TissGeneSummary for MUC21 |
Gene summary |
Basic gene information | Gene symbol | MUC21 |
Gene name | mucin 21, cell surface associated | |
Synonyms | C6orf205|KMQK697|MUC-21|bCX31G15.2 | |
Cytomap | UCSC genome browser: 6p21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001010909.2, | |
Description | epiglycaninmucin-21 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000204544 | ||
HPRD : 16665 | ||
Vega : OTTHUMG00000031216 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MUC21 | |
BioGPS: 394263 | ||
Pathway | NCI Pathway Interaction Database: MUC21 | |
KEGG: MUC21 | ||
REACTOME: MUC21 | ||
Pathway Commons: MUC21 | ||
Context | iHOP: MUC21 | |
ligand binding site mutation search in PubMed: MUC21 | ||
UCL Cancer Institute: MUC21 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
Reference showing the relevant tissue of MUC21 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MUC21 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 2.636644603 | -2.327824888 | 4.964469492 | 5.50E-16 | 8.70E-15 |
HNSC | 0.798939637 | 8.904181497 | -8.10524186 | 4.94E-15 | 4.09E-13 |
LUSC | 0.053558196 | 3.399189568 | -3.345631373 | 5.05E-13 | 2.41E-12 |
LUAD | 5.076328209 | 3.28835752 | 1.78797069 | 0.000372 | 0.000861979 |
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TissGene-miRNA for MUC21 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MUC21 |
TissGeneSNV for MUC21 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V285A | LIHC | 2 |
p.E304G | THYM | 2 |
p.G6E | SKCM | 2 |
p.E274D | LIHC | 2 |
p.T203I | KIRC | 2 |
p.A432V | KIRC | 2 |
p.S163G | BRCA | 2 |
p.S110F | SKCM | 1 |
p.S440P | SKCM | 1 |
p.E229K | BLCA | 1 |
p.S219F | SKCM | 1 |
p.G416E | SKCM | 1 |
p.S365Y | LUAD | 1 |
p.E479K | SKCM | 1 |
p.T143S | THCA | 1 |
p.E161G | PCPG | 1 |
p.I87S | LGG | 1 |
p.E259G | TGCT | 1 |
p.S178N | KIRP | 1 |
p.T203I | DLBC | 1 |
p.P248L | SKCM | 1 |
p.N227K | SKCM | 1 |
p.E244D | COAD | 1 |
p.S365F | BLCA | 1 |
p.V57I | STAD | 1 |
p.V57I | PCPG | 1 |
p.T397P | SKCM | 1 |
p.S385N | COAD | 1 |
p.G311A | KIRC | 1 |
p.S133G | GBM | 1 |
p.S103N | OV | 1 |
p.N433S | KIRC | 1 |
p.S365* | LUAD | 1 |
p.T263P | HNSC | 1 |
p.L506R | STAD | 1 |
p.S140C | BLCA | 1 |
p.G521D | COAD | 1 |
p.E289K | BLCA | 1 |
p.A330T | SKCM | 1 |
p.G34R | SKCM | 1 |
p.A135V | BRCA | 1 |
p.R539S | LUAD | 1 |
p.S438T | KIRP | 1 |
p.P544L | SKCM | 1 |
p.T323A | BRCA | 1 |
p.T436S | LUAD | 1 |
p.S114F | SKCM | 1 |
p.G364E | TGCT | 1 |
p.S438F | SKCM | 1 |
p.S273F | SKCM | 1 |
p.S243C | HNSC | 1 |
p.P544S | SKCM | 1 |
p.G268D | THYM | 1 |
p.S234Y | BLCA | 1 |
p.A432V | LIHC | 1 |
p.P248T | COAD | 1 |
p.V188M | COAD | 1 |
p.A327V | KIRC | 1 |
p.N362I | STAD | 1 |
p.S408Y | LUAD | 1 |
p.N298S | ESCA | 1 |
p.S174F | SKCM | 1 |
p.S168C | HNSC | 1 |
p.S163G | DLBC | 1 |
p.S358N | LUSC | 1 |
p.S318Y | LUAD | 1 |
p.A490V | COAD | 1 |
p.S133R | BRCA | 1 |
p.T331I | PAAD | 1 |
p.S123F | SKCM | 1 |
p.A491V | UCEC | 1 |
p.S250N | CHOL | 1 |
p.S133G | PRAD | 1 |
p.S438C | ESCA | 1 |
p.A162T | SKCM | 1 |
p.G221E | BLCA | 1 |
p.V98A | BRCA | 1 |
p.S309F | SKCM | 1 |
p.N407K | SARC | 1 |
p.G268S | BRCA | 1 |
p.E214D | DLBC | 1 |
p.V67M | BLCA | 1 |
p.S130C | KIRP | 1 |
p.A150D | LUSC | 1 |
p.S320F | SKCM | 1 |
p.T89R | HNSC | 1 |
p.L14I | LUAD | 1 |
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TissGeneCNV for MUC21 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MUC21 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MUC21 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MUC21 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MUC21 |
TissGeneDrug for MUC21 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MUC21 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004943 | Behcet Syndrome | 1 | GAD |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0018213 | Graves Disease | 1 | GAD |
umls:C0020676 | Hypothyroidism | 1 | GAD |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |
umls:C0038325 | Stevens-Johnson Syndrome | 1 | GAD |