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| TissGeneSummary for MAGEA8 |
 Gene summary |
| Basic gene information | Gene symbol | MAGEA8 |
| Gene name | melanoma antigen family A, 8 | |
| Synonyms | CT1.8|MAGE8 | |
| Cytomap | UCSC genome browser: Xq28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001166400.1, NM_001166401.1,NM_005364.4, | |
| Description | MAGE-8 antigencancer/testis antigen 1.8cancer/testis antigen family 1, member 8melanoma-associated antigen 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300341 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000156009 | ||
| HPRD : 02278 | ||
| Vega : OTTHUMG00000022635 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAGEA8 | |
| BioGPS: 4107 | ||
| Pathway | NCI Pathway Interaction Database: MAGEA8 | |
| KEGG: MAGEA8 | ||
| REACTOME: MAGEA8 | ||
| Pathway Commons: MAGEA8 | ||
| Context | iHOP: MAGEA8 | |
| ligand binding site mutation search in PubMed: MAGEA8 | ||
| UCL Cancer Institute: MAGEA8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
| Reference showing the relevant tissue of MAGEA8 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MAGEA8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -0.819684369 | -2.280210369 | 1.460526 | 0.000271 | 0.000841806 |
| LUSC | -1.014630918 | -2.073209349 | 1.058578431 | 0.00012 | 0.000246345 |
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| TissGene-miRNA for MAGEA8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MAGEA8 |
| TissGeneSNV for MAGEA8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q128* | SKCM | 2 |
| p.R121C | SKCM | 2 |
| p.R109W | STAD | 1 |
| p.A264V | GBM | 1 |
| p.R262C | LUAD | 1 |
| p.P269H | STAD | 1 |
| p.E85K | CESC | 1 |
| p.G266D | PAAD | 1 |
| p.V294I | PAAD | 1 |
| p.V230L | LGG | 1 |
| p.T73N | LUAD | 1 |
| p.P151L | LUAD | 1 |
| p.R9C | UCEC | 1 |
| p.A18T | LUAD | 1 |
| p.K126Q | UCEC | 1 |
| p.H149Q | UCEC | 1 |
| p.R301C | READ | 1 |
| p.T199K | LGG | 1 |
| p.L50I | LUAD | 1 |
| p.Q128X | SKCM | 1 |
| p.I212N | LUAD | 1 |
| p.S306F | DLBC | 1 |
| p.C160R | LUSC | 1 |
| p.E171D | LUAD | 1 |
| p.S83F | LUAD | 1 |
| p.E14K | SKCM | 1 |
| p.R271H | LUAD | 1 |
| p.S87Y | LUAD | 1 |
| p.D84V | BLCA | 1 |
| p.R125H | UCS | 1 |
| p.W80C | COAD | 1 |
| p.G232R | UCEC | 1 |
| p.G48E | SKCM | 1 |
| p.E291D | UCEC | 1 |
| p.D173N | UCEC | 1 |
| p.E171K | SKCM | 1 |
| p.Y258N | LGG | 1 |
| p.W80S | HNSC | 1 |
| p.V241A | BRCA | 1 |
| p.A298S | LUAD | 1 |
| p.S81R | LUAD | 1 |
| p.R109W | SKCM | 1 |
| p.R262C | ESCA | 1 |
| p.P220S | SKCM | 1 |
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| TissGeneCNV for MAGEA8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MAGEA8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA831846 | YLPM1-MAGEA8 | chr14:75264461 | chrX:149009985 |
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| TissGeneNet for MAGEA8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for MAGEA8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MAGEA8 |
| TissGeneDrug for MAGEA8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MAGEA8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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