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| TissGeneSummary for IYD |
 Gene summary |
| Basic gene information | Gene symbol | IYD |
| Gene name | iodotyrosine deiodinase | |
| Synonyms | C6orf71|DEHAL1|TDH4|dJ422F24.1 | |
| Cytomap | UCSC genome browser: 6q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001164694.1, NM_001164695.1,NM_203395.2, | |
| Description | IYD-1iodotyrosine dehalogenase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612025 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000009765 | ||
| HPRD : 16668 | ||
| Vega : OTTHUMG00000016347 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IYD | |
| BioGPS: 389434 | ||
| Pathway | NCI Pathway Interaction Database: IYD | |
| KEGG: IYD | ||
| REACTOME: IYD | ||
| Pathway Commons: IYD | ||
| Context | iHOP: IYD | |
| ligand binding site mutation search in PubMed: IYD | ||
| UCL Cancer Institute: IYD | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTHCA | |
| Reference showing the relevant tissue of IYD | Initial characterization of C16orf89, a novel thyroid-specific gene. Afink GB, Veenboer G, de Randamie J, Keijser R, Meischl C, Niessen H, Ris-Stalpers C. Thyroid. 2010 Jul;20(7):811-21. doi: 10.1089/thy.2009.0366. (pmid:20578903) go to article | |
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IYD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | 7.548906245 | 9.893043533 | -2.344137288 | 1.03E-12 | 9.09E-12 |
| LUSC | -2.560380893 | 1.074179891 | -3.634560784 | 6.56E-21 | 8.79E-20 |
| KIRP | 0.801546129 | 4.060696129 | -3.25915 | 1.43E-06 | 7.03E-06 |
| LIHC | 2.859052754 | 5.318804754 | -2.459752 | 2.81E-10 | 3.45E-09 |
| KIRC | -0.304970191 | 3.415739532 | -3.720709722 | 2.61E-17 | 1.60E-16 |
| HNSC | -3.320772549 | -1.496942316 | -1.823830233 | 1.38E-06 | 1.00E-05 |
| STAD | 2.677046129 | 0.001464879 | 2.67558125 | 0.00117 | 0.00602135 |
| KICH | 0.132768754 | 2.671848754 | -2.53908 | 0.0016 | 0.003336235 |
| BRCA | -1.29649658 | -2.474803597 | 1.178307018 | 0.00014 | 0.000305184 |
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| TissGene-miRNA for IYD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for IYD |
| TissGeneSNV for IYD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A203T | PAAD | 4 |
| p.A203T | UVM | 1 |
| p.E85K | SKCM | 1 |
| p.E39K | SKCM | 1 |
| p.P264L | SKCM | 1 |
| p.C13Y | UCEC | 1 |
| p.E33Q | SKCM | 1 |
| p.S15Y | UCEC | 1 |
| p.T235A | PAAD | 1 |
| p.E183Q | KIRC | 1 |
| p.A270V | UCEC | 1 |
| p.V145M | STAD | 1 |
| p.E28D | COAD | 1 |
| p.R253H | LUAD | 1 |
| p.K84N | SKCM | 1 |
| p.L15F | KIRC | 1 |
| p.E83V | LUAD | 1 |
| p.R41C | SKCM | 1 |
| p.E28Q | CESC | 1 |
| p.E33K | SKCM | 1 |
| p.S269R | LUAD | 1 |
| p.C13S | COAD | 1 |
| p.D53E | OV | 1 |
| p.A10V | UCEC | 1 |
| p.D144H | BLCA | 1 |
| p.G244V | BLCA | 1 |
| p.W64R | LUSC | 1 |
| p.D276N | SKCM | 1 |
| p.R253C | UVM | 1 |
| p.R35K | SKCM | 1 |
| p.A227D | UCEC | 1 |
| p.M162I | SKCM | 1 |
| p.A202S | LUSC | 1 |
| p.A203T | LUAD | 1 |
| p.R101W | UCEC | 1 |
| p.V16A | STAD | 1 |
| p.T288I | PRAD | 1 |
| p.T122M | UCEC | 1 |
| p.I152M | BLCA | 1 |
| p.P75T | OV | 1 |
| p.R101W | BRCA | 1 |
| p.E83D | LUAD | 1 |
| p.P290L | UVM | 1 |
| p.M162I | COAD | 1 |
| p.V138M | SKCM | 1 |
| p.E114Q | SKCM | 1 |
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| TissGeneCNV for IYD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IYD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG949184 | NOLC1-IYD | chr10:103921646 | chr6:150713521 | |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-94-7943-01A | ERICH1-IYD | In-Frame | chr8:618597 | chr6:150710487 |
| TCGAfusionPortal | PRADA | THCA | TCGA-EM-A4FK-01A | IYD-BIRC6 | 3UTR-CDS | Chr6:150725764 | Chr2:32820101 |
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| TissGeneNet for IYD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for IYD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IYD |
| TissGeneDrug for IYD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IYD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0342195 | Thyroid Dyshormonogenesis 4 | 4 | BeFree,CLINVAR,CTD_human,UNIPROT |
| umls:C0010308 | Congenital Hypothyroidism | 3 | BeFree,LHGDN |
| umls:C0020676 | Hypothyroidism | 3 | BeFree,LHGDN |
| umls:C0018021 | Goiter | 2 | BeFree,LHGDN |
| umls:C0342200 | Endemic Cretinism | 2 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0030319 | Panic Disorder | 1 | GAD |
| umls:C0040156 | Thyrotoxicosis | 1 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0271826 | Iodide transport defect | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0700502 | Acquired hypothyroidism | 1 | BeFree |
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