![]() |
TissGeneSummary for LRCH4 |
![]() |
Basic gene information | Gene symbol | LRCH4 |
Gene name | leucine-rich repeats and calponin homology (CH) domain containing 4 | |
Synonyms | LRN|LRRN1|LRRN4|PP14183 | |
Cytomap | UCSC genome browser: 7q22 | |
Type of gene | protein-coding | |
RefGenes | NM_001289934.1, NM_002319.4, | |
Description | leucine rich repeat neuronal 4leucine-rich neuronal proteinleucine-rich repeat and calponin homology domain-containing protein 4 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000077454 | ||
HPRD : 10062 | ||
Vega : OTTHUMG00000159544 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LRCH4 | |
BioGPS: 4034 | ||
Pathway | NCI Pathway Interaction Database: LRCH4 | |
KEGG: LRCH4 | ||
REACTOME: LRCH4 | ||
Pathway Commons: LRCH4 | ||
Context | iHOP: LRCH4 | |
ligand binding site mutation search in PubMed: LRCH4 | ||
UCL Cancer Institute: LRCH4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisThymus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTTHYM | |
Reference showing the relevant tissue of LRCH4 | ||
Description by TissGene annotations | Protective TissGene in OS TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for LRCH4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for LRCH4 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for LRCH4 |
TissGeneSNV for LRCH4 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S183F | SKCM | 2 |
p.P485H | ESCA | 1 |
p.D74_splice | LUSC | 1 |
p.Q245* | SKCM | 1 |
p.P397L | COAD | 1 |
p.R104T | LUSC | 1 |
p.R333Q | COAD | 1 |
p.R394Q | DLBC | 1 |
p.P381L | KIRC | 1 |
p.R162Q | UCEC | 1 |
p.S461C | SKCM | 1 |
p.E199K | SARC | 1 |
p.F80V | SKCM | 1 |
p.V663I | STAD | 1 |
p.E316K | HNSC | 1 |
p.S212F | SKCM | 1 |
p.R336W | STAD | 1 |
p.G634E | SKCM | 1 |
p.D350H | BLCA | 1 |
p.L438F | PAAD | 1 |
p.S515G | LUAD | 1 |
p.A452V | SKCM | 1 |
p.R545H | STAD | 1 |
p.G314A | HNSC | 1 |
p.V448M | STAD | 1 |
p.D536N | LGG | 1 |
p.P205S | SKCM | 1 |
p.P362L | SKCM | 1 |
p.P535T | OV | 1 |
p.R644W | STAD | 1 |
p.P555L | SKCM | 1 |
p.R293W | UCEC | 1 |
p.R190W | SKCM | 1 |
p.R190Q | SKCM | 1 |
p.A41V | COAD | 1 |
p.E316V | ACC | 1 |
p.A649V | PRAD | 1 |
p.E177K | SKCM | 1 |
p.P351L | SKCM | 1 |
p.E199K | SKCM | 1 |
p.G456S | OV | 1 |
p.A447T | UCEC | 1 |
p.R215H | UCEC | 1 |
p.E609K | HNSC | 1 |
p.F223I | SKCM | 1 |
p.A446T | THYM | 1 |
p.S346L | SKCM | 1 |
p.E85K | BLCA | 1 |
p.R327Q | STAD | 1 |
p.E562K | ESCA | 1 |
p.E605K | HNSC | 1 |
p.P278L | THYM | 1 |
p.R679P | BLCA | 1 |
p.A268S | KIRP | 1 |
p.E199K | UCEC | 1 |
p.P362S | SKCM | 1 |
p.S359G | LIHC | 1 |
Top |
TissGeneCNV for LRCH4 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for LRCH4 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI052970 | SEC31A-LRCH4 | chr4:83770072 | chr7:100174335 | |
Chimerdb3.0 | ChiTaRs | NA | AV704306 | TNKS1BP1-LRCH4 | chr11:57075591 | chr7:100172283 | |
Chimerdb3.0 | ChiTaRs | NA | BE709716 | LRCH4-TBC1D1 | chr7:100178707 | chr4:38091674 | |
Chimerdb3.0 | ChiTaRs | NA | AW182813 | OXR1-LRCH4 | chr8:107285002 | chr7:100179483 |
Top |
TissGeneNet for LRCH4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for LRCH4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for LRCH4 |
TissGeneDrug for LRCH4 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for LRCH4 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025500 | Mesothelioma | 1 | BeFree |