TissGeneSummary for SPATA31A6 |
Gene summary |
Basic gene information | Gene symbol | SPATA31A6 |
Gene name | SPATA31 subfamily A, member 6 | |
Synonyms | FAM75A6 | |
Cytomap | UCSC genome browser: 9p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001145196.1, | |
Description | family with sequence similarity 75, member A6protein FAM75A6spermatogenesis-associated protein 31A6 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000185775 | ||
Vega : OTTHUMG00000013224 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPATA31A6 | |
BioGPS: 389730 | ||
Pathway | NCI Pathway Interaction Database: SPATA31A6 | |
KEGG: SPATA31A6 | ||
REACTOME: SPATA31A6 | ||
Pathway Commons: SPATA31A6 | ||
Context | iHOP: SPATA31A6 | |
ligand binding site mutation search in PubMed: SPATA31A6 | ||
UCL Cancer Institute: SPATA31A6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPATA31A6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPATA31A6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SPATA31A6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPATA31A6 |
TissGeneSNV for SPATA31A6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P54L | LUAD | 2 |
p.P420L | LUAD | 2 |
p.Q653L | LUAD | 2 |
p.W341C | HNSC | 1 |
p.C1194Y | LUAD | 1 |
p.R623Q | LUAD | 1 |
p.P511S | SKCM | 1 |
p.E1067* | LUAD | 1 |
p.Q441H | SARC | 1 |
p.E373K | BLCA | 1 |
p.S99* | ESCA | 1 |
p.L591V | SARC | 1 |
p.C664Y | LUAD | 1 |
p.R458K | SKCM | 1 |
p.S389L | PRAD | 1 |
p.P522L | SKCM | 1 |
p.S95L | SKCM | 1 |
p.T674I | KIRP | 1 |
p.P88R | PCPG | 1 |
p.M1072I | LUAD | 1 |
p.K410N | LUAD | 1 |
p.K1215M | ESCA | 1 |
p.H538R | KIRC | 1 |
p.T289S | LUAD | 1 |
p.W341R | LUAD | 1 |
p.T1207K | LUAD | 1 |
p.P420L | LGG | 1 |
p.A367T | SARC | 1 |
p.L472P | ACC | 1 |
p.Q658K | LUAD | 1 |
p.S58L | SKCM | 1 |
p.L466F | ACC | 1 |
p.S679Y | LUAD | 1 |
p.S568F | SARC | 1 |
p.T674N | LUAD | 1 |
p.S99X | ESCA | 1 |
p.K1094N | LUAD | 1 |
p.S290L | HNSC | 1 |
p.G37E | LIHC | 1 |
p.G348V | LUAD | 1 |
p.S321I | LUAD | 1 |
p.N452K | LUAD | 1 |
p.Q476K | STAD | 1 |
p.R1076K | SKCM | 1 |
p.P1153L | SKCM | 1 |
p.Q299P | LUAD | 1 |
p.R687Q | SARC | 1 |
p.P420L | BLCA | 1 |
p.T1207M | PRAD | 1 |
p.R1063W | PCPG | 1 |
p.G348* | LUAD | 1 |
p.D27N | SKCM | 1 |
p.S15L | HNSC | 1 |
p.M1217I | LUAD | 1 |
p.P1087Q | HNSC | 1 |
p.K1234N | LUAD | 1 |
p.S679F | SKCM | 1 |
p.Q353K | LUAD | 1 |
p.A523V | UCS | 1 |
p.Q640L | ACC | 1 |
p.D300N | LUAD | 1 |
p.D435Y | SARC | 1 |
p.A18D | LUAD | 1 |
p.C291F | LUAD | 1 |
p.G1123E | SKCM | 1 |
p.Q658R | LUAD | 1 |
p.P675S | SKCM | 1 |
p.R1097K | LIHC | 1 |
p.H359Q | LUAD | 1 |
p.S532F | SKCM | 1 |
p.R68W | LGG | 1 |
p.E342K | SKCM | 1 |
p.G394R | PRAD | 1 |
p.K654* | SKCM | 1 |
p.G1241R | HNSC | 1 |
p.P504Q | LUAD | 1 |
p.D323Y | LUAD | 1 |
p.S524L | SKCM | 1 |
p.S588I | HNSC | 1 |
p.Q1168* | BLCA | 1 |
p.P23S | SKCM | 1 |
p.P1102L | LGG | 1 |
p.P420L | ESCA | 1 |
p.P1101S | SKCM | 1 |
p.R475H | PRAD | 1 |
p.F657V | ESCA | 1 |
p.S524L | HNSC | 1 |
p.P1102L | SKCM | 1 |
p.Q325H | CESC | 1 |
p.S1155L | CESC | 1 |
p.P1102L | PRAD | 1 |
p.P420L | SKCM | 1 |
p.H498Q | LUAD | 1 |
p.S295A | LUAD | 1 |
p.L440S | SKCM | 1 |
p.K1078E | KIRC | 1 |
p.Q484H | PRAD | 1 |
p.Q1140H | LUAD | 1 |
p.R661W | HNSC | 1 |
p.S626L | SKCM | 1 |
p.P23T | LUAD | 1 |
p.Q311E | LUAD | 1 |
p.E1136D | ESCA | 1 |
p.E494D | LUAD | 1 |
p.A336S | BLCA | 1 |
p.A1222E | LUAD | 1 |
p.K656T | STAD | 1 |
p.Q1233H | BLCA | 1 |
p.Q298H | BLCA | 1 |
p.E425Q | SKCM | 1 |
p.A336V | PAAD | 1 |
p.W541C | ACC | 1 |
p.P522H | LUAD | 1 |
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TissGeneCNV for SPATA31A6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPATA31A6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SPATA31A6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPATA31A6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPATA31A6 |
TissGeneDrug for SPATA31A6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPATA31A6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |