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| TissGeneSummary for LRP2 |
 Gene summary |
| Basic gene information | Gene symbol | LRP2 |
| Gene name | low density lipoprotein receptor-related protein 2 | |
| Synonyms | DBS|GP330 | |
| Cytomap | UCSC genome browser: 2q31.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004525.2, | |
| Description | Heymann nephritis antigen homologLRP-2calcium sensor proteinglycoprotein 330low-density lipoprotein receptor-related protein 2megalin | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 600073 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000081479 | ||
| HPRD : 02509 | ||
| Vega : OTTHUMG00000132179 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LRP2 | |
| BioGPS: 4036 | ||
| Pathway | NCI Pathway Interaction Database: LRP2 | |
| KEGG: LRP2 | ||
| REACTOME: LRP2 | ||
| Pathway Commons: LRP2 | ||
| Context | iHOP: LRP2 | |
| ligand binding site mutation search in PubMed: LRP2 | ||
| UCL Cancer Institute: LRP2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTHCA | |
| Reference showing the relevant tissue of LRP2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for LRP2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 1.057439814 | 3.238726021 | -2.181286207 | 1.55E-08 | 6.75E-08 |
| KICH | -3.376882048 | 4.607993952 | -7.984876 | 1.49E-16 | 4.50E-15 |
| THCA | 4.31735463 | 6.682290224 | -2.364935593 | 2.54E-15 | 3.41E-14 |
| LUSC | -0.983913499 | 3.340429639 | -4.324343137 | 1.88E-15 | 1.23E-14 |
| KIRC | 7.162863952 | 6.151722286 | 1.011141667 | 0.00757 | 0.012989564 |
| LIHC | -3.359982048 | -1.796942048 | -1.56304 | 5.84E-05 | 0.000213333 |
| Top |
| TissGene-miRNA for LRP2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for LRP2 |
| TissGeneSNV for LRP2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R34C | SKCM | 4 |
| p.R1311C | SKCM | 3 |
| p.R2432I | UCEC | 3 |
| p.R1412W | COAD | 2 |
| p.S3392F | SKCM | 2 |
| p.G3965E | SKCM | 2 |
| p.R4127H | COAD | 2 |
| p.R3551C | STAD | 2 |
| p.E3932K | BLCA | 2 |
| p.R1953* | SKCM | 2 |
| p.P3923L | SKCM | 2 |
| p.S1108F | SKCM | 2 |
| p.A4611V | UCEC | 2 |
| p.R3192W | STAD | 2 |
| p.M4039I | LUAD | 2 |
| p.E4372K | SKCM | 2 |
| p.E2785K | SKCM | 2 |
| p.R1292W | UCEC | 2 |
| p.R2699Q | SKCM | 2 |
| p.G4107E | SKCM | 2 |
| p.R2614I | UCEC | 2 |
| p.R2182H | STAD | 2 |
| p.A516V | LUSC | 2 |
| p.R2095Q | SKCM | 2 |
| p.E3996K | SKCM | 2 |
| p.P3925S | SKCM | 2 |
| p.C1404Y | UCEC | 1 |
| p.R2148W | UCEC | 1 |
| p.E393K | READ | 1 |
| p.P4054S | SKCM | 1 |
| p.G3058V | LUAD | 1 |
| p.C1230R | STAD | 1 |
| p.G136A | LUAD | 1 |
| p.D1786H | BRCA | 1 |
| p.M1004I | CHOL | 1 |
| p.E2814D | UCEC | 1 |
| p.R4117H | READ | 1 |
| p.S3357T | STAD | 1 |
| p.S465F | CESC | 1 |
| p.S1070L | UCEC | 1 |
| p.H3919Q | CESC | 1 |
| p.R4063Q | SKCM | 1 |
| p.G193E | HNSC | 1 |
| p.E1981Q | ESCA | 1 |
| p.G4026R | SKCM | 1 |
| p.Y572S | SKCM | 1 |
| p.F4225L | LIHC | 1 |
| p.V584L | HNSC | 1 |
| p.T4308M | DLBC | 1 |
| p.P3186T | LUSC | 1 |
| p.N3887K | BRCA | 1 |
| p.R2095Q | SARC | 1 |
| p.R570H | GBM | 1 |
| p.C4389X | COAD | 1 |
| p.V3050I | STAD | 1 |
| p.G1891E | LGG | 1 |
| p.S2018Y | THYM | 1 |
| p.S1138C | LUAD | 1 |
| p.P3856S | SKCM | 1 |
| p.G3504V | UCEC | 1 |
| p.T4182I | LUSC | 1 |
| p.K3008N | LUAD | 1 |
| p.G2539E | SKCM | 1 |
| p.P980S | SKCM | 1 |
| p.L2580P | KICH | 1 |
| p.N826K | STAD | 1 |
| p.A2123V | COAD | 1 |
| p.D1653Y | READ | 1 |
| p.C1713X | ACC | 1 |
| p.N1144S | SKCM | 1 |
| p.R951Q | UCEC | 1 |
| p.R34L | LUAD | 1 |
| p.T2284I | SKCM | 1 |
| p.H1362Y | SKCM | 1 |
| p.R3895C | UCEC | 1 |
| p.E4472K | SKCM | 1 |
| p.R2148W | HNSC | 1 |
| p.L3326H | STAD | 1 |
| p.D2765G | HNSC | 1 |
| p.P1368S | SKCM | 1 |
| p.R702H | STAD | 1 |
| p.E323Q | BLCA | 1 |
| p.E3395G | OV | 1 |
| p.G2362E | READ | 1 |
| p.L2398F | ESCA | 1 |
| p.R3791W | ESCA | 1 |
| p.E1944* | LUSC | 1 |
| p.P3608L | SKCM | 1 |
| p.D2256N | HNSC | 1 |
| p.D4548V | STAD | 1 |
| p.N682I | OV | 1 |
| p.R2175W | COAD | 1 |
| p.P916L | GBM | 1 |
| p.S3514I | COAD | 1 |
| p.F1225L | BLCA | 1 |
| p.Q1718* | STAD | 1 |
| p.P4380L | SKCM | 1 |
| p.M4384I | UCEC | 1 |
| p.P4208H | SARC | 1 |
| p.T1204I | HNSC | 1 |
| p.E1020K | SKCM | 1 |
| p.R1206H | UCEC | 1 |
| p.N471T | STAD | 1 |
| p.E3089K | BRCA | 1 |
| p.K4550R | KIRC | 1 |
| p.T3969A | LIHC | 1 |
| p.H32R | KIRC | 1 |
| p.Q4540H | BRCA | 1 |
| p.G1799C | KIRC | 1 |
| p.S2498F | UCS | 1 |
| p.D575H | CESC | 1 |
| p.I1597S | SKCM | 1 |
| p.E1024K | HNSC | 1 |
| p.R2272C | SKCM | 1 |
| p.R4243Q | BRCA | 1 |
| p.E2733K | SKCM | 1 |
| p.W166* | SKCM | 1 |
| p.Q162E | BLCA | 1 |
| p.R3206H | ESCA | 1 |
| p.E4564Q | HNSC | 1 |
| p.F2372S | SKCM | 1 |
| p.R4220L | LUAD | 1 |
| p.D3105N | UCEC | 1 |
| p.R2126T | BLCA | 1 |
| p.I4371V | LUAD | 1 |
| p.P4059L | LUSC | 1 |
| p.T1649P | UCEC | 1 |
| p.I4375S | KIRP | 1 |
| p.A2151S | SARC | 1 |
| p.R4065P | BLCA | 1 |
| p.R1663S | HNSC | 1 |
| p.T2420A | LIHC | 1 |
| p.S3664L | UCEC | 1 |
| p.E4522Q | HNSC | 1 |
| p.R1841I | UCS | 1 |
| p.D3052Y | LUSC | 1 |
| p.D1255Y | LUAD | 1 |
| p.E4545K | SKCM | 1 |
| p.R3726H | UCEC | 1 |
| p.D1879E | SKCM | 1 |
| p.V1048L | LUSC | 1 |
| p.G4292E | SKCM | 1 |
| p.A57V | COAD | 1 |
| p.S106R | KIRC | 1 |
| p.S4503L | BRCA | 1 |
| p.N3894K | OV | 1 |
| p.C3678R | LUSC | 1 |
| p.G3486E | SKCM | 1 |
| p.N1340D | STAD | 1 |
| p.D4160H | BLCA | 1 |
| p.M1563I | SKCM | 1 |
| p.R2796H | UCS | 1 |
| p.G3225E | BRCA | 1 |
| p.F2541V | ESCA | 1 |
| p.E2886V | PRAD | 1 |
| p.H264Y | LIHC | 1 |
| p.D1744N | UCEC | 1 |
| p.G327A | LUAD | 1 |
| p.D2850H | BLCA | 1 |
| p.G1137E | LUAD | 1 |
| p.Y4175S | BRCA | 1 |
| p.Q2986* | SKCM | 1 |
| p.S2423F | SKCM | 1 |
| p.R198C | HNSC | 1 |
| p.R2838S | THYM | 1 |
| p.G1334D | STAD | 1 |
| p.L1063H | LGG | 1 |
| p.D246E | UCEC | 1 |
| p.D3911Y | UCEC | 1 |
| p.G4229C | GBM | 1 |
| p.M2422L | LUSC | 1 |
| p.N3644D | LGG | 1 |
| p.T3929S | LUAD | 1 |
| p.K537E | LUAD | 1 |
| p.V1957L | HNSC | 1 |
| p.I2799N | LUAD | 1 |
| p.P4620S | SKCM | 1 |
| p.R4065* | SKCM | 1 |
| p.K4534T | UCEC | 1 |
| p.I2640T | DLBC | 1 |
| p.C62F | LUSC | 1 |
| p.Y3332* | LUSC | 1 |
| p.P1561L | LGG | 1 |
| p.R3551H | LGG | 1 |
| p.V1655L | LUSC | 1 |
| p.G251V | UCEC | 1 |
| p.H1362N | ESCA | 1 |
| p.P1339T | LGG | 1 |
| p.L2363F | LUAD | 1 |
| p.E3544K | SKCM | 1 |
| p.P293T | UCEC | 1 |
| p.E3024K | BLCA | 1 |
| p.Q976* | SKCM | 1 |
| p.P4614S | LUAD | 1 |
| p.R3043C | COAD | 1 |
| p.D3059E | ESCA | 1 |
| p.S2023R | SARC | 1 |
| p.S4618L | SKCM | 1 |
| p.A3344T | PAAD | 1 |
| p.G4574E | SKCM | 1 |
| p.L1044F | SKCM | 1 |
| p.G2238S | LIHC | 1 |
| p.S4627L | ESCA | 1 |
| p.W2206C | HNSC | 1 |
| p.K1911E | STAD | 1 |
| p.W2923C | HNSC | 1 |
| p.M2552I | STAD | 1 |
| p.C2033Y | COAD | 1 |
| p.Q75H | BLCA | 1 |
| p.E2922K | HNSC | 1 |
| p.P723L | SKCM | 1 |
| p.H3400R | STAD | 1 |
| p.M1588K | LUAD | 1 |
| p.Y638S | STAD | 1 |
| p.A837V | PAAD | 1 |
| p.R819C | LGG | 1 |
| p.L1557P | SARC | 1 |
| p.E2562D | HNSC | 1 |
| p.S3274N | STAD | 1 |
| p.R4585Q | GBM | 1 |
| p.R1160* | STAD | 1 |
| p.A1265V | SKCM | 1 |
| p.R3043H | ESCA | 1 |
| p.E3669K | SKCM | 1 |
| p.E194G | SKCM | 1 |
| p.D3580H | LUAD | 1 |
| p.Y3858H | PRAD | 1 |
| p.E2266* | STAD | 1 |
| p.E4255Q | COAD | 1 |
| p.G1061C | LUAD | 1 |
| p.L4171P | ESCA | 1 |
| p.E1764D | UCEC | 1 |
| p.C2835S | STAD | 1 |
| p.P1081S | SKCM | 1 |
| p.R2432K | SKCM | 1 |
| p.S2395P | OV | 1 |
| p.G1370E | SKCM | 1 |
| p.R1089H | LGG | 1 |
| p.L4196I | LUAD | 1 |
| p.R3498H | STAD | 1 |
| p.G1252E | SKCM | 1 |
| p.D2425G | UCEC | 1 |
| p.G2362E | SKCM | 1 |
| p.C103S | SKCM | 1 |
| p.S1314C | LUAD | 1 |
| p.R3498H | UCEC | 1 |
| p.V1701M | COAD | 1 |
| p.G2769A | LIHC | 1 |
| p.C3784R | BRCA | 1 |
| p.C4334Y | THYM | 1 |
| p.R932S | STAD | 1 |
| p.S576Y | UCEC | 1 |
| p.F3133L | UCS | 1 |
| p.A4086D | LUAD | 1 |
| p.C3538S | LUAD | 1 |
| p.S2452Y | UCEC | 1 |
| p.P3942S | UCEC | 1 |
| p.S2447F | SKCM | 1 |
| p.H678R | HNSC | 1 |
| p.V4141L | HNSC | 1 |
| p.H1217Y | SKCM | 1 |
| p.R3641Q | STAD | 1 |
| p.P4054L | SKCM | 1 |
| p.R3086H | UCEC | 1 |
| p.G745R | BRCA | 1 |
| p.G561V | LUAD | 1 |
| p.E1978D | LUSC | 1 |
| p.P1376S | SKCM | 1 |
| p.A3675T | KIRP | 1 |
| p.A1903T | LIHC | 1 |
| p.R3138L | STAD | 1 |
| p.C1086R | STAD | 1 |
| p.R3014W | PAAD | 1 |
| p.P3160S | UCEC | 1 |
| p.E2984D | BLCA | 1 |
| p.C4032R | LUAD | 1 |
| p.V2839I | BLCA | 1 |
| p.I1777M | CESC | 1 |
| p.D3792N | BLCA | 1 |
| p.S962* | HNSC | 1 |
| p.T1976N | LUSC | 1 |
| p.I2834V | LUSC | 1 |
| p.R1643W | GBM | 1 |
| p.E1463K | UCEC | 1 |
| p.C1067F | ESCA | 1 |
| p.D3105N | SKCM | 1 |
| p.A1287T | COAD | 1 |
| p.K1124N | UCEC | 1 |
| p.V2506I | SARC | 1 |
| p.S4070* | CESC | 1 |
| p.A3327D | LUAD | 1 |
| p.E176K | SKCM | 1 |
| p.E3848X | ESCA | 1 |
| p.Y4526* | KIRC | 1 |
| p.N2055I | COAD | 1 |
| p.V2506I | COAD | 1 |
| p.V240D | SARC | 1 |
| p.L2297S | THYM | 1 |
| p.R2074K | SKCM | 1 |
| p.F3517L | READ | 1 |
| p.L3221F | LUAD | 1 |
| p.A4646T | LUSC | 1 |
| p.R2125H | HNSC | 1 |
| p.G4404C | ESCA | 1 |
| p.M2026I | SKCM | 1 |
| p.E3996K | UCEC | 1 |
| p.R1521H | LGG | 1 |
| p.A541T | COAD | 1 |
| p.R570C | STAD | 1 |
| p.L1868I | READ | 1 |
| p.R3343C | UCEC | 1 |
| p.I3454T | BLCA | 1 |
| p.Q4085* | SKCM | 1 |
| p.Y4552C | UCEC | 1 |
| p.P3323L | HNSC | 1 |
| p.I808N | SKCM | 1 |
| p.R34H | COAD | 1 |
| p.C3883Y | LUSC | 1 |
| p.R4165C | GBM | 1 |
| p.A1967E | OV | 1 |
| p.R3498H | COAD | 1 |
| p.I1641_splice | LUSC | 1 |
| p.N508D | SKCM | 1 |
| p.R4127H | SARC | 1 |
| p.S3274N | SARC | 1 |
| p.Y2763C | BLCA | 1 |
| p.R3775Q | SKCM | 1 |
| p.R1663C | SKCM | 1 |
| p.Q237* | BLCA | 1 |
| p.T1188I | UCEC | 1 |
| p.C3057W | LUAD | 1 |
| p.K2214N | CESC | 1 |
| p.R2875H | ESCA | 1 |
| p.E4076A | KIRC | 1 |
| p.E4306K | LUSC | 1 |
| p.L3209F | CESC | 1 |
| p.R3757L | LUAD | 1 |
| p.G1556R | SKCM | 1 |
| p.S2042C | OV | 1 |
| p.K2718R | LIHC | 1 |
| p.E187Q | BLCA | 1 |
| p.A1705T | UCEC | 1 |
| p.C3732Y | STAD | 1 |
| p.S2742* | LUSC | 1 |
| p.R2095* | STAD | 1 |
| p.S737L | READ | 1 |
| p.V4168M | LUAD | 1 |
| p.E1919K | SKCM | 1 |
| p.D1298N | SKCM | 1 |
| p.G1629E | SKCM | 1 |
| p.D1807N | UCEC | 1 |
| p.S4040N | STAD | 1 |
| p.E2995K | SKCM | 1 |
| p.S1352N | UCEC | 1 |
| p.K796N | UCEC | 1 |
| p.E776* | UCEC | 1 |
| p.N2590I | BLCA | 1 |
| p.T1103N | LUAD | 1 |
| p.N2024K | LGG | 1 |
| p.D1392H | HNSC | 1 |
| p.I4210L | COAD | 1 |
| p.R2574K | BLCA | 1 |
| p.I3251N | SKCM | 1 |
| p.R2796C | UCS | 1 |
| p.L504F | SKCM | 1 |
| p.R1089C | STAD | 1 |
| p.R4127H | HNSC | 1 |
| p.L3588F | SKCM | 1 |
| p.E776D | COAD | 1 |
| p.E1234K | BRCA | 1 |
| p.C1213G | LIHC | 1 |
| p.H2011D | BLCA | 1 |
| p.R4319X | UCS | 1 |
| p.S962L | SKCM | 1 |
| p.R3641W | READ | 1 |
| p.E4226K | COAD | 1 |
| p.D2975N | SKCM | 1 |
| p.E4293Q | LIHC | 1 |
| p.A2595S | CESC | 1 |
| p.R2212I | BRCA | 1 |
| p.D3907V | THCA | 1 |
| p.E3716V | SARC | 1 |
| p.C3137S | LUAD | 1 |
| p.D681Y | HNSC | 1 |
| p.E3598K | SKCM | 1 |
| p.L1737F | BLCA | 1 |
| p.A3830D | UCEC | 1 |
| p.R278Q | UCEC | 1 |
| p.I3464T | STAD | 1 |
| p.R702C | COAD | 1 |
| p.R3086C | STAD | 1 |
| p.E2656* | KIRC | 1 |
| p.Q383H | HNSC | 1 |
| p.R4065* | BLCA | 1 |
| p.S4053Y | COAD | 1 |
| p.A3826V | STAD | 1 |
| p.P2837S | SKCM | 1 |
| p.R2542C | SKCM | 1 |
| p.P2896L | UCEC | 1 |
| p.E176D | LUAD | 1 |
| p.C3642Y | UCEC | 1 |
| p.M733I | LUAD | 1 |
| p.N339I | KIRC | 1 |
| p.R368H | UCEC | 1 |
| p.R1479C | ESCA | 1 |
| p.Q4336H | HNSC | 1 |
| p.C103F | SKCM | 1 |
| p.S830L | COAD | 1 |
| p.Q320K | LUAD | 1 |
| p.N1132S | KIRC | 1 |
| p.P1306A | SKCM | 1 |
| p.S2492F | CESC | 1 |
| p.G2927D | SKCM | 1 |
| p.I3202M | COAD | 1 |
| p.P992S | CESC | 1 |
| p.F3847L | PAAD | 1 |
| p.C3671F | LUAD | 1 |
| p.A779T | ESCA | 1 |
| p.S1548G | LGG | 1 |
| p.W1288X | SKCM | 1 |
| p.G514E | SKCM | 1 |
| p.R2752* | STAD | 1 |
| p.V2183A | CESC | 1 |
| p.R2479I | UCEC | 1 |
| p.P2002S | SKCM | 1 |
| p.G2466V | LUAD | 1 |
| p.I1446M | UCS | 1 |
| p.E3492G | SKCM | 1 |
| p.M1622I | SKCM | 1 |
| p.R1589H | COAD | 1 |
| p.R1085C | COAD | 1 |
| p.S1695L | LUSC | 1 |
| p.S546N | THYM | 1 |
| p.T728N | LGG | 1 |
| p.D1163N | SKCM | 1 |
| p.G597R | SKCM | 1 |
| p.C2842R | HNSC | 1 |
| p.S3673R | LUSC | 1 |
| p.E3544Q | LUAD | 1 |
| p.G3353R | SKCM | 1 |
| p.R2202G | LUAD | 1 |
| p.W476* | UCEC | 1 |
| p.A3344T | DLBC | 1 |
| p.R1610G | LUSC | 1 |
| p.G3713S | SKCM | 1 |
| p.D2242N | SKCM | 1 |
| p.E3063D | UCEC | 1 |
| p.A1647V | SKCM | 1 |
| p.R829W | ESCA | 1 |
| p.G3302R | SKCM | 1 |
| p.L3547F | SKCM | 1 |
| p.R3043H | OV | 1 |
| p.Y3841C | UCS | 1 |
| p.Y3334* | LGG | 1 |
| p.R1500G | LUSC | 1 |
| p.R4106Q | STAD | 1 |
| p.R2500H | SKCM | 1 |
| p.L2004M | BLCA | 1 |
| p.E1534* | BLCA | 1 |
| p.D2622G | STAD | 1 |
| p.S4627L | SKCM | 1 |
| p.S1707F | SKCM | 1 |
| p.L4284S | SKCM | 1 |
| p.G2351C | HNSC | 1 |
| p.G874D | UCEC | 1 |
| p.R3736C | SKCM | 1 |
| p.M2493I | BLCA | 1 |
| p.C3114Y | UCEC | 1 |
| p.A3344T | UCEC | 1 |
| p.A3412D | OV | 1 |
| p.S1414T | ESCA | 1 |
| p.D2973G | LIHC | 1 |
| p.C1601S | LUAD | 1 |
| p.E3252Q | HNSC | 1 |
| p.P333L | SKCM | 1 |
| p.R2752Q | HNSC | 1 |
| p.P4018L | SKCM | 1 |
| p.P2878L | SKCM | 1 |
| p.N463S | KIRC | 1 |
| p.C2906Y | THYM | 1 |
| p.K480X | KIRP | 1 |
| p.R951Q | COAD | 1 |
| p.E1014K | LIHC | 1 |
| p.P3882S | CESC | 1 |
| p.Q4085X | SKCM | 1 |
| p.K3147R | LUSC | 1 |
| p.P3451Q | STAD | 1 |
| p.T2188A | SKCM | 1 |
| p.G3060R | LUSC | 1 |
| p.R402L | BLCA | 1 |
| p.G738R | BLCA | 1 |
| p.E2984K | LUAD | 1 |
| p.Y2763C | LIHC | 1 |
| p.Y3174F | LUAD | 1 |
| p.Y3421N | SKCM | 1 |
| p.R3184P | HNSC | 1 |
| p.G3563S | LIHC | 1 |
| p.A2393V | SKCM | 1 |
| p.R3736C | HNSC | 1 |
| p.D1218N | SKCM | 1 |
| p.R501W | STAD | 1 |
| p.E2656X | KIRC | 1 |
| p.G4026E | SKCM | 1 |
| p.R2542C | UCEC | 1 |
| p.N2641D | BRCA | 1 |
| p.Q3804K | READ | 1 |
| p.T1877S | SKCM | 1 |
| p.P1339T | LUAD | 1 |
| p.L2297F | BLCA | 1 |
| p.L960S | UCEC | 1 |
| p.Y482C | LIHC | 1 |
| p.G2232C | HNSC | 1 |
| p.S2218Y | UCEC | 1 |
| p.K480* | KIRP | 1 |
| p.G774E | SKCM | 1 |
| p.L2572_splice | LUSC | 1 |
| p.E4211K | KIRP | 1 |
| p.Y2520C | UCEC | 1 |
| p.S3664* | LUSC | 1 |
| p.G4490A | CESC | 1 |
| p.L2228F | STAD | 1 |
| p.G2623R | BRCA | 1 |
| p.R3888C | UCEC | 1 |
| p.Q3034H | BLCA | 1 |
| p.R402Q | UCEC | 1 |
| p.R2875C | UCEC | 1 |
| p.R577W | COAD | 1 |
| p.S2400R | SARC | 1 |
| p.A3382V | STAD | 1 |
| p.G4015E | SKCM | 1 |
| p.R883Q | STAD | 1 |
| p.W1084L | LUAD | 1 |
| p.S3709N | UCEC | 1 |
| p.W1964C | LUAD | 1 |
| p.V595D | THYM | 1 |
| p.E2814K | SKCM | 1 |
| p.H3069L | LIHC | 1 |
| p.L2174M | UCEC | 1 |
| p.A4646T | ESCA | 1 |
| p.P519R | SKCM | 1 |
| p.V4436I | UCS | 1 |
| p.P3773S | SKCM | 1 |
| p.D3724N | SKCM | 1 |
| p.G4146E | SKCM | 1 |
| p.R2617L | BRCA | 1 |
| p.T1224I | STAD | 1 |
| p.D246N | SKCM | 1 |
| p.S97L | STAD | 1 |
| p.R4046Q | UVM | 1 |
| p.N4023H | UCEC | 1 |
| p.G3905D | SKCM | 1 |
| p.S1138F | DLBC | 1 |
| p.D4263H | HNSC | 1 |
| p.G3661A | LUAD | 1 |
| p.C3519G | OV | 1 |
| p.E3751D | UCEC | 1 |
| p.R3210K | UCEC | 1 |
| p.R819C | GBM | 1 |
| p.F2435L | CHOL | 1 |
| p.T2284A | DLBC | 1 |
| p.Q162E | LUAD | 1 |
| p.G1875S | SKCM | 1 |
| p.D4150Y | BLCA | 1 |
| p.G4217R | SKCM | 1 |
| p.D3116E | HNSC | 1 |
| p.W2970C | LUAD | 1 |
| p.R3554Q | UCEC | 1 |
| p.Q2413K | LUAD | 1 |
| p.E895* | LUAD | 1 |
| p.D1301N | BLCA | 1 |
| p.G49E | UCEC | 1 |
| p.V717L | LUSC | 1 |
| p.R1501T | LUAD | 1 |
| p.L4130P | GBM | 1 |
| p.R2013H | COAD | 1 |
| p.D1049N | MESO | 1 |
| p.R4065Q | SKCM | 1 |
| p.A3574D | SKCM | 1 |
| p.R1643Q | UCEC | 1 |
| p.L4454P | THCA | 1 |
| p.S3357F | BLCA | 1 |
| p.E4251D | UCEC | 1 |
| p.E4472G | SKCM | 1 |
| p.S2549N | PRAD | 1 |
| p.V4435I | BLCA | 1 |
| p.R679I | COAD | 1 |
| p.A2044T | CESC | 1 |
| p.D1053V | KIRC | 1 |
| p.A3520T | COAD | 1 |
| p.W1288* | SKCM | 1 |
| p.E3584K | HNSC | 1 |
| p.E582Q | LUAD | 1 |
| p.C2806R | KIRP | 1 |
| p.R2095* | GBM | 1 |
| p.H3455R | UCEC | 1 |
| p.C1143F | LIHC | 1 |
| p.R1633I | UCEC | 1 |
| p.E3967* | UCEC | 1 |
| p.E194K | READ | 1 |
| p.R3890W | LGG | 1 |
| p.W2970L | KIRC | 1 |
| p.Q421H | UCEC | 1 |
| p.R4585Q | UCEC | 1 |
| p.R3736C | READ | 1 |
| p.L2185F | SKCM | 1 |
| p.I515L | KIRC | 1 |
| p.R4127C | GBM | 1 |
| p.R3765Q | SKCM | 1 |
| p.G4301E | SKCM | 1 |
| p.S84C | BLCA | 1 |
| p.R3192Q | LUSC | 1 |
| p.R2875C | ESCA | 1 |
| p.P4187T | LUAD | 1 |
| p.D2515Y | LUAD | 1 |
| p.Y2601H | OV | 1 |
| p.R577Q | SARC | 1 |
| p.T1859I | LUAD | 1 |
| p.R2617Q | LGG | 1 |
| p.R2272C | LUSC | 1 |
| p.R4319* | UCS | 1 |
| p.T1544A | LGG | 1 |
| p.N2407S | BRCA | 1 |
| p.G259R | COAD | 1 |
| p.D3377N | SKCM | 1 |
| p.E2937K | GBM | 1 |
| p.N3937D | LUSC | 1 |
| p.E3996K | BLCA | 1 |
| p.K2299N | COAD | 1 |
| p.E2231K | HNSC | 1 |
| p.S123C | CESC | 1 |
| p.G510A | LUAD | 1 |
| p.L2134V | CESC | 1 |
| p.L1619F | GBM | 1 |
| p.T554A | COAD | 1 |
| p.S1145X | ESCA | 1 |
| p.K1445T | LGG | 1 |
| p.V2248I | BRCA | 1 |
| p.W3956C | BLCA | 1 |
| p.R2419I | UCEC | 1 |
| p.Q912L | LUAD | 1 |
| p.R490C | STAD | 1 |
| p.E2716Q | UCEC | 1 |
| p.G2728V | STAD | 1 |
| p.H596Y | CESC | 1 |
| p.H1851Q | SKCM | 1 |
| p.R2262H | HNSC | 1 |
| p.A541E | BRCA | 1 |
| p.S97T | LUSC | 1 |
| p.E1344Q | BLCA | 1 |
| p.R2964K | SKCM | 1 |
| p.R1412Q | TGCT | 1 |
| p.D2609E | DLBC | 1 |
| p.H3385Y | READ | 1 |
| p.C1713* | ACC | 1 |
| p.G1758R | STAD | 1 |
| p.S3813G | GBM | 1 |
| p.C2848Y | HNSC | 1 |
| p.R2796H | STAD | 1 |
| p.L2360V | BLCA | 1 |
| p.W166X | SKCM | 1 |
| p.H1076N | LUAD | 1 |
| p.E4207K | SKCM | 1 |
| p.C208Y | UCEC | 1 |
| p.R2095X | COAD | 1 |
| p.H1920Q | ESCA | 1 |
| p.F1192L | HNSC | 1 |
| p.I4337V | SARC | 1 |
| p.E582K | SKCM | 1 |
| p.L1913I | READ | 1 |
| p.A4443V | LUAD | 1 |
| p.A3382E | COAD | 1 |
| p.R2056W | SKCM | 1 |
| p.D2190H | BLCA | 1 |
| p.C1101F | LUAD | 1 |
| p.G1209S | HNSC | 1 |
| p.G2210R | LUAD | 1 |
| p.R4243* | MESO | 1 |
| p.S1190Y | UCEC | 1 |
| p.R1037I | LUAD | 1 |
| p.F3558L | STAD | 1 |
| p.T1938S | BLCA | 1 |
| p.D135G | KIRC | 1 |
| p.D1572Y | LUAD | 1 |
| p.G4051C | STAD | 1 |
| p.D2950N | SKCM | 1 |
| p.F4000I | SKCM | 1 |
| p.R2759L | LIHC | 1 |
| p.D1474N | SKCM | 1 |
| p.G2639E | SKCM | 1 |
| p.K73T | LGG | 1 |
| p.E2079K | SKCM | 1 |
| p.Q1959K | ESCA | 1 |
| p.A2872T | COAD | 1 |
| p.R2875S | UCEC | 1 |
| p.R2752X | STAD | 1 |
| p.N2659K | HNSC | 1 |
| p.G3325E | UCEC | 1 |
| p.S1070L | STAD | 1 |
| p.I1831F | COAD | 1 |
| p.Q1718X | STAD | 1 |
| p.L4056F | BRCA | 1 |
| p.G3819V | LGG | 1 |
| p.R1311L | COAD | 1 |
| p.C3771R | KIRC | 1 |
| p.P3527L | SKCM | 1 |
| p.V4535M | SKCM | 1 |
| p.S737L | DLBC | 1 |
| p.R2505C | PRAD | 1 |
| p.E3976K | UCEC | 1 |
| p.F2435Y | LUSC | 1 |
| p.R2838H | PCPG | 1 |
| p.E3976Q | LUAD | 1 |
| p.S4403G | LUAD | 1 |
| p.D1056N | UCEC | 1 |
| p.R4127H | LUSC | 1 |
| p.R4319* | SKCM | 1 |
| p.Y1836C | BRCA | 1 |
| p.I1749T | KIRP | 1 |
| p.D3023N | UCEC | 1 |
| p.D3880H | LUSC | 1 |
| p.R1311H | STAD | 1 |
| p.R344C | GBM | 1 |
| p.D4088N | SKCM | 1 |
| p.R3290C | LGG | 1 |
| p.R490H | UCS | 1 |
| p.L798I | READ | 1 |
| p.P122S | SKCM | 1 |
| p.H369Y | SKCM | 1 |
| p.I2258L | UCS | 1 |
| p.A3602T | BRCA | 1 |
| p.D3710N | SKCM | 1 |
| p.R1581Q | PAAD | 1 |
| p.P2361L | LUAD | 1 |
| p.P3734L | SKCM | 1 |
| p.R2505H | LGG | 1 |
| p.R365Q | SKCM | 1 |
| p.R4319X | COAD | 1 |
| p.V484L | BRCA | 1 |
| p.D1301N | CESC | 1 |
| p.F2541V | SKCM | 1 |
| p.Y336S | COAD | 1 |
| p.C152Y | COAD | 1 |
| p.E3848* | ESCA | 1 |
| p.W355L | PRAD | 1 |
| p.G3042E | SKCM | 1 |
| p.A2440T | SKCM | 1 |
| p.F3133S | BLCA | 1 |
| p.G606A | LUAD | 1 |
| p.F4074L | STAD | 1 |
| p.G2602D | CESC | 1 |
| p.H3078D | CESC | 1 |
| p.S1165W | BRCA | 1 |
| p.E2533D | LUSC | 1 |
| p.R3498C | STAD | 1 |
| p.L1913I | UCEC | 1 |
| p.G3042R | GBM | 1 |
| p.S856N | UCEC | 1 |
| p.P4420L | SKCM | 1 |
| p.S4559F | LUAD | 1 |
| p.D2983N | ESCA | 1 |
| p.E4604G | KIRC | 1 |
| p.R3551H | COAD | 1 |
| p.G1061D | STAD | 1 |
| p.Q4323* | SKCM | 1 |
| p.E3761K | LUAD | 1 |
| p.S174L | LUSC | 1 |
| p.D1987A | BRCA | 1 |
| p.A4413V | READ | 1 |
| p.S1961F | LUAD | 1 |
| p.R847H | UCEC | 1 |
| p.E2731V | THYM | 1 |
| p.L861P | SKCM | 1 |
| p.N339K | LUAD | 1 |
| p.Y2160C | LUAD | 1 |
| p.K2214N | LUAD | 1 |
| p.E4290K | SKCM | 1 |
| p.R2577C | GBM | 1 |
| p.G2210W | LUAD | 1 |
| p.E784K | SKCM | 1 |
| p.N159S | SKCM | 1 |
| p.G1465C | LUAD | 1 |
| p.D3146A | SKCM | 1 |
| p.N4327S | LUAD | 1 |
| p.P3568S | SKCM | 1 |
| p.R3184* | BLCA | 1 |
| p.V477F | SKCM | 1 |
| p.G3910V | UCEC | 1 |
| p.D2256E | LUAD | 1 |
| p.R2990S | BLCA | 1 |
| p.V263I | OV | 1 |
| p.R4063* | UCEC | 1 |
| p.D403N | LUSC | 1 |
| Top |
| TissGeneCNV for LRP2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for LRP2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CV324821 | LRP2-PAPPA | chr2:169983795 | chr9:118988097 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ369809 | PAPPA-LRP2 | chr9:118988381 | chr2:169983691 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-64-5779-01A | POFUT2-LRP2 | Out-of-frame | Chr21:46707656 | Chr2:170151220 |
| Top |
| TissGeneNet for LRP2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LRP2, CTNNB1, DLG2, DLG4, ITGB1BP1, ALB, NOS1AP, CBX5, MAPK8IP2, ANKRA2, TLN1, ANKS1B, LCN2, RBP1, APBA2, MDK, DLG3, LPL, LRP2BP, LDLRAP1, CUBN (tumor) | LRP2, MAGI1, GIPC1, APOE, DLG4, ITGB1BP1, PLAU, NOS1AP, MAPK8IP1, MAPK8IP2, GPRASP1, DAB1, ANKRA2, APBB1, ANKS1B, LCN2, APBA2, CLU, LRP2BP, SYNJ2BP, SCN3A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| LRP2, MAGI1, CTNNB1, DLG2, DLG4, ITGB1BP1, PLAU, THBS1, ALB, SLC9A3, ABL1, GC, SNX17, LPA, APBB1, ANKS1B, APBA2, DLG3, LPL, ANAPC10, TG (tumor) | LRP2, APOE, DLG2, DLG4, SERPINE1, THBS1, APOB, MAPK8IP1, MAPK8IP2, GPRASP1, APBB1, TLN1, INS, ANKS1B, RBP1, DLG3, LPL, CLU, CUBN, SCGB1A1, SCN3A (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| LRP2, MAGI1, ITGB1BP1, SERPINE1, NOS1AP, LRPAP1, CBX5, MAPK8IP1, MAPK8IP2, TTR, GPRASP1, LPA, DAB1, ANKRA2, ANKS1B, PIP5K1C, DLG3, LRP2BP, LDLRAP1, TG, SCGB1A1 (tumor) | LRP2, ATN1, GIPC1, SERPINE1, PLAU, NOS1AP, MAPK8IP1, GPRASP1, LPA, DAB1, APBB1, ANKS1B, APBA2, MDK, DLG3, LPL, CLU, LRP2BP, LDLRAP1, CUBN, TG (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| LRP2, GIPC1, APOE, DLG2, DLG4, ITGB1BP1, PLAU, ALB, SLC9A3, DAB2, APOB, MAPK8IP2, LPA, APBB1, DLG3, CLU, LRP2BP, LDLRAP1, APOH, CUBN, TG (tumor) | LRP2, APOE, DLG2, DLG4, ITGB1BP1, SLC9A3, ABL1, DAB2, GC, NOS1AP, APOB, SNX17, GPRASP1, LPA, RBP1, LPL, CLU, APOH, TG, SYNJ2BP, SCN3A (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| LRP2, GIPC1, APOE, DLG2, DLG4, ITGB1BP1, PLAU, ALB, ABL1, DAB2, GC, CBX5, MAPK8IP2, LPA, ANKS1B, DLG3, CLU, LDLRAP1, APOH, CUBN, TG (tumor) | LRP2, ATN1, GIPC1, ITGB1BP1, THBS1, SLC9A3, DAB2, GC, NOS1AP, APOB, MAPK8IP1, TTR, ANKS1B, LCN2, RBP1, MDK, LPL, CLU, LDLRAP1, CUBN, SCN3A (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| LRP2, GIPC1, APOE, CTNNB1, DLG2, DLG4, ITGB1BP1, PLAU, ALB, DAB2, GC, APOB, LPA, ANKS1B, DLG3, LRP2BP, LDLRAP1, APOH, CUBN, TG, SCN3A (tumor) | LRP2, ATN1, GIPC1, APOE, DLG4, SLC9A3, DAB2, NOS1AP, APOB, CBX5, MAPK8IP1, SNX17, DLG1, APBB1, RBP1, PIP5K1C, LDLRAP1, APOH, CUBN, SYNJ2BP, SCN3A (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| LRP2, MAGI1, GIPC1, APOE, SERPINE1, ABL1, NOS1AP, LRPAP1, APOB, CBX5, MAPK8IP2, LPA, DLG1, RBP1, APBA2, MDK, DLG3, LPL, LRP2BP, APOH, SYNJ2BP (tumor) | LRP2, CTNNB1, ITGB1BP1, PLAU, THBS1, DAB2, CBX5, MAPK8IP1, TTR, GPRASP1, LPA, ANKRA2, LCN2, RBP1, PIP5K1C, APBA2, MDK, LRP2BP, LDLRAP1, TG, SCN3A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| LRP2, MAGI1, ATN1, GIPC1, ITGB1BP1, ABL1, GC, NOS1AP, CBX5, SNX17, ANKRA2, TLN1, RBP1, MDK, DLG3, CLU, LRP2BP, LDLRAP1, APOH, ANAPC10, SCGB1A1 (tumor) | LRP2, MAGI1, GIPC1, ITGB1BP1, SERPINE1, PLAU, NOS1AP, CBX5, GPRASP1, APBB1, TLN1, ANKS1B, RBP1, DLG3, LPL, CLU, LRP2BP, APOH, SYNJ2BP, SCGB1A1, SCN3A (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| LRP2, DLG4, ITGB1BP1, SERPINE1, SLC9A3, DAB2, GC, NOS1AP, CBX5, MAPK8IP2, GPRASP1, APBB1, RBP1, PIP5K1C, APBA2, MDK, DLG3, CUBN, ANAPC10, TG, SCGB1A1 (tumor) | LRP2, MAGI1, GIPC1, APOE, DLG2, ITGB1BP1, PLAU, THBS1, SLC9A3, DAB2, LRPAP1, APOB, APBB1, TLN1, ANKS1B, LPL, CLU, LRP2BP, APOH, SCGB1A1, SCN3A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| LRP2, MAGI1, ATN1, DLG2, ITGB1BP1, PLAU, SLC9A3, GC, NOS1AP, MAPK8IP1, SNX17, TTR, GPRASP1, LPA, APBA2, MDK, LPL, LRP2BP, CUBN, TG, SYNJ2BP (tumor) | LRP2, MAGI1, CTNNB1, DLG4, PLAU, THBS1, DAB2, NOS1AP, APOB, GPRASP1, LPA, APBB1, TLN1, LCN2, RBP1, APBA2, CLU, CUBN, TG, SCGB1A1, SCN3A (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| LRP2, APOE, CTNNB1, PLAU, ALB, DAB2, GC, APOB, SNX17, MAPK8IP2, LPA, DLG1, ANKRA2, TLN1, INS, LCN2, MDK, CLU, ANAPC10, TG, SCN3A (tumor) | LRP2, CTNNB1, ITGB1BP1, ALB, APOB, CBX5, MAPK8IP1, MAPK8IP2, TTR, LPA, DAB1, ANKRA2, APBB1, RBP1, PIP5K1C, DLG3, APOH, CUBN, TG, SCGB1A1, SCN3A (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| LRP2, MAGI1, ATN1, APOE, CTNNB1, DLG2, ITGB1BP1, ABL1, CBX5, SNX17, GPRASP1, DLG1, ANKRA2, TLN1, ANKS1B, MDK, LRP2BP, LDLRAP1, CUBN, TG, SYNJ2BP (tumor) | LRP2, MAGI1, GIPC1, APOE, DLG2, DLG4, ITGB1BP1, PLAU, ABL1, MAPK8IP1, GPRASP1, DLG1, ANKS1B, LCN2, RBP1, MDK, CLU, LDLRAP1, TG, SYNJ2BP, SCN3A (normal) |
 |  |
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| TissGeneProg for LRP2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LRP2 |
| TissGeneDrug for LRP2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00071 | Insulin Pork | Biotech | Approved | |
| DB00030 | Insulin Human | Biotech | Approved|Investigational | |
| DB00013 | Urokinase | Biotech | Approved|Investigational|Withdrawn | |
| DB00798 | Gentamicin | Other/unknown | Small molecule | Approved|Vet_approved |
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| TissGeneDisease for LRP2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019693 | HIV Infections | 9 | BeFree |
| umls:C1704378 | Heymann Nephritis | 7 | BeFree |
| umls:C0015230 | Exanthema | 5 | BeFree |
| umls:C0848332 | Spots on skin | 5 | BeFree |
| umls:C0017665 | Membranous glomerulonephritis | 4 | BeFree,RGD |
| umls:C1857277 | Donnai-Barrow syndrome | 4 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0013421 | Dystonia | 3 | BeFree |
| umls:C0393593 | Dystonia Disorders | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | GAD |
| umls:C0005940 | Bone Diseases | 2 | BeFree |
| umls:C0013384 | Dyskinetic syndrome | 2 | BeFree |
| umls:C0018784 | Sensorineural Hearing Loss (disorder) | 2 | BeFree,CTD_human |
| umls:C0019284 | Diaphragmatic Hernia | 2 | BeFree,CTD_human |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree,RGD |
| umls:C0033578 | Prostatic Neoplasms | 2 | CTD_human,LHGDN |
| umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 2 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 2 | BeFree |
| umls:C0262587 | Parathyroid Adenoma | 2 | BeFree |
| umls:C0878681 | Dent's disease | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0001925 | Albuminuria | 1 | RGD |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0003125 | Anorexia Nervosa | 1 | GAD |
| umls:C0003873 | Rheumatoid Arthritis | 1 | LHGDN |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0008073 | Developmental Disabilities | 1 | CTD_human |
| umls:C0010823 | Cytomegalovirus Infections | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0015398 | Eye Diseases, Hereditary | 1 | CTD_human |
| umls:C0015624 | Fanconi Syndrome | 1 | BeFree |
| umls:C0015625 | Fanconi Anemia | 1 | BeFree |
| umls:C0020438 | Hypercalciuria | 1 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 1 | GAD |
| umls:C0020473 | Hyperlipidemia | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | RGD |
| umls:C0022658 | Kidney Diseases | 1 | CTD_human |
| umls:C0022660 | Kidney Failure, Acute | 1 | BeFree |
| umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 1 | BeFree |
| umls:C0027709 | Nephrocalcinosis | 1 | BeFree |
| umls:C0027720 | Nephrosis | 1 | RGD |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0027960 | Nevus | 1 | BeFree |
| umls:C0027962 | Melanocytic nevus | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029442 | Osteomalacia | 1 | BeFree |
| umls:C0034951 | Refractive Errors | 1 | BeFree |
| umls:C0035579 | Rickets | 1 | BeFree |
| umls:C0040128 | Thyroid Diseases | 1 | LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0040822 | Tremor | 1 | BeFree |
| umls:C0042749 | Viremia | 1 | BeFree |
| umls:C0042847 | Vitamin B 12 Deficiency | 1 | BeFree |
| umls:C0042870 | Vitamin D Deficiency | 1 | BeFree,CTD_human |
| umls:C0079541 | Holoprosencephaly | 1 | BeFree |
| umls:C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | RGD |
| umls:C0158945 | Congenital cytomegalovirus infection | 1 | BeFree |
| umls:C0175754 | Agenesis of corpus callosum | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0236848 | Age-related cognitive decline | 1 | BeFree |
| umls:C0265253 | Stickler syndrome (disorder) | 1 | BeFree |
| umls:C0266617 | Congenital anomaly of face | 1 | BeFree |
| umls:C0268731 | Renal glomerular disease | 1 | BeFree |
| umls:C0271183 | Severe myopia | 1 | BeFree |
| umls:C0279530 | Malignant Bone Neoplasm | 1 | BeFree |
| umls:C0281267 | bilateral breast cancer | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0338656 | Impaired cognition | 1 | BeFree |
| umls:C0342790 | Carnitine palmitoyl transferase 2 deficiency | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree,GAD |
| umls:C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| umls:C0445118 | Nephrotic range proteinuria | 1 | BeFree |
| umls:C0456844 | Light chain myeloma | 1 | BeFree |
| umls:C0497552 | Congenital neurologic anomalies | 1 | LHGDN |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0752207 | Familial Dystonia | 1 | BeFree |
| umls:C1271104 | Blood pressure finding | 1 | GWASCAT |
| umls:C1272641 | Systemic arterial pressure | 1 | GWASCAT |
| umls:C1275808 | Congenital central hypoventilation | 1 | BeFree |
| umls:C1392786 | Cognitive changes | 1 | BeFree |
| umls:C1456781 | Benign melanocytic nevus | 1 | BeFree |
| umls:C1848954 | Generalized dystonia | 1 | BeFree |
| umls:C1857395 | De Toni-Debre-Fanconi Syndrome | 1 | BeFree |
| umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
| umls:C3665593 | Melanocytic nevus of skin | 1 | BeFree |
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