TissGDB

Home

	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MMP1

Gene summary

Basic gene information	Gene symbol	MMP1
	Gene name	matrix metallopeptidase 1 (interstitial collagenase)
	Synonyms	CLG\|CLGN
	Cytomap	UCSC genome browser: 11q22.3
	Type of gene	protein-coding
	RefGenes	NM_001145938.1, NM_002421.3,
	Description	fibroblast collagenaseinterstitial collagenasematrix metalloprotease 1matrix metalloproteinase 1
	Modification date	20141222
dbXrefs	MIM : 120353
	HGNC : HGNC
	Ensembl : ENSG00000196611
	HPRD : 00384
	Vega : OTTHUMG00000048192
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MMP1
	BioGPS: 4312
Pathway	NCI Pathway Interaction Database: MMP1
	KEGG: MMP1
	REACTOME: MMP1
	Pathway Commons: MMP1
Context	iHOP: MMP1
	ligand binding site mutation search in PubMed: MMP1
	UCL Cancer Institute: MMP1
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Soft tissueSkinStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	SARCSKCMSTAD
Reference showing the relevant tissue of MMP1
Description by TissGene annotations

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006508	proteolysis	15863497
GO:0032461	positive regulation of protein oligomerization	19022250
GO:0006508	proteolysis	15863497
GO:0032461	positive regulation of protein oligomerization	19022250

Top

TissGeneExp for MMP1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
BRCA	1.701379158	-3.506120842	5.2075	3.12E-38	8.08E-37
LUSC	5.337508003	0.158957022	5.17855098	2.77E-19	2.96E-18
THCA	-1.552892994	-4.272096384	2.71920339	1.26E-16	2.20E-15
COAD	4.882464111	0.774898727	4.107565385	1.39E-10	1.92E-09
HNSC	7.212569836	1.511900068	5.700669767	1.19E-16	1.67E-14
LUAD	3.972398063	-1.041900212	5.014298276	6.49E-20	1.28E-18
BLCA	3.951230913	0.609236176	3.341994737	0.00137	0.009317676
KICH	-1.74711035	-0.08377835	-1.663332	0.00406	0.007808237
LIHC	-1.89320835	-3.16161035	1.268402	0.00276	0.006788439
ESCA	5.851843831	0.500662013	5.351181818	0.000226	0.005647461
STAD	4.38080065	1.2168569	3.16394375	0.000209	0.001437434

Top

TissGene-miRNA for MMP1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

Top

TissGeneMut for MMP1

TissGeneSNV for MMP1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.G179E	SKCM	2
p.P361H	PRAD	2
p.G113E	SKCM	2
p.R291W	UCS	1
p.K446N	READ	1
p.Q186P	OV	1
p.H183R	STAD	1
p.A286V	STAD	1
p.E69K	SKCM	1
p.E313K	LUAD	1
p.V426D	LUAD	1
p.F174S	LUSC	1
p.R337G	LIHC	1
p.N211Y	LUAD	1
p.S229F	SARC	1
p.W13X	SKCM	1
p.M414I	UCS	1
p.A286D	LUSC	1
p.T451M	HNSC	1
p.D175V	BLCA	1
p.G279E	SKCM	1
p.L224V	HNSC	1
p.P5S	BLCA	1
p.P13S	COAD	1
p.D96V	LUAD	1
p.E402K	SKCM	1
p.Q120X	SKCM	1
p.E311K	SKCM	1
p.P200S	SKCM	1
p.G190C	ESCA	1
p.P412H	HNSC	1
p.F308L	HNSC	1
p.R214S	LUAD	1
p.E336K	SKCM	1
p.E201G	KICH	1
p.D285E	GBM	1
p.G387E	SKCM	1
p.I134T	LUAD	1
p.R214C	UCEC	1
p.E62K	PAAD	1
p.M414I	SKCM	1
p.G303D	COAD	1
p.P412L	SKCM	1
p.H132Q	LUAD	1
p.D363N	SKCM	1
p.P412S	SKCM	1
p.G178A	CESC	1
p.Y309C	STAD	1
p.I253F	LUAD	1
p.P266S	SKCM	1
p.P412S	LUAD	1
p.E317K	COAD	1
p.D297N	SKCM	1
p.E135Q	CESC	1
p.M160I	BLCA	1
p.S162Y	UCEC	1
p.G434_splice	LUSC	1
p.R214C	HNSC	1
p.G387R	SKCM	1
p.P346L	SKCM	1
p.Q139K	LUAD	1
p.L455V	UCEC	1
p.W13*	SKCM	1
p.G434E	LIHC	1
p.G441E	SKCM	1
p.E135Q	LUAD	1
p.Q264*	SKCM	1
p.W398*	SKCM	1
p.R341W	CESC	1
p.K452R	SKCM	1
p.E333K	GBM	1
p.M348I	SKCM	1
p.Q186*	SKCM	1
p.G166E	SKCM	1
p.E245K	SKCM	1

Top

TissGeneCNV for MMP1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

Top

TissGeneFusions for MMP1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

Top

TissGeneNet for MMP1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
MMP1, CD44, NR3C1, JUN, ETV4, TRIP6, CEBPB, ETS1, SOX8, TNFSF11, SMAD4, SERPINA3, COL2A1, BCAN, MMP7, BSG, TFPI, ACAN, ITGA2, CCL2, TIMP1 (tumor)	MMP1, NR3C1, SMAD3, JUN, ETV4, FOS, CEBPB, ETS1, TNFSF11, SMAD4, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, MMP7, IGFBP3, ACAN, CCL2, CCL13, CMA1 (normal)

COAD (tumor)	COAD (normal)
MMP1, CD44, NR3C1, SMAD3, JUN, ETV4, FOS, CEBPB, ATF3, SMAD4, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, BSG, IGFBP3, CCL2, CCL13, TIMP1, CMA1 (tumor)	MMP1, NR3C1, SMAD3, FOS, CEBPB, ETS1, ATF3, TNFSF11, SMAD4, SERPINA3, CCL7, FOSL1, MMP7, IGFBP3, TFPI, ACAN, ITGA2, CCL2, CCL13, TIMP1, CMA1 (normal)

HNSC (tumor)	HNSC (normal)
MMP1, CD44, NR3C1, SMAD3, JUN, TRIP6, FOS, CEBPB, ATF3, SOX8, TNFSF11, SMAD4, COL2A1, CCL7, FOSL1, BSG, IGFBP3, CCL2, CCL13, TIMP1, CMA1 (tumor)	MMP1, CD44, SMAD3, JUN, FOS, CEBPB, ETS1, SOX8, SMAD4, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, BSG, IGFBP3, ACAN, CCL2, CCL13, TIMP1, CMA1 (normal)

KICH (tumor)	KICH (normal)
MMP1, CD44, NR3C1, JUN, ETV4, TRIP6, CEBPB, ETS1, ATF3, COL2A1, BCAN, CCL7, FOSL1, MMP7, BSG, IGFBP3, ACAN, ITGA2, CCL2, CCL13, CMA1 (tumor)	MMP1, CD44, NR3C1, SMAD3, ETV4, TRIP6, CEBPB, SOX8, SMAD4, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, MMP7, IGFBP3, TFPI, ACAN, ITGA2, CCL13, TIMP1 (normal)

KIRC (tumor)	KIRC (normal)
MMP1, CD44, NR3C1, SMAD3, FOS, CEBPB, ATF3, SOX8, TNFSF11, SERPINA3, COL2A1, CCL7, FOSL1, MMP7, BSG, IGFBP3, TFPI, ACAN, ITGA2, CCL2, TIMP1 (tumor)	MMP1, CD44, NR3C1, ETV4, TRIP6, FOS, CEBPB, ATF3, SOX8, TNFSF11, SERPINA3, CCL7, FOSL1, MMP7, BSG, IGFBP3, TFPI, ACAN, CCL13, TIMP1, CMA1 (normal)

KIRP (tumor)	KIRP (normal)
MMP1, CD44, NR3C1, JUN, ETV4, TRIP6, CEBPB, ETS1, ATF3, SOX8, SMAD4, COL2A1, CCL7, FOSL1, MMP7, IGFBP3, TFPI, ACAN, CCL2, TIMP1, CMA1 (tumor)	MMP1, CD44, ETV4, TRIP6, CEBPB, ETS1, ATF3, SOX8, SMAD4, SERPINA3, CCL7, FOSL1, MMP7, BSG, IGFBP3, TFPI, ACAN, ITGA2, CCL13, TIMP1, CMA1 (normal)

LIHC (tumor)	LIHC (normal)
MMP1, CD44, SMAD3, ETV4, CEBPB, ETS1, ATF3, SOX8, TNFSF11, SERPINA3, BCAN, CCL7, FOSL1, MMP7, BSG, IGFBP3, ACAN, ITGA2, CCL2, CCL13, TIMP1 (tumor)	MMP1, CD44, NR3C1, SMAD3, ETV4, TRIP6, FOS, CEBPB, TNFSF11, SERPINA3, CCL7, FOSL1, MMP7, BSG, IGFBP3, TFPI, ACAN, ITGA2, CCL2, CCL13, TIMP1 (normal)

LUAD (tumor)	LUAD (normal)
MMP1, CD44, NR3C1, SMAD3, JUN, FOS, CEBPB, ETS1, TNFSF11, SMAD4, SERPINA3, BCAN, CCL7, FOSL1, MMP7, BSG, IGFBP3, ACAN, CCL2, CCL13, TIMP1 (tumor)	MMP1, CD44, NR3C1, SMAD3, JUN, CEBPB, ETS1, TNFSF11, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, MMP7, IGFBP3, TFPI, ACAN, ITGA2, CCL2, CCL13, TIMP1 (normal)

LUSC (tumor)	LUSC (normal)
MMP1, NR3C1, SMAD3, ETV4, TRIP6, FOS, SOX8, TNFSF11, SMAD4, SERPINA3, COL2A1, CCL7, FOSL1, MMP7, BSG, ACAN, ITGA2, CCL2, CCL13, TIMP1, CMA1 (tumor)	MMP1, CD44, ETV4, FOS, CEBPB, ETS1, ATF3, TNFSF11, SMAD4, SERPINA3, BCAN, CCL7, FOSL1, MMP7, BSG, IGFBP3, TFPI, ITGA2, CCL2, CCL13, TIMP1 (normal)

PRAD (tumor)	PRAD (normal)
MMP1, CD44, NR3C1, FOS, CEBPB, ETS1, SOX8, TNFSF11, SMAD4, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, MMP7, BSG, TFPI, ITGA2, CCL2, CCL13, CMA1 (tumor)	MMP1, CD44, SMAD3, ETV4, FOS, CEBPB, ETS1, ATF3, TNFSF11, SMAD4, SERPINA3, BCAN, CCL7, FOSL1, MMP7, TFPI, ITGA2, CCL2, CCL13, TIMP1, CMA1 (normal)

STAD (tumor)	STAD (normal)
MMP1, CD44, NR3C1, SMAD3, ETV4, TRIP6, FOS, ETS1, ATF3, SOX8, TNFSF11, SMAD4, SERPINA3, COL2A1, BCAN, MMP7, BSG, IGFBP3, TFPI, CCL2, TIMP1 (tumor)	MMP1, CD44, NR3C1, JUN, ETV4, FOS, ATF3, SOX8, SERPINA3, CCL7, FOSL1, MMP7, BSG, IGFBP3, TFPI, ACAN, ITGA2, CCL2, CCL13, TIMP1, CMA1 (normal)

THCA (tumor)	THCA (normal)
MMP1, CD44, NR3C1, SMAD3, JUN, ETV4, CEBPB, ETS1, ATF3, SOX8, TNFSF11, SMAD4, SERPINA3, CCL7, FOSL1, MMP7, IGFBP3, CCL2, CCL13, TIMP1, CMA1 (tumor)	MMP1, CD44, NR3C1, ETV4, CEBPB, ATF3, TNFSF11, SERPINA3, COL2A1, BCAN, CCL7, FOSL1, MMP7, BSG, IGFBP3, ACAN, ITGA2, CCL2, CCL13, TIMP1, CMA1 (normal)

Top

TissGeneProg for MMP1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Top

TissGeneClin for MMP1

TissGeneDrug for MMP1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB00786	Marimastat	Inhibitor	Small molecule	Approved\|Investigational

Top

TissGeneDisease for MMP1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0027627	Neoplasm Metastasis	74	BeFree,CTD_human,LHGDN
umls:C0003873	Rheumatoid Arthritis	41	BeFree,GAD,LHGDN
umls:C0006142	Malignant neoplasm of breast	37	BeFree,GAD
umls:C0678222	Breast Carcinoma	35	BeFree
umls:C0025202	melanoma	29	BeFree,LHGDN
umls:C0029408	Degenerative polyarthritis	22	BeFree,LHGDN
umls:C0009402	Colorectal Carcinoma	20	BeFree
umls:C1527249	Colorectal Cancer	20	BeFree,GAD
umls:C0007137	Squamous cell carcinoma	18	BeFree,GAD,LHGDN
umls:C0699791	Stomach Carcinoma	18	BeFree
umls:C0024623	Malignant neoplasm of stomach	17	BeFree,GAD
umls:C0036421	Systemic Scleroderma	17	BeFree,LHGDN
umls:C0242379	Malignant neoplasm of lung	17	BeFree,GAD
umls:C0024117	Chronic Obstructive Airway Disease	16	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0031099	Periodontitis	15	BeFree,GAD
umls:C1458155	Mammary Neoplasms	15	BeFree,CTD_human,LHGDN
umls:C0034067	Pulmonary Emphysema	14	BeFree
umls:C0178874	Tumor Progression	14	BeFree
umls:C0266929	Chronic Periodontitis	13	BeFree,GAD,LHGDN
umls:C0004153	Atherosclerosis	12	BeFree,CTD_human,GAD,LHGDN
umls:C0027051	Myocardial Infarction	12	BeFree,GAD,LHGDN,RGD
umls:C0684249	Carcinoma of lung	12	BeFree
umls:C0009404	Colorectal Neoplasms	11	CTD_human,GAD,LHGDN
umls:C0005684	Malignant neoplasm of urinary bladder	9	BeFree,GAD
umls:C0041296	Tuberculosis	9	BeFree
umls:C0596263	Carcinogenesis	9	BeFree
umls:C2239176	Liver carcinoma	9	BeFree,GAD,LHGDN
umls:C0003850	Arteriosclerosis	8	BeFree
umls:C0010068	Coronary heart disease	8	BeFree,GAD
umls:C0024121	Lung Neoplasms	8	BeFree,CTD_human,GAD,LHGDN
umls:C0376358	Malignant neoplasm of prostate	8	BeFree,GAD
umls:C0600139	Prostate carcinoma	8	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	8	BeFree
umls:C0001418	Adenocarcinoma	7	BeFree,GAD,LHGDN
umls:C0001430	Adenoma	7	BeFree,LHGDN
umls:C0008479	Chondrosarcoma	7	BeFree,LHGDN
umls:C0009324	Ulcerative Colitis	7	BeFree,GAD,LHGDN,RGD
umls:C0014175	Endometriosis	7	BeFree,GAD,LHGDN
umls:C0029925	Ovarian Carcinoma	7	BeFree
umls:C0010054	Coronary Arteriosclerosis	6	BeFree,GAD
umls:C0153381	Malignant neoplasm of mouth	6	BeFree,GAD
umls:C0239946	Fibrosis, Liver	6	BeFree
umls:C0699885	Carcinoma of bladder	6	BeFree
umls:C1140680	Malignant neoplasm of ovary	6	BeFree,GAD
umls:C1168401	Squamous cell carcinoma of the head and neck	6	BeFree
umls:C2931822	Nasopharyngeal carcinoma	6	BeFree
umls:C0003864	Arthritis	5	BeFree,GAD
umls:C0011644	Scleroderma	5	BeFree
umls:C0020538	Hypertensive disease	5	BeFree,GAD
umls:C0021368	Inflammation	5	GAD,LHGDN
umls:C0027092	Myopia	5	BeFree,GAD
umls:C0029172	Oral Submucous Fibrosis	5	BeFree,CTD_human,GAD
umls:C0235974	Pancreatic carcinoma	5	BeFree
umls:C0302592	Cervix carcinoma	5	BeFree
umls:C0699790	Colon Carcinoma	5	BeFree
umls:C1956346	Coronary Artery Disease	5	BeFree,GAD
umls:C0004096	Asthma	4	BeFree,GAD,LHGDN
umls:C0007131	Non-Small Cell Lung Carcinoma	4	BeFree,CTD_human,GAD
umls:C0007134	Renal Cell Carcinoma	4	BeFree,GAD,LHGDN
umls:C0007222	Cardiovascular Diseases	4	BeFree,GAD
umls:C0007847	Malignant tumor of cervix	4	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	4	BeFree,GAD,RGD
umls:C0017636	Glioblastoma	4	BeFree
umls:C0017638	Glioma	4	BeFree
umls:C0021390	Inflammatory Bowel Diseases	4	BeFree,LHGDN
umls:C0023890	Liver Cirrhosis	4	BeFree,GAD,RGD
umls:C0024232	Lymphatic Metastasis	4	BeFree,LHGDN
umls:C0033578	Prostatic Neoplasms	4	BeFree,LHGDN
umls:C0041327	Tuberculosis, Pulmonary	4	BeFree,GAD
umls:C0079474	Hallopeau-Siemens Disease	4	BeFree,ORPHANET
umls:C0278996	Cancer of Head and Neck	4	BeFree,GAD
umls:C0346647	Malignant neoplasm of pancreas	4	BeFree
umls:C0476089	Endometrial Carcinoma	4	BeFree,GAD
umls:C0524910	Hepatitis C, Chronic	4	BeFree,GAD
umls:C0677886	Epithelial ovarian cancer	4	BeFree
umls:C0740457	Malignant neoplasm of kidney	4	BeFree,GAD
umls:C1261473	Sarcoma	4	BeFree,LHGDN
umls:C0010346	Crohn Disease	3	BeFree,LHGDN
umls:C0011847	Diabetes	3	BeFree
umls:C0011849	Diabetes Mellitus	3	BeFree
umls:C0016057	Fibrosarcoma	3	BeFree
umls:C0018801	Heart failure	3	BeFree,RGD
umls:C0019196	Hepatitis C	3	BeFree,GAD
umls:C0023267	Fibroid Tumor	3	BeFree
umls:C0027626	Neoplasm Invasiveness	3	CTD_human,GAD,LHGDN
umls:C0031090	Periodontal Diseases	3	BeFree,GAD
umls:C0033999	Pterygium	3	BeFree
umls:C0034069	Pulmonary Fibrosis	3	BeFree,RGD
umls:C0042133	Uterine Fibroids	3	BeFree
umls:C0042345	Varicosity	3	BeFree,GAD
umls:C0085110	Severe Combined Immunodeficiency	3	BeFree
umls:C0151526	Premature Birth	3	GAD
umls:C0151779	Cutaneous Melanoma	3	BeFree
umls:C0152018	Esophageal carcinoma	3	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	3	BeFree
umls:C0153690	Secondary malignant neoplasm of bone	3	BeFree
umls:C0155626	Acute myocardial infarction	3	BeFree
umls:C0220641	Lip and Oral Cavity Carcinoma	3	BeFree
umls:C0220650	Metastatic malignant neoplasm to brain	3	BeFree
umls:C0243026	Sepsis	3	BeFree,RGD
umls:C0279626	Squamous cell carcinoma of esophagus	3	BeFree
umls:C0279628	Adenocarcinoma Of Esophagus	3	BeFree
umls:C0333307	Superficial ulcer	3	BeFree
umls:C0339573	Glaucoma, Primary Open Angle	3	BeFree
umls:C0409959	Osteoarthritis, Knee	3	BeFree,GAD,RGD
umls:C0853879	Invasive breast carcinoma	3	BeFree
umls:C0877015	Pelvic Organ Prolapse	3	BeFree
umls:C0948089	Acute Coronary Syndrome	3	BeFree,GAD
umls:C0993582	Arthritis, Experimental	3	RGD
umls:C1561643	Chronic Kidney Diseases	3	BeFree
umls:C1568272	Tendinopathy	3	BeFree,RGD
umls:C1708565	Invasive Skin Melanoma	3	BeFree
umls:C1800706	Idiopathic Pulmonary Fibrosis	3	BeFree,GAD,LHGDN
umls:C0002395	Alzheimer's Disease	2	BeFree,GAD
umls:C0002940	Aneurysm	2	BeFree,CTD_human
umls:C0003130	Anoxia	2	GAD,LHGDN
umls:C0003486	Aortic Aneurysm	2	BeFree
umls:C0005695	Bladder Neoplasm	2	LHGDN
umls:C0006267	Bronchiectasis	2	BeFree,GAD
umls:C0007102	Malignant tumor of colon	2	BeFree
umls:C0007193	Cardiomyopathy, Dilated	2	BeFree,GAD,LHGDN
umls:C0007282	Carotid Stenosis	2	BeFree,GAD
umls:C0007570	Celiac Disease	2	BeFree
umls:C0009782	Connective Tissue Diseases	2	GAD,LHGDN
umls:C0010674	Cystic Fibrosis	2	BeFree
umls:C0011608	Dermatitis Herpetiformis	2	BeFree
umls:C0012813	Diverticulitis	2	BeFree
umls:C0014859	Esophageal Neoplasms	2	BeFree,GAD
umls:C0015944	Fetal Membranes, Premature Rupture	2	GAD
umls:C0016034	Breast Fibrocystic Disease	2	BeFree
umls:C0017168	Gastroesophageal reflux disease	2	BeFree
umls:C0017563	Gingival Diseases	2	BeFree
umls:C0017601	Glaucoma	2	BeFree
umls:C0018802	Congestive heart failure	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0022548	Keloid	2	BeFree
umls:C0022661	Kidney Failure, Chronic	2	BeFree,GAD
umls:C0023903	Liver neoplasms	2	GAD
umls:C0024115	Lung diseases	2	BeFree,LHGDN
umls:C0025286	Meningioma	2	BeFree
umls:C0026640	Mouth Neoplasms	2	GAD
umls:C0027430	Nasal Polyps	2	BeFree
umls:C0028754	Obesity	2	BeFree
umls:C0029463	Osteosarcoma	2	BeFree
umls:C0031106	Periodontitis, Juvenile	2	BeFree,GAD
umls:C0032914	Pre-Eclampsia	2	GAD
umls:C0036690	Septicemia	2	BeFree
umls:C0037274	Dermatologic disorders	2	BeFree,GAD
umls:C0038356	Stomach Neoplasms	2	BeFree,LHGDN
umls:C0038454	Cerebrovascular accident	2	BeFree,GAD
umls:C0042025	Urinary Stress Incontinence	2	BeFree,GAD
umls:C0042373	Vascular Diseases	2	BeFree
umls:C0149521	Pancreatitis, Chronic	2	BeFree
umls:C0152013	Adenocarcinoma of lung (disorder)	2	BeFree
umls:C0153633	Malignant neoplasm of brain	2	GAD
umls:C0158266	Intervertebral Disc Degeneration	2	BeFree,RGD
umls:C0162672	MERRF Syndrome	2	BeFree
umls:C0205647	Follicular adenoma	2	BeFree
umls:C0206368	Exfoliation Syndrome	2	BeFree
umls:C0238067	Colitis, Collagenous	2	BeFree
umls:C0280324	Laryngeal Squamous Cell Carcinoma	2	BeFree
umls:C0341439	Chronic liver disease	2	BeFree,GAD
umls:C0346429	Multiple malignancy	2	BeFree
umls:C0349566	Squamous cell carcinoma of tongue	2	BeFree
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0399440	Hereditary gingival fibromatosis	2	BeFree
umls:C0524620	Metabolic Syndrome X	2	BeFree,GAD
umls:C0549473	Thyroid carcinoma	2	BeFree
umls:C0553580	Ewings sarcoma	2	BeFree
umls:C0555198	Malignant Glioma	2	BeFree
umls:C0577631	Carotid Atherosclerosis	2	BeFree
umls:C0585442	Osteosarcoma of bone	2	BeFree
umls:C0598935	Tumor Initiation	2	BeFree
umls:C0685938	Malignant neoplasm of gastrointestinal tract	2	BeFree
umls:C0850666	Helicobacter pylori infection	2	BeFree
umls:C0878500	Intraepithelial Neoplasia	2	BeFree
umls:C0878693	Conjunctivochalasis	2	BeFree
umls:C1302401	Adenoma of large intestine	2	BeFree
umls:C1378703	Renal carcinoma	2	BeFree
umls:C1520166	Xenograft Model	2	BeFree
umls:C1621958	Glioblastoma Multiforme	2	BeFree
umls:C0001883	Airway Obstruction	1	BeFree,GAD,LHGDN
umls:C0002382	Alveolar Bone Loss	1	GAD
umls:C0002736	Amyotrophic Lateral Sclerosis	1	GAD
umls:C0003855	Arteriovenous fistula	1	BeFree
umls:C0003872	Arthritis, Psoriatic	1	BeFree
umls:C0004114	Astrocytoma	1	BeFree
umls:C0004364	Autoimmune Diseases	1	BeFree
umls:C0005940	Bone Diseases	1	BeFree,LHGDN
umls:C0006261	Bronchial Diseases	1	GAD
umls:C0006277	Bronchitis	1	GAD
umls:C0007103	Malignant neoplasm of endometrium	1	BeFree
umls:C0007114	Malignant neoplasm of skin	1	BeFree
umls:C0007138	Carcinoma, Transitional Cell	1	BeFree
umls:C0007273	Carotid Artery Diseases	1	GAD
umls:C0007758	Cerebellar Ataxia	1	BeFree
umls:C0007787	Transient Ischemic Attack	1	BeFree
umls:C0008149	Chlamydia Infections	1	BeFree
umls:C0008313	Cholangitis, Sclerosing	1	BeFree,GAD
umls:C0008487	Chordoma	1	LHGDN
umls:C0008495	Chorioamnionitis	1	GAD
umls:C0009917	Contracture	1	BeFree
umls:C0010051	Coronary Aneurysm	1	GAD
umls:C0010495	Cutis Laxa	1	BeFree
umls:C0010709	Cyst	1	BeFree
umls:C0011057	Hearing Loss, Sudden	1	GAD
umls:C0011065	Cessation of life	1	LHGDN
umls:C0011620	Stasis dermatitis	1	BeFree
umls:C0011633	Dermatomyositis	1	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	1	RGD
umls:C0011875	Diabetic Angiopathies	1	GAD
umls:C0013537	Eclampsia	1	GAD
umls:C0013990	Pathological accumulation of air in tissues	1	GAD
umls:C0014335	Enteritis	1	BeFree
umls:C0014457	Eosinophilia	1	BeFree
umls:C0014527	Epidermolysis Bullosa	1	BeFree,GAD
umls:C0015929	Fetal Diseases	1	GAD
umls:C0016033	Nonproliferative fibrocystic disease	1	BeFree
umls:C0016059	Fibrosis	1	GAD
umls:C0017661	IGA Glomerulonephritis	1	CTD_human
umls:C0018128	Graft Occlusion, Vascular	1	GAD
umls:C0018188	Granuloma	1	LHGDN
umls:C0018621	Hay fever	1	GAD
umls:C0018671	Head and Neck Neoplasms	1	GAD
umls:C0019189	Hepatitis, Chronic	1	BeFree
umls:C0019270	Hernia	1	BeFree
umls:C0019284	Diaphragmatic Hernia	1	LHGDN
umls:C0019562	Von Hippel-Lindau Syndrome	1	BeFree
umls:C0020445	Hypercholesterolemia, Familial	1	BeFree
umls:C0020507	Hyperplasia	1	RGD
umls:C0020542	Pulmonary Hypertension	1	RGD
umls:C0021051	Immunologic Deficiency Syndromes	1	BeFree
umls:C0022602	Actinic keratosis	1	BeFree
umls:C0022665	Kidney Neoplasm	1	GAD
umls:C0022876	Premature Obstetric Labor	1	GAD
umls:C0023893	Liver Cirrhosis, Experimental	1	CTD_human
umls:C0023895	Liver diseases	1	LHGDN
umls:C0024031	Low Back Pain	1	BeFree
umls:C0024198	Lyme Disease	1	LHGDN
umls:C0024299	Lymphoma	1	BeFree
umls:C0024305	Lymphoma, Non-Hodgkin	1	GAD
umls:C0024534	Malaria, Cerebral	1	LHGDN
umls:C0026266	Mitral Valve Insufficiency	1	GAD
umls:C0026267	Mitral Valve Prolapse Syndrome	1	GAD
umls:C0026691	Mucocutaneous Lymph Node Syndrome	1	GAD
umls:C0026764	Multiple Myeloma	1	LHGDN
umls:C0026769	Multiple Sclerosis	1	GAD
umls:C0026850	Muscular Dystrophy	1	BeFree
umls:C0026857	Musculoskeletal Diseases	1	GAD
umls:C0027055	Myocardial Reperfusion Injury	1	RGD
umls:C0027439	Nasopharyngeal Neoplasms	1	GAD
umls:C0027533	Neck Neoplasms	1	BeFree
umls:C0027643	Neoplasm Recurrence, Local	1	GAD
umls:C0027726	Nephrotic Syndrome	1	CTD_mouse
umls:C0027962	Melanocytic nevus	1	BeFree
umls:C0028840	Ocular Hypertension	1	CTD_human
umls:C0029443	Osteomyelitis	1	BeFree
umls:C0029456	Osteoporosis	1	BeFree
umls:C0029927	Ovarian Cysts	1	BeFree
umls:C0029928	Ovarian Diseases	1	BeFree
umls:C0030193	Pain	1	BeFree
umls:C0030354	Papilloma	1	BeFree
umls:C0030567	Parkinson Disease	1	GAD
umls:C0031094	Periodontal Pocket	1	GAD
umls:C0032000	Pituitary Adenoma	1	BeFree
umls:C0032285	Pneumonia	1	GAD
umls:C0032326	Pneumothorax	1	BeFree
umls:C0032460	Polycystic Ovary Syndrome	1	BeFree,GAD
umls:C0032927	Precancerous Conditions	1	BeFree
umls:C0032964	Pregnancy Complications, Hematologic	1	GAD
umls:C0033774	Pruritus	1	BeFree,GAD
umls:C0035204	Respiration Disorders	1	BeFree
umls:C0035242	Respiratory Tract Diseases	1	BeFree
umls:C0035450	Rheumatoid Nodule	1	BeFree
umls:C0036420	Localized scleroderma	1	LHGDN
umls:C0036439	Scoliosis, unspecified	1	RGD
umls:C0037933	Spinal Diseases	1	GAD
umls:C0038358	Gastric ulcer	1	GAD
umls:C0038449	Stricture of artery	1	BeFree
umls:C0039106	Pigmented villonodular synovitis	1	BeFree,LHGDN
umls:C0040053	Thrombosis	1	GAD
umls:C0040411	Tongue Neoplasms	1	GAD
umls:C0040583	Tracheal Stenosis	1	GAD
umls:C0041834	Erythema	1	BeFree
umls:C0043346	Xeroderma Pigmentosum	1	BeFree
umls:C0079293	Epidermolysis Bullosa Acquisita	1	BeFree
umls:C0079294	Epidermolysis Bullosa Dystrophica	1	BeFree,CTD_human
umls:C0085096	Peripheral Vascular Diseases	1	GAD
umls:C0085655	Polymyositis	1	BeFree
umls:C0085762	Alcohol abuse	1	BeFree
umls:C0149721	Left Ventricular Hypertrophy	1	GAD
umls:C0149793	Amaurosis Fugax	1	BeFree
umls:C0151468	Thyroid Gland Follicular Adenoma	1	BeFree
umls:C0151846	Periosteal Disorder	1	BeFree
umls:C0154051	Hemangioma of retina	1	BeFree
umls:C0155668	Old myocardial infarction	1	BeFree
umls:C0156344	Endometriosis of ovary	1	BeFree
umls:C0162666	Mitochondrial Encephalomyopathies	1	BeFree
umls:C0162810	Cicatrix, Hypertrophic	1	BeFree
umls:C0162871	Aortic Aneurysm, Abdominal	1	GAD
umls:C0205696	Anaplastic carcinoma	1	BeFree
umls:C0206114	Periodontal Attachment Loss	1	GAD
umls:C0206139	Lichen Planus, Oral	1	GAD
umls:C0206172	Diabetic Foot	1	BeFree
umls:C0206638	Giant Cell Tumor of Bone	1	BeFree
umls:C0206682	Follicular thyroid carcinoma	1	BeFree
umls:C0206692	Carcinoma, Lobular	1	BeFree
umls:C0206698	Cholangiocarcinoma	1	BeFree,LHGDN
umls:C0206706	Verrucous carcinoma	1	BeFree
umls:C0206734	Hemangioblastoma	1	BeFree
umls:C0221014	Reactive systemic amyloidosis	1	BeFree
umls:C0221056	Adult type dermatomyositis	1	BeFree
umls:C0221259	Trichiasis	1	BeFree
umls:C0221757	alpha 1-Antitrypsin Deficiency	1	BeFree,GAD
umls:C0238190	Inclusion Body Myositis (disorder)	1	BeFree
umls:C0238239	Light chain disease	1	BeFree
umls:C0238301	Cancer of Nasopharynx	1	GAD
umls:C0241910	Hepatitis, Autoimmune	1	BeFree
umls:C0242381	Lyme Arthritis	1	BeFree
umls:C0242383	Age related macular degeneration	1	BeFree
umls:C0268381	Primary amyloidosis	1	BeFree
umls:C0271183	Severe myopia	1	BeFree
umls:C0275524	Coinfection	1	BeFree
umls:C0278701	Gastric Adenocarcinoma	1	BeFree
umls:C0278883	Metastatic melanoma	1	BeFree
umls:C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	BeFree,GAD
umls:C0281361	Adenocarcinoma of pancreas	1	BeFree
umls:C0281899	Prolapsed lumbar disc	1	BeFree
umls:C0333186	Restenosis	1	BeFree
umls:C0334163	Fibrous bands	1	BeFree
umls:C0338106	Adenocarcinoma of colon	1	BeFree
umls:C0339229	Superior limbic keratoconjunctivitis	1	BeFree
umls:C0341299	Collagenous Sprue	1	BeFree
umls:C0341858	Endometriosis of uterus	1	BeFree
umls:C0349458	Cervical intraepithelial neoplasia grade 1	1	BeFree
umls:C0349489	Fetal Hypoxia	1	RGD
umls:C0349516	Isolated aortic stenosis	1	BeFree
umls:C0400966	Non-alcoholic Fatty Liver Disease	1	CTD_human
umls:C0432215	Progressive pseudorheumatoid dysplasia	1	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	1	BeFree
umls:C0521858	Decreased drug resistance	1	BeFree
umls:C0546837	Malignant neoplasm of esophagus	1	BeFree
umls:C0566602	Primary sclerosing cholangitis	1	BeFree
umls:C0677898	invasive cancer	1	BeFree
umls:C0699949	airway disease	1	BeFree
umls:C0748540	Scleroderma, Limited	1	GAD
umls:C0751674	Lymphangioleiomyomatosis	1	BeFree
umls:C0751815	Carotid Artery, Internal, Dissection	1	GAD
umls:C0852036	Pregnancy associated hypertension	1	GAD
umls:C0852949	Arteriopathic disease	1	BeFree
umls:C0877009	Muscle fibrosis	1	BeFree
umls:C0878544	Cardiomyopathies	1	LHGDN
umls:C0919267	ovarian neoplasm	1	BeFree
umls:C0948008	Ischemic stroke	1	BeFree
umls:C1136321	HIV-Associated Lipodystrophy Syndrome	1	GAD
umls:C1258104	Diffuse Scleroderma	1	GAD
umls:C1261287	Stenosis	1	GAD
umls:C1271104	Blood pressure finding	1	GAD
umls:C1272641	Systemic arterial pressure	1	GAD
umls:C1275114	Epidermolysis Bullosa Pruriginosa	1	BeFree
umls:C1306557	Chronic venous insufficiency	1	BeFree
umls:C1306759	Eosinophilic disorder	1	BeFree
umls:C1306889	Peripheral arterial occlusive disease	1	BeFree
umls:C1319315	Adenocarcinoma of large intestine	1	BeFree
umls:C1333990	Hereditary Nonpolyposis Colorectal Cancer	1	BeFree
umls:C1334177	Infiltrating Cervical Carcinoma	1	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	1	BeFree
umls:C1368683	Epithelioma	1	BeFree
umls:C1456868	Diabetic foot ulcer	1	BeFree
umls:C1561921	Non-ST elevation (NSTEMI) myocardial infarction	1	BeFree
umls:C1623038	Cirrhosis	1	BeFree
umls:C1636667	Disorder characterized by eosinophilia	1	BeFree
umls:C1707758	Direct Contact Transmission Infection	1	BeFree
umls:C1709246	Non-Neoplastic Disorder	1	BeFree
umls:C1762616	Meningioma, benign, no ICD-O subtype	1	BeFree
umls:C1883486	Uterine Corpus Cancer	1	BeFree
umls:C1955934	Trichothiodystrophy Syndromes	1	BeFree
umls:C1968949	Cakut	1	BeFree
umls:C2752147	XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C	1	BeFree
umls:C2919032	Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified	1	GAD
umls:C2945759	aggressive cancer	1	BeFree
umls:C3241937	Nonalcoholic Steatohepatitis	1	BeFree
umls:C3272363	Ischemic Cerebrovascular Accident	1	BeFree
umls:C3273019	Early Hepatocellular Carcinoma	1	BeFree
umls:C3536715	AA amyloidosis	1	BeFree
umls:C3695127	Astrocytoma of brain	1	BeFree
umls:C3714514	Infection	1	GAD
umls:C0729264	Preterm premature rupture of membranes (disorder)	0	CLINVAR
umls:C2751329	PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, RATE OF DECLINE OF LUNG FUNCTION IN	0	CLINVAR