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| TissGeneSummary for MAT1A |
 Gene summary |
| Basic gene information | Gene symbol | MAT1A |
| Gene name | methionine adenosyltransferase I, alpha | |
| Synonyms | MAT|MATA1|SAMS|SAMS1 | |
| Cytomap | UCSC genome browser: 10q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000429.2, | |
| Description | MAT 1MAT-I/IIIS-adenosylmethionine synthase isoform type-1S-adenosylmethionine synthetase isoform type-1adoMet synthase 1adoMet synthetase 1methionine adenosyltransferase 1methionine adenosyltransferase I/III | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610550 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151224 | ||
| HPRD : 02013 | ||
| Vega : OTTHUMG00000018613 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAT1A | |
| BioGPS: 4143 | ||
| Pathway | NCI Pathway Interaction Database: MAT1A | |
| KEGG: MAT1A | ||
| REACTOME: MAT1A | ||
| Pathway Commons: MAT1A | ||
| Context | iHOP: MAT1A | |
| ligand binding site mutation search in PubMed: MAT1A | ||
| UCL Cancer Institute: MAT1A | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of MAT1A | Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. Torres L, Avila MA, Carretero MV, Latasa MU, Caballería J, López-Rodas G, Boukaba A, Lu SC, Franco L, Mato JM. FASEB J. 2000 Jan;14(1):95-102. (pmid:10627284) go to article | |
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MAT1A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.892022049 | 1.705197951 | -2.59722 | 2.15E-06 | 7.63E-06 |
| PRAD | -2.862294203 | -1.397436511 | -1.464857692 | 9.52E-07 | 6.82E-06 |
| LIHC | 9.132277951 | 11.46322195 | -2.330944 | 3.21E-09 | 3.17E-08 |
| THCA | -2.232301439 | -0.328670931 | -1.903630508 | 6.01E-09 | 3.07E-08 |
| KIRC | -0.814073049 | 1.192558895 | -2.006631944 | 8.67E-08 | 2.43E-07 |
| COAD | -0.175882665 | -1.658109588 | 1.482226923 | 0.00357 | 0.008898601 |
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| TissGene-miRNA for MAT1A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MAT1A |
| TissGeneSNV for MAT1A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E211K | SKCM | 2 |
| p.P197S | SKCM | 2 |
| p.L364V | SKCM | 1 |
| p.P174H | LIHC | 1 |
| p.L167R | UCEC | 1 |
| p.E23K | STAD | 1 |
| p.W175R | SKCM | 1 |
| p.V359I | BRCA | 1 |
| p.M150L | STAD | 1 |
| p.V77E | LUAD | 1 |
| p.D39E | STAD | 1 |
| p.H277R | COAD | 1 |
| p.Y320N | LIHC | 1 |
| p.S170C | HNSC | 1 |
| p.K159N | LUAD | 1 |
| p.Q245H | COAD | 1 |
| p.R249W | ESCA | 1 |
| p.R219C | COAD | 1 |
| p.P30L | STAD | 1 |
| p.G69D | LUAD | 1 |
| p.V198L | PRAD | 1 |
| p.D93N | BLCA | 1 |
| p.D85N | SKCM | 1 |
| p.R343* | PRAD | 1 |
| p.L222P | UCEC | 1 |
| p.V5A | LIHC | 1 |
| p.R169C | STAD | 1 |
| p.G248V | STAD | 1 |
| p.V241I | THCA | 1 |
| p.Q208H | LUAD | 1 |
| p.R219C | STAD | 1 |
| p.G253* | UCEC | 1 |
| p.R163Q | LAML | 1 |
| p.V361F | LUAD | 1 |
| p.E128K | BLCA | 1 |
| p.R292C | CESC | 1 |
| p.G63R | SKCM | 1 |
| p.L160F | LUSC | 1 |
| p.R169H | UCEC | 1 |
| p.W387S | BLCA | 1 |
| p.P390S | SKCM | 1 |
| p.A259V | COAD | 1 |
| p.R219C | PRAD | 1 |
| p.T341K | LIHC | 1 |
| p.R312W | GBM | 1 |
| p.G26R | SKCM | 1 |
| p.R169S | KIRP | 1 |
| p.S206A | LIHC | 1 |
| p.K47* | LUAD | 1 |
| p.I252V | LIHC | 1 |
| p.V204I | COAD | 1 |
| p.Y188* | BLCA | 1 |
| p.R343Q | GBM | 1 |
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| TissGeneCNV for MAT1A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MAT1A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0AJ-01A | STK39-MAT1A | Out-of-frame | Chr2:168931492 | Chr10:82045345 |
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| TissGeneNet for MAT1A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for MAT1A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MAT1A |
| TissGeneDrug for MAT1A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00118 | S-Adenosylmethionine | Cofactor | Small molecule | Approved|Nutraceutical |
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| TissGeneDisease for MAT1A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 22 | BeFree,CTD_human |
| umls:C0268621 | Hepatic methionine adenosyltransferase deficiency | 10 | BeFree,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0023364 | Leptospirosis | 5 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree |
| umls:C0600139 | Prostate carcinoma | 4 | BeFree |
| umls:C0023903 | Liver neoplasms | 3 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 3 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 3 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 3 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 3 | BeFree |
| umls:C0002514 | Amino Acid Metabolism, Inborn Errors | 2 | CTD_human |
| umls:C0025517 | Metabolic Diseases | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0027819 | Neuroblastoma | 2 | BeFree |
| umls:C0341439 | Chronic liver disease | 2 | BeFree |
| umls:C0700095 | Central neuroblastoma | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C1865361 | SHORT STATURE, AUDITORY CANAL ATRESIA, MANDIBULAR HYPOPLASIA, SKELETAL ABNORMALITIES | 2 | BeFree |
| umls:C2711227 | Steatohepatitis | 2 | BeFree |
| umls:C3669246 | Mammary adenocarcinoma | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0006111 | Brain Diseases | 1 | CTD_human |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0008924 | Cleft Lip | 1 | GAD |
| umls:C0008925 | Cleft Palate | 1 | GAD |
| umls:C0011303 | Demyelinating Diseases | 1 | CTD_human |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| umls:C0015695 | Fatty Liver | 1 | CTD_human |
| umls:C0019208 | Hepatoma, Novikoff | 1 | BeFree |
| umls:C0019880 | Homocystinuria | 1 | BeFree |
| umls:C0020507 | Hyperplasia | 1 | CTD_human |
| umls:C0020538 | Hypertensive disease | 1 | BeFree,GAD |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 1 | BeFree |
| umls:C0030587 | Paroxysmal atrial tachycardia | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0039538 | Teratoma | 1 | BeFree |
| umls:C0080178 | Spina Bifida | 1 | GAD |
| umls:C0162872 | Aortic Aneurysm, Thoracic | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0268490 | Tyrosinemia, Type I | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0751202 | Cystathionine beta-Synthase Deficiency Disease | 1 | BeFree |
| umls:C1264606 | Persistent infection | 1 | BeFree |
| umls:C1368683 | Epithelioma | 1 | BeFree |
| umls:C1512981 | Mammary Tumorigenesis | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C1863535 | INTELLIGENCE QUANTITATIVE TRAIT LOCUS 1 | 1 | BeFree |
| umls:C1979904 | Hypermethioninemias | 1 | BeFree |
| umls:C2718067 | Alcoholic Steatohepatitis | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
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