TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MME

Gene summary

Basic gene information	Gene symbol	MME
	Gene name	membrane metallo-endopeptidase
	Synonyms	CALLA\|CD10\|NEP\|SFE
	Cytomap	UCSC genome browser: 3q25.2
	Type of gene	protein-coding
	RefGenes	NM_000902.3, NM_007287.2,NM_007288.2,NM_007289.2,
	Description	atriopeptidasecommon acute lymphocytic leukemia antigenenkephalinasemembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)membrane metallo-endopeptidase
	Modification date	20141207
dbXrefs	MIM : 120520
	HGNC : HGNC
	Ensembl : ENSG00000196549
	HPRD : 00392
	Vega : OTTHUMG00000158455
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MME
	BioGPS: 4311
Pathway	NCI Pathway Interaction Database: MME
	KEGG: MME
	REACTOME: MME
	Pathway Commons: MME
Context	iHOP: MME
	ligand binding site mutation search in PubMed: MME
	UCL Cancer Institute: MME
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	KidneySkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	KIRC,KIRP,KICHSKCM
Reference showing the relevant tissue of MME
Description by TissGene annotations	Risk TissGene in OS Fused withTSGene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006508	proteolysis	20876573
GO:0071345	cellular response to cytokine stimulus	20876573
GO:0071492	cellular response to UV-A	20876573
GO:0071493	cellular response to UV-B	20876573
GO:0006508	proteolysis	20876573
GO:0071345	cellular response to cytokine stimulus	20876573
GO:0071492	cellular response to UV-A	20876573
GO:0071493	cellular response to UV-B	20876573

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TissGeneExp for MME

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LUSC	1.481633694	3.320402321	-1.838768627	2.22E-07	6.00E-07
KIRP	1.448806243	4.530265618	-3.081459375	1.23E-05	5.02E-05
COAD	0.245202397	-1.753905296	1.999107692	9.48E-06	4.39E-05
LIHC	-0.619049757	2.655766243	-3.274816	7.49E-07	4.15E-06
LUAD	0.27142176	3.515156243	-3.243734483	7.56E-23	2.26E-21
BRCA	1.178843962	4.983397471	-3.804553509	1.43E-50	1.01E-48
HNSC	0.700236475	-0.489786781	1.190023256	0.0029	0.008529412
KICH	-0.414169757	3.248294243	-3.662464	0.000143	0.000361851

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TissGene-miRNA for MME

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
TGCT	hsa-miR-409-3p	MIMAT0001639	0.00094	-0.26	155
UCS	hsa-miR-186-5p	MIMAT0000456	0.048	-0.27	56

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TissGeneMut for MME

TissGeneSNV for MME

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.S739L	SKCM	2
p.E329K	SKCM	2
p.L426F	SKCM	2
p.G641R	SKCM	2
p.E272K	SKCM	2
p.R23*	UCEC	2
p.W174X	SKCM	1
p.K197E	UCEC	1
p.E172K	SKCM	1
p.I70M	BLCA	1
p.R410P	LIHC	1
p.V33A	LIHC	1
p.F326V	HNSC	1
p.E233K	SKCM	1
p.E185K	BLCA	1
p.Q620K	ESCA	1
p.D112Y	LUAD	1
p.R152S	LUAD	1
p.R748Q	COAD	1
p.E278K	SKCM	1
p.Y626C	LUAD	1
p.L383I	LUSC	1
p.K197E	STAD	1
p.N514H	CESC	1
p.G576W	LUAD	1
p.E585K	SKCM	1
p.R293Q	SKCM	1
p.W535*	SKCM	1
p.A286T	SKCM	1
p.S570Y	ACC	1
p.W631*	BLCA	1
p.P263H	LUAD	1
p.A170S	LUAD	1
p.D378N	SKCM	1
p.S613R	HNSC	1
p.T360N	CESC	1
p.R385Q	SKCM	1
p.Y624C	BLCA	1
p.E282Q	SKCM	1
p.R103L	OV	1
p.N514I	STAD	1
p.K388M	LIHC	1
p.E282K	STAD	1
p.G196A	HNSC	1
p.D163G	UCEC	1
p.Q561H	LUSC	1
p.T402A	SKCM	1
p.Y740H	HNSC	1
p.G641E	SKCM	1
p.N514T	STAD	1
p.E672D	READ	1
p.G594V	COAD	1
p.K126E	LUSC	1
p.K437E	SKCM	1
p.I536T	UCEC	1
p.A138T	COAD	1
p.G196W	LUAD	1
p.P296L	SKCM	1
p.D651V	BLCA	1
p.G90C	COAD	1
p.R23*	HNSC	1
p.R293Q	READ	1
p.R736H	BLCA	1
p.A397S	HNSC	1
p.P26S	SKCM	1
p.E280K	READ	1
p.R748W	ESCA	1
p.T333I	LGG	1
p.P483A	LUSC	1
p.H584R	UCEC	1
p.A286_splice	UCEC	1
p.S548L	BLCA	1
p.S382R	LUSC	1
p.E28K	SKCM	1
p.D12N	SKCM	1
p.N614K	BLCA	1
p.G318W	LUSC	1
p.R254T	OV	1
p.P483S	SKCM	1
p.R395S	KIRP	1
p.D602H	STAD	1
p.A284S	KIRC	1
p.Y231D	UCEC	1
p.L37F	SKCM	1
p.A393D	PRAD	1
p.D129H	LUAD	1
p.M371I	COAD	1
p.R293Q	COAD	1
p.D456G	LUAD	1
p.D82Y	PAAD	1
p.M277I	SKCM	1
p.K388N	COAD	1
p.Y347C	DLBC	1
p.N628H	LIHC	1
p.S60*	HNSC	1
p.P162A	HNSC	1
p.D378N	DLBC	1
p.G2D	COAD	1
p.W174*	SKCM	1
p.P16L	SKCM	1
p.R94C	STAD	1
p.D220N	CHOL	1
p.R410C	STAD	1
p.P357S	SKCM	1
p.R23*	LGG	1
p.R103H	HNSC	1
p.Q620*	SKCM	1
p.M377I	SKCM	1
p.H218P	OV	1
p.Q453E	BLCA	1
p.S372F	SKCM	1
p.R23Q	COAD	1
p.K19M	LUSC	1
p.P714S	SKCM	1
p.V334L	LUSC	1
p.S548T	LIHC	1
p.A703V	HNSC	1
p.T15I	HNSC	1
p.S30G	LUAD	1
p.P296S	SKCM	1
p.V121I	OV	1
p.D295V	UCEC	1
p.E672Q	LUAD	1
p.Y195C	PAAD	1
p.F312L	KIRC	1
p.V169E	COAD	1
p.A431V	STAD	1
p.G549R	LUAD	1
p.W408*	SKCM	1
p.G589C	PRAD	1
p.D112H	LUAD	1
p.A691S	ESCA	1
p.S630F	SKCM	1
p.E280K	SKCM	1
p.S547F	SKCM	1
p.Q309H	CHOL	1
p.D12H	BLCA	1
p.M73I	SKCM	1
p.S520R	SKCM	1
p.R152T	BLCA	1
p.Q307H	LUAD	1
p.P676H	LUAD	1
p.E534Q	HNSC	1
p.L367I	READ	1
p.L674V	UCEC	1
p.D82N	SKCM	1
p.A567V	COAD	1
p.A284G	KIRC	1
p.E671K	SKCM	1
p.R257C	UCEC	1
p.E341V	ESCA	1
p.R257C	SKCM	1
p.M580I	ACC	1
p.K396M	HNSC	1
p.N72S	BLCA	1
p.Q513R	UCEC	1
p.I70V	LIHC	1
p.A286T	UCEC	1
p.Q552E	HNSC	1
p.G577C	ACC	1
p.M273I	BLCA	1
p.A75V	COAD	1
p.N340I	SARC	1
p.R391T	HNSC	1
p.D9N	SKCM	1
p.D591Y	LUAD	1
p.S547Y	LUSC	1

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TissGeneCNV for MME

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for MME

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BU631638	FAM172A-MME		chr5:93018301	chr3:154866337
Chimerdb3.0	ChiTaRs	NA	CN417628	MME-MME		chr3:154898954	chr3:154864973

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TissGeneNet for MME

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
MME, RUVBL2, NOLC1, TNPO1, ALDH3A2, VIP, CDK5RAP3, UTRN, PCNA, RUVBL1, PSME1, MTHFD1, PIK3CB, NDRG1, MTDH, UBAC2, RGPD6, FAAH, PDIA5, MRVI1, METTL7A (tumor)	MME, RUVBL2, IRAK2, SHC1, EDN1, CD4, LYN, PIK3R1, CDK5RAP3, UTRN, MYL12A, CSNK2B, SLC16A1, MYH9, INPP5D, ADM, ADCYAP1, EDN2, RAP2B, FAAH, MRVI1 (normal)

COAD (tumor)	COAD (normal)
MME, CSNK2A1, IRAK2, HSPA4, HSPA1B, HSPA1A, SLC16A1, MYH9, VDAC2, KRT10, HSPB1, IMPDH2, SDF4, FAHD1, FLOT2, NDUFA10, RGPD6, NNT, FECH, FOLH1, METTL7A (tumor)	MME, IRAK2, SHC1, CD4, ALDH3A2, MYL12A, MYH9, VDAC2, PSME1, MRPL44, DNAJB12, RBM39, TM9SF1, NDUFA9, LMNA, MRPS25, MTDH, NDUFA10, FOLH1, MRVI1, NDUFB4 (normal)

HNSC (tumor)	HNSC (normal)
MME, XRCC5, CPSF6, HSPA4, NOLC1, PIK3R1, SLC9A3R1, PCNA, RUVBL1, NDRG1, NPPA, ITFG3, CLEC4M, RAP2B, TUBB8, NNT, FECH, ARMC10, PDIA5, MRVI1, FAM83F (tumor)	MME, SHC1, TNPO1, ALDH3A2, PIK3R1, SLC9A3R1, CDK5RAP3, PCNA, MYH9, PSME1, HSPB1, NPPC, RBM39, MRPS25, MTDH, NDUFA10, TUBB8, PDIA5, MRVI1, NDUFB4, ZMPSTE24 (normal)

KICH (tumor)	KICH (normal)
MME, OPA1, EDN1, CD4, ALDH3A2, VIP, HIST1H2AG, SLC9A3R1, CDK5RAP3, UTRN, MYL12A, SLC16A1, MTHFD1, NPPC, MRPL44, DNAJB12, RBM39, FAHD1, ADCYAP1, RGPD6, FOLH1 (tumor)	MME, RPS10, RPL30, SHC1, NOLC1, HSPA1B, HIST1H2AG, SLC9A3R1, HSPA1A, EEF1A1, PIK3CB, MRPL44, ADM, IMPDH2, FAHD1, NDUFA10, FAAH, FECH, FAM83F, METTL7A, KBTBD3 (normal)

KIRC (tumor)	KIRC (normal)
MME, XRCC5, NOLC1, EDN1, LYN, SLC9A3R1, UTRN, MYL12A, PCNA, SLC16A1, PSME1, MTHFD1, NPPC, MRPL44, TM9SF1, FAHD1, ARL1, FLOT2, ADCYAP1, UBAC2, FOLH1 (tumor)	MME, EDN1, CD4, ALDH3A2, PIK3R1, SLC9A3R1, SLC16A1, MTHFD1, PIK3CB, MRPL44, NDRG1, MRPS25, IMPDH2, FAHD1, RGPD6, TUBB8, FAAH, FOLH1, PDIA5, METTL7A, ZMPSTE24 (normal)

KIRP (tumor)	KIRP (normal)
MME, OPA1, TNPO1, HSPA8, ALDH3A2, SLC9A3R1, CDK5RAP3, UTRN, MYL12A, PCNA, SLC16A1, KRT10, MTHFD1, MRPL44, RBM39, CLEC4M, FAHD1, ADCYAP1, UBAC2, TUBB8, FOLH1 (tumor)	MME, OPA1, HSPA4, HSPA8, ALDH3A2, SLC9A3R1, CDK5RAP3, UTRN, SLC16A1, KRT10, MTHFD1, MRPL44, RBM39, NDUFA9, LONP1, FAHD1, NDUFA10, RGPD6, METTL7A, NDUFB4, ZMPSTE24 (normal)

LIHC (tumor)	LIHC (normal)
MME, OPA1, SHC1, CPSF6, EDN1, LYN, PIK3R1, CDK5RAP3, MYL12A, RUVBL1, MTHFD1, HSPB1, LMNA, IMPDH2, NUCKS1, SDF4, ARL1, FLOT2, RAP2B, NNT, METTL7A (tumor)	MME, RPS10, RPL30, OPA1, ALDH3A2, PIK3R1, HIST1H2AG, SLC16A1, EEF1A1, MTHFD1, ADM, LMNA, IMPDH2, ADCYAP1, RPS23, TUBB8, FAAH, FECH, FOLH1, METTL7A, ZMPSTE24 (normal)

LUAD (tumor)	LUAD (normal)
MME, IRAK2, SSR4, SHC1, CD4, VIP, SLC9A3R1, MYL12A, MYH9, KRT10, PSME1, MTHFD1, NPPC, INPP5D, NDRG1, MRPS25, IMPDH2, UBAC2, RAP2B, FECH, FOLH1 (tumor)	MME, RPL30, SSR4, OPA1, EDN1, CD4, ALDH3A2, PIK3R1, SLC16A1, INPP5D, ADM, MRPS25, IMPDH2, CLEC4M, NDUFA10, RPS23, EDN2, ATP12A, RAP2B, FAAH, MRVI1 (normal)

LUSC (tumor)	LUSC (normal)
MME, SSR4, SHC1, TNPO1, CDK5RAP3, UTRN, MYL12A, CSNK2B, MRPS25, LONP1, ITFG3, NUCKS1, SDF4, RGPD6, RAP2B, FECH, GAST, PDIA5, MRVI1, METTL7A, ZMPSTE24 (tumor)	MME, XRCC5, SHC1, CPSF6, NOLC1, HSPA8, CD4, HSPA1B, SLC9A3R1, CDK5RAP3, MYL12A, NPPC, DNAJB12, MRPS25, LONP1, SDF4, UBAC2, TUBB8, MRVI1, FAM83F, ZMPSTE24 (normal)

PRAD (tumor)	PRAD (normal)
MME, RUVBL2, SHC1, ALDH3A2, PIK3R1, HIST1H2AG, UTRN, CSNK2B, SLC16A1, RUVBL1, VDAC2, KRT10, HSPB1, PIK3CB, NDRG1, MRPS25, NDUFA10, FECH, PDIA5, METTL7A, NDUFB4 (tumor)	MME, XRCC5, EDN1, ALDH3A2, PIK3R1, CSNK2B, VDAC2, HSPB1, PIK3CB, NPPC, INPP5D, MRPL44, MRPS25, IMPDH2, NUCKS1, NDUFA10, RPS23, FECH, FAM83F, METTL7A, NDUFB4 (normal)

STAD (tumor)	STAD (normal)
MME, XRCC5, SHC1, HSPA4, HSPA8, LYN, HIST1H2AG, UTRN, KRT10, PSME1, HSPB1, NPPC, NDUFA9, ITFG3, SDF4, FAHD1, ATP12A, FAAH, FECH, ARMC10, FOLH1 (tumor)	MME, CSNK2A1, IRAK2, RPS10, SHC1, HSPA8, LYN, VIP, EEF1A1, ADM, NDRG1, TM9SF1, NUCKS1, RPS23, UBAC2, RAP2B, GAST, FOLH1, PDIA5, FAM83F, KBTBD3 (normal)

THCA (tumor)	THCA (normal)
MME, IRAK2, HSPA4, EDN1, CD4, LYN, PIK3R1, PCNA, SLC16A1, NPPC, INPP5D, DNAJB12, TM9SF1, MTDH, ITFG3, FAHD1, RAP2B, FAAH, PDIA5, FAM83F, METTL7A (tumor)	MME, XRCC5, IRAK2, EDN1, CD4, LYN, VIP, PIK3R1, CDK5RAP3, UTRN, MYL12A, PCNA, MYH9, KRT10, NPPC, INPP5D, TM9SF1, LMNA, RAP2B, FAAH, METTL7A (normal)

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TissGeneProg for MME

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for MME

TissGeneDrug for MME

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB09292	Sacubitril	Antagonist\|Inhibitor	Small molecule	Approved

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TissGeneDisease for MME

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0023449	Acute lymphocytic leukemia	59	BeFree
umls:C1292769	Precursor B-cell lymphoblastic leukemia	56	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	50	BeFree,GAD,LHGDN
umls:C0024301	Lymphoma, Follicular	30	BeFree,LHGDN
umls:C0079744	Diffuse Large B-Cell Lymphoma	28	BeFree
umls:C0002395	Alzheimer's Disease	24	BeFree,GAD,LHGDN,MGD
umls:C0024299	Lymphoma	23	BeFree
umls:C0349637	Common acute lymphoblastic leukemia	19	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	17	BeFree
umls:C0006413	Burkitt Lymphoma	14	BeFree
umls:C0023418	leukemia	14	BeFree
umls:C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	12	BeFree
umls:C0079731	B-Cell Lymphomas	11	BeFree
umls:C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	11	BeFree,LHGDN
umls:C0376358	Malignant neoplasm of prostate	11	BeFree
umls:C0333463	Senile Plaques	10	BeFree
umls:C0600139	Prostate carcinoma	10	BeFree
umls:C0023452	Leukemia, Lymphocytic, Acute, L1	9	BeFree
umls:C0027627	Neoplasm Metastasis	8	BeFree,LHGDN
umls:C0033578	Prostatic Neoplasms	8	BeFree,CTD_human,LHGDN
umls:C0233794	Memory impairment	8	BeFree
umls:C2936349	Plaque, Amyloid	8	BeFree
umls:C0020981	Angioimmunoblastic Lymphadenopathy	7	BeFree
umls:C0023434	Chronic Lymphocytic Leukemia	7	BeFree,LHGDN
umls:C0007134	Renal Cell Carcinoma	6	BeFree,LHGDN
umls:C0023473	Myeloid Leukemia, Chronic	6	BeFree,LHGDN
umls:C0026764	Multiple Myeloma	6	BeFree
umls:C0027819	Neuroblastoma	5	BeFree
umls:C0079774	Peripheral T-Cell Lymphoma	5	BeFree
umls:C0085220	Cerebral Amyloid Angiopathy	5	BeFree,GAD,LHGDN
umls:C0085669	Acute leukemia	5	BeFree
umls:C0242647	Mucosa-Associated Lymphoid Tissue Lymphoma	5	BeFree
umls:C0700095	Central neuroblastoma	5	BeFree
umls:C0751606	Adult Acute Lymphocytic Leukemia	5	BeFree
umls:C1842937	AURAL ATRESIA, CONGENITAL	5	BeFree
umls:C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5	BeFree
umls:C0002726	Amyloidosis	4	BeFree,LHGDN
umls:C0006142	Malignant neoplasm of breast	4	BeFree
umls:C0025202	melanoma	4	BeFree,LHGDN
umls:C0242596	Neoplasm, Residual	4	BeFree
umls:C0678222	Breast Carcinoma	4	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	4	BeFree
umls:C0023448	Lymphoid leukemia	3	BeFree
umls:C0024305	Lymphoma, Non-Hodgkin	3	BeFree
umls:C0178874	Tumor Progression	3	BeFree
umls:C0206630	Endometrial Stromal Sarcoma	3	BeFree
umls:C0235974	Pancreatic carcinoma	3	BeFree
umls:C0346647	Malignant neoplasm of pancreas	3	BeFree
umls:C1367654	Marginal Zone B-Cell Lymphoma	3	BeFree
umls:C2239176	Liver carcinoma	3	BeFree
umls:C0001430	Adenoma	2	BeFree,LHGDN
umls:C0005699	Blast Phase	2	BeFree
umls:C0007124	Noninfiltrating Intraductal Carcinoma	2	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	2	BeFree
umls:C0009402	Colorectal Carcinoma	2	BeFree
umls:C0011265	Presenile dementia	2	BeFree
umls:C0014175	Endometriosis	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0024314	Lymphoproliferative Disorders	2	BeFree
umls:C0042769	Virus Diseases	2	BeFree
umls:C0079746	Immunoblastic Large-Cell Lymphoma	2	BeFree
umls:C0079772	T-Cell Lymphoma	2	BeFree,LHGDN
umls:C0206622	Adenomyoma	2	BeFree,LHGDN
umls:C0220621	pediatric acute myeloblastic leukemia	2	BeFree
umls:C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	2	BeFree
umls:C0338656	Impaired cognition	2	BeFree
umls:C0349636	Pre B-cell acute lymphoblastic leukemia	2	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	2	BeFree
umls:C0497327	Dementia	2	BeFree
umls:C0596263	Carcinogenesis	2	BeFree
umls:C0699790	Colon Carcinoma	2	BeFree
umls:C1261473	Sarcoma	2	BeFree
umls:C1458155	Mammary Neoplasms	2	CTD_human,LHGDN
umls:C1840451	MULTICYSTIC RENAL DYSPLASIA, BILATERAL	2	BeFree
umls:C1956130	Lymphoma, Follicular, Grade 1	2	BeFree
umls:C1960397	Philadelphia chromosome-positive acute lymphoblastic leukemia	2	BeFree
umls:C2004493	Leukemia, B-Cell	2	BeFree,LHGDN
umls:C3472614	Plasmablastic lymphoma	2	BeFree
umls:C3838965	Microcystic stromal tumor	2	BeFree
umls:C0001418	Adenocarcinoma	1	LHGDN
umls:C0002893	Refractory anemias	1	BeFree
umls:C0002894	Refractory anaemia with excess blasts	1	BeFree
umls:C0003467	Anxiety	1	GAD
umls:C0003469	Anxiety Disorders	1	BeFree,GAD
umls:C0003507	Aortic Valve Stenosis	1	BeFree
umls:C0004153	Atherosclerosis	1	GAD
umls:C0005695	Bladder Neoplasm	1	BeFree
umls:C0007102	Malignant tumor of colon	1	BeFree
umls:C0007103	Malignant neoplasm of endometrium	1	BeFree
umls:C0007140	Carcinosarcoma	1	BeFree
umls:C0007193	Cardiomyopathy, Dilated	1	BeFree
umls:C0007222	Cardiovascular Diseases	1	GAD
umls:C0007682	CNS disorder	1	BeFree
umls:C0008309	Bile duct adenoma	1	BeFree
umls:C0008370	Cholestasis	1	BeFree
umls:C0009404	Colorectal Neoplasms	1	LHGDN
umls:C0010200	Coughing	1	BeFree
umls:C0010674	Cystic Fibrosis	1	BeFree
umls:C0010823	Cytomegalovirus Infections	1	BeFree
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	1	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	BeFree
umls:C0011881	Diabetic Nephropathy	1	BeFree
umls:C0011882	Diabetic Neuropathies	1	CTD_human
umls:C0011884	Diabetic Retinopathy	1	LHGDN
umls:C0011991	Diarrhea	1	BeFree
umls:C0014170	Endometrial Neoplasms	1	LHGDN
umls:C0015230	Exanthema	1	BeFree
umls:C0017160	Gastroenteritis	1	BeFree
umls:C0017638	Glioma	1	BeFree
umls:C0018801	Heart failure	1	BeFree
umls:C0018802	Congestive heart failure	1	BeFree
umls:C0020538	Hypertensive disease	1	BeFree
umls:C0021368	Inflammation	1	LHGDN
umls:C0023267	Fibroid Tumor	1	BeFree
umls:C0023453	Leukemia, Lymphocytic, Acute, L2	1	BeFree
umls:C0023893	Liver Cirrhosis, Experimental	1	CTD_human
umls:C0024282	Lymphocytosis	1	BeFree
umls:C0026010	Microphthalmos	1	BeFree
umls:C0028754	Obesity	1	BeFree
umls:C0030297	Pancreatic Neoplasm	1	BeFree,LHGDN
umls:C0041107	Trisomy	1	BeFree
umls:C0041582	Ulcer	1	LHGDN
umls:C0042133	Uterine Fibroids	1	BeFree
umls:C0042963	Vomiting	1	BeFree
umls:C0079770	Lymphoma, Small Noncleaved-Cell	1	BeFree
umls:C0085096	Peripheral Vascular Diseases	1	BeFree
umls:C0085110	Severe Combined Immunodeficiency	1	BeFree
umls:C0085183	Neoplasms, Second Primary	1	BeFree
umls:C0085280	Alagille Syndrome	1	BeFree
umls:C0149678	Epstein-Barr Virus Infections	1	BeFree
umls:C0206698	Cholangiocarcinoma	1	BeFree
umls:C0206734	Hemangioblastoma	1	LHGDN
umls:C0234958	Muscle degeneration	1	BeFree
umls:C0242379	Malignant neoplasm of lung	1	BeFree
umls:C0273115	Lung Injury	1	CTD_human
umls:C0278803	Adenocarcinoma of small intestine	1	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	1	BeFree
umls:C0280100	Solid tumour	1	BeFree
umls:C0282612	Prostatic Intraepithelial Neoplasias	1	BeFree
umls:C0333641	Atrophic	1	LHGDN
umls:C0334635	Malignant lymphoma - centrocytic	1	BeFree
umls:C0334695	Endometrial Stromal Tumors	1	LHGDN
umls:C0349632	Splenic Marginal Zone B-Cell Lymphoma	1	BeFree
umls:C0392788	Nasal Type Extranodal NK/T-Cell Lymphoma	1	BeFree
umls:C0432487	Post-transplant lymphoproliferative disorder	1	BeFree
umls:C0476089	Endometrial Carcinoma	1	BeFree
umls:C0524620	Metabolic Syndrome X	1	BeFree
umls:C0558920	Lump on thigh	1	BeFree
umls:C0684249	Carcinoma of lung	1	BeFree
umls:C0740457	Malignant neoplasm of kidney	1	BeFree
umls:C0796126	AICARDI-GOUTIERES SYNDROME 1	1	BeFree
umls:C0848332	Spots on skin	1	BeFree
umls:C0853879	Invasive breast carcinoma	1	BeFree
umls:C0855095	Small Lymphocytic Lymphoma	1	BeFree
umls:C0919267	ovarian neoplasm	1	BeFree
umls:C0948201	Alloimmunisation	1	BeFree
umls:C1168401	Squamous cell carcinoma of the head and neck	1	BeFree
umls:C1260959	Drusen	1	BeFree
umls:C1301359	Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma	1	BeFree
umls:C1332051	AIDS-Related Non-Hodgkin Lymphoma	1	BeFree
umls:C1332884	Central nervous system leukaemia	1	BeFree
umls:C1332977	Childhood Leukemia	1	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	1	BeFree
umls:C1336076	Sporadic Breast Carcinoma	1	BeFree
umls:C1378703	Renal carcinoma	1	BeFree
umls:C1511306	Breast Diffuse Large B-Cell Lymphoma	1	BeFree
umls:C1565489	Renal Insufficiency	1	CTD_human
umls:C1654637	androgen independent prostate cancer	1	BeFree
umls:C1709246	Non-Neoplastic Disorder	1	BeFree
umls:C1709656	Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type	1	BeFree
umls:C1853926	NONAKA MYOPATHY	1	BeFree
umls:C1883486	Uterine Corpus Cancer	1	BeFree
umls:C1956346	Coronary Artery Disease	1	BeFree
umls:C2316212	Cryopyrin-Associated Periodic Syndromes	1	CTD_human
umls:C2931784	Amyloid angiopathy	1	BeFree
umls:C3472608	Micropapillary carcinoma	1	BeFree
umls:C3542024	AORTIC VALVE DISEASE 2	1	BeFree