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| TissGeneSummary for LOR |
 Gene summary |
| Basic gene information | Gene symbol | LOR |
| Gene name | loricrin | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000427.2, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 152445 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000203782 | ||
| HPRD : 01070 | ||
| Vega : OTTHUMG00000013938 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LOR | |
| BioGPS: 4014 | ||
| Pathway | NCI Pathway Interaction Database: LOR | |
| KEGG: LOR | ||
| REACTOME: LOR | ||
| Pathway Commons: LOR | ||
| Context | iHOP: LOR | |
| ligand binding site mutation search in PubMed: LOR | ||
| UCL Cancer Institute: LOR | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of LOR | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0018149 | peptide cross-linking | 10908733 | GO:0030216 | keratinocyte differentiation | 10908733 | GO:0018149 | peptide cross-linking | 10908733 | GO:0030216 | keratinocyte differentiation | 10908733 |
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| TissGeneExp for LOR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.702914389 | -1.836424193 | 1.133509804 | 3.93E-05 | 8.46E-05 |
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| TissGene-miRNA for LOR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LOR |
| TissGeneSNV for LOR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S152L | ESCA | 1 |
| p.W309L | LUAD | 1 |
| p.G127C | ACC | 1 |
| p.G282V | SARC | 1 |
| p.A306V | LIHC | 1 |
| p.P310L | COAD | 1 |
| p.G278E | SKCM | 1 |
| p.Y189C | KIRP | 1 |
| p.T301A | SKCM | 1 |
| p.G22S | LUAD | 1 |
| p.V295I | STAD | 1 |
| p.S91F | COAD | 1 |
| p.G31D | STAD | 1 |
| p.S235C | LIHC | 1 |
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| TissGeneCNV for LOR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LOR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LOR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| COAD (tumor) | COAD (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| KICH (tumor) | KICH (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| STAD (tumor) | STAD (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| THCA (tumor) | THCA (normal) |
| LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (tumor) | LOR, SP1, FOS, IVL, CREB1, KRT1, ATF1, EVPL, SP3, CSTA, VIM, PI3, SPRR3 (normal) |
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| TissGeneProg for LOR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LOR |
| TissGeneDrug for LOR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LOR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1858805 | Vohwinkel Syndrome, Variant Form | 9 | BeFree,CLINVAR,CTD_human,ORPHANET |
| umls:C0011615 | Dermatitis, Atopic | 7 | BeFree,GAD,LHGDN |
| umls:C0013595 | Eczema | 5 | BeFree |
| umls:C0022579 | Keratoderma | 4 | BeFree |
| umls:C0022596 | Palmoplantar Keratosis | 4 | BeFree |
| umls:C0033860 | Psoriasis | 4 | BeFree |
| umls:C0334166 | Pseudoainhum | 4 | BeFree |
| umls:C0020757 | Ichthyoses | 3 | BeFree |
| umls:C0020758 | Congenital ichthyosis | 3 | BeFree |
| umls:C0432330 | Erythrokeratoderma | 3 | BeFree |
| umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,CTD_human |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 2 | BeFree |
| umls:C0037274 | Dermatologic disorders | 2 | BeFree |
| umls:C0265964 | Mutilating keratoderma | 2 | BeFree |
| umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
| umls:C0023531 | Leukoplakia | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029172 | Oral Submucous Fibrosis | 1 | BeFree |
| umls:C0037268 | Skin Abnormalities | 1 | BeFree |
| umls:C0037286 | Skin Neoplasms | 1 | CTD_human |
| umls:C0079583 | Ichthyosiform Erythroderma, Congenital | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0265961 | Erythrokeratodermia variabilis | 1 | BeFree |
| umls:C0278488 | Carcinoma breast stage IV | 1 | BeFree |
| umls:C0870082 | Hyperkeratosis | 1 | BeFree |
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