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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MAD2L1
check button Gene summary
Basic gene informationGene symbolMAD2L1
Gene nameMAD2 mitotic arrest deficient-like 1 (yeast)
SynonymsHSMAD2|MAD2
CytomapUCSC genome browser: 4q27
Type of geneprotein-coding
RefGenesNM_002358.3,
DescriptionMAD2 (mitotic arrest deficient, yeast, homolog)-like 1MAD2-like protein 1mitotic arrest deficient 2-like protein 1mitotic arrest deficient, yeast, homolog-like 1mitotic spindle assembly checkpoint protein MAD2A
Modification date20141207
dbXrefs MIM : 601467
HGNC : HGNC
HPRD : 03274
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAD2L1
BioGPS: 4085
PathwayNCI Pathway Interaction Database: MAD2L1
KEGG: MAD2L1
REACTOME: MAD2L1
Pathway Commons: MAD2L1
ContextiHOP: MAD2L1
ligand binding site mutation search in PubMed: MAD2L1
UCL Cancer Institute: MAD2L1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Bone marrowTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LAMLTGCT
Reference showing the relevant tissue of MAD2L1
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007093mitotic cell cycle checkpoint8824189
GO:0042177negative regulation of protein catabolic process11459825
GO:0060564negative regulation of mitotic anaphase-promoting complex activity11459825
GO:0007093mitotic cell cycle checkpoint8824189
GO:0042177negative regulation of protein catabolic process11459825
GO:0060564negative regulation of mitotic anaphase-promoting complex activity11459825


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TissGeneExp for MAD2L1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BLCA0.62802249-1.3428827731.9709052633.42E-068.64E-05
LUAD0.039878025-2.4283633542.4682413799.13E-243.25E-22
LIHC-0.982356457-3.0457344572.0633786.81E-162.44E-14
LUSC1.098888641-2.3537466533.4526352949.99E-372.07E-34
BRCA0.245805823-1.6872178611.9330236846.90E-391.90E-37
COAD1.616916620.1743320041.4425846158.47E-111.24E-09
STAD0.464243543-1.2215252071.685768753.32E-081.19E-06
HNSC0.720185403-0.4734494811.1936348845.86E-101.02E-08
ESCA0.893888997-1.8416291852.7355181822.00E-050.001235556


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TissGene-miRNA for MAD2L1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MAD2L1
TissGeneSNV for MAD2L1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G15RBLCA1
p.F23LUCEC1
p.L3RLUAD1
p.R45*UCEC1
p.R117ILUAD1
p.S80LBLCA1
p.L161WUCEC1
p.Y77FBRCA1
p.P172TBRCA1
p.D205NLUAD1
p.R182LLUAD1
p.P202SSKCM1
p.R133KLUSC1
p.G27STHYM1
p.S150LPAAD1
p.S150XCOAD1
p.I190VDLBC1
p.P116TLIHC1
p.S88FUCEC1
p.R129CPRAD1
p.I11NSTAD1
p.V203IKIRC1
p.R133KBLCA1
p.S195GLUSC1
p.E22DHNSC1
p.C149RPRAD1


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TissGeneCNV for MAD2L1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MAD2L1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAU65410MAD2L1-FAM168Bchr4:120987922chr2:131809762


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TissGeneNet for MAD2L1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MAD2L1, IKBKE, CUL3, TSC22D4, TP73, ADAM15, NDC80, TNFRSF1B, BUB1B, UBE2C, ZWINT, ANAPC4, REV3L, CDC23, UBD, ADAM17, ESR2, CDC20, MBL2, KLHL13, ADAM10 (tumor)MAD2L1, RABAC1, NDC80, TNFRSF1B, BUB1B, INSR, CDC27, UBE2C, KEAP1, MAD2L1BP, ZWINT, ANAPC2, CDC23, UBD, ADAM17, HSF1, CHFR, EIF6, CDC20, MAD2L2, CUEDC2 (normal)
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COAD (tumor)COAD (normal)
MAD2L1, IKBKE, APC, DSTYK, TSC22D4, TP73, ADAM15, NDC80, BUB1B, INSR, UBE2C, MAD2L1BP, ZWINT, ANAPC4, REV3L, NSL1, CDC23, HSF1, CDC20, REST, MAD2L2 (tumor)MAD2L1, APC, DSTYK, TSC22D4, DYNC1LI1, CSF2RB, NDC80, BUB1B, INSR, CDC27, UBE2C, MAD2L1BP, ZWINT, ANAPC4, REV3L, NSL1, CDC23, MAD1L1, CHFR, CDC20, MAD2L2 (normal)
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HNSC (tumor)HNSC (normal)
MAD2L1, IKBKE, CUL3, TP73, RABAC1, ADAM15, NDC80, BUB1B, PTP4A3, INSR, UBE2C, ZWINT, NSL1, CDC23, ADAM17, HSF1, CHFR, EIF6, CDC20, MAD2L2, CUEDC2 (tumor)MAD2L1, DSTYK, TSC22D4, RABAC1, ADAM15, CSF2RB, NDC80, BUB1B, INSR, CDC27, UBE2C, MAD2L1BP, ZWINT, ANAPC4, NSL1, CDC23, UBD, CDC20, KLHL13, MAD2L2, CUEDC2 (normal)
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KICH (tumor)KICH (normal)
MAD2L1, APC, DSTYK, RABAC1, CSF2RB, TNFRSF1B, BUB1B, INSR, CDC16, UBE2C, MAD2L1BP, ZWINT, ANAPC4, ANAPC2, REV3L, NSL1, EIF6, CDC20, KLHL13, MAD2L2, CUEDC2 (tumor)MAD2L1, APC, DYNC1LI1, RABAC1, NDC80, TNFRSF1B, BUB1B, CDC16, UBE2C, KEAP1, MAD2L1BP, ZWINT, ANAPC4, CDC23, UBD, CHFR, EIF6, CDC20, REST, CUEDC2, ADAM10 (normal)
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KIRC (tumor)KIRC (normal)
MAD2L1, IKBKE, DSTYK, TP73, ADAM15, NDC80, BUB1B, INSR, CDC16, CDC27, UBE2C, ZWINT, ANAPC4, MAGEB2, NSL1, UBD, ADAM17, HSF1, CDC20, MBL2, ADAM10 (tumor)MAD2L1, IKBKE, DSTYK, TP73, NDC80, BUB1B, PTP4A3, INSR, CDC16, CDC27, UBE2C, ZWINT, ANAPC2, MAGEB2, NSL1, CDC23, ADAM17, CDC20, REST, MBL2, ADAM10 (normal)
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KIRP (tumor)KIRP (normal)
MAD2L1, IKBKE, ADAM15, BUB1B, INSR, CDC16, CDC27, UBE2C, ZWINT, ANAPC4, ANAPC2, NSL1, CDC23, ADAM17, MAD1L1, CHFR, ESR2, CDC20, MAD2L2, CUEDC2, ADAM10 (tumor)MAD2L1, APC, CUL3, TP73, ADAM15, NDC80, BUB1B, CDC16, CDC27, UBE2C, ZWINT, ANAPC4, ANAPC2, NSL1, CDC23, UBD, ADAM17, MAD1L1, CDC20, REST, KLHL13 (normal)
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LIHC (tumor)LIHC (normal)
MAD2L1, IKBKE, APC, CUL3, TSC22D4, TP73, NDC80, BUB1B, INSR, UBE2C, ZWINT, ANAPC4, NSL1, CDC23, UBD, HSF1, CHFR, CDC20, MBL2, KLHL13, MAD2L2 (tumor)MAD2L1, IKBKE, TP73, DYNC1LI1, ADAM15, NDC80, BUB1B, PTP4A3, INSR, CDC27, UBE2C, ZWINT, ANAPC4, MAGEB2, CDC23, UBD, ADAM17, CDC20, REST, MBL2, ADAM10 (normal)
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LUAD (tumor)LUAD (normal)
MAD2L1, IKBKE, APC, DSTYK, DYNC1LI1, RABAC1, NDC80, BUB1B, INSR, UBE2C, KEAP1, MAD2L1BP, ZWINT, REV3L, NSL1, UBD, EIF6, CDC20, REST, MAD2L2, CUEDC2 (tumor)MAD2L1, APC, DSTYK, DYNC1LI1, NDC80, BUB1B, INSR, CDC27, UBE2C, ZWINT, ANAPC2, MAGEB2, REV3L, NSL1, UBD, ADAM17, CHFR, EIF6, CDC20, MAD2L2, ADAM10 (normal)
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LUSC (tumor)LUSC (normal)
MAD2L1, IKBKE, TP73, DYNC1LI1, NDC80, BUB1B, INSR, CDC16, UBE2C, ZWINT, ANAPC4, REV3L, NSL1, CDC23, UBD, ADAM17, HSF1, CDC20, KLHL13, MAD2L2, CUEDC2 (tumor)MAD2L1, DSTYK, TSC22D4, DYNC1LI1, RABAC1, NDC80, TNFRSF1B, BUB1B, PTP4A3, INSR, CDC27, UBE2C, KEAP1, MAD2L1BP, ZWINT, NSL1, CDC23, MAD1L1, CHFR, CDC20, MAD2L2 (normal)
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PRAD (tumor)PRAD (normal)
MAD2L1, CUL3, DSTYK, DYNC1LI1, ADAM15, BUB1B, PTP4A3, INSR, UBE2C, MAD2L1BP, ZWINT, ANAPC4, ANAPC2, REV3L, NSL1, CDC23, UBD, HSF1, CDC20, MAD2L2, ADAM10 (tumor)MAD2L1, CUL3, DYNC1LI1, RABAC1, NDC80, BUB1B, INSR, CDC16, CDC27, UBE2C, ZWINT, ANAPC2, NSL1, CDC23, ADAM17, MAD1L1, EIF6, CDC20, REST, KLHL13, ADAM10 (normal)
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STAD (tumor)STAD (normal)
MAD2L1, IKBKE, DSTYK, TSC22D4, TP73, ADAM15, NDC80, BUB1B, PTP4A3, INSR, UBE2C, MAD2L1BP, ZWINT, REV3L, HSF1, EIF6, ESR2, CDC20, KLHL13, CUEDC2, ADAM10 (tumor)MAD2L1, IKBKE, APC, CUL3, DSTYK, CSF2RB, NDC80, BUB1B, PTP4A3, INSR, CDC16, CDC27, UBE2C, MAD2L1BP, ZWINT, ANAPC4, CDC23, CHFR, EIF6, CDC20, KLHL13 (normal)
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THCA (tumor)THCA (normal)
MAD2L1, IKBKE, DSTYK, TSC22D4, TP73, DYNC1LI1, CSF2RB, NDC80, TNFRSF1B, BUB1B, PTP4A3, UBE2C, ZWINT, CDC23, UBD, MAD1L1, CHFR, ESR2, CDC20, MBL2, MAD2L2 (tumor)MAD2L1, TP73, CSF2RB, NDC80, BUB1B, INSR, UBE2C, MAD2L1BP, ZWINT, ANAPC4, ANAPC2, NSL1, CDC23, UBD, ADAM17, CDC20, REST, MBL2, KLHL13, MAD2L2, ADAM10 (normal)
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TissGeneProg for MAD2L1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MAD2L1
TissGeneDrug for MAD2L1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for MAD2L1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0596263Carcinogenesis12BeFree
umls:C2239176Liver carcinoma7BeFree,LHGDN
umls:C0006142Malignant neoplasm of breast6BeFree,GAD
umls:C0024623Malignant neoplasm of stomach6BeFree
umls:C0178874Tumor Progression6BeFree
umls:C0699791Stomach Carcinoma6BeFree
umls:C0001418Adenocarcinoma5BeFree
umls:C0029925Ovarian Carcinoma4BeFree
umls:C0038356Stomach Neoplasms3LHGDN
umls:C0678222Breast Carcinoma3BeFree
umls:C1140680Malignant neoplasm of ovary3BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0009404Colorectal Neoplasms2BeFree,LHGDN
umls:C0024121Lung Neoplasms2BeFree
umls:C0029463Osteosarcoma2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree,GAD
umls:C0546837Malignant neoplasm of esophagus2BeFree
umls:C0585442Osteosarcoma of bone2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C1261473Sarcoma2BeFree,LHGDN
umls:C1527249Colorectal Cancer2BeFree
umls:C2931822Nasopharyngeal carcinoma2BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0004763Barrett Esophagus1LHGDN
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0005695Bladder Neoplasm1BeFree
umls:C0007133Carcinoma, Papillary1LHGDN
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0009324Ulcerative Colitis1BeFree
umls:C0017661IGA Glomerulonephritis1CTD_human
umls:C0021367Mammary Ductal Carcinoma1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0032460Polycystic Ovary Syndrome1CTD_human
umls:C0035335Retinoblastoma1BeFree
umls:C0040136Thyroid Neoplasm1LHGDN
umls:C0279626Squamous cell carcinoma of esophagus1CTD_human
umls:C0279702Conventional (Clear Cell) Renal Cell Carcinoma1BeFree
umls:C0376545Hematologic Neoplasms1BeFree
umls:C0598766Leukemogenesis1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0740457Malignant neoplasm of kidney1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1527349Ductal Breast Carcinoma1BeFree
umls:C1561955Fibrinogen Adverse Event1GAD
umls:C2145472Urothelial Carcinoma1BeFree