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| TissGeneSummary for SFTA2 |
 Gene summary |
| Basic gene information | Gene symbol | SFTA2 |
| Gene name | surfactant associated 2 | |
| Synonyms | GSGL541|SFTPG|SP-G|UNQ541 | |
| Cytomap | UCSC genome browser: 6p21.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_205854.2, | |
| Description | surfactant associated protein Gsurfactant-associated protein 2surfactant-associated protein G | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000196260 | ||
| HPRD : 18265 | ||
| Vega : OTTHUMG00000031183 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SFTA2 | |
| BioGPS: 389376 | ||
| Pathway | NCI Pathway Interaction Database: SFTA2 | |
| KEGG: SFTA2 | ||
| REACTOME: SFTA2 | ||
| Pathway Commons: SFTA2 | ||
| Context | iHOP: SFTA2 | |
| ligand binding site mutation search in PubMed: SFTA2 | ||
| UCL Cancer Institute: SFTA2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of SFTA2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SFTA2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | 0.281527516 | -1.495779263 | 1.77730678 | 1.63E-08 | 7.91E-08 |
| HNSC | -2.480749267 | 0.220801896 | -2.701551163 | 9.50E-07 | 7.27E-06 |
| LUSC | 0.833157892 | 7.440506912 | -6.60734902 | 1.40E-19 | 1.56E-18 |
| KIRC | -2.888816128 | 0.497653317 | -3.386469444 | 9.81E-28 | 1.51E-26 |
| KICH | -2.466447128 | 1.434488872 | -3.900936 | 1.47E-11 | 1.37E-10 |
| COAD | -0.194964205 | -3.620452666 | 3.425488462 | 1.41E-08 | 1.22E-07 |
| LUAD | 6.436993355 | 7.554072666 | -1.11707931 | 0.000597 | 0.00134987 |
| KIRP | -1.439175503 | 0.406536997 | -1.8457125 | 5.33E-05 | 0.000193991 |
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| TissGene-miRNA for SFTA2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SFTA2 |
| TissGeneSNV for SFTA2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G19E | BLCA | 1 |
| p.K31N | SKCM | 1 |
| p.L14F | SKCM | 1 |
| p.T12A | COAD | 1 |
| p.E32* | SKCM | 1 |
| p.H67R | LIHC | 1 |
| p.S70F | UCEC | 1 |
| p.N37S | COAD | 1 |
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| TissGeneCNV for SFTA2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SFTA2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SFTA2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SFTA2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SFTA2 |
| TissGeneDrug for SFTA2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SFTA2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004943 | Behcet Syndrome | 1 | GAD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
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