TissGeneSummary for NBR1 |
Gene summary |
Basic gene information | Gene symbol | NBR1 |
Gene name | neighbor of BRCA1 gene 1 | |
Synonyms | 1A1-3B|IAI3B|M17S2 | |
Cytomap | UCSC genome browser: 17q21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001291571.1, NM_001291572.1,NM_005899.4,NM_031862.3,NM_031858.2, | |
Description | B-box proteincell migration-inducing gene 19 proteinmembrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)migration-inducing protein 19next to BRCA1 gene 1 protein | |
Modification date | 20141222 | |
dbXrefs | MIM : 166945 | |
HGNC : HGNC | ||
Ensembl : ENSG00000188554 | ||
HPRD : 01326 | ||
Vega : OTTHUMG00000180878 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NBR1 | |
BioGPS: 4077 | ||
Pathway | NCI Pathway Interaction Database: NBR1 | |
KEGG: NBR1 | ||
REACTOME: NBR1 | ||
Pathway Commons: NBR1 | ||
Context | iHOP: NBR1 | |
ligand binding site mutation search in PubMed: NBR1 | ||
UCL Cancer Institute: NBR1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCTGCT | |
Reference showing the relevant tissue of NBR1 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016236 | macroautophagy | 19250911 | GO:0051259 | protein oligomerization | 19250911 | GO:0016236 | macroautophagy | 19250911 | GO:0051259 | protein oligomerization | 19250911 |
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TissGeneExp for NBR1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for NBR1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-429 | MIMAT0001536 | 0.0058 | -0.31 | 78 |
ACC | hsa-miR-429 | MIMAT0001536 | 0.0058 | -0.31 | 78 |
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TissGeneMut for NBR1 |
TissGeneSNV for NBR1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R312C | STAD | 2 |
p.E171D | LUAD | 1 |
p.K426N | CESC | 1 |
p.R162S | LIHC | 1 |
p.N943Y | LUSC | 1 |
p.L954I | UCEC | 1 |
p.S354C | KIRP | 1 |
p.Y248C | UCEC | 1 |
p.S372G | ESCA | 1 |
p.S276C | BLCA | 1 |
p.E544K | LIHC | 1 |
p.P140A | LUSC | 1 |
p.Q948R | ESCA | 1 |
p.R228S | PAAD | 1 |
p.E244K | HNSC | 1 |
p.E163K | CESC | 1 |
p.P140S | SKCM | 1 |
p.D142H | BLCA | 1 |
p.P482S | SKCM | 1 |
p.R853S | KIRP | 1 |
p.P269S | SKCM | 1 |
p.I58M | BLCA | 1 |
p.E171K | CESC | 1 |
p.S457F | SKCM | 1 |
p.H923R | COAD | 1 |
p.E318X | COAD | 1 |
p.L323F | SKCM | 1 |
p.R306X | STAD | 1 |
p.E163K | BRCA | 1 |
p.S462F | STAD | 1 |
p.S891F | BLCA | 1 |
p.D382N | BLCA | 1 |
p.T199I | SKCM | 1 |
p.H463Y | LIHC | 1 |
p.P341L | SKCM | 1 |
p.E813Q | LIHC | 1 |
p.H330Y | KIRC | 1 |
p.Q45E | BLCA | 1 |
p.Q466K | KIRC | 1 |
p.P344S | SKCM | 1 |
p.E168K | KIRC | 1 |
p.I335F | BLCA | 1 |
p.P470L | SKCM | 1 |
p.S895F | BLCA | 1 |
p.A614V | CESC | 1 |
p.H272D | BLCA | 1 |
p.E651* | BRCA | 1 |
p.Q774L | LUAD | 1 |
p.E168K | PRAD | 1 |
p.M398I | BLCA | 1 |
p.K317N | UCEC | 1 |
p.E378D | UCEC | 1 |
p.D144H | LUSC | 1 |
p.Q558H | ESCA | 1 |
p.I568V | LIHC | 1 |
p.K427N | LUAD | 1 |
p.P582H | LGG | 1 |
p.I568V | HNSC | 1 |
p.E637K | BLCA | 1 |
p.S21C | BLCA | 1 |
p.S190F | LUAD | 1 |
p.A67V | SARC | 1 |
p.P235L | THCA | 1 |
p.L305S | KIRP | 1 |
p.G785V | BLCA | 1 |
p.R306Q | COAD | 1 |
p.T646A | LIHC | 1 |
p.P192S | SKCM | 1 |
p.R670G | BLCA | 1 |
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TissGeneCNV for NBR1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NBR1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8SC-01A | NBR1-C17orf104 | Out-of-Frame | chr17:41345655 | chr17:42751343 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OS-01A | NBR1-ZNF680 | 5'UTR-CDS | chr17:41322628 | chr7:63982878 |
Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-YL-A8SC-01A | NBR1-MEIOC | Out-of-Frame | chr17:41345654 | chr17:42751343 |
TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A2FS-01A | NBR1-RUNDC3A | Out-of-frame | Chr17:41355803 | Chr17:42395464 |
TCGAfusionPortal | PRADA | LAML | TCGA-AB-2920-03B | WSB1-NBR1 | CDS-5UTR | Chr17:25621461 | Chr17:41327808 |
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TissGeneNet for NBR1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NBR1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NBR1 |
TissGeneDrug for NBR1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NBR1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029925 | Ovarian Carcinoma | 94 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 79 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 32 | BeFree |
umls:C0919267 | ovarian neoplasm | 12 | BeFree |
umls:C0014175 | Endometriosis | 7 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
umls:C0678222 | Breast Carcinoma | 5 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
umls:C0004997 | Benign Ovarian Neoplasm | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
umls:C0278689 | Ovarian epithelial cancer recurrent | 3 | BeFree |
umls:C0279672 | Cervical Adenocarcinoma | 3 | BeFree |
umls:C0280220 | stage, ovarian epithelial cancer | 3 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 3 | BeFree |
umls:C1559271 | Non-Malignant Ascites Adverse Event | 3 | BeFree |
umls:C0001418 | Adenocarcinoma | 2 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
umls:C0153579 | Malignant neoplasm of fallopian tube | 2 | BeFree |
umls:C0238122 | Fallopian Tube Carcinoma | 2 | BeFree |
umls:C0269102 | Endometrioma | 2 | BeFree |
umls:C1153706 | Endometrial adenocarcinoma | 2 | BeFree |
umls:C1368683 | Epithelioma | 2 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0007133 | Carcinoma, Papillary | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0008479 | Chondrosarcoma | 1 | BeFree |
umls:C0010246 | Coxsackievirus Infections | 1 | BeFree |
umls:C0010709 | Cyst | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0014378 | Enterovirus Infections | 1 | BeFree |
umls:C0025500 | Mesothelioma | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0037284 | Skin lesion | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0149614 | Adnexal mass | 1 | BeFree |
umls:C0205698 | Undifferentiated carcinoma | 1 | BeFree |
umls:C0206627 | Mixed Tumor, Mullerian | 1 | BeFree |
umls:C0206687 | Carcinoma, Endometrioid | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0278493 | Breast cancer recurrent | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
umls:C0333693 | Triploidy syndrome | 1 | BeFree |
umls:C0345967 | Malignant mesothelioma | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C0677932 | Progressive Neoplastic Disease | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0699889 | Malignant Female Reproductive System Neoplasm | 1 | BeFree |
umls:C0740651 | Abdominal symptom | 1 | BeFree |
umls:C0751713 | Inclusion Body Myopathy, Sporadic | 1 | BeFree |
umls:C0796563 | Localized Malignant Neoplasm | 1 | BeFree |
umls:C0877550 | Carcinomatous ascites | 1 | BeFree |
umls:C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 1 | BeFree |
umls:C1333992 | Hereditary Ovarian Carcinoma | 1 | BeFree |
umls:C1334603 | Malignant Mixed Mesodermal (Mullerian) Tumor | 1 | BeFree |
umls:C1377610 | Peritoneal Mesothelioma | 1 | BeFree |
umls:C1569637 | Adenocarcinoma, Endometrioid | 1 | BeFree |
umls:C3539781 | Progressive cGVHD | 1 | BeFree |
umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |