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| TissGeneSummary for ASIP |
 Gene summary |
| Basic gene information | Gene symbol | ASIP |
| Gene name | agouti signaling protein | |
| Synonyms | AGSW|AGTI|AGTIL|ASP|SHEP9 | |
| Cytomap | UCSC genome browser: 20q11.2-q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001672.2, | |
| Description | agouti signaling protein, nonagouti homologagouti switch proteinagouti-signaling proteinnonagouti homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600201 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101440 | ||
| HPRD : 02562 | ||
| Vega : OTTHUMG00000032289 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ASIP | |
| BioGPS: 434 | ||
| Pathway | NCI Pathway Interaction Database: ASIP | |
| KEGG: ASIP | ||
| REACTOME: ASIP | ||
| Pathway Commons: ASIP | ||
| Context | iHOP: ASIP | |
| ligand binding site mutation search in PubMed: ASIP | ||
| UCL Cancer Institute: ASIP | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Ovary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OV | |
| Reference showing the relevant tissue of ASIP | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ASIP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 0.006693629 | -1.647846996 | 1.654540625 | 9.65E-06 | 4.04E-05 |
| THCA | -0.625620195 | -1.665365958 | 1.039745763 | 5.12E-06 | 1.73E-05 |
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| TissGene-miRNA for ASIP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ASIP |
| TissGeneSNV for ASIP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K75E | KIRP | 2 |
| p.E27K | LUAD | 1 |
| p.S129R | OV | 1 |
| p.R5H | SARC | 1 |
| p.R97L | LGG | 1 |
| p.D2H | BLCA | 1 |
| p.S72F | SKCM | 1 |
| p.R97H | COAD | 1 |
| p.K80N | COAD | 1 |
| p.P25S | STAD | 1 |
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| TissGeneCNV for ASIP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ASIP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-55-7903-01A | ITCH-ASIP | 5'UTR-5'UTR | chr20:32957276 | chr20:32848170 |
| Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5KY-01A | B4GALT5-ASIP | CDS-5'UTR | chr20:48330112 | chr20:32848170 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1FD-01A | ITCH-ASIP | CDS-5UTR | Chr20:32981687 | Chr20:32848171 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-GM-A2DD-01A | ITCH-ASIP | CDS-5UTR | Chr20:33012331 | Chr20:32848171 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-BA-6871-01A | ITCH-ASIP | 5UTR-CDS | Chr20:32957276 | Chr20:32856797 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-7903-01A | ITCH-ASIP | 5UTR-5UTR | Chr20:32957276 | Chr20:32848171 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-37-3783-01A | ITCH-ASIP | In-frame | Chr20:33057925 | Chr20:32856797 |
| TCGAfusionPortal | PRADA | OV | TCGA-24-0968-01A | ITCH-ASIP | 5UTR-5UTR | Chr20:32951155 | Chr20:32848171 |
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| TissGeneNet for ASIP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| COAD (tumor) | COAD (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| KICH (tumor) | KICH (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| STAD (tumor) | STAD (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| THCA (tumor) | THCA (normal) |
| ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (tumor) | ASIP, MC2R, MC4R, MC3R, F11R, MC5R, MC1R (normal) |
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| TissGeneProg for ASIP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ASIP |
| TissGeneDrug for ASIP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ASIP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025202 | melanoma | 12 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0028754 | Obesity | 8 | BeFree,CTD_mouse,MGD |
| umls:C0151779 | Cutaneous Melanoma | 4 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 3 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 3 | CTD_human,GAD,LHGDN |
| umls:C0019693 | HIV Infections | 3 | BeFree |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 3 | BeFree |
| umls:C0037286 | Skin Neoplasms | 3 | CTD_human,GAD |
| umls:C3714757 | Juvenile rheumatoid arthritis | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0016037 | Fibrodysplasia Ossificans Progressiva | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree,GAD |
| umls:C0233523 | Antisocial behavior | 2 | BeFree |
| umls:C3665492 | Structure showing abnormal deposition of pigment (morphologic abnormality) | 2 | GAD |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0007114 | Malignant neoplasm of skin | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree,GAD |
| umls:C0008350 | Cholelithiasis | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | CTD_mouse |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_mouse,MGD |
| umls:C0016689 | Freckles | 1 | GAD |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | CTD_mouse |
| umls:C0026946 | Mycoses | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
| umls:C0549567 | Pigmentation Disorders | 1 | CTD_mouse |
| umls:C0751651 | Mitochondrial Diseases | 1 | BeFree |
| umls:C0947622 | Cholecystolithiasis | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |
| umls:C1512419 | Hereditary Melanoma | 1 | BeFree |
| umls:C1535939 | Pneumocystis jiroveci pneumonia | 1 | BeFree |
| umls:C1704421 | Skin Pigmentation Disorder | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | LHGDN |
| umls:C3532239 | Mitochondrial cardiomyopathy | 1 | BeFree |
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