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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NBR1
check button Gene summary
Basic gene informationGene symbolNBR1
Gene nameneighbor of BRCA1 gene 1
Synonyms1A1-3B|IAI3B|M17S2
CytomapUCSC genome browser: 17q21.31
Type of geneprotein-coding
RefGenesNM_001291571.1,
NM_001291572.1,NM_005899.4,NM_031862.3,NM_031858.2,
DescriptionB-box proteincell migration-inducing gene 19 proteinmembrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)migration-inducing protein 19next to BRCA1 gene 1 protein
Modification date20141222
dbXrefs MIM : 166945
HGNC : HGNC
Ensembl : ENSG00000188554
HPRD : 01326
Vega : OTTHUMG00000180878
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NBR1
BioGPS: 4077
PathwayNCI Pathway Interaction Database: NBR1
KEGG: NBR1
REACTOME: NBR1
Pathway Commons: NBR1
ContextiHOP: NBR1
ligand binding site mutation search in PubMed: NBR1
UCL Cancer Institute: NBR1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCTGCT
Reference showing the relevant tissue of NBR1
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
TissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0016236macroautophagy19250911
GO:0051259protein oligomerization19250911
GO:0016236macroautophagy19250911
GO:0051259protein oligomerization19250911


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TissGeneExp for NBR1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for NBR1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-429MIMAT00015360.0058-0.3178
ACChsa-miR-429MIMAT00015360.0058-0.3178


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TissGeneMut for NBR1
TissGeneSNV for NBR1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R312CSTAD2
p.E171DLUAD1
p.K426NCESC1
p.R162SLIHC1
p.N943YLUSC1
p.L954IUCEC1
p.S354CKIRP1
p.Y248CUCEC1
p.S372GESCA1
p.S276CBLCA1
p.E544KLIHC1
p.P140ALUSC1
p.Q948RESCA1
p.R228SPAAD1
p.E244KHNSC1
p.E163KCESC1
p.P140SSKCM1
p.D142HBLCA1
p.P482SSKCM1
p.R853SKIRP1
p.P269SSKCM1
p.I58MBLCA1
p.E171KCESC1
p.S457FSKCM1
p.H923RCOAD1
p.E318XCOAD1
p.L323FSKCM1
p.R306XSTAD1
p.E163KBRCA1
p.S462FSTAD1
p.S891FBLCA1
p.D382NBLCA1
p.T199ISKCM1
p.H463YLIHC1
p.P341LSKCM1
p.E813QLIHC1
p.H330YKIRC1
p.Q45EBLCA1
p.Q466KKIRC1
p.P344SSKCM1
p.E168KKIRC1
p.I335FBLCA1
p.P470LSKCM1
p.S895FBLCA1
p.A614VCESC1
p.H272DBLCA1
p.E651*BRCA1
p.Q774LLUAD1
p.E168KPRAD1
p.M398IBLCA1
p.K317NUCEC1
p.E378DUCEC1
p.D144HLUSC1
p.Q558HESCA1
p.I568VLIHC1
p.K427NLUAD1
p.P582HLGG1
p.I568VHNSC1
p.E637KBLCA1
p.S21CBLCA1
p.S190FLUAD1
p.A67VSARC1
p.P235LTHCA1
p.L305SKIRP1
p.G785VBLCA1
p.R306QCOAD1
p.T646ALIHC1
p.P192SSKCM1
p.R670GBLCA1


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TissGeneCNV for NBR1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for NBR1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanPRADTCGA-YL-A8SC-01ANBR1-C17orf104Out-of-Framechr17:41345655chr17:42751343
Chimerdb3.0FusionScanESCATCGA-L5-A4OS-01ANBR1-ZNF6805'UTR-CDSchr17:41322628chr7:63982878
Chimerdb3.0TopHat-FusionPRADTCGA-YL-A8SC-01ANBR1-MEIOCOut-of-Framechr17:41345654chr17:42751343
TCGAfusionPortalPRADABRCATCGA-EW-A2FS-01ANBR1-RUNDC3AOut-of-frameChr17:41355803Chr17:42395464
TCGAfusionPortalPRADALAMLTCGA-AB-2920-03BWSB1-NBR1CDS-5UTRChr17:25621461Chr17:41327808


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TissGeneNet for NBR1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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COAD (tumor)COAD (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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HNSC (tumor)HNSC (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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KICH (tumor)KICH (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, USP8, VTA1, GSK3A (normal)
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KIRC (tumor)KIRC (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1 (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, USP8, VTA1, GSK3A (normal)
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KIRP (tumor)KIRP (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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LIHC (tumor)LIHC (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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LUAD (tumor)LUAD (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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LUSC (tumor)LUSC (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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PRAD (tumor)PRAD (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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STAD (tumor)STAD (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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THCA (tumor)THCA (normal)
NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, HNF1A, HTT, CIB1, UBB, USP8, VTA1, GSK3A (tumor)NBR1, SQSTM1, GABARAPL1, HNF4A, UBC, ONECUT1, GABARAP, GABARAPL2, CALM1, MAP1LC3B, MAP1LC3C, ITSN2, FEZ1, MAP1LC3A, TTN, HTT, CIB1, UBB, USP8, VTA1, GSK3A (normal)
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TissGeneProg for NBR1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for NBR1
TissGeneDrug for NBR1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for NBR1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0029925Ovarian Carcinoma94BeFree
umls:C1140680Malignant neoplasm of ovary79BeFree
umls:C0677886Epithelial ovarian cancer32BeFree
umls:C0919267ovarian neoplasm12BeFree
umls:C0014175Endometriosis7BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0027627Neoplasm Metastasis4BeFree
umls:C0004997Benign Ovarian Neoplasm3BeFree
umls:C0007137Squamous cell carcinoma3BeFree
umls:C0278689Ovarian epithelial cancer recurrent3BeFree
umls:C0279672Cervical Adenocarcinoma3BeFree
umls:C0280220stage, ovarian epithelial cancer3BeFree
umls:C0476089Endometrial Carcinoma3BeFree
umls:C1559271Non-Malignant Ascites Adverse Event3BeFree
umls:C0001418Adenocarcinoma2BeFree
umls:C0007103Malignant neoplasm of endometrium2BeFree
umls:C0152013Adenocarcinoma of lung (disorder)2BeFree
umls:C0153579Malignant neoplasm of fallopian tube2BeFree
umls:C0238122Fallopian Tube Carcinoma2BeFree
umls:C0269102Endometrioma2BeFree
umls:C1153706Endometrial adenocarcinoma2BeFree
umls:C1368683Epithelioma2BeFree
umls:C1883486Uterine Corpus Cancer2BeFree
umls:C0004096Asthma1BeFree
umls:C0007133Carcinoma, Papillary1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0008479Chondrosarcoma1BeFree
umls:C0010246Coxsackievirus Infections1BeFree
umls:C0010709Cyst1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0014378Enterovirus Infections1BeFree
umls:C0025500Mesothelioma1BeFree
umls:C0028754Obesity1BeFree
umls:C0037284Skin lesion1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0042769Virus Diseases1BeFree
umls:C0149614Adnexal mass1BeFree
umls:C0205698Undifferentiated carcinoma1BeFree
umls:C0206627Mixed Tumor, Mullerian1BeFree
umls:C0206687Carcinoma, Endometrioid1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0278493Breast cancer recurrent1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0333693Triploidy syndrome1BeFree
umls:C0345967Malignant mesothelioma1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0524620Metabolic Syndrome X1BeFree
umls:C0677932Progressive Neoplastic Disease1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0699889Malignant Female Reproductive System Neoplasm1BeFree
umls:C0740651Abdominal symptom1BeFree
umls:C0751713Inclusion Body Myopathy, Sporadic1BeFree
umls:C0796563Localized Malignant Neoplasm1BeFree
umls:C0877550Carcinomatous ascites1BeFree
umls:C1333990Hereditary Nonpolyposis Colorectal Cancer1BeFree
umls:C1333992Hereditary Ovarian Carcinoma1BeFree
umls:C1334603Malignant Mixed Mesodermal (Mullerian) Tumor1BeFree
umls:C1377610Peritoneal Mesothelioma1BeFree
umls:C1569637Adenocarcinoma, Endometrioid1BeFree
umls:C3539781Progressive cGVHD1BeFree
umls:C3539878Triple Negative Breast Neoplasms1BeFree