TissGeneSummary for FSIP2 |
Gene summary |
Basic gene information | Gene symbol | FSIP2 |
Gene name | fibrous sheath interacting protein 2 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q32.1 | |
Type of gene | protein-coding | |
RefGenes | NM_207482.2, NM_173651.2, | |
Description | fibrous sheath-interacting protein 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 615796 | |
HGNC : HGNC | ||
Ensembl : ENSG00000188738 | ||
HPRD : 13483 | ||
Vega : OTTHUMG00000153874 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FSIP2 | |
BioGPS: 401024 | ||
Pathway | NCI Pathway Interaction Database: FSIP2 | |
KEGG: FSIP2 | ||
REACTOME: FSIP2 | ||
Pathway Commons: FSIP2 | ||
Context | iHOP: FSIP2 | |
ligand binding site mutation search in PubMed: FSIP2 | ||
UCL Cancer Institute: FSIP2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FSIP2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FSIP2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FSIP2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FSIP2 |
TissGeneSNV for FSIP2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E6399K | SKCM | 2 |
p.E6422K | SKCM | 2 |
p.E6045K | SKCM | 2 |
p.R6450K | SKCM | 2 |
p.E5652K | SKCM | 2 |
p.D5859N | SKCM | 2 |
p.E6168K | SKCM | 2 |
p.T6161I | SKCM | 2 |
p.S5676L | SKCM | 2 |
p.E6236K | SKCM | 2 |
p.S6963Y | LUAD | 2 |
p.V6207L | SKCM | 1 |
p.E6086K | SKCM | 1 |
p.P5854L | PRAD | 1 |
p.K5874R | STAD | 1 |
p.S6855* | HNSC | 1 |
p.N5624K | ACC | 1 |
p.Q3154K | CHOL | 1 |
p.V5614L | LUAD | 1 |
p.D6598H | BLCA | 1 |
p.A388T | BRCA | 1 |
p.Q3096H | THYM | 1 |
p.E5253* | CESC | 1 |
p.K6642E | SKCM | 1 |
p.I3628T | ESCA | 1 |
p.S3869L | ESCA | 1 |
p.S1611X | ESCA | 1 |
p.S6926R | SKCM | 1 |
p.D6534Y | READ | 1 |
p.E6527D | SKCM | 1 |
p.G5468V | LUAD | 1 |
p.S5497L | SKCM | 1 |
p.G5942E | PAAD | 1 |
p.D6273Y | UCEC | 1 |
p.A5523T | CESC | 1 |
p.K6868N | READ | 1 |
p.E5608K | SKCM | 1 |
p.V5580I | COAD | 1 |
p.Q5943* | KIRP | 1 |
p.S6314F | SKCM | 1 |
p.R6750Q | SKCM | 1 |
p.S5826L | HNSC | 1 |
p.S5901Y | UCEC | 1 |
p.I5718S | UCEC | 1 |
p.M5985I | SKCM | 1 |
p.V6611I | SKCM | 1 |
p.E6748K | BLCA | 1 |
p.S6916Y | COAD | 1 |
p.D6712N | SKCM | 1 |
p.N6340D | STAD | 1 |
p.P6331H | LUAD | 1 |
p.E5943* | UCEC | 1 |
p.I6106F | HNSC | 1 |
p.S5626* | LUAD | 1 |
p.P5892H | PAAD | 1 |
p.S6264Y | LUAD | 1 |
p.D6994N | SKCM | 1 |
p.M5469V | LIHC | 1 |
p.E6766X | COAD | 1 |
p.E6859K | SKCM | 1 |
p.P437R | ESCA | 1 |
p.E6189D | STAD | 1 |
p.E6901D | COAD | 1 |
p.G6031E | PAAD | 1 |
p.A6748D | UCEC | 1 |
p.G6225R | SKCM | 1 |
p.P6693S | UCEC | 1 |
p.A5873T | SARC | 1 |
p.A6442T | LGG | 1 |
p.S5929* | KIRP | 1 |
p.S5407F | SKCM | 1 |
p.I6746L | KIRP | 1 |
p.E5525K | BLCA | 1 |
p.E4610K | CESC | 1 |
p.P6331T | STAD | 1 |
p.T6139A | UCEC | 1 |
p.E6269K | SKCM | 1 |
p.A6701V | PAAD | 1 |
p.G6652V | LUAD | 1 |
p.P6907T | LUAD | 1 |
p.V6072I | COAD | 1 |
p.I6113L | STAD | 1 |
p.A6381P | LUAD | 1 |
p.E6899X | THYM | 1 |
p.S6316R | ESCA | 1 |
p.E6866* | LUAD | 1 |
p.F6355L | UCEC | 1 |
p.I6318T | KIRP | 1 |
p.L1322F | SARC | 1 |
p.E5611K | SKCM | 1 |
p.E5696* | UCEC | 1 |
p.L5727I | BLCA | 1 |
p.I6443V | UCEC | 1 |
p.M5558T | LUAD | 1 |
p.D6362G | STAD | 1 |
p.R5739G | HNSC | 1 |
p.E6918K | SKCM | 1 |
p.E6124* | UCEC | 1 |
p.S5290Y | UCEC | 1 |
p.G5615R | SKCM | 1 |
p.A6854E | UCEC | 1 |
p.R1062I | ESCA | 1 |
p.D6165H | THCA | 1 |
p.L6261F | UCEC | 1 |
p.Q6979* | SKCM | 1 |
p.D6557N | STAD | 1 |
p.S5814L | LUAD | 1 |
p.K6920N | LUAD | 1 |
p.R6986I | BLCA | 1 |
p.A5586G | LUAD | 1 |
p.I6414S | LIHC | 1 |
p.T6027A | UCEC | 1 |
p.L6639R | UCEC | 1 |
p.K5403* | SKCM | 1 |
p.T5632I | SKCM | 1 |
p.K6315Q | ESCA | 1 |
p.E6495D | COAD | 1 |
p.A6612V | PAAD | 1 |
p.A2259V | THYM | 1 |
p.R6650K | SKCM | 1 |
p.S5693Y | LUAD | 1 |
p.L6122I | UCEC | 1 |
p.D6774N | CESC | 1 |
p.S6926N | SKCM | 1 |
p.S5492F | LIHC | 1 |
p.D6803Y | UCEC | 1 |
p.P6607S | UCEC | 1 |
p.E5450Q | HNSC | 1 |
p.D6416E | LIHC | 1 |
p.S1483I | THYM | 1 |
p.D5669N | HNSC | 1 |
p.D6902N | LUAD | 1 |
p.D6557N | SKCM | 1 |
p.A6661T | MESO | 1 |
p.S6463* | LUAD | 1 |
p.D5977N | SKCM | 1 |
p.F6801I | STAD | 1 |
p.A1594E | LUAD | 1 |
p.K5912R | COAD | 1 |
p.F6025V | UCEC | 1 |
p.K228Q | CESC | 1 |
p.D5915N | LUAD | 1 |
p.P5981H | LUAD | 1 |
p.E5462X | COAD | 1 |
p.S5801Y | UCEC | 1 |
p.T6982N | LUAD | 1 |
p.E3203K | CESC | 1 |
p.R5105K | ESCA | 1 |
p.P5981H | STAD | 1 |
p.D5850Y | UCEC | 1 |
p.P5981H | PAAD | 1 |
p.F5889L | STAD | 1 |
p.Q6192R | HNSC | 1 |
p.S6314Y | HNSC | 1 |
p.W4091X | ESCA | 1 |
p.P6195A | BRCA | 1 |
p.V6574I | KIRC | 1 |
p.P5798L | SKCM | 1 |
p.N5743I | STAD | 1 |
p.V5444L | THYM | 1 |
p.D5610N | SKCM | 1 |
p.K5845N | COAD | 1 |
p.G5696D | LGG | 1 |
p.E6409K | SKCM | 1 |
p.P6846T | HNSC | 1 |
p.S5636R | SKCM | 1 |
p.Q3884K | ESCA | 1 |
p.L6181I | COAD | 1 |
p.C2748F | THYM | 1 |
p.E5839Q | LIHC | 1 |
p.I6023F | READ | 1 |
p.E6409K | SARC | 1 |
p.L5404R | STAD | 1 |
p.D6297N | CESC | 1 |
p.D5438N | HNSC | 1 |
p.E6527K | SKCM | 1 |
p.A5472V | SKCM | 1 |
p.E5744K | BLCA | 1 |
p.P6540S | SKCM | 1 |
p.T6535K | STAD | 1 |
p.T5517P | BLCA | 1 |
p.E6126K | BLCA | 1 |
p.H4441D | CESC | 1 |
p.K6070E | LIHC | 1 |
p.I1696S | SARC | 1 |
p.A6585V | COAD | 1 |
p.E5230* | UCEC | 1 |
p.L1442S | ESCA | 1 |
p.L4232F | CHOL | 1 |
p.E6270X | PAAD | 1 |
p.T6082K | LUAD | 1 |
p.S6293F | HNSC | 1 |
p.E5446* | LIHC | 1 |
p.E6527K | LUAD | 1 |
p.M5986I | ESCA | 1 |
p.A5873T | LIHC | 1 |
p.K5413R | SKCM | 1 |
p.D6165N | BLCA | 1 |
p.R5739X | COAD | 1 |
p.S6561L | SKCM | 1 |
p.G5399S | SKCM | 1 |
p.S5826* | SKCM | 1 |
p.F6878I | LUAD | 1 |
p.A6080T | SKCM | 1 |
p.S1723P | ESCA | 1 |
p.S5725L | UCEC | 1 |
p.D2280Y | THYM | 1 |
p.L6254Q | COAD | 1 |
p.R5739Q | SKCM | 1 |
p.Q6050K | LUAD | 1 |
p.G6962E | SKCM | 1 |
p.T5596A | SKCM | 1 |
p.D6458E | SKCM | 1 |
p.V5803A | CESC | 1 |
p.P6607T | LUAD | 1 |
p.M6883I | SKCM | 1 |
p.G6523R | SKCM | 1 |
p.D5813N | SKCM | 1 |
p.M5883I | SKCM | 1 |
p.I1827N | ESCA | 1 |
p.P5980S | SARC | 1 |
p.E6496G | STAD | 1 |
p.R5755K | SKCM | 1 |
p.P6284T | ESCA | 1 |
p.Q5395* | BRCA | 1 |
p.D6573N | COAD | 1 |
p.E6604Q | BLCA | 1 |
p.D5748N | SKCM | 1 |
p.G6962* | BLCA | 1 |
p.F6439C | UCEC | 1 |
p.I6267K | SKCM | 1 |
p.E6181* | PAAD | 1 |
p.E5865D | BLCA | 1 |
p.S6176Y | LUAD | 1 |
p.S645L | CESC | 1 |
p.Y3579X | ESCA | 1 |
p.E5411V | KIRC | 1 |
p.C6143Y | UCEC | 1 |
p.S5761L | LUAD | 1 |
p.P6389T | LUAD | 1 |
p.R6682K | SKCM | 1 |
p.G6615E | SKCM | 1 |
p.F6840S | UCEC | 1 |
p.D5888N | BRCA | 1 |
p.R5555G | LIHC | 1 |
p.E1971* | CESC | 1 |
p.D6557H | BLCA | 1 |
p.R5471I | UCEC | 1 |
p.S6022F | SKCM | 1 |
p.I6414S | COAD | 1 |
p.E6270* | PAAD | 1 |
p.F6801I | PRAD | 1 |
p.D6416A | COAD | 1 |
p.E6234K | UCS | 1 |
p.K5724N | LUAD | 1 |
p.Y5788X | READ | 1 |
p.P6183T | HNSC | 1 |
p.N5772D | PAAD | 1 |
p.K5756E | UCEC | 1 |
p.G5598R | SKCM | 1 |
p.K6617Q | COAD | 1 |
p.R5739Q | BLCA | 1 |
p.E5446X | LIHC | 1 |
p.P6389L | LIHC | 1 |
p.K3514M | SARC | 1 |
p.L6597V | STAD | 1 |
p.D6531N | BLCA | 1 |
p.P6623Q | LUAD | 1 |
p.E5966K | SKCM | 1 |
p.E6481K | BLCA | 1 |
p.Q5943X | KIRP | 1 |
p.S6522* | BLCA | 1 |
p.I6532M | LGG | 1 |
p.N5683D | PAAD | 1 |
p.E6899D | STAD | 1 |
p.T5557A | HNSC | 1 |
p.S6255Y | UCEC | 1 |
p.E6339K | ESCA | 1 |
p.S5441F | HNSC | 1 |
p.V6588M | LIHC | 1 |
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TissGeneCNV for FSIP2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FSIP2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE704322 | RBM17-FSIP2 | chr10:6148174 | chr2:186678427 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A1-A0SP-01A | GULP1-FSIP2 | In-frame | Chr2:189434847 | Chr2:186604073 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7261-01A | PCCA-FSIP2 | Out-of-frame | Chr13:100809594 | Chr2:186692883 |
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TissGeneNet for FSIP2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FSIP2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FSIP2 |
TissGeneDrug for FSIP2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FSIP2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |