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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MAT1A
check button Gene summary
Basic gene informationGene symbolMAT1A
Gene namemethionine adenosyltransferase I, alpha
SynonymsMAT|MATA1|SAMS|SAMS1
CytomapUCSC genome browser: 10q22
Type of geneprotein-coding
RefGenesNM_000429.2,
DescriptionMAT 1MAT-I/IIIS-adenosylmethionine synthase isoform type-1S-adenosylmethionine synthetase isoform type-1adoMet synthase 1adoMet synthetase 1methionine adenosyltransferase 1methionine adenosyltransferase I/III
Modification date20141207
dbXrefs MIM : 610550
HGNC : HGNC
Ensembl : ENSG00000151224
HPRD : 02013
Vega : OTTHUMG00000018613
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAT1A
BioGPS: 4143
PathwayNCI Pathway Interaction Database: MAT1A
KEGG: MAT1A
REACTOME: MAT1A
Pathway Commons: MAT1A
ContextiHOP: MAT1A
ligand binding site mutation search in PubMed: MAT1A
UCL Cancer Institute: MAT1A
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of MAT1ALiver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. Torres L, Avila MA, Carretero MV, Latasa MU, Caballería J, López-Rodas G, Boukaba A, Lu SC, Franco L, Mato JM. FASEB J. 2000 Jan;14(1):95-102. (pmid:10627284)
go to article
Description by TissGene annotationsTissgsKTS
CNV lost TissGeneKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for MAT1A

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-0.8920220491.705197951-2.597222.15E-067.63E-06
PRAD-2.862294203-1.397436511-1.4648576929.52E-076.82E-06
LIHC9.13227795111.46322195-2.3309443.21E-093.17E-08
THCA-2.232301439-0.328670931-1.9036305086.01E-093.07E-08
KIRC-0.8140730491.192558895-2.0066319448.67E-082.43E-07
COAD-0.175882665-1.6581095881.4822269230.003570.008898601


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TissGene-miRNA for MAT1A

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MAT1A
TissGeneSNV for MAT1A

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E211KSKCM2
p.P197SSKCM2
p.L364VSKCM1
p.P174HLIHC1
p.L167RUCEC1
p.E23KSTAD1
p.W175RSKCM1
p.V359IBRCA1
p.M150LSTAD1
p.V77ELUAD1
p.D39ESTAD1
p.H277RCOAD1
p.Y320NLIHC1
p.S170CHNSC1
p.K159NLUAD1
p.Q245HCOAD1
p.R249WESCA1
p.R219CCOAD1
p.P30LSTAD1
p.G69DLUAD1
p.V198LPRAD1
p.D93NBLCA1
p.D85NSKCM1
p.R343*PRAD1
p.L222PUCEC1
p.V5ALIHC1
p.R169CSTAD1
p.G248VSTAD1
p.V241ITHCA1
p.Q208HLUAD1
p.R219CSTAD1
p.G253*UCEC1
p.R163QLAML1
p.V361FLUAD1
p.E128KBLCA1
p.R292CCESC1
p.G63RSKCM1
p.L160FLUSC1
p.R169HUCEC1
p.W387SBLCA1
p.P390SSKCM1
p.A259VCOAD1
p.R219CPRAD1
p.T341KLIHC1
p.R312WGBM1
p.G26RSKCM1
p.R169SKIRP1
p.S206ALIHC1
p.K47*LUAD1
p.I252VLIHC1
p.V204ICOAD1
p.Y188*BLCA1
p.R343QGBM1


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TissGeneCNV for MAT1A

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MAT1A

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADABRCATCGA-AN-A0AJ-01ASTK39-MAT1AOut-of-frameChr2:168931492Chr10:82045345


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TissGeneNet for MAT1A

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for MAT1A

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MAT1A
TissGeneDrug for MAT1A

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00118S-AdenosylmethionineCofactorSmall moleculeApproved|Nutraceutical


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TissGeneDisease for MAT1A

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C2239176Liver carcinoma22BeFree,CTD_human
umls:C0268621Hepatic methionine adenosyltransferase deficiency10BeFree,CTD_human,MGD,ORPHANET,UNIPROT
umls:C0023364Leptospirosis5BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C0600139Prostate carcinoma4BeFree
umls:C0023903Liver neoplasms3BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma3BeFree
umls:C0345904Malignant neoplasm of liver3BeFree
umls:C1512409Hepatocarcinogenesis3BeFree
umls:C1516170Cancer Cell Growth3BeFree
umls:C0002514Amino Acid Metabolism, Inborn Errors2CTD_human
umls:C0025517Metabolic Diseases2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0027819Neuroblastoma2BeFree
umls:C0341439Chronic liver disease2BeFree
umls:C0700095Central neuroblastoma2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C1865361SHORT STATURE, AUDITORY CANAL ATRESIA, MANDIBULAR HYPOPLASIA, SKELETAL ABNORMALITIES2BeFree
umls:C2711227Steatohepatitis2BeFree
umls:C3669246Mammary adenocarcinoma2BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0006111Brain Diseases1CTD_human
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0008924Cleft Lip1GAD
umls:C0008925Cleft Palate1GAD
umls:C0011303Demyelinating Diseases1CTD_human
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
umls:C0015695Fatty Liver1CTD_human
umls:C0019208Hepatoma, Novikoff1BeFree
umls:C0019880Homocystinuria1BeFree
umls:C0020507Hyperplasia1CTD_human
umls:C0020538Hypertensive disease1BeFree,GAD
umls:C0023890Liver Cirrhosis1BeFree
umls:C0025521Inborn Errors of Metabolism1BeFree
umls:C0030587Paroxysmal atrial tachycardia1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0038454Cerebrovascular accident1BeFree
umls:C0039538Teratoma1BeFree
umls:C0080178Spina Bifida1GAD
umls:C0162872Aortic Aneurysm, Thoracic1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0268490Tyrosinemia, Type I1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0751202Cystathionine beta-Synthase Deficiency Disease1BeFree
umls:C1264606Persistent infection1BeFree
umls:C1368683Epithelioma1BeFree
umls:C1512981Mammary Tumorigenesis1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C1863535INTELLIGENCE QUANTITATIVE TRAIT LOCUS 11BeFree
umls:C1979904Hypermethioninemias1BeFree
umls:C2718067Alcoholic Steatohepatitis1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree