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| TissGeneSummary for KLK14 |
 Gene summary |
| Basic gene information | Gene symbol | KLK14 |
| Gene name | kallikrein-related peptidase 14 | |
| Synonyms | KLK-L6 | |
| Cytomap | UCSC genome browser: 19q13.3-q13.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022046.4, | |
| Description | hK14kallikrein 14kallikrein-14kallikrein-like protein 6 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606135 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129437 | ||
| HPRD : 05844 | ||
| Vega : OTTHUMG00000143721 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KLK14 | |
| BioGPS: 43847 | ||
| Pathway | NCI Pathway Interaction Database: KLK14 | |
| KEGG: KLK14 | ||
| REACTOME: KLK14 | ||
| Pathway Commons: KLK14 | ||
| Context | iHOP: KLK14 | |
| ligand binding site mutation search in PubMed: KLK14 | ||
| UCL Cancer Institute: KLK14 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of KLK14 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006508 | proteolysis | 15654974 | GO:0009566 | fertilization | 18482984 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | 16885167 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 16885167 | GO:0048730 | epidermis morphogenesis | 17158887 | GO:0070684 | seminal clot liquefaction | 18482984 | GO:0006508 | proteolysis | 15654974 | GO:0009566 | fertilization | 18482984 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | 16885167 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 16885167 | GO:0048730 | epidermis morphogenesis | 17158887 | GO:0070684 | seminal clot liquefaction | 18482984 |
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| TissGeneExp for KLK14 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.895373897 | -0.587748458 | -1.307625439 | 5.77E-06 | 1.45E-05 |
| LUAD | -2.399984907 | -1.37601939 | -1.023965517 | 0.0085 | 0.015338294 |
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| TissGene-miRNA for KLK14 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KLK14 |
| TissGeneSNV for KLK14 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q33R | PCPG | 2 |
| p.R64H | LGG | 2 |
| p.D125N | SKCM | 1 |
| p.V249I | LUAD | 1 |
| p.R265W | THYM | 1 |
| p.R112H | GBM | 1 |
| p.I171N | KIRC | 1 |
| p.N39D | BRCA | 1 |
| p.R160X | PRAD | 1 |
| p.A28V | SKCM | 1 |
| p.L19I | PRAD | 1 |
| p.R64H | THCA | 1 |
| p.Q90* | SKCM | 1 |
| p.T263M | UCEC | 1 |
| p.D219G | KIRP | 1 |
| p.S169R | STAD | 1 |
| p.T115R | SKCM | 1 |
| p.R112S | TGCT | 1 |
| p.R112C | SKCM | 1 |
| p.A176T | UCEC | 1 |
| p.S220C | BRCA | 1 |
| p.Y174S | LIHC | 1 |
| p.H45Y | SKCM | 1 |
| p.S215C | BLCA | 1 |
| p.P145L | SKCM | 1 |
| p.Q25H | KIRC | 1 |
| p.T200M | PAAD | 1 |
| p.R122Q | SKCM | 1 |
| p.A23T | ESCA | 1 |
| p.H45Y | PCPG | 1 |
| p.R160* | PRAD | 1 |
| p.Q210H | LUAD | 1 |
| p.V204A | BLCA | 1 |
| p.R112H | BLCA | 1 |
| p.H45Y | COAD | 1 |
| p.G221W | BLCA | 1 |
| p.L3Q | LUAD | 1 |
| p.D219G | SKCM | 1 |
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| TissGeneCNV for KLK14 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KLK14 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KLK14 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for KLK14 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KLK14 |
| TissGeneDrug for KLK14 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KLK14 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 6 | BeFree |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 6 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 4 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 3 | LHGDN |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree,LHGDN |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0007112 | Adenocarcinoma of prostate | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0039590 | Testicular Neoplasms | 1 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0971858 | Arthritis, Collagen-Induced | 1 | BeFree |
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