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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CXCL9
check button Gene summary
Basic gene informationGene symbolCXCL9
Gene namechemokine (C-X-C motif) ligand 9
SynonymsCMK|Humig|MIG|SCYB9|crg-10
CytomapUCSC genome browser: 4q21
Type of geneprotein-coding
RefGenesNM_002416.2,
DescriptionC-X-C motif chemokine 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9
Modification date20141222
dbXrefs MIM : 601704
HGNC : HGNC
Ensembl : ENSG00000138755
HPRD : 03416
Vega : OTTHUMG00000160889
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CXCL9
BioGPS: 4283
PathwayNCI Pathway Interaction Database: CXCL9
KEGG: CXCL9
REACTOME: CXCL9
Pathway Commons: CXCL9
ContextiHOP: CXCL9
ligand binding site mutation search in PubMed: CXCL9
UCL Cancer Institute: CXCL9
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LungStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LUAD,LUSCSTAD
Reference showing the relevant tissue of CXCL9
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006935chemotaxis12782716
GO:0030816positive regulation of cAMP metabolic process12782716
GO:0042127regulation of cell proliferation12782716
GO:0043950positive regulation of cAMP-mediated signaling12782716
GO:0051281positive regulation of release of sequestered calcium ion into cytosol12782716
GO:0006935chemotaxis12782716
GO:0030816positive regulation of cAMP metabolic process12782716
GO:0042127regulation of cell proliferation12782716
GO:0043950positive regulation of cAMP-mediated signaling12782716
GO:0051281positive regulation of release of sequestered calcium ion into cytosol12782716


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TissGeneExp for CXCL9

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC2.6539494-0.8588589333.5128083336.27E-257.51E-24
STAD2.6013994-0.100481852.701881253.23E-076.66E-06
BRCA2.162043479-0.0063784512.168421931.88E-151.01E-14
KICH0.2134559-1.00230811.2157640.01110.019745278
PRAD0.331838823-0.7655573311.0973961540.001190.003750759
HNSC2.1223491090.258232831.8641162790.0007150.002529481
COAD1.563284977-0.1583688691.7216538460.0006510.001951219


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TissGene-miRNA for CXCL9

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CXCL9
TissGeneSNV for CXCL9

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S79XACC1
p.G102ESKCM1
p.K100TSKCM1
p.R30HLGG1
p.L10FSKCM1
p.R114QESCA1
p.G11SSKCM1
p.I13FTHYM1
p.K104NOV1
p.R114QSTAD1
p.R114*SKCM1
p.S79*ACC1
p.R114QPRAD1
p.G70ABLCA1
p.D78YUCEC1
p.Q92HSTAD1
p.V25AHNSC1
p.R114XREAD1
p.K100NCOAD1
p.K122NLUAD1
p.S119CCESC1
p.E90DUCEC1
p.C31*LUAD1
p.R120CSKCM1
p.P24SSKCM1
p.H42NLUAD1
p.N69KBLCA1
p.L7VBLCA1
p.R118HCOAD1


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TissGeneCNV for CXCL9

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CXCL9

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAW801916CXCL9-CARD6chr4:76927415chr5:40842770
Chimerdb3.0ChiTaRsNAAW389351SOD1-CXCL9chr21:33040852chr4:76924037
Chimerdb3.0FusionScanLUADTCGA-69-8255-01ANUP54-CXCL9Out-of-Framechr4:77045801chr4:76927427
Chimerdb3.0TopHat-FusionSTADTCGA-VR-AA7I-01A3LOC101928809-CXCL9Out-of-Framechr4:76924836chr4:76928655
Chimerdb3.0TopHat-FusionSTADTCGA-VR-AA7I-01A3LOC101928809-CXCL9Out-of-Framechr4:76924846chr4:76928646
Chimerdb3.0TopHat-FusionSTADTCGA-VR-AA7I-01A3LOC101928809-CXCL9Out-of-Framechr4:76924854chr4:76928655
Chimerdb3.0TopHat-FusionSTADTCGA-VR-AA7I-01A3LOC101928809-CXCL9Out-of-Framechr4:76925988chr4:76928654
Chimerdb3.0TopHat-FusionSTADTCGA-VR-AA7I-01A3LOC101928809-CXCL9Out-of-Framechr4:76926001chr4:76928636


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TissGeneNet for CXCL9

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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COAD (tumor)COAD (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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HNSC (tumor)HNSC (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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KICH (tumor)KICH (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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KIRC (tumor)KIRC (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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KIRP (tumor)KIRP (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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LIHC (tumor)LIHC (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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LUAD (tumor)LUAD (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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LUSC (tumor)LUSC (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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PRAD (tumor)PRAD (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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STAD (tumor)STAD (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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THCA (tumor)THCA (normal)
CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (tumor)CXCL9, STAT1, DPP4, PRMT1, PAX8, PIAS1, BMF, CXCR3, CCR3, FBN1 (normal)
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TissGeneProg for CXCL9

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CXCL9
TissGeneDrug for CXCL9

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CXCL9

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0023462Acute Megakaryocytic Leukemias7BeFree
umls:C0003873Rheumatoid Arthritis4BeFree
umls:C0019693HIV Infections4BeFree
umls:C0024530Malaria4BeFree
umls:C0027627Neoplasm Metastasis4BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0009324Ulcerative Colitis3BeFree,GAD
umls:C0013080Down Syndrome3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C2239176Liver carcinoma3BeFree
umls:C0002171Alopecia Areata2BeFree,CTD_human
umls:C0004096Asthma2BeFree,GAD
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0010346Crohn Disease2BeFree,GAD,LHGDN
umls:C0011615Dermatitis, Atopic2BeFree,LHGDN
umls:C0017638Glioma2BeFree
umls:C0019196Hepatitis C2BeFree
umls:C0019348Herpes Simplex Infections2BeFree
umls:C0023646Lichen Planus2BeFree
umls:C0023892Biliary cirrhosis2CTD_human,LHGDN
umls:C0023895Liver diseases2BeFree
umls:C0024299Lymphoma2BeFree
umls:C0033860Psoriasis2BeFree
umls:C0041327Tuberculosis, Pulmonary2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0239946Fibrosis, Liver2BeFree
umls:C0275524Coinfection2BeFree
umls:C1333064Classical Hodgkin's Lymphoma2BeFree
umls:C0001416Adenitis1BeFree
umls:C0004153Atherosclerosis1GAD
umls:C0006272Bronchiolitis Obliterans1BeFree
umls:C0006274Bronchiolitis, Viral1GAD
umls:C0007930Chagas Cardiomyopathy1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0008489Chorea1LHGDN
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree,GAD
umls:C0013595Eczema1BeFree
umls:C0017658Glomerulonephritis1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0018621Hay fever1BeFree
umls:C0019163Hepatitis B1BeFree
umls:C0020517Hypersensitivity1CTD_human
umls:C0020981Angioimmunoblastic Lymphadenopathy1BeFree
umls:C0021390Inflammatory Bowel Diseases1GAD
umls:C0021400Influenza1BeFree
umls:C0023440Acute Erythroblastic Leukemia1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0023904Liver Neoplasms, Experimental1CTD_human
umls:C0024205Lymphadenitis1BeFree
umls:C0024291Lymphohistiocytosis, Hemophagocytic1BeFree
umls:C0025202melanoma1BeFree
umls:C0027059Myocarditis1BeFree
umls:C0027643Neoplasm Recurrence, Local1CTD_human
umls:C0029172Oral Submucous Fibrosis1BeFree
umls:C0032285Pneumonia1CTD_human
umls:C0033817Pseudomonas Infections1BeFree
umls:C0035235Respiratory Syncytial Virus Infections1GAD
umls:C0036202Sarcoidosis1BeFree
umls:C0036429Sclerosis1LHGDN
umls:C0037274Dermatologic disorders1BeFree
umls:C0042769Virus Diseases1BeFree
umls:C0079731B-Cell Lymphomas1BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0085110Severe Combined Immunodeficiency1BeFree
umls:C0152268Hodgkin's disease, nodular sclerosis (clinical)1BeFree
umls:C0242647Mucosa-Associated Lymphoid Tissue Lymphoma1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0282488Interstitial Cystitis1CTD_human
umls:C0333516Tumor necrosis1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0524909Hepatitis B, Chronic1BeFree
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C0585362Squamous cell carcinoma of mouth1BeFree
umls:C0751713Inclusion Body Myopathy, Sporadic1BeFree
umls:C0752087Myasthenia Gravis, Autoimmune, Experimental1RGD
umls:C1140680Malignant neoplasm of ovary1GAD
umls:C1175175Severe Acute Respiratory Syndrome1GAD
umls:C1458155Mammary Neoplasms1CTD_human
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1527336Sjogren's Syndrome1LHGDN
umls:C2919828Chronic ulcerative colitis1GAD
umls:C3714514Infection1LHGDN
umls:C3811653Experimental Organism Basal Cell Carcinoma1BeFree