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| TissGeneSummary for CXCL9 |
 Gene summary |
| Basic gene information | Gene symbol | CXCL9 |
| Gene name | chemokine (C-X-C motif) ligand 9 | |
| Synonyms | CMK|Humig|MIG|SCYB9|crg-10 | |
| Cytomap | UCSC genome browser: 4q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002416.2, | |
| Description | C-X-C motif chemokine 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 601704 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138755 | ||
| HPRD : 03416 | ||
| Vega : OTTHUMG00000160889 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CXCL9 | |
| BioGPS: 4283 | ||
| Pathway | NCI Pathway Interaction Database: CXCL9 | |
| KEGG: CXCL9 | ||
| REACTOME: CXCL9 | ||
| Pathway Commons: CXCL9 | ||
| Context | iHOP: CXCL9 | |
| ligand binding site mutation search in PubMed: CXCL9 | ||
| UCL Cancer Institute: CXCL9 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSTAD | |
| Reference showing the relevant tissue of CXCL9 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006935 | chemotaxis | 12782716 | GO:0030816 | positive regulation of cAMP metabolic process | 12782716 | GO:0042127 | regulation of cell proliferation | 12782716 | GO:0043950 | positive regulation of cAMP-mediated signaling | 12782716 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12782716 | GO:0006935 | chemotaxis | 12782716 | GO:0030816 | positive regulation of cAMP metabolic process | 12782716 | GO:0042127 | regulation of cell proliferation | 12782716 | GO:0043950 | positive regulation of cAMP-mediated signaling | 12782716 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12782716 |
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| TissGeneExp for CXCL9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 2.6539494 | -0.858858933 | 3.512808333 | 6.27E-25 | 7.51E-24 |
| STAD | 2.6013994 | -0.10048185 | 2.70188125 | 3.23E-07 | 6.66E-06 |
| BRCA | 2.162043479 | -0.006378451 | 2.16842193 | 1.88E-15 | 1.01E-14 |
| KICH | 0.2134559 | -1.0023081 | 1.215764 | 0.0111 | 0.019745278 |
| PRAD | 0.331838823 | -0.765557331 | 1.097396154 | 0.00119 | 0.003750759 |
| HNSC | 2.122349109 | 0.25823283 | 1.864116279 | 0.000715 | 0.002529481 |
| COAD | 1.563284977 | -0.158368869 | 1.721653846 | 0.000651 | 0.001951219 |
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| TissGene-miRNA for CXCL9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CXCL9 |
| TissGeneSNV for CXCL9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S79X | ACC | 1 |
| p.G102E | SKCM | 1 |
| p.K100T | SKCM | 1 |
| p.R30H | LGG | 1 |
| p.L10F | SKCM | 1 |
| p.R114Q | ESCA | 1 |
| p.G11S | SKCM | 1 |
| p.I13F | THYM | 1 |
| p.K104N | OV | 1 |
| p.R114Q | STAD | 1 |
| p.R114* | SKCM | 1 |
| p.S79* | ACC | 1 |
| p.R114Q | PRAD | 1 |
| p.G70A | BLCA | 1 |
| p.D78Y | UCEC | 1 |
| p.Q92H | STAD | 1 |
| p.V25A | HNSC | 1 |
| p.R114X | READ | 1 |
| p.K100N | COAD | 1 |
| p.K122N | LUAD | 1 |
| p.S119C | CESC | 1 |
| p.E90D | UCEC | 1 |
| p.C31* | LUAD | 1 |
| p.R120C | SKCM | 1 |
| p.P24S | SKCM | 1 |
| p.H42N | LUAD | 1 |
| p.N69K | BLCA | 1 |
| p.L7V | BLCA | 1 |
| p.R118H | COAD | 1 |
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| TissGeneCNV for CXCL9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CXCL9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW801916 | CXCL9-CARD6 | chr4:76927415 | chr5:40842770 | |
| Chimerdb3.0 | ChiTaRs | NA | AW389351 | SOD1-CXCL9 | chr21:33040852 | chr4:76924037 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-69-8255-01A | NUP54-CXCL9 | Out-of-Frame | chr4:77045801 | chr4:76927427 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-VR-AA7I-01A3 | LOC101928809-CXCL9 | Out-of-Frame | chr4:76924836 | chr4:76928655 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-VR-AA7I-01A3 | LOC101928809-CXCL9 | Out-of-Frame | chr4:76924846 | chr4:76928646 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-VR-AA7I-01A3 | LOC101928809-CXCL9 | Out-of-Frame | chr4:76924854 | chr4:76928655 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-VR-AA7I-01A3 | LOC101928809-CXCL9 | Out-of-Frame | chr4:76925988 | chr4:76928654 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-VR-AA7I-01A3 | LOC101928809-CXCL9 | Out-of-Frame | chr4:76926001 | chr4:76928636 |
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| TissGeneNet for CXCL9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor) | CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal) |
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| TissGeneProg for CXCL9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CXCL9 |
| TissGeneDrug for CXCL9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CXCL9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023462 | Acute Megakaryocytic Leukemias | 7 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 4 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0024530 | Malaria | 4 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 3 | BeFree,GAD |
| umls:C0013080 | Down Syndrome | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0002171 | Alopecia Areata | 2 | BeFree,CTD_human |
| umls:C0004096 | Asthma | 2 | BeFree,GAD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0010346 | Crohn Disease | 2 | BeFree,GAD,LHGDN |
| umls:C0011615 | Dermatitis, Atopic | 2 | BeFree,LHGDN |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0019196 | Hepatitis C | 2 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 2 | BeFree |
| umls:C0023646 | Lichen Planus | 2 | BeFree |
| umls:C0023892 | Biliary cirrhosis | 2 | CTD_human,LHGDN |
| umls:C0023895 | Liver diseases | 2 | BeFree |
| umls:C0024299 | Lymphoma | 2 | BeFree |
| umls:C0033860 | Psoriasis | 2 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 2 | BeFree |
| umls:C0275524 | Coinfection | 2 | BeFree |
| umls:C1333064 | Classical Hodgkin's Lymphoma | 2 | BeFree |
| umls:C0001416 | Adenitis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | GAD |
| umls:C0006272 | Bronchiolitis Obliterans | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0007930 | Chagas Cardiomyopathy | 1 | BeFree |
| umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
| umls:C0008489 | Chorea | 1 | LHGDN |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree,GAD |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0017658 | Glomerulonephritis | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0018621 | Hay fever | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0020517 | Hypersensitivity | 1 | CTD_human |
| umls:C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | GAD |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| umls:C0024205 | Lymphadenitis | 1 | BeFree |
| umls:C0024291 | Lymphohistiocytosis, Hemophagocytic | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027059 | Myocarditis | 1 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| umls:C0029172 | Oral Submucous Fibrosis | 1 | BeFree |
| umls:C0032285 | Pneumonia | 1 | CTD_human |
| umls:C0033817 | Pseudomonas Infections | 1 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0036202 | Sarcoidosis | 1 | BeFree |
| umls:C0036429 | Sclerosis | 1 | LHGDN |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0152268 | Hodgkin's disease, nodular sclerosis (clinical) | 1 | BeFree |
| umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0282488 | Interstitial Cystitis | 1 | CTD_human |
| umls:C0333516 | Tumor necrosis | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0585362 | Squamous cell carcinoma of mouth | 1 | BeFree |
| umls:C0751713 | Inclusion Body Myopathy, Sporadic | 1 | BeFree |
| umls:C0752087 | Myasthenia Gravis, Autoimmune, Experimental | 1 | RGD |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | GAD |
| umls:C1175175 | Severe Acute Respiratory Syndrome | 1 | GAD |
| umls:C1458155 | Mammary Neoplasms | 1 | CTD_human |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1527336 | Sjogren's Syndrome | 1 | LHGDN |
| umls:C2919828 | Chronic ulcerative colitis | 1 | GAD |
| umls:C3714514 | Infection | 1 | LHGDN |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
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