TissGeneSummary for MCF2 |
Gene summary |
Basic gene information | Gene symbol | MCF2 |
Gene name | MCF.2 cell line derived transforming sequence | |
Synonyms | ARHGEF21|DBL | |
Cytomap | UCSC genome browser: Xq27 | |
Type of gene | protein-coding | |
RefGenes | NM_001099855.1, NM_001171876.1,NM_001171877.1,NM_001171878.1,NM_001171879.1, NM_005369.4, | |
Description | Oncogene MCF2 (oncogene DBL)proto-oncogene DBLproto-oncogene MCF-2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 311030 | |
HGNC : HGNC | ||
Ensembl : ENSG00000101977 | ||
HPRD : 02406 | ||
Vega : OTTHUMG00000022537 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MCF2 | |
BioGPS: 4168 | ||
Pathway | NCI Pathway Interaction Database: MCF2 | |
KEGG: MCF2 | ||
REACTOME: MCF2 | ||
Pathway Commons: MCF2 | ||
Context | iHOP: MCF2 | |
ligand binding site mutation search in PubMed: MCF2 | ||
UCL Cancer Institute: MCF2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MCF2 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MCF2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.195586429 | 0.998670515 | -2.194256944 | 7.17E-20 | 5.58E-19 |
KICH | -1.920151485 | 0.723792515 | -2.643944 | 3.10E-12 | 3.28E-11 |
KIRP | -0.611948235 | 0.99076739 | -1.602715625 | 6.61E-06 | 2.86E-05 |
PRAD | -1.058583331 | 1.92275513 | -2.981338462 | 9.79E-11 | 2.13E-09 |
THCA | -1.132594739 | 0.128667973 | -1.261262712 | 2.44E-07 | 1.01E-06 |
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TissGene-miRNA for MCF2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-6088 | MIMAT0023713 | 0.0042 | -0.32 | 78 |
ACC | hsa-miR-6088 | MIMAT0023713 | 0.0042 | -0.32 | 78 |
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TissGeneMut for MCF2 |
TissGeneSNV for MCF2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E409K | SKCM | 3 |
p.R694Q | SKCM | 2 |
p.R471Q | COAD | 2 |
p.D775N | SARC | 1 |
p.I695T | BLCA | 1 |
p.T876K | HNSC | 1 |
p.E777Q | BLCA | 1 |
p.K466N | UCEC | 1 |
p.A419S | LUAD | 1 |
p.E573X | COAD | 1 |
p.K556Q | LGG | 1 |
p.D855Y | LGG | 1 |
p.A312V | SARC | 1 |
p.D187E | HNSC | 1 |
p.E32D | READ | 1 |
p.A36S | LUAD | 1 |
p.F814V | UCEC | 1 |
p.R7Q | MESO | 1 |
p.Q699H | LUAD | 1 |
p.T384A | LIHC | 1 |
p.K819E | ESCA | 1 |
p.L76F | OV | 1 |
p.S511L | SKCM | 1 |
p.E313D | HNSC | 1 |
p.R815H | ESCA | 1 |
p.S895F | SKCM | 1 |
p.D772Y | LUAD | 1 |
p.R815H | PAAD | 1 |
p.R633* | HNSC | 1 |
p.K386I | STAD | 1 |
p.D543Y | HNSC | 1 |
p.M821T | GBM | 1 |
p.Q97L | HNSC | 1 |
p.N866H | COAD | 1 |
p.W151X | STAD | 1 |
p.D411N | SKCM | 1 |
p.K282T | STAD | 1 |
p.I437K | OV | 1 |
p.E863K | SKCM | 1 |
p.R784* | UCEC | 1 |
p.L24V | STAD | 1 |
p.V256E | LUAD | 1 |
p.L219M | UCEC | 1 |
p.A609S | LUAD | 1 |
p.E178D | LGG | 1 |
p.P499L | SKCM | 1 |
p.C941Y | THYM | 1 |
p.A685T | KIRP | 1 |
p.P973S | UCEC | 1 |
p.I838S | UCEC | 1 |
p.E167* | UCEC | 1 |
p.L321* | LUAD | 1 |
p.D602N | ESCA | 1 |
p.T918A | UCEC | 1 |
p.P92T | LUAD | 1 |
p.R471Q | UCEC | 1 |
p.L84V | STAD | 1 |
p.L430I | COAD | 1 |
p.E431K | STAD | 1 |
p.M253I | LUSC | 1 |
p.R98Q | BLCA | 1 |
p.Y812X | COAD | 1 |
p.K572N | STAD | 1 |
p.C817R | COAD | 1 |
p.L430I | UCEC | 1 |
p.Q135L | KIRC | 1 |
p.D884N | SKCM | 1 |
p.A211S | MESO | 1 |
p.P454T | STAD | 1 |
p.V849F | LUAD | 1 |
p.Q48X | PAAD | 1 |
p.R799H | PAAD | 1 |
p.V34L | LIHC | 1 |
p.E573K | UCEC | 1 |
p.F27C | BLCA | 1 |
p.R304H | LUAD | 1 |
p.E373D | HNSC | 1 |
p.R471Q | READ | 1 |
p.H85Q | CESC | 1 |
p.F864L | CESC | 1 |
p.T333A | LUSC | 1 |
p.V922E | BLCA | 1 |
p.I120T | CESC | 1 |
p.D821A | UCEC | 1 |
p.T248R | PAAD | 1 |
p.L204R | SKCM | 1 |
p.P32N | LUAD | 1 |
p.P508S | STAD | 1 |
p.Q699* | SKCM | 1 |
p.Y581* | LUAD | 1 |
p.G12E | SKCM | 1 |
p.R799H | ESCA | 1 |
p.K375E | COAD | 1 |
p.R573* | HNSC | 1 |
p.F795V | UCEC | 1 |
p.S979L | UCEC | 1 |
p.A754T | KIRP | 1 |
p.R676I | UCEC | 1 |
p.K835E | ESCA | 1 |
p.R880K | SKCM | 1 |
p.N361D | SKCM | 1 |
p.G541V | LUAD | 1 |
p.N299H | READ | 1 |
p.A121S | LUAD | 1 |
p.S544F | SKCM | 1 |
p.L722I | UCEC | 1 |
p.Q414* | HNSC | 1 |
p.S210I | LUSC | 1 |
p.G607E | HNSC | 1 |
p.E260K | SKCM | 1 |
p.F161V | UCEC | 1 |
p.D796Y | LUSC | 1 |
p.R61* | BLCA | 1 |
p.D643N | SKCM | 1 |
p.G506W | SKCM | 1 |
p.R364H | LUAD | 1 |
p.E614K | SKCM | 1 |
p.R572Q | SKCM | 1 |
p.W662* | SKCM | 1 |
p.S233R | COAD | 1 |
p.Q639H | LUAD | 1 |
p.A669T | KIRP | 1 |
p.D940H | LUSC | 1 |
p.L298X | COAD | 1 |
p.R739H | PAAD | 1 |
p.E750K | SKCM | 1 |
p.G841D | SKCM | 1 |
p.E667K | SKCM | 1 |
p.S979L | HNSC | 1 |
p.D603Y | HNSC | 1 |
p.Y772H | LUSC | 1 |
p.E275* | LUAD | 1 |
p.N428H | UCEC | 1 |
p.Q424K | ESCA | 1 |
p.Y521* | LUAD | 1 |
p.I153T | ACC | 1 |
p.E322K | SKCM | 1 |
p.S945Y | COAD | 1 |
p.E912K | SKCM | 1 |
p.L163M | LUAD | 1 |
p.E873K | SKCM | 1 |
p.P92H | LUAD | 1 |
p.Q885* | SKCM | 1 |
p.K891N | OV | 1 |
p.S956T | SKCM | 1 |
p.L223M | COAD | 1 |
p.S751P | STAD | 1 |
p.A4G | UCS | 1 |
p.T816K | HNSC | 1 |
p.P177R | LUSC | 1 |
p.G481V | LUAD | 1 |
p.Y146F | COAD | 1 |
p.E371K | STAD | 1 |
p.A669S | LUAD | 1 |
p.Q229H | HNSC | 1 |
p.D906A | UCEC | 1 |
p.D734N | SKCM | 1 |
p.P448S | STAD | 1 |
p.I4V | LIHC | 1 |
p.H257Y | BLCA | 1 |
p.W91* | STAD | 1 |
p.R463Q | LUSC | 1 |
p.L297Q | LIHC | 1 |
p.R7W | COAD | 1 |
p.I35T | CESC | 1 |
p.M1I | CESC | 1 |
p.Q459K | UCEC | 1 |
p.A359S | LUAD | 1 |
p.T308R | PAAD | 1 |
p.E837Q | BLCA | 1 |
p.R572X | COAD | 1 |
p.K326I | STAD | 1 |
p.R198C | SKCM | 1 |
p.P499H | LUAD | 1 |
p.E969D | LUAD | 1 |
p.R784Q | UCEC | 1 |
p.D813N | SKCM | 1 |
p.V196E | LUAD | 1 |
p.S818L | READ | 1 |
p.P542T | LUAD | 1 |
p.L223M | LUAD | 1 |
p.K10N | STAD | 1 |
p.Q354* | HNSC | 1 |
p.A695V | LUSC | 1 |
p.E427K | SKCM | 1 |
p.Q893E | BLCA | 1 |
p.E970Q | UCEC | 1 |
p.S827P | STAD | 1 |
p.L611* | LUSC | 1 |
p.Q505* | CESC | 1 |
p.L786I | SARC | 1 |
p.D425N | SKCM | 1 |
p.K496N | STAD | 1 |
p.Q478K | ESCA | 1 |
p.K13E | SKCM | 1 |
p.G859C | UCEC | 1 |
p.S909N | THCA | 1 |
p.L416I | LUSC | 1 |
p.E632* | UCEC | 1 |
p.A433S | LUAD | 1 |
p.L705I | HNSC | 1 |
p.D832N | LUAD | 1 |
p.D258N | SKCM | 1 |
p.I635V | LIHC | 1 |
p.L868F | LUAD | 1 |
p.D832Y | LUAD | 1 |
p.P22S | SKCM | 1 |
p.D775N | SKCM | 1 |
p.C29F | LUAD | 1 |
p.T963A | HNSC | 1 |
p.W662X | SKCM | 1 |
p.Q885X | SKCM | 1 |
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TissGeneCNV for MCF2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MCF2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA274457 | DHX57-MCF2 | chr2:39070933 | chrX:138686840 | |
Chimerdb3.0 | ChiTaRs | NA | AI708084 | MCF2-MYB | chrX:138688390 | chr6:135540074 | |
Chimerdb3.0 | ChiTaRs | NA | X13230 | TMOD3-MCF2 | chr15:52122035 | chrX:138664301 | |
Chimerdb3.0 | ChiTaRs | NA | AB209679 | DIXDC1-MCF2 | chr11:111817226 | chrX:138663930 |
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TissGeneNet for MCF2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MCF2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MCF2 |
TissGeneDrug for MCF2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MCF2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024530 | Malaria | 2 | BeFree |
umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
umls:C0205851 | Germ cell tumor | 1 | BeFree |
umls:C0206093 | Neuroectodermal Tumors | 1 | BeFree |
umls:C0342344 | Hypoparathyroidism - X-linked | 1 | BeFree |
umls:C0431663 | Bilateral Cryptorchidism | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |