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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for LIPC
check button Gene summary
Basic gene informationGene symbolLIPC
Gene namelipase, hepatic
SynonymsHDLCQ12|HL|HTGL|LIPH
CytomapUCSC genome browser: 15q21-q23
Type of geneprotein-coding
RefGenesNM_000236.2,
Descriptionhepatic lipasehepatic triacylglycerol lipaselipase member C
Modification date20141211
dbXrefs MIM : 151670
HGNC : HGNC
Ensembl : ENSG00000166035
HPRD : 01058
Vega : OTTHUMG00000132632
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_LIPC
BioGPS: 3990
PathwayNCI Pathway Interaction Database: LIPC
KEGG: LIPC
REACTOME: LIPC
Pathway Commons: LIPC
ContextiHOP: LIPC
ligand binding site mutation search in PubMed: LIPC
UCL Cancer Institute: LIPC
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of LIPCComparative studies of zebrafish Danio rerio lipoprotein lipase (lpl) and hepatic lipase (lipc) genes belonging to the lipase gene family: evolution and expression pattern. Feng D, Huang QY, Liu K, Zhang SC, Liu ZH. J Fish Biol. 2014 Aug;85(2):329-42. doi: 10.1111/jfb.12423. Epub 2014 Jun 6. (pmid:24905963)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006633fatty acid biosynthetic process182536
GO:0019433triglyceride catabolic process182536
GO:0034372very-low-density lipoprotein particle remodeling8640403
GO:0006633fatty acid biosynthetic process182536
GO:0019433triglyceride catabolic process182536
GO:0034372very-low-density lipoprotein particle remodeling8640403


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TissGeneExp for LIPC

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD-2.909163009-1.789459163-1.1197038461.91E-059.77E-05
THCA-1.266871810.773762088-2.0406338989.99E-127.68E-11
COAD-2.262582240.426048529-2.6886307695.83E-095.58E-08
KICH0.5582805293.920716529-3.3624366.62E-115.32E-10
BRCA-2.187052348-0.955692699-1.2313596496.22E-173.62E-16
LIHC5.9025405297.778560529-1.876021.81E-071.19E-06


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TissGene-miRNA for LIPC

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for LIPC
TissGeneSNV for LIPC

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R281QSKCM2
p.R51TBRCA1
p.E258QBLCA1
p.R189KBLCA1
p.V433ISKCM1
p.G178SKIRC1
p.S210TOV1
p.E57KUCEC1
p.L259FUCEC1
p.T432RSKCM1
p.D409HBLCA1
p.S80FLIHC1
p.P387SSTAD1
p.T184MLUAD1
p.P29AHNSC1
p.G202ESKCM1
p.E412KUCEC1
p.R463ISTAD1
p.G202ELGG1
p.V115AHNSC1
p.R65XREAD1
p.P211SSARC1
p.Q359HCESC1
p.S440NSARC1
p.G411RBLCA1
p.S315NLIHC1
p.T493AUCEC1
p.T3ISTAD1
p.S494*BLCA1
p.M48TUCEC1
p.R281*LUAD1
p.G170CLUAD1
p.T58ISKCM1
p.D212HBLCA1
p.E143KTHYM1
p.R159QLUSC1
p.W430*SKCM1
p.R65*PRAD1
p.K335RHNSC1
p.D213YREAD1
p.L448FSKCM1
p.E40KSKCM1
p.S282LSTAD1
p.Q60HLUAD1
p.A177VSKCM1
p.A293VCOAD1
p.G393RSKCM1
p.D288NREAD1
p.L81MLUAD1
p.K417NSKCM1
p.L199MHNSC1
p.G391SSKCM1
p.A427VLGG1
p.P211LSARC1
p.Q73HCOAD1
p.G182DSKCM1
p.H185LLUAD1
p.W430CHNSC1
p.S289FLUAD1
p.T366RLUAD1
p.R344QSKCM1
p.V283MSKCM1
p.K417NLUAD1
p.T366KLUSC1
p.G411DSKCM1
p.G247ESKCM1
p.R496XCOAD1
p.I234TSTAD1
p.L54IUCEC1
p.K419RSKCM1


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TissGeneCNV for LIPC

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for LIPC

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAT89564ATP8A1-LIPCchr4:42437539chr15:58856857
Chimerdb3.0ChiTaRsNAAI589684RPS11-LIPCchr19:50002946chr15:58805185


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TissGeneNet for LIPC

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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COAD (tumor)COAD (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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HNSC (tumor)HNSC (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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KICH (tumor)KICH (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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KIRC (tumor)KIRC (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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KIRP (tumor)KIRP (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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LIHC (tumor)LIHC (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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LUAD (tumor)LUAD (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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LUSC (tumor)LUSC (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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PRAD (tumor)PRAD (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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STAD (tumor)STAD (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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THCA (tumor)THCA (normal)
LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (tumor)LIPC, HNF4A, APOB, NR2F1, LRP1, ADHFE1 (normal)
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TissGeneProg for LIPC

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for LIPC
TissGeneDrug for LIPC

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for LIPC

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C1956346Coronary Artery Disease24BeFree,GAD,LHGDN
umls:C0010054Coronary Arteriosclerosis21BeFree,GAD
umls:C0010068Coronary heart disease21BeFree,GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent16BeFree,CLINVAR,CTD_human,GAD
umls:C0028754Obesity11BeFree,GAD,RGD
umls:C0020443Hypercholesterolemia10BeFree,GAD,RGD
umls:C0004153Atherosclerosis9BeFree,GAD,LHGDN
umls:C0242383Age related macular degeneration9BeFree,GAD
umls:C0007222Cardiovascular Diseases8BeFree,GAD
umls:C0020473Hyperlipidemia8CTD_human,GAD,RGD
umls:C0011849Diabetes Mellitus7BeFree,GAD,LHGDN
umls:C0020538Hypertensive disease7BeFree,GAD,LHGDN
umls:C0242339Dyslipidemias7BeFree,GAD
umls:C0021655Insulin Resistance6CTD_human,GAD
umls:C0027051Myocardial Infarction6BeFree,GAD,LHGDN
umls:C0011847Diabetes5BeFree
umls:C0020474Hyperlipidemia, Familial Combined5BeFree
umls:C0020678Hypotrichosis5BeFree
umls:C3502073Woolly Hair, Autosomal Recessive5BeFree
umls:C0342883Cholesteryl Ester Transfer Protein Deficiency4BeFree
umls:C0343073Wooly hair4BeFree
umls:C1836672Total Hypotrichosis, Mari type4BeFree
umls:C0003850Arteriosclerosis3BeFree
umls:C0020445Hypercholesterolemia, Familial3BeFree,CTD_human
umls:C0020476Hyperlipoproteinemias3CTD_human,GAD,RGD
umls:C0023772Lipid Metabolism, Inborn Errors3CTD_human
umls:C0032914Pre-Eclampsia3GAD,LHGDN
umls:C0038454Cerebrovascular accident3BeFree,GAD
umls:C0085096Peripheral Vascular Diseases3BeFree,GAD,LHGDN
umls:C0151744Myocardial Ischemia3BeFree,GAD
umls:C0524620Metabolic Syndrome X3BeFree,GAD
umls:C1854310Hypotrichosis simplex3BeFree
umls:C0002736Amyotrophic Lateral Sclerosis2GAD
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0011853Diabetes Mellitus, Experimental2RGD
umls:C0011881Diabetic Nephropathy2GAD,LHGDN
umls:C0020557Hypertriglyceridemia2GAD
umls:C0020676Hypothyroidism2RGD
umls:C0022658Kidney Diseases2BeFree,GAD
umls:C0022661Kidney Failure, Chronic2GAD,RGD
umls:C0154251Lipid Metabolism Disorders2BeFree,GAD
umls:C0242379Malignant neoplasm of lung2BeFree,GAD
umls:C0271650Impaired glucose tolerance2BeFree
umls:C0311277Obesity, Abdominal2BeFree
umls:C1260959Drusen2BeFree
umls:C1522137Hypertriglyceridemia result2GAD
umls:C1527249Colorectal Cancer2BeFree,GAD
umls:C1704436Peripheral Arterial Diseases2BeFree
umls:C3151466HEPATIC LIPASE DEFICIENCY (disorder)2BeFree,CLINVAR,ORPHANET,UNIPROT
umls:C0002395Alzheimer's Disease1GAD
umls:C0005684Malignant neoplasm of urinary bladder1GAD
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007273Carotid Artery Diseases1LHGDN
umls:C0007282Carotid Stenosis1BeFree,GAD
umls:C0007785Cerebral Infarction1GAD
umls:C0008495Chorioamnionitis1GAD
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0013274Patent ductus arteriosus1GAD
umls:C0014175Endometriosis1BeFree
umls:C0015695Fatty Liver1GAD
umls:C0015938Fetal Macrosomia1RGD
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0017327Generalized atherosclerosis1GAD
umls:C0017668Focal glomerulosclerosis1RGD
umls:C0018799Heart Diseases1GAD
umls:C0019158Hepatitis1RGD
umls:C0019693HIV Infections1GAD
umls:C0020452Hyperemia1CTD_human,GAD
umls:C0020459Hyperinsulinism1RGD
umls:C0020479Hyperlipoproteinemia Type III1GAD
umls:C0020639Hypoproteinemia1RGD
umls:C0021368Inflammation1GAD
umls:C0022116Ischemia1RGD
umls:C0022876Premature Obstetric Labor1GAD
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0024305Lymphoma, Non-Hodgkin1GAD
umls:C0027726Nephrotic Syndrome1RGD
umls:C0033677Protein-Energy Malnutrition1RGD
umls:C0042373Vascular Diseases1LHGDN
umls:C0085298Sudden Cardiac Death1LHGDN
umls:C0151526Premature Birth1GAD
umls:C0243026Sepsis1RGD
umls:C0333186Restenosis1GAD
umls:C0342257Complications of Diabetes Mellitus1GAD
umls:C0376297Cardiac Death1GAD
umls:C0497327Dementia1GAD
umls:C0497406Overweight1BeFree
umls:C0518010body mass1GAD
umls:C0577631Carotid Atherosclerosis1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0600518Choroidal Neovascularization1GAD
umls:C0730362Disorder of macula of retina1BeFree
umls:C0852036Pregnancy associated hypertension1LHGDN
umls:C0948008Ischemic stroke1GAD
umls:C0948089Acute Coronary Syndrome1GAD
umls:C1271104Blood pressure finding1GAD
umls:C1272641Systemic arterial pressure1GAD
umls:C1536085Geographic Atrophy1GAD
umls:C1861172Venous Thromboembolism1GAD
umls:C2712907Combined hyperlipidemia1BeFree
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C2937358Cerebral Hemorrhage1GAD
umls:C2675071HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 120CLINVAR,CTD_human