TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MBL2

Gene summary

Basic gene information	Gene symbol	MBL2
	Gene name	mannose-binding lectin (protein C) 2, soluble
	Synonyms	COLEC1\|HSMBPC\|MBL\|MBL2D\|MBP\|MBP-C\|MBP1\|MBPD
	Cytomap	UCSC genome browser: 10q11.2
	Type of gene	protein-coding
	RefGenes	NM_000242.2,
	Description	collectin-1mannan-binding lectinmannose-binding lectin (protein C) 2, soluble (opsonic defect)mannose-binding lectin 2, soluble (opsonic defect)mannose-binding protein C
	Modification date	20141207
dbXrefs	MIM : 154545
	HGNC : HGNC
	Ensembl : ENSG00000165471
	HPRD : 01107
	Vega : OTTHUMG00000150270
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MBL2
	BioGPS: 4153
Pathway	NCI Pathway Interaction Database: MBL2
	KEGG: MBL2
	REACTOME: MBL2
	Pathway Commons: MBL2
Context	iHOP: MBL2
	ligand binding site mutation search in PubMed: MBL2
	UCL Cancer Institute: MBL2
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	HPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of MBL2
Description by TissGene annotations

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0001867	complement activation, lectin pathway	15148336
GO:0044130	negative regulation of growth of symbiont in host	15148336
GO:0045087	innate immune response	23544079
GO:0048525	negative regulation of viral process	23544079
GO:0050830	defense response to Gram-positive bacterium	15148336
GO:0001867	complement activation, lectin pathway	15148336
GO:0044130	negative regulation of growth of symbiont in host	15148336
GO:0045087	innate immune response	23544079
GO:0048525	negative regulation of viral process	23544079
GO:0050830	defense response to Gram-positive bacterium	15148336

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TissGeneExp for MBL2

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LIHC	8.572680957	11.50036096	-2.92768	3.23E-09	3.17E-08

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TissGene-miRNA for MBL2

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for MBL2

TissGeneSNV for MBL2

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.P82S	SKCM	2
p.G98E	SKCM	2
p.S161Y	COAD	1
p.E21*	LUSC	1
p.E210D	LUAD	1
p.G54D	COAD	1
p.P247L	STAD	1
p.S2Y	GBM	1
p.L107M	LUSC	1
p.W125*	LUAD	1
p.A120T	COAD	1
p.F246V	DLBC	1
p.P84L	SKCM	1
p.G74E	SKCM	1
p.L10F	SKCM	1
p.P8H	ESCA	1
p.S110*	HNSC	1
p.D104Y	LUAD	1
p.G172E	LUSC	1
p.L225P	KIRP	1
p.A242T	OV	1
p.T24N	LUAD	1
p.I43M	BLCA	1
p.G217D	LUAD	1
p.T55A	LGG	1
p.G229D	UCEC	1
p.S40F	SKCM	1
p.K227T	READ	1
p.I43F	LUAD	1
p.D188Y	ESCA	1
p.D53Y	LUAD	1
p.P101L	UCEC	1
p.G200E	SKCM	1
p.G74E	LGG	1
p.S2F	SKCM	1
p.G71D	LUAD	1
p.K99R	SKCM	1
p.E144K	LUAD	1
p.E170D	COAD	1
p.T117I	LUSC	1
p.P41L	LUAD	1
p.P247H	THYM	1
p.D102N	SKCM	1
p.E149K	SKCM	1
p.T127I	UCEC	1
p.G57R	SKCM	1
p.C236Y	KIRC	1
p.C32F	ESCA	1
p.P82L	SARC	1
p.A37S	LUAD	1
p.G135R	HNSC	1
p.V243I	STAD	1
p.T206P	BRCA	1
p.L198M	LUAD	1
p.R121C	UCEC	1
p.E111X	ESCA	1

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TissGeneCNV for MBL2

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for MBL2

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for MBL2

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

COAD (tumor)	COAD (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

HNSC (tumor)	HNSC (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

KICH (tumor)	KICH (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

KIRC (tumor)	KIRC (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

KIRP (tumor)	KIRP (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

LIHC (tumor)	LIHC (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

LUAD (tumor)	LUAD (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

LUSC (tumor)	LUSC (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

PRAD (tumor)	PRAD (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

STAD (tumor)	STAD (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

THCA (tumor)	THCA (normal)
MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (tumor)	MBL2, PTPRC, KRT1, LY96, APCS, CALR, MAD2L1, CALCR, TLR4, CD93, MASP2, PTX3, MASP1 (normal)

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TissGeneProg for MBL2

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for MBL2

TissGeneDrug for MBL2

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for MBL2

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0024141	Lupus Erythematosus, Systemic	50	BeFree,GAD,LHGDN
umls:C0019693	HIV Infections	43	BeFree,CTD_human,GAD,LHGDN
umls:C3280586	Mannose-Binding Protein Deficiency	37	BeFree
umls:C0004364	Autoimmune Diseases	31	BeFree,GAD,LHGDN
umls:C0243026	Sepsis	30	BeFree,GAD,LHGDN
umls:C0041296	Tuberculosis	29	BeFree,GAD,LHGDN
umls:C0003873	Rheumatoid Arthritis	27	BeFree,GAD,LHGDN
umls:C0036690	Septicemia	25	BeFree
umls:C3714514	Infection	21	CTD_human,GAD,LHGDN
umls:C0010674	Cystic Fibrosis	20	BeFree,GAD
umls:C0035243	Respiratory Tract Infections	20	BeFree,GAD,LHGDN
umls:C0004623	Bacterial Infections	19	BeFree,GAD,LHGDN
umls:C0042769	Virus Diseases	16	BeFree,GAD
umls:C0019163	Hepatitis B	15	BeFree,GAD,LHGDN
umls:C0032285	Pneumonia	15	BeFree,GAD
umls:C0004096	Asthma	14	BeFree,GAD,LHGDN
umls:C0041327	Tuberculosis, Pulmonary	14	BeFree,GAD
umls:C0019196	Hepatitis C	13	BeFree,GAD
umls:C0024115	Lung diseases	13	BeFree,GAD,LHGDN
umls:C0025303	Meningococcal Infections	13	BeFree,GAD
umls:C0026769	Multiple Sclerosis	13	BeFree
umls:C1846064	Recurrent infections (sinusitis and bacterial pneumonia and meningitis)	13	BeFree
umls:C0003850	Arteriosclerosis	12	BeFree,GAD
umls:C0004153	Atherosclerosis	12	BeFree,GAD
umls:C0024530	Malaria	12	BeFree,GAD,LHGDN
umls:C0010346	Crohn Disease	10	BeFree,GAD,LHGDN
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	10	BeFree,GAD
umls:C0007222	Cardiovascular Diseases	9	BeFree,GAD,LHGDN
umls:C0023890	Liver Cirrhosis	9	BeFree,GAD
umls:C0524909	Hepatitis B, Chronic	9	BeFree,GAD
umls:C2239176	Liver carcinoma	9	BeFree,GAD,LHGDN
umls:C0004610	Bacteremia	8	BeFree,GAD
umls:C0009324	Ulcerative Colitis	8	BeFree,GAD
umls:C0022116	Ischemia	8	BeFree,GAD
umls:C0409974	Lupus Erythematosus	8	BeFree,GAD
umls:C0010823	Cytomegalovirus Infections	7	BeFree,GAD
umls:C0023895	Liver diseases	7	BeFree,GAD
umls:C0151526	Premature Birth	7	CTD_human,GAD
umls:C0021368	Inflammation	6	GAD,LHGDN
umls:C0023343	Leprosy	6	BeFree,GAD
umls:C0026691	Mucocutaneous Lymph Node Syndrome	6	BeFree,GAD,LHGDN
umls:C0026946	Mycoses	6	BeFree
umls:C0027947	Neutropenia	6	BeFree,GAD
umls:C0029882	Otitis Media	6	BeFree,GAD,LHGDN
umls:C0700345	Candidiasis, Vulvovaginal	6	BeFree,GAD,LHGDN
umls:C0746883	Febrile Neutropenia	6	BeFree
umls:C1175175	Severe Acute Respiratory Syndrome	6	BeFree,GAD
umls:C0002895	Anemia, Sickle Cell	5	BeFree,GAD
umls:C0006142	Malignant neoplasm of breast	5	BeFree,GAD
umls:C0011881	Diabetic Nephropathy	5	BeFree
umls:C0024138	Lupus Erythematosus, Discoid	5	BeFree,GAD
umls:C0024535	Malaria, Falciparum	5	BeFree,GAD
umls:C0032269	Pneumococcal Infections	5	BeFree,GAD,LHGDN
umls:C0032914	Pre-Eclampsia	5	GAD,LHGDN
umls:C0242966	Systemic Inflammatory Response Syndrome	5	BeFree,GAD,LHGDN
umls:C0275524	Coinfection	5	BeFree
umls:C0456103	Sepsis of the newborn	5	BeFree
umls:C0524910	Hepatitis C, Chronic	5	BeFree,GAD
umls:C0678222	Breast Carcinoma	5	BeFree
umls:C0694549	Community acquired pneumonia	5	BeFree
umls:C3665339	Bacterial sepsis of newborn	5	BeFree
umls:C3826128	Infection in children	5	BeFree
umls:C0001175	Acquired Immunodeficiency Syndrome	4	BeFree,GAD,LHGDN
umls:C0006840	Candidiasis	4	BeFree,GAD
umls:C0009402	Colorectal Carcinoma	4	BeFree
umls:C0009447	Common Variable Immunodeficiency	4	BeFree,GAD
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	4	BeFree,GAD
umls:C0013537	Eclampsia	4	BeFree
umls:C0014072	Experimental Autoimmune Encephalomyelitis	4	BeFree
umls:C0020538	Hypertensive disease	4	BeFree,GAD,LHGDN
umls:C0021053	Immune System Diseases	4	BeFree
umls:C0021390	Inflammatory Bowel Diseases	4	BeFree
umls:C0022658	Kidney Diseases	4	BeFree,GAD
umls:C0023290	Leishmaniasis, Visceral	4	BeFree,GAD,LHGDN
umls:C0023530	Leukopenia	4	BeFree
umls:C0023903	Liver neoplasms	4	BeFree
umls:C0024131	Lupus Vulgaris	4	BeFree,GAD
umls:C0025289	Meningitis	4	BeFree
umls:C0027051	Myocardial Infarction	4	BeFree,GAD,LHGDN
umls:C0033817	Pseudomonas Infections	4	GAD
umls:C0035439	Rheumatic Heart Disease	4	BeFree,GAD
umls:C0079487	Helicobacter Infections	4	GAD
umls:C0242379	Malignant neoplasm of lung	4	BeFree,GAD
umls:C0333186	Restenosis	4	BeFree
umls:C1527336	Sjogren's Syndrome	4	GAD
umls:C1719672	Severe Sepsis	4	BeFree
umls:C1956346	Coronary Artery Disease	4	BeFree,GAD
umls:C2827407	Infectious Otitis Media	4	BeFree
umls:C0003864	Arthritis	3	BeFree,GAD
umls:C0004031	Aspergillosis, Allergic Bronchopulmonary	3	BeFree
umls:C0004626	Pneumonia, Bacterial	3	GAD
umls:C0004943	Behcet Syndrome	3	BeFree,GAD,LHGDN
umls:C0006012	Borderline Personality Disorder	3	BeFree
umls:C0006267	Bronchiectasis	3	BeFree
umls:C0006287	Bronchopulmonary Dysplasia	3	BeFree,GAD
umls:C0007570	Celiac Disease	3	BeFree,GAD,LHGDN
umls:C0007789	Cerebral Palsy	3	BeFree,GAD,LHGDN
umls:C0010054	Coronary Arteriosclerosis	3	BeFree
umls:C0010068	Coronary heart disease	3	BeFree
umls:C0011615	Dermatitis, Atopic	3	BeFree,GAD,LHGDN
umls:C0011847	Diabetes	3	BeFree
umls:C0011849	Diabetes Mellitus	3	BeFree
umls:C0014457	Eosinophilia	3	BeFree
umls:C0017152	Gastritis	3	BeFree,GAD
umls:C0018133	Graft-vs-Host Disease	3	BeFree,GAD
umls:C0019348	Herpes Simplex Infections	3	BeFree
umls:C0024117	Chronic Obstructive Airway Disease	3	BeFree,GAD,LHGDN
umls:C0029883	Otitis Media with Effusion	3	BeFree
umls:C0031154	Peritonitis	3	BeFree
umls:C0032787	Postoperative Complications	3	GAD
umls:C0035220	Respiratory Distress Syndrome, Newborn	3	BeFree,GAD
umls:C0035436	Rheumatic Fever	3	BeFree,GAD,LHGDN
umls:C0036341	Schizophrenia	3	BeFree
umls:C0041912	Upper Respiratory Infections	3	BeFree
umls:C0042029	Urinary tract infection	3	BeFree,LHGDN
umls:C0042384	Vasculitis	3	BeFree,GAD
umls:C0042900	Vitiligo	3	BeFree,GAD
umls:C0085166	Bacterial Vaginosis	3	BeFree,GAD,LHGDN
umls:C0155862	Streptococcal pneumonia	3	BeFree,GAD
umls:C0206171	Community-Acquired Infections	3	GAD
umls:C0242656	Disease Progression	3	LHGDN
umls:C0343641	Human papilloma virus infection	3	BeFree
umls:C0596263	Carcinogenesis	3	BeFree
umls:C0684249	Carcinoma of lung	3	BeFree
umls:C0948192	Primary infection NOS	3	BeFree
umls:C1306759	Eosinophilic disorder	3	BeFree
umls:C1512326	Human T-cell lymphotropic virus 1 infection	3	BeFree,GAD
umls:C1527249	Colorectal Cancer	3	BeFree,GAD
umls:C1623038	Cirrhosis	3	BeFree
umls:C1636667	Disorder characterized by eosinophilia	3	BeFree
umls:C3151085	MASP2 Deficiency	3	BeFree
umls:C3495559	Juvenile arthritis	3	BeFree,GAD
umls:C3714757	Juvenile rheumatoid arthritis	3	BeFree
umls:C0001349	Acute-Phase Reaction	2	GAD
umls:C0002395	Alzheimer's Disease	2	BeFree
umls:C0002871	Anemia	2	BeFree,GAD,LHGDN
umls:C0006271	Bronchiolitis	2	BeFree
umls:C0006272	Bronchiolitis Obliterans	2	BeFree,GAD
umls:C0006274	Bronchiolitis, Viral	2	GAD
umls:C0007115	Malignant neoplasm of thyroid	2	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	2	BeFree
umls:C0007282	Carotid Stenosis	2	GAD
umls:C0007682	CNS disorder	2	BeFree,GAD
umls:C0007847	Malignant tumor of cervix	2	BeFree
umls:C0010418	Cryptosporidiosis	2	BeFree,GAD
umls:C0011311	Dengue Fever	2	BeFree,GAD
umls:C0011334	Dental caries	2	BeFree,GAD
umls:C0011991	Diarrhea	2	BeFree
umls:C0012739	Disseminated Intravascular Coagulation	2	BeFree
umls:C0013595	Eczema	2	BeFree
umls:C0015934	Fetal Growth Retardation	2	GAD,LHGDN
umls:C0015967	Fever	2	GAD
umls:C0016059	Fibrosis	2	LHGDN
umls:C0017638	Glioma	2	BeFree
umls:C0017661	IGA Glomerulonephritis	2	BeFree,GAD
umls:C0018213	Graves Disease	2	BeFree,GAD
umls:C0020517	Hypersensitivity	2	GAD
umls:C0021051	Immunologic Deficiency Syndromes	2	BeFree
umls:C0021400	Influenza	2	BeFree
umls:C0022661	Kidney Failure, Chronic	2	BeFree
umls:C0023348	Leprosy, Lepromatous	2	BeFree
umls:C0023434	Chronic Lymphocytic Leukemia	2	BeFree
umls:C0023452	Leukemia, Lymphocytic, Acute, L1	2	BeFree
umls:C0024301	Lymphoma, Follicular	2	BeFree
umls:C0024305	Lymphoma, Non-Hodgkin	2	BeFree,GAD
umls:C0024623	Malignant neoplasm of stomach	2	BeFree
umls:C0025268	Multiple Endocrine Neoplasia Type 2a	2	BeFree
umls:C0025306	Meningococcemia	2	BeFree
umls:C0026269	Mitral Valve Stenosis	2	BeFree
umls:C0026764	Multiple Myeloma	2	BeFree,GAD
umls:C0027697	Nephritis	2	BeFree
umls:C0028754	Obesity	2	BeFree
umls:C0028945	oligodendroglioma	2	BeFree
umls:C0029118	Opportunistic Infections	2	BeFree,GAD
umls:C0029925	Ovarian Carcinoma	2	BeFree
umls:C0031099	Periodontitis	2	BeFree,GAD
umls:C0032300	Lobar Pneumonia	2	BeFree
umls:C0032965	Pregnancy Complications, Infectious	2	GAD
umls:C0035126	Reperfusion Injury	2	GAD
umls:C0035222	Respiratory Distress Syndrome, Adult	2	BeFree,GAD
umls:C0035235	Respiratory Syncytial Virus Infections	2	GAD
umls:C0035435	Rheumatism	2	GAD
umls:C0038013	Ankylosing spondylitis	2	BeFree,LHGDN
umls:C0038356	Stomach Neoplasms	2	GAD,LHGDN
umls:C0040053	Thrombosis	2	GAD
umls:C0040425	Tonsillitis	2	BeFree,GAD
umls:C0043144	Wheezing	2	BeFree
umls:C0079744	Diffuse Large B-Cell Lymphoma	2	BeFree,GAD
umls:C0085207	Gestational Diabetes	2	BeFree,CTD_human,GAD,LHGDN
umls:C0085426	Gram-Positive Bacterial Infections	2	BeFree,GAD
umls:C0085605	Liver Failure	2	GAD
umls:C0151744	Myocardial Ischemia	2	BeFree,GAD
umls:C0153252	Systemic candidiasis	2	BeFree
umls:C0158944	Infections specific to perinatal period	2	BeFree
umls:C0162323	Polyarthritis	2	BeFree
umls:C0178468	Autoimmune thyroid disease	2	BeFree
umls:C0221056	Adult type dermatomyositis	2	BeFree
umls:C0239946	Fibrosis, Liver	2	BeFree
umls:C0242338	HTLV Infections	2	BeFree
umls:C0242723	Parasitemia	2	GAD
umls:C0262655	Recurrent urinary tract infection	2	BeFree
umls:C0266929	Chronic Periodontitis	2	BeFree,GAD
umls:C0269084	Vulvar Vestibulitis	2	BeFree,GAD,LHGDN
umls:C0272242	Complement deficiency disease	2	BeFree
umls:C0275522	Asymptomatic Infections	2	BeFree
umls:C0276609	Acute type B viral hepatitis	2	BeFree
umls:C0302592	Cervix carcinoma	2	BeFree,GAD
umls:C0333519	Caries (morphologic abnormality)	2	BeFree
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0375023	Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0376545	Hematologic Neoplasms	2	BeFree,GAD
umls:C0392164	Pulmonary Cystic Fibrosis	2	BeFree
umls:C0410808	Prosthetic joint infection	2	BeFree
umls:C0424755	Fever symptoms (finding)	2	GAD
umls:C0520459	Necrotizing Enterocolitis	2	BeFree
umls:C0549473	Thyroid carcinoma	2	BeFree
umls:C0577631	Carotid Atherosclerosis	2	BeFree
umls:C0597745	secondary immune deficiency	2	BeFree
umls:C0677886	Epithelial ovarian cancer	2	BeFree,GAD
umls:C0699791	Stomach Carcinoma	2	BeFree
umls:C0745287	infertility tubal factor	2	BeFree
umls:C0747845	early pregnancy	2	BeFree
umls:C0751396	Well Differentiated Oligodendroglioma	2	BeFree
umls:C0850666	Helicobacter pylori infection	2	BeFree
umls:C0854706	Neonatal infection	2	BeFree
umls:C0856825	Acute GVH disease	2	BeFree
umls:C0863094	Recurrent respiratory tract infections	2	BeFree
umls:C0950124	Papillomavirus Infections	2	GAD
umls:C1140680	Malignant neoplasm of ovary	2	BeFree
umls:C1290884	Inflammatory disorder	2	BeFree
umls:C1847835	VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	2	BeFree
umls:C2350529	Pulmonary Aspergillosis	2	BeFree
umls:C2350530	Bronchopulmonary Aspergillosis	2	BeFree
umls:C0000786	Spontaneous abortion	1	LHGDN
umls:C0000809	Abortion, Habitual	1	GAD
umls:C0001339	Acute pancreatitis	1	BeFree
umls:C0001824	Agranulocytosis	1	BeFree
umls:C0001925	Albuminuria	1	GAD
umls:C0001973	Alcoholic Intoxication, Chronic	1	BeFree,GAD
umls:C0002382	Alveolar Bone Loss	1	GAD
umls:C0002726	Amyloidosis	1	BeFree,GAD,LHGDN
umls:C0002965	Angina, Unstable	1	BeFree
umls:C0003165	Anthracosis	1	BeFree,LHGDN
umls:C0003504	Aortic Valve Insufficiency	1	BeFree,GAD
umls:C0005612	Birth Weight	1	CTD_human
umls:C0005684	Malignant neoplasm of urinary bladder	1	GAD
umls:C0007102	Malignant tumor of colon	1	BeFree
umls:C0007785	Cerebral Infarction	1	BeFree
umls:C0007786	Brain Ischemia	1	GAD
umls:C0007873	Uterine Cervical Neoplasm	1	GAD
umls:C0008149	Chlamydia Infections	1	BeFree,GAD
umls:C0008312	Primary biliary cirrhosis	1	BeFree,GAD
umls:C0008495	Chorioamnionitis	1	GAD
umls:C0009663	Condylomata Acuminata	1	BeFree
umls:C0009782	Connective Tissue Diseases	1	GAD
umls:C0010051	Coronary Aneurysm	1	BeFree
umls:C0010356	Cross Infection	1	GAD
umls:C0011633	Dermatomyositis	1	BeFree,GAD
umls:C0011875	Diabetic Angiopathies	1	BeFree
umls:C0013295	Duodenal Ulcer	1	GAD
umls:C0013884	Filarial Elephantiases	1	GAD
umls:C0014175	Endometriosis	1	BeFree
umls:C0015230	Exanthema	1	BeFree
umls:C0015929	Fetal Diseases	1	GAD
umls:C0015944	Fetal Membranes, Premature Rupture	1	GAD
umls:C0016397	Focal Infection	1	BeFree
umls:C0016867	Furunculosis	1	BeFree
umls:C0017154	Gastritis, Atrophic	1	GAD
umls:C0017536	Giardiasis	1	BeFree
umls:C0017565	Gingival Hemorrhage	1	GAD
umls:C0017636	Glioblastoma	1	BeFree
umls:C0018128	Graft Occlusion, Vascular	1	GAD
umls:C0018378	Guillain-Barre Syndrome	1	BeFree,GAD,LHGDN
umls:C0018991	Hemiplegia	1	GAD
umls:C0019099	Hemorrhagic Fever, Crimean	1	BeFree
umls:C0019100	Severe Dengue	1	BeFree,GAD
umls:C0019243	Angioedemas, Hereditary	1	BeFree
umls:C0019340	Herpes NOS	1	BeFree
umls:C0019342	Genital Herpes	1	GAD
umls:C0019360	Herpes zoster disease	1	BeFree
umls:C0020097	HTLV-I Infections	1	GAD
umls:C0020102	HTLV-II Infections	1	GAD
umls:C0020456	Hyperglycemia	1	BeFree
umls:C0020541	Hypertension, Portal	1	GAD
umls:C0020550	Hyperthyroidism	1	BeFree
umls:C0020676	Hypothyroidism	1	BeFree
umls:C0021290	Neonatal disorder	1	GAD
umls:C0021295	Infant, Premature, Diseases	1	GAD
umls:C0021308	Infarction	1	GAD
umls:C0021655	Insulin Resistance	1	GAD
umls:C0022104	Irritable Bowel Syndrome	1	LHGDN
umls:C0022660	Kidney Failure, Acute	1	BeFree
umls:C0022876	Premature Obstetric Labor	1	GAD
umls:C0023241	Legionnaires' Disease	1	GAD
umls:C0023418	leukemia	1	BeFree
umls:C0023449	Acute lymphocytic leukemia	1	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	1	BeFree,GAD
umls:C0024137	Lupus Erythematosus, Cutaneous	1	GAD
umls:C0024140	Lupus Erythematosus, Subacute Cutaneous	1	BeFree
umls:C0024205	Lymphadenitis	1	BeFree
umls:C0024299	Lymphoma	1	GAD
umls:C0024534	Malaria, Cerebral	1	BeFree
umls:C0025294	Meningococcal meningitis	1	BeFree
umls:C0025295	Meningitis, Pneumococcal	1	BeFree
umls:C0026850	Muscular Dystrophy	1	BeFree
umls:C0026857	Musculoskeletal Diseases	1	GAD
umls:C0026936	Mycoplasma Infections	1	BeFree
umls:C0027059	Myocarditis	1	GAD
umls:C0027643	Neoplasm Recurrence, Local	1	GAD
umls:C0027765	nervous system disorder	1	GAD
umls:C0029877	Ear Inflammation	1	BeFree
umls:C0029927	Ovarian Cysts	1	BeFree
umls:C0030305	Pancreatitis	1	GAD,LHGDN
umls:C0030499	Parasitic Diseases	1	BeFree
umls:C0030567	Parkinson Disease	1	GAD
umls:C0031117	Peripheral Neuropathy	1	CTD_human
umls:C0032045	Placenta Disorders	1	GAD
umls:C0032273	Pneumoconiosis	1	GAD
umls:C0032310	Pneumonia, Viral	1	GAD
umls:C0032533	Polymyalgia Rheumatica	1	BeFree
umls:C0032964	Pregnancy Complications, Hematologic	1	GAD
umls:C0032969	Pregnancy in Diabetics	1	BeFree
umls:C0033578	Prostatic Neoplasms	1	BeFree
umls:C0034040	Puerperal Disorders	1	GAD
umls:C0034362	Q Fever	1	GAD
umls:C0034372	Quadriplegia	1	BeFree
umls:C0035204	Respiration Disorders	1	BeFree
umls:C0035242	Respiratory Tract Diseases	1	BeFree
umls:C0035450	Rheumatoid Nodule	1	BeFree
umls:C0035455	Rhinitis	1	LHGDN
umls:C0036202	Sarcoidosis	1	BeFree
umls:C0036323	Schistosomiasis	1	BeFree
umls:C0036983	Septic Shock	1	GAD
umls:C0037274	Dermatologic disorders	1	GAD
umls:C0038395	Streptococcal Infections	1	GAD
umls:C0038454	Cerebrovascular accident	1	BeFree,GAD
umls:C0039103	Synovitis	1	BeFree
umls:C0039483	Giant Cell Arteritis	1	BeFree
umls:C0040034	Thrombocytopenia	1	GAD,LHGDN
umls:C0040128	Thyroid Diseases	1	BeFree
umls:C0040147	Thyroiditis	1	BeFree
umls:C0040592	Trachoma	1	GAD
umls:C0041234	Chagas Disease	1	BeFree
umls:C0041321	Tuberculosis, Miliary	1	BeFree
umls:C0041582	Ulcer	1	GAD
umls:C0041948	Uremia	1	BeFree
umls:C0042373	Vascular Diseases	1	BeFree,GAD
umls:C0042749	Viremia	1	GAD
umls:C0079745	Lymphoma, Large-Cell, Follicular	1	BeFree
umls:C0079773	Lymphoma, T-Cell, Cutaneous	1	BeFree
umls:C0085278	Antiphospholipid Syndrome	1	BeFree
umls:C0085409	Polyendocrinopathies, Autoimmune	1	BeFree
umls:C0085423	Gram-Negative Bacterial Infections	1	GAD
umls:C0085436	Meningitis, Cryptococcal	1	BeFree
umls:C0085437	Meningitis, Bacterial	1	BeFree,GAD,LHGDN
umls:C0085669	Acute leukemia	1	BeFree
umls:C0149678	Epstein-Barr Virus Infections	1	BeFree,GAD
umls:C0151281	Genital ulceration	1	BeFree
umls:C0151332	Active tuberculosis	1	BeFree
umls:C0151449	Primary Sj�gren's syndrome	1	BeFree
umls:C0151450	Secondary Sj�gren's syndrome	1	BeFree
umls:C0151942	Arterial thrombosis	1	BeFree
umls:C0152031	Joint swelling	1	BeFree
umls:C0152966	Septicemia due to streptococcus pneumoniae	1	BeFree
umls:C0155626	Acute myocardial infarction	1	BeFree
umls:C0155877	Allergic asthma	1	BeFree
umls:C0156149	Gastrointestinal tract vascular insufficiency	1	BeFree
umls:C0158940	Transitory tachypnea of newborn	1	BeFree
umls:C0162494	Pregnancy Complications, Parasitic	1	GAD
umls:C0162526	AIDS-Related Opportunistic Infections	1	GAD
umls:C0162538	Immunoglobulin A deficiency (disorder)	1	BeFree
umls:C0162539	IgG Deficiency	1	BeFree
umls:C0162739	HELLP Syndrome	1	BeFree,GAD,LHGDN
umls:C0175708	Chronic rheumatic heart disease	1	BeFree
umls:C0205721	Infections, Hospital	1	BeFree
umls:C0206114	Periodontal Attachment Loss	1	GAD
umls:C0206750	Coronavirus Infections	1	BeFree
umls:C0221014	Reactive systemic amyloidosis	1	BeFree
umls:C0221165	Diplegia	1	BeFree
umls:C0238644	Anemia, severe	1	BeFree
umls:C0242383	Age related macular degeneration	1	BeFree,GAD
umls:C0243050	Cardiovascular Abnormalities	1	BeFree,GAD
umls:C0264408	Childhood asthma	1	BeFree
umls:C0264423	Asthma, Occupational	1	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	1	BeFree
umls:C0280100	Solid tumour	1	BeFree
umls:C0282313	Condition, Preneoplastic	1	BeFree
umls:C0282677	Burkholderia Infections	1	GAD
umls:C0333307	Superficial ulcer	1	BeFree
umls:C0334590	Anaplastic Oligodendroglioma	1	BeFree
umls:C0338656	Impaired cognition	1	BeFree
umls:C0339961	Fungal pneumonia	1	BeFree
umls:C0339968	Neonatal pneumonia	1	BeFree
umls:C0341439	Chronic liver disease	1	BeFree
umls:C0342739	Trimethylaminuria	1	BeFree
umls:C0343386	Clostridium difficile infection	1	BeFree
umls:C0343804	Chronic Chagas' disease	1	BeFree
umls:C0362046	Prediabetes syndrome	1	BeFree
umls:C0395866	Recurrent acute otitis media	1	BeFree
umls:C0404521	Infective vaginitis	1	BeFree
umls:C0409208	Arthritis of hand	1	BeFree
umls:C0409702	Undifferentiated inflammatory oligoarthritis	1	BeFree
umls:C0497169	hiv-infection/aids	1	BeFree
umls:C0497327	Dementia	1	GAD
umls:C0547065	Mixed oligoastrocytoma	1	BeFree
umls:C0559470	Allergy to peanuts	1	BeFree
umls:C0578159	Antibiotic-associated diarrhea	1	BeFree
umls:C0589368	Postoperative myocardial infarction	1	BeFree
umls:C0677607	Hashimoto Disease	1	BeFree
umls:C0679362	Tuberculosis, extrapulmonary	1	BeFree
umls:C0687675	Pregnancy loss	1	GAD
umls:C0699744	Infection of ear	1	BeFree
umls:C0699790	Colon Carcinoma	1	BeFree
umls:C0702135	Primary atypical pneumonia	1	BeFree
umls:C0743188	diarrhea persistent	1	BeFree
umls:C0744471	Gram-negative bacteremia	1	BeFree
umls:C0745744	End Stage Liver Disease	1	BeFree
umls:C0747085	Otitis media recurrent	1	BeFree
umls:C0747256	Parasitic infection	1	BeFree
umls:C0751689	Peripheral Nerve Sheath Neoplasm	1	BeFree
umls:C0752143	Intracranial Thrombosis	1	GAD
umls:C0848332	Spots on skin	1	BeFree
umls:C0856774	High altitude illness	1	GAD
umls:C0869523	Carditis	1	BeFree
umls:C0878555	Diffuse panbronchiolitis	1	BeFree
umls:C0917798	Cerebral Ischemia	1	BeFree
umls:C0948089	Acute Coronary Syndrome	1	BeFree
umls:C1096000	Bronchopulmonary disease	1	BeFree
umls:C1142423	Bacteremia due to Staphylococcus aureus	1	BeFree
umls:C1145670	Respiratory Failure	1	BeFree
umls:C1271104	Blood pressure finding	1	GAD
umls:C1272641	Systemic arterial pressure	1	GAD
umls:C1292769	Precursor B-cell lymphoblastic leukemia	1	BeFree
umls:C1301752	Respiratory morbidity	1	BeFree
umls:C1304470	Generalized vitiligo	1	BeFree
umls:C1412002	Atypical pneumonia	1	BeFree
umls:C1458155	Mammary Neoplasms	1	LHGDN
umls:C1559271	Non-Malignant Ascites Adverse Event	1	BeFree
umls:C1562908	Leprosy, Paucibacillary	1	BeFree
umls:C1609535	Invasive Candidiasis	1	BeFree
umls:C1704430	Urinary Schistosomiasis	1	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	BeFree
umls:C2004435	Vascular insufficiency of intestine	1	BeFree
umls:C2607914	Allergic rhinitis (disorder)	1	BeFree
umls:C2919032	Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified	1	GAD
umls:C2919828	Chronic ulcerative colitis	1	GAD
umls:C3266628	Persistent asthma	1	BeFree
umls:C3495801	Granulomatosis with polyangiitis	1	GAD
umls:C3536715	AA amyloidosis	1	BeFree
umls:C3714636	Pneumonitis	1	BeFree
umls:C3825570	Tuberculosis in children	1	BeFree
umls:C3825879	Otitis media in children	1	BeFree
umls:C3826452	Diarrhea in children	1	BeFree