TissGeneSummary for MAGEA4 |
Gene summary |
Basic gene information | Gene symbol | MAGEA4 |
Gene name | melanoma antigen family A, 4 | |
Synonyms | CT1.4|MAGE-41|MAGE-X2|MAGE4|MAGE4A|MAGE4B | |
Cytomap | UCSC genome browser: Xq28 | |
Type of gene | protein-coding | |
RefGenes | NM_001011548.1, NM_001011549.1,NM_001011550.1,NM_002362.4, | |
Description | MAGE-4 antigenMAGE-41 antigenMAGE-X2 antigencancer/testis antigen 1.4cancer/testis antigen family 1, member 4melanoma-associated antigen 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300175 | |
HGNC : HGNC | ||
Ensembl : ENSG00000147381 | ||
HPRD : 02167 | ||
Vega : OTTHUMG00000024174 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAGEA4 | |
BioGPS: 4103 | ||
Pathway | NCI Pathway Interaction Database: MAGEA4 | |
KEGG: MAGEA4 | ||
REACTOME: MAGEA4 | ||
Pathway Commons: MAGEA4 | ||
Context | iHOP: MAGEA4 | |
ligand binding site mutation search in PubMed: MAGEA4 | ||
UCL Cancer Institute: MAGEA4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MAGEA4 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for MAGEA4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 3.859025896 | -1.956925084 | 5.81595098 | 1.60E-11 | 6.52E-11 |
LUAD | -1.90272549 | -3.025322042 | 1.122596552 | 0.00664 | 0.012329073 |
HNSC | 2.007792153 | -1.822482266 | 3.830274419 | 2.74E-05 | 0.000141076 |
Top |
TissGene-miRNA for MAGEA4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for MAGEA4 |
TissGeneSNV for MAGEA4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M161I | SKCM | 2 |
p.P100L | SKCM | 2 |
p.E17Q | LUSC | 1 |
p.R269C | BRCA | 1 |
p.E315* | LUSC | 1 |
p.Q83R | STAD | 1 |
p.V26L | LUSC | 1 |
p.V54M | HNSC | 1 |
p.Q29K | LUAD | 1 |
p.L46V | LGG | 1 |
p.A173T | COAD | 1 |
p.R299C | UCS | 1 |
p.Y284N | HNSC | 1 |
p.P198S | SKCM | 1 |
p.R277M | LGG | 1 |
p.R123H | STAD | 1 |
p.P55S | LGG | 1 |
p.T248A | STAD | 1 |
p.Q195* | SKCM | 1 |
p.Y187C | LUSC | 1 |
p.E34K | BLCA | 1 |
p.P66S | SKCM | 1 |
p.R299H | LUAD | 1 |
p.A217D | LUAD | 1 |
p.E254X | THYM | 1 |
p.I76N | LUAD | 1 |
p.L25M | LUAD | 1 |
p.P149S | SKCM | 1 |
p.R235K | STAD | 1 |
p.S89N | LUAD | 1 |
p.R299C | SKCM | 1 |
p.K160N | KIRC | 1 |
p.R244M | STAD | 1 |
p.D188N | SKCM | 1 |
p.I151N | OV | 1 |
p.A278S | DLBC | 1 |
p.P45S | SKCM | 1 |
p.P149L | COAD | 1 |
p.P48T | PRAD | 1 |
p.E92V | UCEC | 1 |
p.A211E | LUAD | 1 |
p.E53K | SKCM | 1 |
p.I12V | BRCA | 1 |
p.E225K | LUAD | 1 |
p.F197Y | SKCM | 1 |
p.V206I | UCEC | 1 |
p.A39S | LUAD | 1 |
p.R126* | SKCM | 1 |
p.E271K | SKCM | 1 |
p.E94K | UCEC | 1 |
p.K133Q | UCEC | 1 |
p.S43F | SKCM | 1 |
p.E86D | LGG | 1 |
p.R306C | CESC | 1 |
p.A280V | KIRP | 1 |
p.E220Q | ESCA | 1 |
p.E315V | LUAD | 1 |
p.E103Q | SARC | 1 |
p.H119Y | SKCM | 1 |
p.R299C | GBM | 1 |
p.Q249H | STAD | 1 |
p.A28V | LGG | 1 |
p.E52D | LUSC | 1 |
p.P96Q | LUSC | 1 |
p.P55S | UCEC | 1 |
p.G201S | SKCM | 1 |
p.R299C | PRAD | 1 |
p.S156F | SKCM | 1 |
p.Q195X | SKCM | 1 |
p.R299H | UCEC | 1 |
p.T248I | SKCM | 1 |
p.G264C | BLCA | 1 |
p.S186F | SKCM | 1 |
p.A268V | UCEC | 1 |
p.D215E | LUAD | 1 |
p.E314V | LIHC | 1 |
p.C182* | LUAD | 1 |
Top |
TissGeneCNV for MAGEA4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for MAGEA4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW951504 | MAGEA4-SMPD1 | chrX:151092837 | chr11:6413115 |
Top |
TissGeneNet for MAGEA4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for MAGEA4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for MAGEA4 |
TissGeneDrug for MAGEA4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for MAGEA4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0153594 | Malignant neoplasm of testis | 3 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree,LHGDN |
umls:C0025202 | melanoma | 2 | BeFree,GAD |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | LHGDN |
umls:C0007138 | Carcinoma, Transitional Cell | 1 | LHGDN |
umls:C0007140 | Carcinosarcoma | 1 | LHGDN |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C2937421 | Prostatic Hyperplasia | 1 | LHGDN |