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| TissGeneSummary for LBP |
 Gene summary |
| Basic gene information | Gene symbol | LBP |
| Gene name | lipopolysaccharide binding protein | |
| Synonyms | BPIFD2 | |
| Cytomap | UCSC genome browser: 20q11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004139.4, | |
| Description | BPI fold containing family D, member 2LPS-binding proteinlipopolysaccharide-binding protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 151990 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129988 | ||
| HPRD : 07175 | ||
| Vega : OTTHUMG00000032447 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LBP | |
| BioGPS: 3929 | ||
| Pathway | NCI Pathway Interaction Database: LBP | |
| KEGG: LBP | ||
| REACTOME: LBP | ||
| Pathway Commons: LBP | ||
| Context | iHOP: LBP | |
| ligand binding site mutation search in PubMed: LBP | ||
| UCL Cancer Institute: LBP | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of LBP | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0015920 | lipopolysaccharide transport | 8985160 | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 11739189 | GO:0032490 | detection of molecule of bacterial origin | 11528597 | GO:0032496 | response to lipopolysaccharide | 11739189 | GO:0032720 | negative regulation of tumor necrosis factor production | 11739189 | GO:0032755 | positive regulation of interleukin-6 production | 8409400 | GO:0032757 | positive regulation of interleukin-8 production | 8409400 | GO:0032760 | positive regulation of tumor necrosis factor production | 12594207 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | 11528597 | GO:0043032 | positive regulation of macrophage activation | 8409400 | GO:0050829 | defense response to Gram-negative bacterium | 11528597 | GO:0050830 | defense response to Gram-positive bacterium | 12932360 | GO:0071222 | cellular response to lipopolysaccharide | 12594207 | GO:0071223 | cellular response to lipoteichoic acid | 12594207 | GO:0015920 | lipopolysaccharide transport | 8985160 | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 11739189 | GO:0032490 | detection of molecule of bacterial origin | 11528597 | GO:0032496 | response to lipopolysaccharide | 11739189 | GO:0032720 | negative regulation of tumor necrosis factor production | 11739189 | GO:0032755 | positive regulation of interleukin-6 production | 8409400 | GO:0032757 | positive regulation of interleukin-8 production | 8409400 | GO:0032760 | positive regulation of tumor necrosis factor production | 12594207 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | 11528597 | GO:0043032 | positive regulation of macrophage activation | 8409400 | GO:0050829 | defense response to Gram-negative bacterium | 11528597 | GO:0050830 | defense response to Gram-positive bacterium | 12932360 | GO:0071222 | cellular response to lipopolysaccharide | 12594207 | GO:0071223 | cellular response to lipoteichoic acid | 12594207 |
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| TissGeneExp for LBP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.525689965 | -0.078969965 | -3.44672 | 6.76E-09 | 3.74E-08 |
| KIRP | -1.63333559 | 1.31212066 | -2.94545625 | 4.87E-07 | 2.65E-06 |
| KIRC | 1.80842448 | 0.566282813 | 1.242141667 | 0.0185 | 0.029826259 |
| LUAD | -1.265616517 | -2.603032034 | 1.337415517 | 0.001 | 0.00219043 |
| STAD | -1.006144965 | -2.831682465 | 1.8255375 | 0.000245 | 0.00165467 |
| BRCA | 1.009756351 | 2.293523018 | -1.283766667 | 0.000198 | 0.000422625 |
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| TissGene-miRNA for LBP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LBP |
| TissGeneSNV for LBP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D283N | SKCM | 2 |
| p.A226T | COAD | 1 |
| p.L262F | SKCM | 1 |
| p.L213F | GBM | 1 |
| p.N274K | LUAD | 1 |
| p.T18K | LUAD | 1 |
| p.P309S | SKCM | 1 |
| p.I138L | PAAD | 1 |
| p.P333L | COAD | 1 |
| p.P323H | SKCM | 1 |
| p.G38A | LUSC | 1 |
| p.A32T | READ | 1 |
| p.A426V | HNSC | 1 |
| p.S373T | STAD | 1 |
| p.E410K | SKCM | 1 |
| p.S160I | LUAD | 1 |
| p.A426V | UCEC | 1 |
| p.P217A | KIRC | 1 |
| p.S108F | SKCM | 1 |
| p.S345C | LUAD | 1 |
| p.A264V | LGG | 1 |
| p.P21S | SKCM | 1 |
| p.E199K | SKCM | 1 |
| p.A164T | READ | 1 |
| p.Y431S | MESO | 1 |
| p.R33S | LUSC | 1 |
| p.S10F | SKCM | 1 |
| p.Y361N | LUAD | 1 |
| p.R237W | BLCA | 1 |
| p.V218_splice | LUSC | 1 |
| p.I281V | UCEC | 1 |
| p.S414F | SKCM | 1 |
| p.T304K | LUAD | 1 |
| p.M170V | KIRC | 1 |
| p.Q44* | UCEC | 1 |
| p.M335I | SKCM | 1 |
| p.P344S | ACC | 1 |
| p.A240S | HNSC | 1 |
| p.C86S | LUAD | 1 |
| p.L213I | LUSC | 1 |
| p.P347L | COAD | 1 |
| p.E413* | UCS | 1 |
| p.Q457E | BLCA | 1 |
| p.E234K | SKCM | 1 |
| p.A226T | GBM | 1 |
| p.S157C | DLBC | 1 |
| p.N420D | STAD | 1 |
| p.P347L | SKCM | 1 |
| p.L213P | LIHC | 1 |
| p.M267V | BRCA | 1 |
| p.R455H | THCA | 1 |
| p.S320F | SKCM | 1 |
| p.R254H | HNSC | 1 |
| p.P270S | SKCM | 1 |
| p.E77D | THYM | 1 |
| p.E272K | HNSC | 1 |
| p.A14T | UCEC | 1 |
| p.P259S | SKCM | 1 |
| p.S396N | LIHC | 1 |
| p.R237W | HNSC | 1 |
| p.Y230F | HNSC | 1 |
| p.R315Q | GBM | 1 |
| p.P309L | UCEC | 1 |
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| TissGeneCNV for LBP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LBP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A0FT-01A | SSH2-LBP | Out-of-Frame | chr17:28022476 | chr20:37002580 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AN-A0FT-01A | SSH2-LBP | Out-of-Frame | chr17:28022476 | chr20:37002580 |
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| TissGeneNet for LBP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LBP, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, CFHR1 (normal) |
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| COAD (tumor) | COAD (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, IRF6, PYCRL, CFHR1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, CFHR1 (normal) |
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| KICH (tumor) | KICH (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LBP, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, IRF6, PYCRL, CFHR1 (normal) |
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| STAD (tumor) | STAD (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, SMAD3, PRDX4, CAMP, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| THCA (tumor) | THCA (normal) |
| LBP, HNF4A, SMAD3, PRDX4, CAMP, SETD1A, TSC22D4, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (tumor) | LBP, HNF4A, PRDX4, CAMP, SETD1A, TSC22D4, PITX3, PSMA3, HNF1A, FTH1, CD14, APOA1, HSPB1, C4BPA, CBFA2T2, BST1, TRA2A, RPS21, IRF6, PYCRL, CFHR1 (normal) |
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| TissGeneProg for LBP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LBP |
| TissGeneDrug for LBP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LBP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0243026 | Sepsis | 7 | BeFree,CTD_human,GAD |
| umls:C0036690 | Septicemia | 6 | BeFree |
| umls:C0028754 | Obesity | 4 | BeFree,CTD_human,RGD |
| umls:C0010346 | Crohn Disease | 3 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 2 | GAD,RGD |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0004610 | Bacteremia | 1 | BeFree,LHGDN |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 1 | BeFree |
| umls:C0011065 | Cessation of life | 1 | LHGDN |
| umls:C0014121 | Bacterial Endocarditis | 1 | BeFree,GAD |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0022354 | Jaundice, Obstructive | 1 | RGD |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0025289 | Meningitis | 1 | BeFree |
| umls:C0026766 | Multiple Organ Failure | 1 | CTD_human |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0027947 | Neutropenia | 1 | GAD |
| umls:C0031099 | Periodontitis | 1 | RGD |
| umls:C0032965 | Pregnancy Complications, Infectious | 1 | GAD |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 1 | BeFree |
| umls:C0036117 | Salmonella infections | 1 | BeFree |
| umls:C0036685 | Septicaemia due to gram-negative organism, unspecified | 1 | BeFree |
| umls:C0038160 | Staphylococcal Infections | 1 | GAD |
| umls:C0038443 | Stress, Psychological | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0043094 | Weight Gain | 1 | CTD_human |
| umls:C0085166 | Bacterial Vaginosis | 1 | GAD |
| umls:C0085423 | Gram-Negative Bacterial Infections | 1 | GAD |
| umls:C0085426 | Gram-Positive Bacterial Infections | 1 | GAD |
| umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
| umls:C0311277 | Obesity, Abdominal | 1 | BeFree |
| umls:C0376618 | Endotoxemia | 1 | RGD |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree,CTD_human |
| umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
| umls:C0744471 | Gram-negative bacteremia | 1 | BeFree |
| umls:C0851980 | Peritoneal infections | 1 | BeFree |
| umls:C1719672 | Severe Sepsis | 1 | BeFree |
| umls:C2711227 | Steatohepatitis | 1 | BeFree |
| umls:C2718067 | Alcoholic Steatohepatitis | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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