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| TissGeneSummary for LIPC |
 Gene summary |
| Basic gene information | Gene symbol | LIPC |
| Gene name | lipase, hepatic | |
| Synonyms | HDLCQ12|HL|HTGL|LIPH | |
| Cytomap | UCSC genome browser: 15q21-q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000236.2, | |
| Description | hepatic lipasehepatic triacylglycerol lipaselipase member C | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 151670 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166035 | ||
| HPRD : 01058 | ||
| Vega : OTTHUMG00000132632 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LIPC | |
| BioGPS: 3990 | ||
| Pathway | NCI Pathway Interaction Database: LIPC | |
| KEGG: LIPC | ||
| REACTOME: LIPC | ||
| Pathway Commons: LIPC | ||
| Context | iHOP: LIPC | |
| ligand binding site mutation search in PubMed: LIPC | ||
| UCL Cancer Institute: LIPC | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of LIPC | Comparative studies of zebrafish Danio rerio lipoprotein lipase (lpl) and hepatic lipase (lipc) genes belonging to the lipase gene family: evolution and expression pattern. Feng D, Huang QY, Liu K, Zhang SC, Liu ZH. J Fish Biol. 2014 Aug;85(2):329-42. doi: 10.1111/jfb.12423. Epub 2014 Jun 6. (pmid:24905963) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006633 | fatty acid biosynthetic process | 182536 | GO:0019433 | triglyceride catabolic process | 182536 | GO:0034372 | very-low-density lipoprotein particle remodeling | 8640403 | GO:0006633 | fatty acid biosynthetic process | 182536 | GO:0019433 | triglyceride catabolic process | 182536 | GO:0034372 | very-low-density lipoprotein particle remodeling | 8640403 |
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| TissGeneExp for LIPC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | -2.909163009 | -1.789459163 | -1.119703846 | 1.91E-05 | 9.77E-05 |
| THCA | -1.26687181 | 0.773762088 | -2.040633898 | 9.99E-12 | 7.68E-11 |
| COAD | -2.26258224 | 0.426048529 | -2.688630769 | 5.83E-09 | 5.58E-08 |
| KICH | 0.558280529 | 3.920716529 | -3.362436 | 6.62E-11 | 5.32E-10 |
| BRCA | -2.187052348 | -0.955692699 | -1.231359649 | 6.22E-17 | 3.62E-16 |
| LIHC | 5.902540529 | 7.778560529 | -1.87602 | 1.81E-07 | 1.19E-06 |
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| TissGene-miRNA for LIPC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LIPC |
| TissGeneSNV for LIPC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R281Q | SKCM | 2 |
| p.R51T | BRCA | 1 |
| p.E258Q | BLCA | 1 |
| p.R189K | BLCA | 1 |
| p.V433I | SKCM | 1 |
| p.G178S | KIRC | 1 |
| p.S210T | OV | 1 |
| p.E57K | UCEC | 1 |
| p.L259F | UCEC | 1 |
| p.T432R | SKCM | 1 |
| p.D409H | BLCA | 1 |
| p.S80F | LIHC | 1 |
| p.P387S | STAD | 1 |
| p.T184M | LUAD | 1 |
| p.P29A | HNSC | 1 |
| p.G202E | SKCM | 1 |
| p.E412K | UCEC | 1 |
| p.R463I | STAD | 1 |
| p.G202E | LGG | 1 |
| p.V115A | HNSC | 1 |
| p.R65X | READ | 1 |
| p.P211S | SARC | 1 |
| p.Q359H | CESC | 1 |
| p.S440N | SARC | 1 |
| p.G411R | BLCA | 1 |
| p.S315N | LIHC | 1 |
| p.T493A | UCEC | 1 |
| p.T3I | STAD | 1 |
| p.S494* | BLCA | 1 |
| p.M48T | UCEC | 1 |
| p.R281* | LUAD | 1 |
| p.G170C | LUAD | 1 |
| p.T58I | SKCM | 1 |
| p.D212H | BLCA | 1 |
| p.E143K | THYM | 1 |
| p.R159Q | LUSC | 1 |
| p.W430* | SKCM | 1 |
| p.R65* | PRAD | 1 |
| p.K335R | HNSC | 1 |
| p.D213Y | READ | 1 |
| p.L448F | SKCM | 1 |
| p.E40K | SKCM | 1 |
| p.S282L | STAD | 1 |
| p.Q60H | LUAD | 1 |
| p.A177V | SKCM | 1 |
| p.A293V | COAD | 1 |
| p.G393R | SKCM | 1 |
| p.D288N | READ | 1 |
| p.L81M | LUAD | 1 |
| p.K417N | SKCM | 1 |
| p.L199M | HNSC | 1 |
| p.G391S | SKCM | 1 |
| p.A427V | LGG | 1 |
| p.P211L | SARC | 1 |
| p.Q73H | COAD | 1 |
| p.G182D | SKCM | 1 |
| p.H185L | LUAD | 1 |
| p.W430C | HNSC | 1 |
| p.S289F | LUAD | 1 |
| p.T366R | LUAD | 1 |
| p.R344Q | SKCM | 1 |
| p.V283M | SKCM | 1 |
| p.K417N | LUAD | 1 |
| p.T366K | LUSC | 1 |
| p.G411D | SKCM | 1 |
| p.G247E | SKCM | 1 |
| p.R496X | COAD | 1 |
| p.I234T | STAD | 1 |
| p.L54I | UCEC | 1 |
| p.K419R | SKCM | 1 |
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| TissGeneCNV for LIPC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LIPC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | T89564 | ATP8A1-LIPC | chr4:42437539 | chr15:58856857 | |
| Chimerdb3.0 | ChiTaRs | NA | AI589684 | RPS11-LIPC | chr19:50002946 | chr15:58805185 |
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| TissGeneNet for LIPC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor) | LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal) |
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| TissGeneProg for LIPC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LIPC |
| TissGeneDrug for LIPC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LIPC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1956346 | Coronary Artery Disease | 24 | BeFree,GAD,LHGDN |
| umls:C0010054 | Coronary Arteriosclerosis | 21 | BeFree,GAD |
| umls:C0010068 | Coronary heart disease | 21 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 16 | BeFree,CLINVAR,CTD_human,GAD |
| umls:C0028754 | Obesity | 11 | BeFree,GAD,RGD |
| umls:C0020443 | Hypercholesterolemia | 10 | BeFree,GAD,RGD |
| umls:C0004153 | Atherosclerosis | 9 | BeFree,GAD,LHGDN |
| umls:C0242383 | Age related macular degeneration | 9 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 8 | BeFree,GAD |
| umls:C0020473 | Hyperlipidemia | 8 | CTD_human,GAD,RGD |
| umls:C0011849 | Diabetes Mellitus | 7 | BeFree,GAD,LHGDN |
| umls:C0020538 | Hypertensive disease | 7 | BeFree,GAD,LHGDN |
| umls:C0242339 | Dyslipidemias | 7 | BeFree,GAD |
| umls:C0021655 | Insulin Resistance | 6 | CTD_human,GAD |
| umls:C0027051 | Myocardial Infarction | 6 | BeFree,GAD,LHGDN |
| umls:C0011847 | Diabetes | 5 | BeFree |
| umls:C0020474 | Hyperlipidemia, Familial Combined | 5 | BeFree |
| umls:C0020678 | Hypotrichosis | 5 | BeFree |
| umls:C3502073 | Woolly Hair, Autosomal Recessive | 5 | BeFree |
| umls:C0342883 | Cholesteryl Ester Transfer Protein Deficiency | 4 | BeFree |
| umls:C0343073 | Wooly hair | 4 | BeFree |
| umls:C1836672 | Total Hypotrichosis, Mari type | 4 | BeFree |
| umls:C0003850 | Arteriosclerosis | 3 | BeFree |
| umls:C0020445 | Hypercholesterolemia, Familial | 3 | BeFree,CTD_human |
| umls:C0020476 | Hyperlipoproteinemias | 3 | CTD_human,GAD,RGD |
| umls:C0023772 | Lipid Metabolism, Inborn Errors | 3 | CTD_human |
| umls:C0032914 | Pre-Eclampsia | 3 | GAD,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 3 | BeFree,GAD |
| umls:C0085096 | Peripheral Vascular Diseases | 3 | BeFree,GAD,LHGDN |
| umls:C0151744 | Myocardial Ischemia | 3 | BeFree,GAD |
| umls:C0524620 | Metabolic Syndrome X | 3 | BeFree,GAD |
| umls:C1854310 | Hypotrichosis simplex | 3 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 2 | RGD |
| umls:C0011881 | Diabetic Nephropathy | 2 | GAD,LHGDN |
| umls:C0020557 | Hypertriglyceridemia | 2 | GAD |
| umls:C0020676 | Hypothyroidism | 2 | RGD |
| umls:C0022658 | Kidney Diseases | 2 | BeFree,GAD |
| umls:C0022661 | Kidney Failure, Chronic | 2 | GAD,RGD |
| umls:C0154251 | Lipid Metabolism Disorders | 2 | BeFree,GAD |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree,GAD |
| umls:C0271650 | Impaired glucose tolerance | 2 | BeFree |
| umls:C0311277 | Obesity, Abdominal | 2 | BeFree |
| umls:C1260959 | Drusen | 2 | BeFree |
| umls:C1522137 | Hypertriglyceridemia result | 2 | GAD |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree,GAD |
| umls:C1704436 | Peripheral Arterial Diseases | 2 | BeFree |
| umls:C3151466 | HEPATIC LIPASE DEFICIENCY (disorder) | 2 | BeFree,CLINVAR,ORPHANET,UNIPROT |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | LHGDN |
| umls:C0007282 | Carotid Stenosis | 1 | BeFree,GAD |
| umls:C0007785 | Cerebral Infarction | 1 | GAD |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0013274 | Patent ductus arteriosus | 1 | GAD |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0015695 | Fatty Liver | 1 | GAD |
| umls:C0015938 | Fetal Macrosomia | 1 | RGD |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0017327 | Generalized atherosclerosis | 1 | GAD |
| umls:C0017668 | Focal glomerulosclerosis | 1 | RGD |
| umls:C0018799 | Heart Diseases | 1 | GAD |
| umls:C0019158 | Hepatitis | 1 | RGD |
| umls:C0019693 | HIV Infections | 1 | GAD |
| umls:C0020452 | Hyperemia | 1 | CTD_human,GAD |
| umls:C0020459 | Hyperinsulinism | 1 | RGD |
| umls:C0020479 | Hyperlipoproteinemia Type III | 1 | GAD |
| umls:C0020639 | Hypoproteinemia | 1 | RGD |
| umls:C0021368 | Inflammation | 1 | GAD |
| umls:C0022116 | Ischemia | 1 | RGD |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0027726 | Nephrotic Syndrome | 1 | RGD |
| umls:C0033677 | Protein-Energy Malnutrition | 1 | RGD |
| umls:C0042373 | Vascular Diseases | 1 | LHGDN |
| umls:C0085298 | Sudden Cardiac Death | 1 | LHGDN |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0243026 | Sepsis | 1 | RGD |
| umls:C0333186 | Restenosis | 1 | GAD |
| umls:C0342257 | Complications of Diabetes Mellitus | 1 | GAD |
| umls:C0376297 | Cardiac Death | 1 | GAD |
| umls:C0497327 | Dementia | 1 | GAD |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0518010 | body mass | 1 | GAD |
| umls:C0577631 | Carotid Atherosclerosis | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0600518 | Choroidal Neovascularization | 1 | GAD |
| umls:C0730362 | Disorder of macula of retina | 1 | BeFree |
| umls:C0852036 | Pregnancy associated hypertension | 1 | LHGDN |
| umls:C0948008 | Ischemic stroke | 1 | GAD |
| umls:C0948089 | Acute Coronary Syndrome | 1 | GAD |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1536085 | Geographic Atrophy | 1 | GAD |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
| umls:C2712907 | Combined hyperlipidemia | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
| umls:C2675071 | HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 12 | 0 | CLINVAR,CTD_human |
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