TissGeneSummary for MAL |
Gene summary |
Basic gene information | Gene symbol | MAL |
Gene name | mal, T-cell differentiation protein | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q11.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002371.3, NM_022438.2,NM_022439.2,NM_022440.2, | |
Description | T-lymphocyte maturation-associated proteinmyelin and lymphocyte protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 188860 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172005 | ||
HPRD : 01789 | ||
Vega : OTTHUMG00000132011 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAL | |
BioGPS: 4118 | ||
Pathway | NCI Pathway Interaction Database: MAL | |
KEGG: MAL | ||
REACTOME: MAL | ||
Pathway Commons: MAL | ||
Context | iHOP: MAL | |
ligand binding site mutation search in PubMed: MAL | ||
UCL Cancer Institute: MAL | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
Reference showing the relevant tissue of MAL | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MAL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.951950686 | 1.593865001 | -2.545815686 | 1.35E-13 | 6.89E-13 |
KIRC | 1.190370229 | 6.448345229 | -5.257975 | 2.79E-30 | 5.39E-29 |
HNSC | -0.135787393 | 6.552107955 | -6.687895349 | 5.43E-15 | 4.21E-13 |
STAD | -0.918084632 | 3.925537243 | -4.843621875 | 1.55E-07 | 3.83E-06 |
COAD | -3.903867805 | 0.065201426 | -3.969069231 | 7.38E-15 | 3.76E-13 |
KIRP | 3.319355993 | 6.643412243 | -3.32405625 | 6.64E-07 | 3.52E-06 |
LUAD | -0.336642606 | 1.433345325 | -1.769987931 | 4.68E-12 | 3.42E-11 |
PRAD | -2.445325497 | -0.124131266 | -2.321194231 | 1.24E-14 | 1.43E-12 |
ESCA | -2.470568155 | 4.002050027 | -6.472618182 | 9.04E-06 | 0.000913862 |
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TissGene-miRNA for MAL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MAL |
TissGeneSNV for MAL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Y73C | PCPG | 1 |
p.A143V | COAD | 1 |
p.I74V | PCPG | 1 |
p.T112M | COAD | 1 |
p.R120M | COAD | 1 |
p.L147S | STAD | 1 |
p.G79V | STAD | 1 |
p.V140M | LIHC | 1 |
p.S132F | SARC | 1 |
p.A89T | HNSC | 1 |
p.W150* | SKCM | 1 |
p.H121Q | LUAD | 1 |
p.S152F | BLCA | 1 |
p.G34R | PRAD | 1 |
p.V140M | ESCA | 1 |
p.W54L | UCEC | 1 |
p.A95T | PAAD | 1 |
p.A65G | STAD | 1 |
p.P47S | HNSC | 1 |
p.S43T | COAD | 1 |
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TissGeneCNV for MAL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MAL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW950587 | MAL-RGL1 | chr2:95719550 | chr1:183896740 | |
Chimerdb3.0 | ChiTaRs | NA | BF751667 | MAL-CSNK1D | chr2:95705948 | chr17:80218040 | |
Chimerdb3.0 | FusionScan | UCEC | TCGA-AX-A1C7-01A | AACS-MAL | Out-of-Frame | chr12:125561157 | chr2:95713703 |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-7177-11A | MAL-KRT4 | Out-of-Frame | chr2:95719136 | chr12:53205700 |
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TissGeneNet for MAL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MAL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MAL |
TissGeneDrug for MAL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MAL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 6 | BeFree |
umls:C0023462 | Acute Megakaryocytic Leukemias | 5 | BeFree |
umls:C0596263 | Carcinogenesis | 5 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 4 | BeFree |
umls:C1292754 | Mediastinal (Thymic) Large B-Cell Lymphoma | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree,CTD_human,LHGDN |
umls:C0023467 | Leukemia, Myelocytic, Acute | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
umls:C0152018 | Esophageal carcinoma | 3 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 3 | BeFree |
umls:C0302592 | Cervix carcinoma | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C2239176 | Liver carcinoma | 3 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | GAD,LHGDN |
umls:C0007867 | Cervix Diseases | 2 | BeFree |
umls:C0013080 | Down Syndrome | 2 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
umls:C0023903 | Liver neoplasms | 2 | BeFree |
umls:C0024530 | Malaria | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0349459 | Cervical intraepithelial neoplasia grade 2 | 2 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree,GAD |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
umls:C0001430 | Adenoma | 1 | LHGDN |
umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
umls:C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
umls:C0018852 | Heavy Chain Disease | 1 | BeFree |
umls:C0019829 | Hodgkin Disease | 1 | BeFree |
umls:C0022548 | Keloid | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0041107 | Trisomy | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0598766 | Leukemogenesis | 1 | BeFree |
umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
umls:C0858320 | Plasmodium ovale infection | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1333064 | Classical Hodgkin's Lymphoma | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | CTD_human,LHGDN |