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| TissGeneSummary for MAGEA3 |
 Gene summary |
| Basic gene information | Gene symbol | MAGEA3 |
| Gene name | melanoma antigen family A, 3 | |
| Synonyms | CT1.3|HIP8|HYPD|MAGE3|MAGEA6 | |
| Cytomap | UCSC genome browser: Xq28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005362.3, | |
| Description | MAGE-3 antigenantigen MZ2-Dcancer/testis antigen 1.3cancer/testis antigen family 1, member 3melanoma-associated antigen 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300174 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000221867 | ||
| HPRD : 02166 | ||
| Vega : OTTHUMG00000022640 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAGEA3 | |
| BioGPS: 4102 | ||
| Pathway | NCI Pathway Interaction Database: MAGEA3 | |
| KEGG: MAGEA3 | ||
| REACTOME: MAGEA3 | ||
| Pathway Commons: MAGEA3 | ||
| Context | iHOP: MAGEA3 | |
| ligand binding site mutation search in PubMed: MAGEA3 | ||
| UCL Cancer Institute: MAGEA3 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
| Reference showing the relevant tissue of MAGEA3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MAGEA3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 2.751348205 | -1.159812579 | 3.911160784 | 2.40E-08 | 7.24E-08 |
| LUAD | 1.109719334 | -1.299618597 | 2.409337931 | 2.28E-05 | 6.35E-05 |
| LIHC | 2.578798989 | -0.786623011 | 3.365422 | 4.39E-06 | 2.04E-05 |
| HNSC | 3.661522943 | -0.572393336 | 4.233916279 | 1.55E-06 | 1.11E-05 |
| BLCA | 3.640272147 | 0.113035305 | 3.527236842 | 0.0106 | 0.0471488 |
| ESCA | 4.296836262 | -0.756472829 | 5.053309091 | 0.00222 | 0.023959034 |
| STAD | 0.626690239 | -1.475341011 | 2.10203125 | 0.000976 | 0.005189182 |
| BRCA | -0.124794519 | -1.346402414 | 1.221607895 | 5.72E-05 | 0.000130892 |
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| TissGene-miRNA for MAGEA3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MAGEA3 |
| TissGeneSNV for MAGEA3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D187N | SKCM | 2 |
| p.E219D | COAD | 1 |
| p.Q194X | KIRC | 1 |
| p.S300F | LUAD | 1 |
| p.L175V | HNSC | 1 |
| p.F146L | LUSC | 1 |
| p.P99S | SKCM | 1 |
| p.E235K | SKCM | 1 |
| p.P78S | SKCM | 1 |
| p.P262A | SKCM | 1 |
| p.S81I | LUAD | 1 |
| p.E85Q | LUAD | 1 |
| p.A179V | THYM | 1 |
| p.E314K | BRCA | 1 |
| p.K123R | STAD | 1 |
| p.G137W | HNSC | 1 |
| p.E313K | SKCM | 1 |
| p.E91X | UCS | 1 |
| p.H298R | STAD | 1 |
| p.V161I | SKCM | 1 |
| p.R19* | BRCA | 1 |
| p.S157F | SKCM | 1 |
| p.S157F | LUAD | 1 |
| p.L239F | PAAD | 1 |
| p.H118N | HNSC | 1 |
| p.H298Y | CESC | 1 |
| p.S226I | COAD | 1 |
| p.E280* | LUAD | 1 |
| p.G94E | SKCM | 1 |
| p.V140I | BRCA | 1 |
| p.Q144K | STAD | 1 |
| p.F119Y | SKCM | 1 |
| p.E313V | BLCA | 1 |
| p.R125* | UCEC | 1 |
| p.V279I | LUAD | 1 |
| p.E93* | LGG | 1 |
| p.V251L | LUSC | 1 |
| p.P262L | SKCM | 1 |
| p.H118Y | SKCM | 1 |
| p.Y84N | HNSC | 1 |
| p.G295R | SKCM | 1 |
| p.L182P | STAD | 1 |
| p.E168* | UCEC | 1 |
| p.L256V | STAD | 1 |
| p.V149A | LGG | 1 |
| p.D241E | PAAD | 1 |
| p.A210T | UCEC | 1 |
| p.E91* | UCS | 1 |
| p.R211K | SKCM | 1 |
| p.P303L | SKCM | 1 |
| p.L109H | CESC | 1 |
| p.S300F | SKCM | 1 |
| p.P129L | STAD | 1 |
| p.I150M | BLCA | 1 |
| p.E134A | SKCM | 1 |
| p.D241N | SKCM | 1 |
| p.K220N | THYM | 1 |
| p.P148L | SKCM | 1 |
| p.G141R | COAD | 1 |
| p.P242S | SKCM | 1 |
| p.P275S | SKCM | 1 |
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| TissGeneCNV for MAGEA3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MAGEA3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for MAGEA3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
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| COAD (tumor) | COAD (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
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| KICH (tumor) | KICH (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| MAGEA3, SUMO2, TRIM28, HTT, DNM1L (tumor) | MAGEA3, SUMO2, TRIM28, HTT, DNM1L (normal) |
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| TissGeneProg for MAGEA3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MAGEA3 |
| TissGeneDrug for MAGEA3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MAGEA3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025202 | melanoma | 25 | BeFree,LHGDN |
| umls:C2239176 | Liver carcinoma | 9 | BeFree,LHGDN |
| umls:C0153594 | Malignant neoplasm of testis | 8 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 7 | BeFree |
| umls:C0027819 | Neuroblastoma | 4 | BeFree |
| umls:C0278883 | Metastatic melanoma | 4 | BeFree |
| umls:C0700095 | Central neuroblastoma | 4 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,LHGDN |
| umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
| umls:C0019163 | Hepatitis B | 2 | BeFree |
| umls:C0041296 | Tuberculosis | 2 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0010674 | Cystic Fibrosis | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | LHGDN |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0036631 | Seminoma | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0206701 | Cystadenocarcinoma, Serous | 1 | BeFree |
| umls:C0220656 | Malignant ascites | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0276199 | Canarypox (disorder) | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0334471 | Round cell liposarcoma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0558356 | Malignant melanoma of eye | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
| umls:C0686377 | CNS metastases | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0729233 | Dissecting aneurysm of the thoracic aorta | 1 | BeFree |
| umls:C0740277 | Bile duct carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C2937421 | Prostatic Hyperplasia | 1 | LHGDN |
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