
p.G719E | SKCM | 2 |
p.H379Y | SKCM | 2 |
p.F678L | UCEC | 2 |
p.H500Y | SKCM | 2 |
p.R631H | GBM | 2 |
p.R412W | SKCM | 2 |
p.H752Y | SKCM | 2 |
p.N382Y | SKCM | 1 |
p.R674M | HNSC | 1 |
p.R720K | SKCM | 1 |
p.A232V | SKCM | 1 |
p.E259K | SKCM | 1 |
p.G739V | LUAD | 1 |
p.P686S | SKCM | 1 |
p.R604W | SKCM | 1 |
p.N665I | DLBC | 1 |
p.D594N | SKCM | 1 |
p.R718K | SARC | 1 |
p.R92W | LUAD | 1 |
p.L457V | LUAD | 1 |
p.Q467P | READ | 1 |
p.S570F | SKCM | 1 |
p.D65E | UCEC | 1 |
p.Q796X | SKCM | 1 |
p.G371S | SKCM | 1 |
p.G739E | SKCM | 1 |
p.R430Q | BLCA | 1 |
p.N665T | SKCM | 1 |
p.P208L | LUAD | 1 |
p.E506K | BLCA | 1 |
p.E216G | LUAD | 1 |
p.E763K | SKCM | 1 |
p.S638N | BLCA | 1 |
p.R729K | SKCM | 1 |
p.R789S | LUAD | 1 |
p.W381X | SKCM | 1 |
p.R729T | BLCA | 1 |
p.V306I | LIHC | 1 |
p.P447S | HNSC | 1 |
p.R630H | LUAD | 1 |
p.A722T | LUAD | 1 |
p.E363D | STAD | 1 |
p.K251N | BLCA | 1 |
p.F145L | LUAD | 1 |
p.E341K | SKCM | 1 |
p.E487* | HNSC | 1 |
p.Q708L | LIHC | 1 |
p.L89V | LUAD | 1 |
p.P442L | SKCM | 1 |
p.S313P | COAD | 1 |
p.V73G | CESC | 1 |
p.T778K | LUAD | 1 |
p.A568V | LGG | 1 |
p.G95C | STAD | 1 |
p.L615I | PAAD | 1 |
p.T778A | LGG | 1 |
p.G642D | SKCM | 1 |
p.G719E | LUSC | 1 |
p.D685N | SKCM | 1 |
p.M498I | LUSC | 1 |
p.L275I | BLCA | 1 |
p.P689T | PRAD | 1 |
p.V67A | LIHC | 1 |
p.S585F | SKCM | 1 |
p.R149Q | GBM | 1 |
p.R269Q | COAD | 1 |
p.E765D | STAD | 1 |
p.F678L | STAD | 1 |
p.G276V | BRCA | 1 |
p.I301T | LUAD | 1 |
p.G738D | COAD | 1 |
p.E709* | BLCA | 1 |
p.L443V | BLCA | 1 |
p.G277E | SKCM | 1 |
p.G739R | SKCM | 1 |
p.R219C | UCEC | 1 |
p.V139I | GBM | 1 |
p.V771F | GBM | 1 |
p.N614S | SKCM | 1 |
p.D207H | LUAD | 1 |
p.G274R | HNSC | 1 |
p.Q796* | SKCM | 1 |
p.M370I | ESCA | 1 |
p.M252R | BLCA | 1 |
p.R583G | HNSC | 1 |
p.A20V | SKCM | 1 |
p.S36F | UCEC | 1 |
p.R636K | LUAD | 1 |
p.S344F | SKCM | 1 |
p.A213V | SKCM | 1 |
p.E380K | BLCA | 1 |
p.G95D | STAD | 1 |
p.R630C | LGG | 1 |
p.S121* | LUSC | 1 |
p.G687* | LUAD | 1 |
p.G700E | LUAD | 1 |
p.L279F | LUAD | 1 |
p.E621K | BLCA | 1 |
p.M226I | SKCM | 1 |
p.A555S | STAD | 1 |
p.T389S | LUAD | 1 |
p.V73F | ACC | 1 |
p.W381* | SKCM | 1 |
p.R593K | SKCM | 1 |
p.R604W | READ | 1 |
p.M713I | SARC | 1 |
p.R496C | UCEC | 1 |
p.G468E | SKCM | 1 |
p.G112C | LUAD | 1 |
p.D65N | BLCA | 1 |
p.E99Q | BLCA | 1 |
p.R698Q | BLCA | 1 |
p.A503V | SKCM | 1 |
p.L102P | LIHC | 1 |
p.R604Q | STAD | 1 |
p.A170T | UCEC | 1 |
p.Q296* | SKCM | 1 |
p.D755Y | CESC | 1 |
p.A47S | LUAD | 1 |
p.Q554* | BLCA | 1 |
p.P150A | LUAD | 1 |
p.F678L | LUSC | 1 |
p.E506K | SKCM | 1 |
p.R430Q | STAD | 1 |
p.I543M | UCEC | 1 |
p.R577K | SKCM | 1 |
p.A210S | BRCA | 1 |
p.G172C | STAD | 1 |
p.A41S | LUAD | 1 |
p.S436L | SKCM | 1 |
p.L635V | UCS | 1 |
p.T148P | LUAD | 1 |
p.E492Q | BLCA | 1 |
p.R698L | ESCA | 1 |
p.W512R | LUAD | 1 |
p.S775L | GBM | 1 |
p.L140M | LGG | 1 |
p.L322F | SKCM | 1 |
p.G670E | SKCM | 1 |
p.F286Y | KIRC | 1 |
p.T483N | STAD | 1 |
p.R219H | COAD | 1 |
p.S545Y | READ | 1 |
p.W777C | LUAD | 1 |
p.H88Q | LUAD | 1 |
p.L750M | SKCM | 1 |
p.Q296X | SKCM | 1 |
p.R636S | BRCA | 1 |
p.A575T | SKCM | 1 |
p.W381R | MESO | 1 |
p.A332T | UCS | 1 |
p.L135M | PAAD | 1 |
p.Q39K | LUSC | 1 |
p.E557G | STAD | 1 |
p.G687V | LUSC | 1 |
p.S668T | LIHC | 1 |
p.Q667* | BLCA | 1 |
p.G107W | LUAD | 1 |
p.R630H | SARC | 1 |
p.R630C | GBM | 1 |
p.A403S | ESCA | 1 |
p.Y348C | STAD | 1 |
p.D499N | SKCM | 1 |
p.T561A | STAD | 1 |
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TissGeneCNV for SLC9A4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC9A4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC9A4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC9A4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC9A4 |
TissGeneDrug for SLC9A4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC9A4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001122 | Acidosis | 1 | CTD_human |
umls:C0007570 | Celiac Disease | 1 | GAD |