 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SCGB2A2 |
 Gene summary |
| Basic gene information | Gene symbol | SCGB2A2 |
| Gene name | secretoglobin, family 2A, member 2 | |
| Synonyms | MGB1|UGB2 | |
| Cytomap | UCSC genome browser: 11q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002411.3, | |
| Description | mammaglobin 1mammaglobin-A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605562 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000110484 | ||
| HPRD : 05712 | ||
| Vega : OTTHUMG00000167509 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SCGB2A2 | |
| BioGPS: 4250 | ||
| Pathway | NCI Pathway Interaction Database: SCGB2A2 | |
| KEGG: SCGB2A2 | ||
| REACTOME: SCGB2A2 | ||
| Pathway Commons: SCGB2A2 | ||
| Context | iHOP: SCGB2A2 | |
| ligand binding site mutation search in PubMed: SCGB2A2 | ||
| UCL Cancer Institute: SCGB2A2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Breast | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCA | |
| Reference showing the relevant tissue of SCGB2A2 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SCGB2A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 7.061049758 | 8.511698003 | -1.450648246 | 0.0113 | 0.019078801 |
| HNSC | -2.256859606 | -0.89151542 | -1.365344186 | 0.00532 | 0.01428401 |
| KICH | -2.731910769 | -1.248494769 | -1.483416 | 0.00108 | 0.002333647 |
| Top |
| TissGene-miRNA for SCGB2A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SCGB2A2 |
| TissGeneSNV for SCGB2A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A54T | LUSC | 1 |
| p.L92V | BLCA | 1 |
| p.A54V | LUSC | 1 |
| p.A10V | OV | 1 |
| p.L12H | STAD | 1 |
| p.T73P | ESCA | 1 |
| p.V28G | SARC | 1 |
| Top |
| TissGeneCNV for SCGB2A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SCGB2A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for SCGB2A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SCGB2A2, SCGB1D2 (tumor) | SCGB2A2, SCGB1D2 (normal) |
 |  |
| Top |
| TissGeneProg for SCGB2A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SCGB2A2 |
| TissGeneDrug for SCGB2A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SCGB2A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 28 | BeFree |
| umls:C0678222 | Breast Carcinoma | 28 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 22 | BeFree,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 5 | BeFree,LHGDN |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
| umls:C0032584 | polyps | 2 | BeFree |
| umls:C0278488 | Carcinoma breast stage IV | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0027430 | Nasal Polyps | 1 | BeFree,LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032227 | Pleural effusion disorder | 1 | LHGDN |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1384494 | Metastatic Carcinoma | 1 | BeFree |
| umls:C1519680 | Tumor Immunity | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |