TissGeneSummary for MAGEA1 |
Gene summary |
Basic gene information | Gene symbol | MAGEA1 |
Gene name | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | |
Synonyms | CT1.1|MAGE1 | |
Cytomap | UCSC genome browser: Xq28 | |
Type of gene | protein-coding | |
RefGenes | NM_004988.4, | |
Description | MAGE-1 antigenantigen MZ2-Ecancer/testis antigen 1.1cancer/testis antigen family 1, member 1melanoma antigen MAGE-1melanoma antigen family A 1melanoma-associated antigen 1melanoma-associated antigen MZ2-E | |
Modification date | 20141207 | |
dbXrefs | MIM : 300016 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198681 | ||
HPRD : 02059 | ||
Vega : OTTHUMG00000024192 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAGEA1 | |
BioGPS: 4100 | ||
Pathway | NCI Pathway Interaction Database: MAGEA1 | |
KEGG: MAGEA1 | ||
REACTOME: MAGEA1 | ||
Pathway Commons: MAGEA1 | ||
Context | iHOP: MAGEA1 | |
ligand binding site mutation search in PubMed: MAGEA1 | ||
UCL Cancer Institute: MAGEA1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTExTiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MAGEA1 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15316101 | GO:0045746 | negative regulation of Notch signaling pathway | 15316101 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15316101 | GO:0045746 | negative regulation of Notch signaling pathway | 15316101 |
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TissGeneExp for MAGEA1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | 2.134355485 | -0.796428235 | 2.930783721 | 1.36E-05 | 7.45E-05 |
LUSC | 2.411134464 | -0.710081222 | 3.121215686 | 2.63E-07 | 7.06E-07 |
LIHC | 3.078496974 | -0.815373026 | 3.89387 | 3.93E-09 | 3.80E-08 |
BRCA | 0.305339676 | -0.937706816 | 1.243046491 | 4.97E-07 | 1.39E-06 |
BLCA | 2.821340553 | -0.278948921 | 3.100289474 | 0.00584 | 0.029653333 |
LUAD | 0.61183656 | -0.869482405 | 1.481318966 | 0.000185 | 0.000448116 |
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TissGene-miRNA for MAGEA1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MAGEA1 |
TissGeneSNV for MAGEA1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M204I | SKCM | 1 |
p.A147S | LIHC | 1 |
p.R291C | SKCM | 1 |
p.F70V | BLCA | 1 |
p.S33F | SKCM | 1 |
p.E4Q | LUSC | 1 |
p.E45D | STAD | 1 |
p.E130K | LUSC | 1 |
p.S91Y | UCEC | 1 |
p.A63V | SKCM | 1 |
p.R291C | READ | 1 |
p.S51* | CHOL | 1 |
p.A107P | LUAD | 1 |
p.T66N | ACC | 1 |
p.G267S | SKCM | 1 |
p.P65L | SKCM | 1 |
p.S80A | CHOL | 1 |
p.Q187* | SKCM | 1 |
p.211_212EE>D* | LUAD | 1 |
p.P88L | ESCA | 1 |
p.D158H | LUAD | 1 |
p.E127D | COAD | 1 |
p.Q187E | LUAD | 1 |
p.P259S | ACC | 1 |
p.G111D | COAD | 1 |
p.F293L | UCEC | 1 |
p.A162S | STAD | 1 |
p.T32A | COAD | 1 |
p.V283M | THYM | 1 |
p.S51X | CHOL | 1 |
p.P12S | UCS | 1 |
p.K278I | OV | 1 |
p.G308E | SKCM | 1 |
p.D185N | SKCM | 1 |
p.L171F | SKCM | 1 |
p.G233W | STAD | 1 |
p.V279A | BRCA | 1 |
p.E246K | SKCM | 1 |
p.Q187X | SKCM | 1 |
p.E234K | LUAD | 1 |
p.D163A | STAD | 1 |
p.K191N | READ | 1 |
p.E228K | SKCM | 1 |
p.A272T | PRAD | 1 |
p.E222D | UCEC | 1 |
p.S148F | SKCM | 1 |
p.R291C | CESC | 1 |
p.G207S | KIRC | 1 |
p.P164L | ESCA | 1 |
p.L171F | GBM | 1 |
p.R72* | UCEC | 1 |
p.A300T | THCA | 1 |
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TissGeneCNV for MAGEA1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MAGEA1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MAGEA1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MAGEA1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MAGEA1 |
TissGeneDrug for MAGEA1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MAGEA1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 42 | BeFree,GAD,LHGDN |
umls:C2239176 | Liver carcinoma | 11 | BeFree,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 5 | BeFree |
umls:C0027819 | Neuroblastoma | 3 | BeFree |
umls:C0700095 | Central neuroblastoma | 3 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 2 | LHGDN |
umls:C0023418 | leukemia | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 2 | BeFree |
umls:C0027962 | Melanocytic nevus | 2 | BeFree |
umls:C0038356 | Stomach Neoplasms | 2 | LHGDN |
umls:C0206701 | Cystadenocarcinoma, Serous | 2 | BeFree |
umls:C0549523 | Oropharynx (excludes nasopharynx) | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | LHGDN |
umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
umls:C0015414 | Eye Neoplasms | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0023492 | Leukemia, T-Cell | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0027960 | Nevus | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0036631 | Seminoma | 1 | BeFree |
umls:C0151779 | Cutaneous Melanoma | 1 | BeFree |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 1 | LHGDN |
umls:C0558356 | Malignant melanoma of eye | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0740277 | Bile duct carcinoma | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1456781 | Benign melanocytic nevus | 1 | BeFree |
umls:C1514422 | Primary Glioblastoma | 1 | BeFree |
umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
umls:C2004493 | Leukemia, B-Cell | 1 | BeFree |
umls:C2937421 | Prostatic Hyperplasia | 1 | LHGDN |
umls:C3665593 | Melanocytic nevus of skin | 1 | BeFree |