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| TissGeneSummary for LGALS4 |
 Gene summary |
| Basic gene information | Gene symbol | LGALS4 |
| Gene name | lectin, galactoside-binding, soluble, 4 | |
| Synonyms | GAL4|L36LBP | |
| Cytomap | UCSC genome browser: 19q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006149.3, | |
| Description | L-36 lactose-binding proteinantigen NY-CO-27gal-4galectin 4galectin-4lactose-binding lectin 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602518 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171747 | ||
| HPRD : 03949 | ||
| Vega : OTTHUMG00000182608 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LGALS4 | |
| BioGPS: 3960 | ||
| Pathway | NCI Pathway Interaction Database: LGALS4 | |
| KEGG: LGALS4 | ||
| REACTOME: LGALS4 | ||
| Pathway Commons: LGALS4 | ||
| Context | iHOP: LGALS4 | |
| ligand binding site mutation search in PubMed: LGALS4 | ||
| UCL Cancer Institute: LGALS4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
| Reference showing the relevant tissue of LGALS4 | ||
| Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LGALS4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -4.080815541 | -2.685625191 | -1.395190351 | 6.48E-26 | 6.79E-25 |
| KICH | -4.762533857 | -0.725501857 | -4.037032 | 5.59E-11 | 4.60E-10 |
| PRAD | -2.598001473 | -0.844141857 | -1.753859615 | 3.33E-06 | 2.10E-05 |
| LUSC | -3.181604602 | -0.028528132 | -3.153076471 | 7.56E-25 | 1.61E-23 |
| COAD | 8.665508143 | 10.67951584 | -2.014007692 | 1.54E-15 | 1.16E-13 |
| STAD | 7.458330018 | 4.753348768 | 2.70498125 | 0.00863 | 0.030758906 |
| KIRP | -1.727751232 | 0.192030018 | -1.91978125 | 0.00341 | 0.008328126 |
| KIRC | 0.801491476 | -0.683859913 | 1.485351389 | 0.00375 | 0.0066538 |
| LUAD | -1.033667719 | 0.316685729 | -1.350353448 | 0.00304 | 0.006093584 |
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| TissGene-miRNA for LGALS4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LGALS4 |
| TissGeneSNV for LGALS4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R279G | BLCA | 1 |
| p.F188L | LUAD | 1 |
| p.F273L | COAD | 1 |
| p.G151R | COAD | 1 |
| p.K262T | SKCM | 1 |
| p.G82E | SKCM | 1 |
| p.S302L | BLCA | 1 |
| p.G82R | LUSC | 1 |
| p.P186T | STAD | 1 |
| p.K219N | BLCA | 1 |
| p.R279H | BRCA | 1 |
| p.T181I | SKCM | 1 |
| p.W71* | SKCM | 1 |
| p.Q137* | UCEC | 1 |
| p.R67W | READ | 1 |
| p.P190S | SKCM | 1 |
| p.G242S | LUSC | 1 |
| p.S302L | LUSC | 1 |
| p.R240H | STAD | 1 |
| p.Q322H | ESCA | 1 |
| p.S302L | COAD | 1 |
| p.F121L | UCEC | 1 |
| p.L27P | STAD | 1 |
| p.T78M | HNSC | 1 |
| p.G151R | UCEC | 1 |
| p.R240H | UCEC | 1 |
| p.L235M | UCEC | 1 |
| p.R300C | UCEC | 1 |
| p.A204T | UCEC | 1 |
| p.K73N | BRCA | 1 |
| p.G82W | SKCM | 1 |
| p.H299Y | PAAD | 1 |
| p.P154L | SKCM | 1 |
| p.V246M | LUAD | 1 |
| p.R279C | READ | 1 |
| p.G151R | LIHC | 1 |
| p.P22L | SKCM | 1 |
| p.E41K | SKCM | 1 |
| p.E259K | HNSC | 1 |
| p.R240H | LUAD | 1 |
| p.C172Y | PAAD | 1 |
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| TissGeneCNV for LGALS4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LGALS4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG981808 | ARHGEF10L-LGALS4 | chr1:17909092 | chr19:39292366 | |
| Chimerdb3.0 | ChiTaRs | NA | AW391718 | LGALS4-MUC1 | chr19:39293186 | chr1:155161943 | |
| Chimerdb3.0 | ChiTaRs | NA | BG980034 | LGALS4-ARHGEF10L | chr19:39292540 | chr1:17908981 |
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| TissGeneNet for LGALS4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| COAD (tumor) | COAD (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| KICH (tumor) | KICH (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| STAD (tumor) | STAD (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| THCA (tumor) | THCA (normal) |
| LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (tumor) | LGALS4, CFTR, MLH1, ARPC3, KIAA1549, RRAS2 (normal) |
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| TissGeneProg for LGALS4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LGALS4 |
| TissGeneDrug for LGALS4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LGALS4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
| umls:C1527249 | Colorectal Cancer | 4 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree,LHGDN |
| umls:C0001430 | Adenoma | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0010709 | Cyst | 1 | BeFree |
| umls:C0012546 | Diphtheria | 1 | BeFree |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0851887 | Adenoviral infections | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
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