TissGeneSummary for TEX19 |
Gene summary |
Basic gene information | Gene symbol | TEX19 |
Gene name | testis expressed 19 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17q25.3 | |
Type of gene | protein-coding | |
RefGenes | NM_207459.3, | |
Description | testis-expressed sequence 19 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 615647 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182459 | ||
HPRD : 16940 | ||
Vega : OTTHUMG00000132857 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TEX19 | |
BioGPS: 400629 | ||
Pathway | NCI Pathway Interaction Database: TEX19 | |
KEGG: TEX19 | ||
REACTOME: TEX19 | ||
Pathway Commons: TEX19 | ||
Context | iHOP: TEX19 | |
ligand binding site mutation search in PubMed: TEX19 | ||
UCL Cancer Institute: TEX19 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TEX19 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for TEX19 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -0.90817289 | -2.208638007 | 1.300465116 | 5.04E-06 | 3.12E-05 |
LUSC | -1.215284154 | -2.508835134 | 1.29355098 | 6.43E-13 | 3.04E-12 |
BRCA | -0.928008509 | -2.48956114 | 1.561552632 | 4.55E-14 | 2.23E-13 |
LIHC | -0.623936193 | -2.562190193 | 1.938254 | 1.39E-10 | 1.78E-09 |
LUAD | -1.448354607 | -2.5559684 | 1.107613793 | 2.52E-08 | 1.08E-07 |
BLCA | -1.196624298 | -2.523382193 | 1.326757895 | 0.000229 | 0.00218582 |
KIRP | -1.461719693 | -2.556163443 | 1.09444375 | 0.000136 | 0.00044906 |
COAD | -1.058070654 | -2.341001424 | 1.282930769 | 4.38E-05 | 0.000173223 |
Top |
TissGene-miRNA for TEX19 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for TEX19 |
TissGeneSNV for TEX19 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W147R | PAAD | 2 |
p.E52X | THYM | 1 |
p.E137K | SKCM | 1 |
p.A40T | ESCA | 1 |
p.E123K | STAD | 1 |
p.L17F | UCEC | 1 |
p.L134M | KIRP | 1 |
p.G88E | SKCM | 1 |
p.P126T | LUAD | 1 |
p.R148I | COAD | 1 |
p.H157N | KIRC | 1 |
p.P146L | SKCM | 1 |
p.G93W | DLBC | 1 |
p.H157Y | ESCA | 1 |
p.W98C | UCEC | 1 |
p.G101E | SKCM | 1 |
p.W83* | SKCM | 1 |
p.G99R | SKCM | 1 |
p.P146R | LIHC | 1 |
p.A97T | SKCM | 1 |
p.P121L | SKCM | 1 |
p.E128X | KIRP | 1 |
p.W147* | SKCM | 1 |
p.W147X | SKCM | 1 |
p.E11K | SKCM | 1 |
Top |
TissGeneCNV for TEX19 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for TEX19 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for TEX19 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for TEX19 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for TEX19 |
TissGeneDrug for TEX19 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for TEX19 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |