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TissGeneSummary for SCGB2A2 |
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Basic gene information | Gene symbol | SCGB2A2 |
Gene name | secretoglobin, family 2A, member 2 | |
Synonyms | MGB1|UGB2 | |
Cytomap | UCSC genome browser: 11q13 | |
Type of gene | protein-coding | |
RefGenes | NM_002411.3, | |
Description | mammaglobin 1mammaglobin-A | |
Modification date | 20141207 | |
dbXrefs | MIM : 605562 | |
HGNC : HGNC | ||
Ensembl : ENSG00000110484 | ||
HPRD : 05712 | ||
Vega : OTTHUMG00000167509 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SCGB2A2 | |
BioGPS: 4250 | ||
Pathway | NCI Pathway Interaction Database: SCGB2A2 | |
KEGG: SCGB2A2 | ||
REACTOME: SCGB2A2 | ||
Pathway Commons: SCGB2A2 | ||
Context | iHOP: SCGB2A2 | |
ligand binding site mutation search in PubMed: SCGB2A2 | ||
UCL Cancer Institute: SCGB2A2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Breast | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCA | |
Reference showing the relevant tissue of SCGB2A2 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for SCGB2A2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 7.061049758 | 8.511698003 | -1.450648246 | 0.0113 | 0.019078801 |
HNSC | -2.256859606 | -0.89151542 | -1.365344186 | 0.00532 | 0.01428401 |
KICH | -2.731910769 | -1.248494769 | -1.483416 | 0.00108 | 0.002333647 |
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TissGene-miRNA for SCGB2A2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SCGB2A2 |
TissGeneSNV for SCGB2A2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A54T | LUSC | 1 |
p.L92V | BLCA | 1 |
p.A54V | LUSC | 1 |
p.A10V | OV | 1 |
p.L12H | STAD | 1 |
p.T73P | ESCA | 1 |
p.V28G | SARC | 1 |
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TissGeneCNV for SCGB2A2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SCGB2A2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SCGB2A2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SCGB2A2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SCGB2A2 |
TissGeneDrug for SCGB2A2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SCGB2A2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 28 | BeFree |
umls:C0678222 | Breast Carcinoma | 28 | BeFree |
umls:C1458155 | Mammary Neoplasms | 22 | BeFree,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 5 | BeFree,LHGDN |
umls:C0001418 | Adenocarcinoma | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
umls:C0032584 | polyps | 2 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
umls:C0027430 | Nasal Polyps | 1 | BeFree,LHGDN |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0032227 | Pleural effusion disorder | 1 | LHGDN |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1384494 | Metastatic Carcinoma | 1 | BeFree |
umls:C1519680 | Tumor Immunity | 1 | BeFree |